Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ONTOLOGY REPORT - ANNOTATIONS

Term:VCP-NPL4-UFD1 AAA ATPase complex
go back to main search page
Accession:GO:0034098 term browser browse the term
Definition:A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins. In mammals, this complex includes a hexamer of VCP/p97 (a cytosolic ATPase) and trimers of each of its cofactors UFD1L and NPL4 (NPLOC4) (e.g. a 6:3:3 stoichiometry).
Synonyms:exact_synonym: p97-Ufd1-Npl4 complex
 narrow_synonym: Cdc48p-Npl4p-Ufd1p AAA ATPase complex


show annotations for term's descendants           Sort by:
VCP-NPL4-UFD1 AAA ATPase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07034438.1 part_of IEA GO_REF:0000107 Ensembl GO_REF:0000107 Ensembl chr11:68,398,182...68,460,080 JBrowse link
G Faf1 Fas associated factor 1 part_of ISO
IEA		 (PMID:18775313)
GO_REF:0000107		 RGD
Ensembl		 PMID:18775313 GO_REF:0000107 NCBI chr 5:124,426,032...124,790,014
Ensembl chr 5:124,426,062...124,789,977 		JBrowse link
G Faf2 Fas associated factor family member 2 part_of ISO
IEA		 (PMID:18775313)
GO_REF:0000107		 RGD
Ensembl		 PMID:18775313 GO_REF:0000107 NCBI chr17:9,947,211...9,989,474
Ensembl chr17:9,947,220...9,989,485 		JBrowse link
G Nploc4 NPL4 homolog, ubiquitin recognition factor part_of
located_in		 IDA
ISO
NAS
IEA
EXP		 PMID:17000876
(PMID:26471729)
PMID:18775313
PMID:12847084
PMID:10811609
GO_REF:0000107
(PMID:20414249)
PMID:22232657
(MGI:5914283|PMID:22232657)		 RGD
Ensembl		 PMID:20414249 PMID:22232657 PMID:26471729 PMID:17000876 PMID:18775313 More... GO_REF:0000107 MGI:5914283, RGD:10047192, RGD:8554384, RGD:10047330, RGD:633500, RGD:13432281 NCBI chr10:105,654,395...105,709,958
Ensembl chr10:105,654,812...105,709,913 		JBrowse link
G Rnf125 ring finger protein 125 part_of ISO (PMID:26471729) RGD PMID:26471729 NCBI chr18:12,254,066...12,275,719
Ensembl chr18:12,253,852...12,275,983 		JBrowse link
G Ubxn1 UBX domain protein 1 part_of ISO (PMID:18775313) RGD PMID:18775313 NCBI chr 1:205,765,309...205,769,234
Ensembl chr 1:205,745,120...205,816,520 		JBrowse link
G Ubxn7 UBX domain protein 7 part_of ISO (PMID:18775313) RGD PMID:18775313 NCBI chr11:68,427,896...68,460,100 JBrowse link
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 part_of
located_in		 IPI
ISO
IDA
EXP
IEA
IBA		 PMID:12847084
(PMID:26471729)
PMID:10811609
(PMID:20414249)
PMID:22232657
GO_REF:0000107
GO_REF:0000033
(MGI:5634894|PMID:10811609), (MGI:5640950|PMID:17000876), (MGI:5914283|PMID:22232657)		 RGD
Ensembl
GO_Central		 PMID:10811609 PMID:17000876 PMID:20414249 PMID:22232657 PMID:26471729 More... GO_REF:0000033 GO_REF:0000107 MGI:5634894 MGI:5640950 MGI:5914283, RGD:10047330, RGD:633500, RGD:13432281 NCBI chr11:82,161,618...82,185,107
Ensembl chr11:82,161,619...82,185,087 		JBrowse link
G Vcp valosin-containing protein part_of
located_in		 IDA
ISO
EXP
IBA		 PMID:10811609
(PMID:20414249)
PMID:22232657
GO_REF:0000033
UniProtKB:Q9ES53 (MGI:5634892|PMID:12847084), (MGI:5634894|PMID:10811609), (MGI:5640950|PMID:17000876), (MGI:5914283|PMID:22232657)		 RGD
GO_Central		 PMID:10811609 PMID:12847084 PMID:17000876 PMID:20414249 PMID:22232657 More... GO_REF:0000033 MGI:5634892 MGI:5634894 MGI:5640950 MGI:5914283, RGD:633500, RGD:13432281 NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20624
    protein-containing complex 6602
      endoplasmic reticulum protein-containing complex 139
        VCP-NPL4-UFD1 AAA ATPase complex 9
Path 2
Term Annotations click to browse term
  cellular_component 20624
    cellular anatomical entity 20386
      organelle 13799
        intracellular organelle 13391
          intracellular membrane-bounded organelle 11845
            endoplasmic reticulum 1866
              endoplasmic reticulum subcompartment 1063
                endoplasmic reticulum membrane 1053
                  VCP-NPL4-UFD1 AAA ATPase complex 9
paths to the root