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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:interleukin-18-mediated signaling pathway
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Accession:GO:0035655 term browser browse the term
Definition:The series of molecular signals initiated by interleukin-18 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: interleukin-18-mediated signalling pathway
 xref: Reactome:R-HSA-9012546 "Interleukin-18 signaling"

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interleukin-18-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 involved_in ISO (PMID:21321938) BHF-UCL PMID:21321938 NCBI chrNW_004955538:3,208,711...3,224,386
Ensembl chrNW_004955538:3,208,710...3,229,904 		JBrowse link
G Il18 interleukin 18 involved_in
acts_upstream_of_or_within		 ISO (PMID:14528293), (PMID:21321938), (PMID:25500532), (PMID:37993714)
(PMID:30392956)
(PMID:15843532)		 UniProt
MGI		 PMID:14528293 PMID:15843532 PMID:21321938 PMID:25500532 PMID:30392956 More... NCBI chrNW_004955412:13,807,361...13,826,007
Ensembl chrNW_004955412:13,806,553...13,825,634 		JBrowse link
G Il18r1 interleukin 18 receptor 1 involved_in
acts_upstream_of_or_within		 ISO (PMID:25500532)
(PMID:10227969)		 UniProt
MGI		 PMID:10227969 PMID:25500532 NCBI chrNW_004955470:7,854,995...7,887,810
Ensembl chrNW_004955470:7,854,988...7,887,883 		JBrowse link
G Il18rap interleukin 18 receptor accessory protein involved_in
acts_upstream_of_or_within		 ISO (PMID:25500532)
(PMID:15843532)		 UniProt
MGI		 PMID:15843532 PMID:25500532 NCBI chrNW_004955470:7,894,900...7,923,653
Ensembl chrNW_004955470:7,893,329...7,923,744 		JBrowse link
G Pdgfb platelet derived growth factor subunit B involved_in ISO (PMID:21321938) BHF-UCL PMID:21321938 NCBI chrNW_004955413:25,150,702...25,166,987
Ensembl chrNW_004955413:25,148,062...25,166,987 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 involved_in ISO (PMID:21321938) BHF-UCL PMID:21321938 NCBI chrNW_004955446:1,020,707...1,098,327
Ensembl chrNW_004955446:1,020,043...1,098,820 		JBrowse link
negative regulation of interleukin-18-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyld CYLD lysine 63 deubiquitinase involved_in ISO (PMID:32424362) UniProt PMID:32424362 NCBI chrNW_004955433:8,788,867...8,845,925
Ensembl chrNW_004955433:8,788,655...8,845,925 		JBrowse link
positive regulation of interleukin-18-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC102006100 TIR domain-containing adapter molecule 2 involved_in ISO (PMID:22685567) UniProt PMID:22685567 NCBI chrNW_004955408:35,342,733...35,382,821
Ensembl chrNW_004955408:35,374,508...35,382,314 		JBrowse link
G Nlrp6 NLR family pyrin domain containing 6 involved_in ISO (PMID:33377178), (PMID:34161762)
(PMID:30392956), (PMID:34678144)
(PMID:26638072)		 UniProt PMID:26638072 PMID:30392956 PMID:33377178 PMID:34161762 PMID:34678144 NCBI chrNW_004955476:11,755,489...11,762,781 JBrowse link
G Ticam2 toll like receptor adaptor molecule 2 involved_in ISO (PMID:22685567) UniProt PMID:22685567 NCBI chrNW_004955411:31,010,373...31,042,321 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12561
    cellular process 12000
      signal transduction 4038
        cell surface receptor signaling pathway 2194
          cytokine-mediated signaling pathway 352
            interleukin-18-mediated signaling pathway 10
              negative regulation of interleukin-18-mediated signaling pathway 1
              positive regulation of interleukin-18-mediated signaling pathway 3
              regulation of interleukin-18-mediated signaling pathway + 4
Path 2
Term Annotations click to browse term
  biological_process 12561
    response to stimulus 6776
      response to chemical 3518
        response to peptide 936
          response to cytokine 919
            cellular response to cytokine stimulus 800
              cytokine-mediated signaling pathway 352
                interleukin-18-mediated signaling pathway 10
                  negative regulation of interleukin-18-mediated signaling pathway 1
                  positive regulation of interleukin-18-mediated signaling pathway 3
                  regulation of interleukin-18-mediated signaling pathway + 4
paths to the root