Ticam2 (toll like receptor adaptor molecule 2)

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Gene: Ticam2 (toll like receptor adaptor molecule 2) Chinchilla lanigera

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Symbol:

Ticam2

Name:

toll like receptor adaptor molecule 2

RGD ID:

8917974

Description:

ENCODES a protein that exhibits molecular adaptor activity (ortholog); phospholipid binding (ortholog); INVOLVED IN cellular response to lipopolysaccharide (ortholog); defense response to virus (ortholog); negative regulation of chemokine (C-C motif) ligand 5 production (ortholog); PARTICIPATES IN interleukin-1 signaling pathway; Toll-like receptor signaling pathway; ASSOCIATED WITH autistic disorder (ortholog); Brain Injuries (ortholog); Coronavirus infectious disease (ortholog); FOUND IN early endosome (ortholog); endoplasmic reticulum (ortholog); endosome (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

TIR domain-containing adapter molecule 2; toll-like receptor adaptor molecule 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955411	31,010,373 - 31,042,321 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

Brain Injuries (ISO)

Coronavirus infectious disease (ISO)

familial adenomatous polyposis 1 (ISO)

Hereditary Neoplastic Syndromes (ISO)

Neurodevelopmental Disorders (ISO)

severe acute respiratory syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to lipopolysaccharide (ISO)

defense response to virus (ISO)

negative regulation of chemokine (C-C motif) ligand 5 production (ISO)

negative regulation of toll-like receptor 4 signaling pathway (ISO)

phagocytosis (ISO)

positive regulation of canonical NF-kappaB signal transduction (ISO)

positive regulation of chemokine (C-C motif) ligand 5 production (ISO)

positive regulation of interleukin-18-mediated signaling pathway (ISO)

positive regulation of interleukin-6 production (ISO)

positive regulation of toll-like receptor 4 signaling pathway (ISO)

positive regulation of type I interferon production (ISO)

positive regulation of type II interferon production (ISO)

regulation of cytokine production (ISO)

response to interleukin-12 (ISO)

toll-like receptor 4 signaling pathway (ISO)

TRAM-dependent toll-like receptor 4 signaling pathway (ISO)

Cellular Component

early endosome (ISO)

endoplasmic reticulum (ISO)

endosome (ISO)

endosome membrane (ISO)

late endosome (ISO)

phagocytic cup (ISO)

plasma membrane (ISO)

Molecular Function

molecular adaptor activity (ISO)

phospholipid binding (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

interleukin-1 signaling pathway (ISO)

Toll-like receptor signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Ticam2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955411	31,010,373 - 31,042,321 (-)	NCBI	ChiLan1.0	ChiLan1.0

TICAM2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	115,578,496 - 115,602,479 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	115,578,496 - 115,602,479 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	114,914,193 - 114,938,176 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	114,942,247 - 114,989,610 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	114,942,246 - 114,989,610	NCBI
Celera	5	110,863,614 - 110,887,385 (-)	NCBI		Celera
Cytogenetic Map	5	q22.3	NCBI
HuRef	5	110,095,959 - 110,119,799 (-)	NCBI		HuRef
CHM1_1	5	114,346,984 - 114,370,822 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	116,091,278 - 116,115,262 (-)	NCBI		T2T-CHM13v2.0

Ticam2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	46,691,298 - 46,707,600 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	46,690,358 - 46,707,600 (-)	Ensembl		GRCm39 Ensembl
GRCm38	18	46,558,231 - 46,574,533 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	46,557,291 - 46,574,533 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	46,717,885 - 46,734,187 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	18	46,683,562 - 46,699,863 (-)	NCBI		MGSCv36	mm8
Celera	18	47,917,939 - 47,934,160 (-)	NCBI		Celera
Cytogenetic Map	18	C	NCBI
cM Map	18	24.65	NCBI

Ticam2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	41,481,057 - 41,498,065 (-)	NCBI		GRCr8
mRatBN7.2	18	39,289,902 - 39,311,462 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	39,294,453 - 39,311,462 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	41,327,671 - 41,344,679 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	42,029,916 - 42,046,922 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	39,823,033 - 39,840,039 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	40,555,106 - 40,572,569 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	40,555,106 - 40,572,241 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	40,209,745 - 40,226,880 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	40,776,776 - 40,793,784 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	40,816,374 - 40,845,336 (-)	NCBI
Celera	18	37,546,471 - 37,563,478 (-)	NCBI		Celera
Cytogenetic Map	18	q11	NCBI

TICAM2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	110,826,244 - 110,849,848 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	108,979,905 - 109,003,465 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	110,935,649 - 110,960,019 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	116,732,191 - 116,734,854 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	116,734,092 - 116,734,799 (-)	Ensembl	panpan1.1		panPan2

TICAM2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	5,312,383 - 5,313,099 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	5,312,383 - 5,313,099 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	5,462,955 - 5,463,671 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	5,304,440 - 5,305,156 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	5,302,447 - 5,322,914 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	5,259,716 - 5,260,432 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	5,328,878 - 5,329,594 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	5,582,378 - 5,583,094 (-)	NCBI		UU_Cfam_GSD_1.0

Ticam2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	128,041,670 - 128,065,968 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936742	744,570 - 745,277 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936742	743,191 - 745,332 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TICAM2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	2	119,758,622 - 119,778,650 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	124,610,898 - 124,613,028 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TICAM2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	18,831,361 - 18,855,476 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	18,833,262 - 18,833,969 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666034	59,542,795 - 59,566,451 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013510720	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01012265	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDJ01125148	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_013510720 ⟹ XP_013366174

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955411	31,010,373 - 31,042,321 (-)	NCBI

Sequence:

show sequence

ATTATTCTCACTTAGCTCAAGCCACCAAAGGATGGGTTCCTGGGGAGGGTAAAGAAACACTATT
GAAAATAGAAAGTAATTTAAAAGTTTTCCCTGGGGTGTATACACCTTTCTCAGGCATACTGAAC
TCTCTCAGTGCCGTATGTGGTTGAAACACAGAGATAACAGGCCAAACTTTTTCATAATACAAAC
TGTGGAAAGTAAAGTTACAGCAATCCTTTCTACTGGATCTTCGGAAAATGATGAGAAATGGTGC
GGACAGAGAAATCAGTCAAAGAAGTCTTGGAAATTCTAAATAAGATGCTGCATCAGCAGTTGCT
CAAAAAGAAACAGTTTTCTAGGAGCCAGGGATTATCCTCACTAAAAGACAATTGAAAACTGATA
GCTAAAGTGACTTTTGTTTGACAAGGACATTGTCACTGTTGACAGGAATGACTGGCAGGGTGGA
AAAAGCAGGGTAGGCCATGAAGCTTCTCAGAAAGACTTCAGAGGAAATTGGACACCTTTGAAAC
CACAGGTGTGAAGAGTCGCAGCATGGCTACAAGTCAAGGCCATCTGGAGCCTAAGCGCATGAAG
CCTGAAGCTGTCTCCTTGTGCAATGTTGGGGAACAGAACAATACAGCAGAGGAGCAGACAGGGG
AACAAGAGGAAGCCAAAGTGGGAGAAGAGATTCCCAAAAGGGAAGCAGAAGAGGTGTTCCTCAA
ATTTGTGATCCTACACGCAGAAGATGATATATGTGAGACCCTGAGAGTCCAGGAACTGCTACAA
AATGACTTTGGTATCAAGCTTAGGATAATCTTTGCTGAAATGCTGCGTGGCAGGCAGCATTTAC
AGAATTTGGATGATTCCATAAATGGGTCTGCATGGACAATCTTATTACTTACTGAAAACTTTTT
GAGAAATACTTGGTGTAATTTCCAATTCTATACATCTCTAATGAATTCTGTGGACAGGCAACAC
AAATACAATTCCATTATACCCATGCAGCCCCTGAACAACCCTCTTCCTCGAGAAAGGACTCCCT
TTGTGCTACAAACCATCAATGCCTTAGAAGAAGAAAGTCATGGATTTTCTACACAGGCAGAAAG
AATTTCTCAGGAGTCTGTGTATAAGACACAACAAACTAGATGGAAGGAACAAGAAAGATGGCCC
CATGACAATTTATTGCCTGAGATGAAGTGTGCAACACACAGCTGCCTTCTGTTTTGCAAACCAT
GTAAATCATTAATCAGGTAG

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Protein Sequences


Protein RefSeqs	XP_013366174	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_013366174 ⟸ XM_013510720

- Sequence:

show sequence

MATSQGHLEPKRMKPEAVSLCNVGEQNNTAEEQTGEQEEAKVGEEIPKREAEEVFLKFVILHAE
DDICETLRVQELLQNDFGIKLRIIFAEMLRGRQHLQNLDDSINGSAWTILLLTENFLRNTWCNF
QFYTSLMNSVDRQHKYNSIIPMQPLNNPLPRERTPFVLQTINALEEESHGFSTQAERISQESVY
KTQQTRWKEQERWPHDNLLPEMKCATHSCLLFCKPCKSLIR

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Additional Information

External Database Links

Database	Acc Id	Source(s)
NCBI Gene	LOC102003848	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-12-20	Ticam2	toll like receptor adaptor molecule 2	Ticam2	toll-like receptor adaptor molecule 2	Data merged from RGD:8927063	737654	PROVISIONAL
2016-08-03	Ticam2	toll like receptor adaptor molecule 2		toll-like receptor adaptor molecule 2	Symbol and/or name change	5135510	APPROVED
2015-08-25	Ticam2	toll-like receptor adaptor molecule 2	LOC102003848	TIR domain-containing adapter molecule 2-like	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

RGD Manual Annotations

Imported Annotations - PID (archival)