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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:TRIF-dependent toll-like receptor signaling pathway
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Accession:GO:0035666 term browser browse the term
Definition:The series of molecular signals initiated by a ligand binding to a toll-like receptor where the TRIF adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response.
Synonyms:exact_synonym: TRIF-dependent TLR signaling pathway;   TRIF-dependent toll-like receptor signalling pathway;   Toll/IL-1 receptor (TIR) domain-containing adaptor-dependent TLR signaling pathway


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TRIF-dependent toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd274 CD274 molecule involved_in ISO (PMID:36232715) RGD PMID:36232715 NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450 		JBrowse link
G Cd300lf Cd300 molecule-like family member F involved_in ISO
ISS		 (PMID:22043923)
GO_REF:0000024		 RGD
UniProt		 PMID:22043923 GO_REF:0000024 NCBI chr10:100,359,942...100,376,130
Ensembl chr10:100,359,943...100,376,041 		JBrowse link
G Irf3 interferon regulatory factor 3 involved_in ISO (PMID:25636800) RGD PMID:25636800 NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935 		JBrowse link
G Ticam1 TIR domain containing adaptor molecule 1 involved_in ISO (PMID:25636800)
(MGI:3718934|PMID:17658277)		 RGD PMID:17658277 PMID:25636800 MGI:3718934 NCBI chr 9:1,102,559...1,111,023
Ensembl chr 9:1,102,366...1,123,147 		JBrowse link
G Ticam2 TIR domain containing adaptor molecule 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr18:39,289,902...39,311,462
Ensembl chr18:39,294,453...39,311,462 		JBrowse link
G Tlr4 toll-like receptor 4 involved_in IEA
ISO		 GO_REF:0000107
UniProtKB:Q9EPW9 (MGI:4438693|PMID:20037584)		 Ensembl
RGD		 PMID:20037584 GO_REF:0000107 MGI:4438693 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tlr6 toll-like receptor 6 involved_in ISO UniProtKB:Q9QUK6 (MGI:4438693|PMID:20037584) RGD PMID:20037584 MGI:4438693 NCBI chr14:43,362,164...43,374,500
Ensembl chr14:43,362,164...43,375,685 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19692
    immune system process 2822
      activation of immune response 557
        activation of innate immune response 302
          innate immune response-activating signaling pathway 276
            pattern recognition receptor signaling pathway 264
              toll-like receptor signaling pathway 78
                MyD88-independent toll-like receptor signaling pathway 13
                  TRIF-dependent toll-like receptor signaling pathway 7
                    TRIF-dependent toll-like receptor 4 signaling pathway 0
Path 2
Term Annotations click to browse term
  biological_process 19692
    response to stimulus 10511
      response to biotic stimulus 1869
        response to external biotic stimulus 1825
          response to other organism 1821
            defense response to other organism 1277
              defense response to symbiont 1142
                innate immune response 961
                  regulation of innate immune response 453
                    positive regulation of innate immune response 373
                      activation of innate immune response 302
                        innate immune response-activating signaling pathway 276
                          pattern recognition receptor signaling pathway 264
                            toll-like receptor signaling pathway 78
                              MyD88-independent toll-like receptor signaling pathway 13
                                TRIF-dependent toll-like receptor signaling pathway 7
                                  TRIF-dependent toll-like receptor 4 signaling pathway 0
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