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ONTOLOGY REPORT - ANNOTATIONS

Term:T cell receptor V(D)J recombination
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Accession:GO:0033153 term browser browse the term
Definition:The process in which T cell receptor V, D, and J, or V and J gene segments, depending on the specific locus, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS).
Synonyms:exact_synonym: TCR V(D)J recombination
 narrow_synonym: T cell receptor V-D-J joining;   T cell receptor V-J joining;   T cell receptor V-J recombination


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T cell receptor V(D)J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl11b BCL11 transcription factor B acts_upstream_of_or_within ISO MGI:2663971 (PMID:12717433) RGD PMID:12717433 NCBI chr 6:126,834,531...126,927,720 JBrowse link
G Lef1 lymphoid enhancer binding factor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:98507 (PMID:9462507)		 Ensembl
RGD		 PMID:9462507 GO_REF:0000107 NCBI chr 2:219,666,549...219,779,815 JBrowse link
G Lig4 DNA ligase 4 acts_upstream_of_or_within ISO MGI:1857732 (PMID:10911993) RGD PMID:10911993 NCBI chr16:79,518,393...79,526,956 JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit acts_upstream_of_or_within ISO MGI:2383951 (PMID:9768755) RGD PMID:9768755 NCBI chr11:98,544,952...98,762,499 JBrowse link
G Tcf7 transcription factor 7 acts_upstream_of_or_within ISO MGI:96770 (PMID:9462507) RGD PMID:9462507 NCBI chr10:36,423,443...36,454,350 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20536
    immune system process 3112
      somatic diversification of immune receptors 87
        somatic diversification of immune receptors via germline recombination within a single locus 80
          somatic recombination of T cell receptor gene segments 5
            T cell receptor V(D)J recombination 5
Path 2
Term Annotations click to browse term
  biological_process 20536
    developmental process 7109
      cellular developmental process 4812
        cell differentiation 4811
          cell development 3339
            hemopoiesis 1079
              leukocyte differentiation 685
                mononuclear cell differentiation 549
                  lymphocyte differentiation 446
                    T cell differentiation 332
                      somatic diversification of T cell receptor genes 5
                        somatic recombination of T cell receptor gene segments 5
                          T cell receptor V(D)J recombination 5
paths to the root