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ONTOLOGY REPORT - ANNOTATIONS

Term:TRAIL-activated apoptotic signaling pathway
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Accession:GO:0036462 term browser browse the term
Definition:An extrinsic apoptotic signaling pathway initiated by the binding of the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) to a death receptor on the cell surface.
Synonyms:exact_synonym: TRAIL-activated extrinsic apoptotic signaling pathway;   TRAIL-induced apoptotic signaling pathway;   tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway


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TRAIL-activated apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP8 caspase 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:88,490,611...88,542,132
Ensembl chr2B:206,669,544...206,696,468 		JBrowse link
G FADD Fas associated via death domain involved_in ISO (PMID:21785459) ParkinsonsUK-UCL PMID:21785459 NCBI chr11:65,300,889...65,305,020 JBrowse link
G SPI1 Spi-1 proto-oncogene acts_upstream_of_positive_effect
involved_in		 ISO
IEA		 (PMID:28362429) ARUK-UCL
Ensembl		 PMID:28362429 GO_REF:0000107 NCBI chr11:47,301,245...47,326,891
Ensembl chr11:47,853,991...47,880,259 		JBrowse link
G TNFRSF10A TNF receptor superfamily member 10a involved_in IEA UniProt
TreeGrafter
Ensembl		 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:22,440,502...22,476,790
Ensembl chr 8:19,378,547...19,414,724 		JBrowse link
G TNFRSF10B TNF receptor superfamily member 10b involved_in IEA UniProt
TreeGrafter
Ensembl		 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:22,270,325...22,318,841
Ensembl chr 8:19,209,904...19,258,498 		JBrowse link
G TNFRSF10C TNF receptor superfamily member 10c involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 8:22,352,777...22,368,737
Ensembl chr 8:19,292,020...19,307,719 		JBrowse link
G TNFSF10 TNF superfamily member 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:169,512,491...169,530,706
Ensembl chr 3:177,694,021...177,712,137 		JBrowse link
G TRADD TNFRSF1A associated via death domain involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:47,499,881...47,506,220
Ensembl chr16:66,889,006...66,891,016 		JBrowse link
G ZDHHC3 zinc finger DHHC-type palmitoyltransferase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:44,816,359...44,877,318
Ensembl chr 3:45,880,773...45,931,695 		JBrowse link
negative regulation of TRAIL-activated apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PARK7 Parkinsonism associated deglycase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:6,722,260...6,745,915
Ensembl chr 1:7,969,280...7,993,271 		JBrowse link
positive regulation of TRAIL-activated apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF3 activating transcription factor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:188,176,728...188,188,842
Ensembl chr 1:193,036,793...193,049,150 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16644
    cellular process 16207
      signal transduction 5476
        apoptotic signaling pathway 652
          extrinsic apoptotic signaling pathway 244
            extrinsic apoptotic signaling pathway via death domain receptors 83
              TRAIL-activated apoptotic signaling pathway 11
                TRAIL death-inducing signaling complex assembly 0
                negative regulation of TRAIL-activated apoptotic signaling pathway 1
                positive regulation of TRAIL-activated apoptotic signaling pathway 1
                regulation of TRAIL-activated apoptotic signaling pathway + 2
Path 2
Term Annotations click to browse term
  biological_process 16644
    biological regulation 11629
      regulation of biological process 11252
        regulation of cellular process 10895
          signal transduction 5476
            apoptotic signaling pathway 652
              extrinsic apoptotic signaling pathway 244
                extrinsic apoptotic signaling pathway via death domain receptors 83
                  TRAIL-activated apoptotic signaling pathway 11
                    TRAIL death-inducing signaling complex assembly 0
                    negative regulation of TRAIL-activated apoptotic signaling pathway 1
                    positive regulation of TRAIL-activated apoptotic signaling pathway 1
                    regulation of TRAIL-activated apoptotic signaling pathway + 2
paths to the root