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ONTOLOGY REPORT - ANNOTATIONS

Term:somatic diversification of immune receptors
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Accession:GO:0002200 term browser browse the term
Definition:The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences.
Comment:Note that this process covers somatic recombination, gene conversion, hypermutation, N-region addition, and alternate splicing processes of immune receptor diversification.

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immunoglobulin heavy chain V-D-J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Polb DNA polymerase beta ISO MGI:5427084 (MGI:5553198|PMID:24388753) RGD PMID:24388753 MGI:5553198 NCBI chr16:74,237,001...74,260,272
Ensembl chr16:74,237,001...74,260,271 		JBrowse link
G Yy1 YY1 transcription factor ISO
IEA		 MGI:3624790 (MGI:5484711|PMID:23531880)
GO_REF:0000107		 RGD
Ensembl		 PMID:23531880 GO_REF:0000107 MGI:5484711 NCBI chr 6:132,702,443...132,726,848
Ensembl chr 6:132,702,448...132,727,046 		JBrowse link
immunoglobulin V(D)J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp1 forkhead box P1 ISO MGI:3711150 (MGI:3662963|PMID:16819554) RGD PMID:16819554 MGI:3662963 NCBI chr 4:131,362,178...131,963,466
Ensembl chr 4:131,366,744...131,694,755 		JBrowse link
G Lig4 DNA ligase 4 involved_in ISO
IBA		 MGI:1857732 (MGI:1312981|PMID:9823897)
PMID:21873635		 RGD PMID:9823897, PMID:21873635, PMID:21873635 MGI:1312981, RGD:13792537, RGD:13792537 NCBI chr16:85,331,771...85,339,496
Ensembl chr16:85,331,866...85,337,769 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit involved_in ISO
IBA		 MGI:2383951 (MGI:1290043|PMID:9768755)
PMID:21873635		 RGD PMID:9768755, PMID:21873635, PMID:21873635 MGI:1290043, RGD:13792537, RGD:13792537 NCBI chr11:89,293,547...89,510,948
Ensembl chr11:89,293,696...89,510,871 		JBrowse link
G Tcf3 transcription factor 3 involved_in ISO
IBA		 (PMID:16428437)
PMID:21873635
MGI:2178112 (MGI:3615721|PMID:16428437)		 RGD PMID:16428437, PMID:21873635, PMID:21873635 MGI:3615721, RGD:13792537, RGD:13792537 NCBI chr 7:12,146,642...12,168,400
Ensembl chr 7:12,144,162...12,168,410 		JBrowse link
G Xrcc4 X-ray repair cross complementing 4 involved_in ISO
IBA		 MGI:1926771 (MGI:1913213|PMID:9875844)
PMID:21873635		 RGD PMID:9875844, PMID:21873635, PMID:21873635 MGI:1913213, RGD:13792537, RGD:13792537 NCBI chr 2:18,674,496...18,927,463
Ensembl chr 2:18,677,220...18,927,365 		JBrowse link
isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aicda activation-induced cytidine deaminase ISO (MGI:3761960|PMID:17713479), (MGI:5004983|PMID:21518874) RGD PMID:17713479 PMID:21518874 MGI:3761960 MGI:5004983 NCBI chr 4:155,359,909...155,371,104
Ensembl chr 4:155,359,921...155,369,671 		JBrowse link
G Atad5 ATPase family, AAA domain containing 5 ISO
IEA		 MGI:4127920 (MGI:5763555|PMID:25404367)
GO_REF:0000107		 RGD
Ensembl		 PMID:25404367 GO_REF:0000107 MGI:5763555 NCBI chr10:67,427,042...67,475,825
Ensembl chr10:67,427,066...67,473,649 		JBrowse link
G Batf basic leucine zipper ATF-like transcription factor involved_in ISS
ISO		 GO_REF:0000024
(MGI:4456325|PMID:20421391), (MGI:5004732|PMID:21572431)		 UniProt
RGD		 PMID:20421391 PMID:21572431 GO_REF:0000024 MGI:4456325 MGI:5004732 NCBI chr 6:109,562,415...109,584,541
Ensembl chr 6:109,562,587...109,584,545 		JBrowse link
G Cd40lg CD40 ligand involved_in IEA
ISO		 GO_REF:0000107
(MGI:3687427|PMID:7529792)		 Ensembl
RGD		 PMID:7529792 GO_REF:0000107 MGI:3687427 NCBI chr  X:159,703,703...159,714,886
Ensembl chr  X:159,703,578...159,716,562 		JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit ISO MGI:2183944 (MGI:3052883|PMID:15280420) RGD PMID:15280420 MGI:3052883 NCBI chr 1:80,256,973...80,268,198
Ensembl chr 1:80,256,973...80,268,198 		JBrowse link
G Exo1 exonuclease 1 ISO MGI:2653925 (MGI:3028407|PMID:14716311) RGD PMID:14716311 MGI:3028407 NCBI chr13:93,936,989...93,962,749
Ensembl chr13:93,939,022...93,960,342 		JBrowse link
G Exosc3 exosome component 3 ISO (MGI:5009766|PMID:21255825) RGD PMID:21255825 MGI:5009766 NCBI chr 5:60,866,498...60,871,734
Ensembl chr 5:60,868,502...60,871,705 		JBrowse link
G Exosc6 exosome component 6 ISO (MGI:5009766|PMID:21255825) RGD PMID:21255825 MGI:5009766 NCBI chr19:43,190,879...43,193,164
Ensembl chr19:43,191,390...43,192,208 		JBrowse link
G Lig4 DNA ligase 4 ISO MGI:1857732 (MGI:3761960|PMID:17713479) RGD PMID:17713479 MGI:3761960 NCBI chr16:85,331,771...85,339,496
Ensembl chr16:85,331,866...85,337,769 		JBrowse link
G Mlh1 mutL homolog 1 involved_in IEA
ISO		 GO_REF:0000107
MGI:1857946 (MGI:2662086|PMID:12743174)		 Ensembl
RGD		 PMID:12743174 GO_REF:0000107 MGI:2662086 NCBI chr 8:119,486,655...119,523,716
Ensembl chr 8:119,486,691...119,523,964 		JBrowse link
G Msh2 mutS homolog 2 involved_in IEA
ISO		 GO_REF:0000107
MGI:1857940|MGI:2151801 (MGI:1342394|PMID:10430621), (MGI:2662086|PMID:12743174)		 Ensembl
RGD		 PMID:10430621 PMID:12743174 GO_REF:0000107 MGI:1342394 MGI:2662086 NCBI chr 6:11,215,951...11,274,916
Ensembl chr 6:11,215,963...11,274,932 		JBrowse link
G Msh6 mutS homolog 6 ISO MGI:109352|MGI:3653701 (MGI:3641510|PMID:16618598), (MGI:3723381|PMID:17015724) RGD PMID:16618598 PMID:17015724 MGI:3641510 MGI:3723381 NCBI chr 6:11,644,565...11,662,389
Ensembl chr 6:11,644,578...11,662,499 		JBrowse link
G Nbn nibrin involved_in IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(MGI:3529405|PMID:15668383)		 Ensembl
UniProt
RGD		 PMID:15668383 GO_REF:0000024 GO_REF:0000107 MGI:3529405 NCBI chr 5:29,622,347...29,656,877
Ensembl chr 5:29,622,281...29,656,864 		JBrowse link
G Rnf168 ring finger protein 168 involved_in ISS
ISO		 GO_REF:0000024
(MGI:4420833|PMID:20080757)		 UniProt
RGD		 PMID:20080757 GO_REF:0000024 MGI:4420833 NCBI chr11:71,721,242...71,743,421
Ensembl chr11:71,721,250...71,743,421 		JBrowse link
G Rnf8 ring finger protein 8 involved_in ISS
ISO		 GO_REF:0000024
(MGI:4420833|PMID:20080757)		 UniProt
RGD		 PMID:20080757 GO_REF:0000024 MGI:4420833 NCBI chr20:8,285,380...8,309,858
Ensembl chr20:8,285,296...8,309,908 		JBrowse link
G Swap70 switching B-cell complex subunit SWAP70 ISO (MGI:1270060|PMID:9642267) RGD PMID:9642267 MGI:1270060 NCBI chr 1:174,862,683...174,924,101
Ensembl chr 1:174,862,698...174,924,078 		JBrowse link
G Ung uracil-DNA glycosylase ISO MGI:1343961 (MGI:3723381|PMID:17015724) RGD PMID:17015724 MGI:3723381 NCBI chr12:48,246,593...48,255,547
Ensembl chr12:48,246,569...48,254,822 		JBrowse link
G Xrcc4 X-ray repair cross complementing 4 ISO MGI:1926771|MGI:3047571|MGI:3641440 (MGI:3761960|PMID:17713479) RGD PMID:17713479 MGI:3761960 NCBI chr 2:18,674,496...18,927,463
Ensembl chr 2:18,677,220...18,927,365 		JBrowse link
isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr6 C-C motif chemokine receptor 6 ISO (MGI:5787846|PMID:27174992) RGD PMID:27174992 MGI:5787846 NCBI chr 1:53,063,380...53,087,519
Ensembl chr 1:53,065,025...53,087,474 		JBrowse link
isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hspd1 heat shock protein family D (Hsp60) member 1 involved_in ISO (PMID:16148103) RGD PMID:16148103 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956 		JBrowse link
negative regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Parp3 poly (ADP-ribose) polymerase family, member 3 ISO (MGI:6214451|PMID:26000965) RGD PMID:26000965 MGI:6214451 NCBI chr 8:115,173,440...115,179,543
Ensembl chr 8:115,173,453...115,179,191 		JBrowse link
negative regulation of isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Da2-19 uncharacterized LOC302729 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr  X:48,196,789...48,213,506
Ensembl chr  X:48,196,916...48,213,505 		JBrowse link
G Thoc1 THO complex 1 ISO (MGI:5520039|PMID:22144908) RGD PMID:22144908 MGI:5520039 NCBI chr18:1,142,540...1,177,084
Ensembl chr18:1,142,782...1,176,974 		JBrowse link
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6, transcription repressor ISO MGI:103034|MGI:2158438 (MGI:1345885|PMID:10490661) RGD PMID:10490661 MGI:1345885 NCBI chr11:80,255,790...80,279,075
Ensembl chr11:80,255,790...80,279,075 		JBrowse link
G Foxp3 forkhead box P3 ISO MGI:3696705 (MGI:3695768|PMID:16275384) RGD PMID:16275384 MGI:3695768 NCBI chr  X:15,753,175...15,768,648
Ensembl chr  X:15,753,175...15,768,522 		JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 ISO MGI:3695433 (MGI:3694584|PMID:17137798) RGD PMID:17137798 MGI:3694584 NCBI chr18:31,574,759...31,625,286
Ensembl chr18:31,574,821...31,625,274 		JBrowse link
positive regulation of interleukin-4-dependent isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnfsf4 TNF superfamily member 4 ISO (MGI:3763508|PMID:12496423) RGD PMID:12496423 MGI:3763508 NCBI chr13:79,269,973...79,293,775
Ensembl chr13:79,269,973...79,293,778 		JBrowse link
positive regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Exosc3 exosome component 3 ISO (MGI:5009766|PMID:21255825) RGD PMID:21255825 MGI:5009766 NCBI chr 5:60,866,498...60,871,734
Ensembl chr 5:60,868,502...60,871,705 		JBrowse link
G Exosc6 exosome component 6 ISO (MGI:5009766|PMID:21255825) RGD PMID:21255825 MGI:5009766 NCBI chr19:43,190,879...43,193,164
Ensembl chr19:43,191,390...43,192,208 		JBrowse link
G Hmces 5-hydroxymethylcytosine binding, ES cell specific involved_in ISS
ISO		 GO_REF:0000024
(MGI:6393148|PMID:31806351)		 UniProt
RGD		 PMID:31806351 GO_REF:0000024 MGI:6393148 NCBI chr 4:119,841,088...119,864,115
Ensembl chr 4:119,815,139...119,864,114 		JBrowse link
G Kmt5b lysine methyltransferase 5B involved_in ISS
ISO		 GO_REF:0000024
(MGI:6370097|PMID:28114273)		 UniProt
RGD		 PMID:28114273 GO_REF:0000024 MGI:6370097 NCBI chr 1:219,000,844...219,050,211
Ensembl chr 1:219,000,844...219,050,211 		JBrowse link
G Kmt5c lysine methyltransferase 5C involved_in ISS
ISO		 GO_REF:0000024
(MGI:6370097|PMID:28114273)		 UniProt
RGD		 PMID:28114273 GO_REF:0000024 MGI:6370097 NCBI chr 1:72,666,662...72,674,271
Ensembl chr 1:72,666,665...72,674,271 		JBrowse link
G Mad2l2 mitotic arrest deficient 2 like 2 involved_in ISO (PMID:29656893) RGD PMID:29656893 NCBI chr 5:164,943,183...164,956,255
Ensembl chr 5:164,950,917...164,956,255 		JBrowse link
G Paxip1 PAX interacting protein 1 ISO (MGI:4821506|PMID:20671152) RGD PMID:20671152 MGI:4821506 NCBI chr 4:3,956,931...4,008,326
Ensembl chr 4:3,959,640...4,008,326 		JBrowse link
G Rif1 replication timing regulatory factor 1 ISO (MGI:5468036|PMID:23306439), (MGI:5476381|PMID:23333305), (MGI:5490831|PMID:23333306) RGD PMID:23306439 PMID:23333305 PMID:23333306 MGI:5468036 MGI:5476381 MGI:5490831 NCBI chr 3:37,599,540...37,648,818
Ensembl chr 3:37,599,728...37,647,631 		JBrowse link
G Shld1 shieldin complex subunit 1 involved_in ISO
IBA		 (PMID:29656893)
PMID:21873635		 RGD PMID:29656893, PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr 3:125,318,682...125,396,705
Ensembl chr 3:125,320,680...125,396,821 		JBrowse link
G Shld2 shieldin complex subunit 2 involved_in ISO (PMID:29656893) RGD PMID:29656893 NCBI chr16:10,570,307...10,661,528
Ensembl chr16:10,570,314...10,661,528 		JBrowse link
G Shld3 shieldin complex subunit 3 involved_in ISO (PMID:29656893) RGD PMID:29656893
G Tfrc transferrin receptor involved_in ISO
ISS		 (PMID:26642240)
GO_REF:0000024		 RGD
UniProt		 PMID:26642240 GO_REF:0000024 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223 		JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 involved_in ISO (PMID:23345425), (PMID:23760478)
(MGI:3041657|PMID:15077110), (MGI:3046005|PMID:15159415)		 RGD PMID:15077110 PMID:15159415 PMID:23345425 PMID:23760478 MGI:3041657 MGI:3046005 NCBI chr 3:113,160,030...113,259,701
Ensembl chr 3:113,160,000...113,231,790 		JBrowse link
positive regulation of isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mlh1 mutL homolog 1 involved_in IEA
ISO		 GO_REF:0000107
(MGI:1342394|PMID:10430621)		 Ensembl
RGD		 PMID:10430621 GO_REF:0000107 MGI:1342394 NCBI chr 8:119,486,655...119,523,716
Ensembl chr 8:119,486,691...119,523,964 		JBrowse link
G Msh2 mutS homolog 2 involved_in IEA
ISO		 GO_REF:0000107
(MGI:1342394|PMID:10430621)		 Ensembl
RGD		 PMID:10430621 GO_REF:0000107 MGI:1342394 NCBI chr 6:11,215,951...11,274,916
Ensembl chr 6:11,215,963...11,274,932 		JBrowse link
G Nsd2 nuclear receptor binding SET domain protein 2 ISO (MGI:5462481|PMID:23241889) RGD PMID:23241889 MGI:5462481 NCBI chr14:82,119,210...82,196,501
Ensembl chr14:82,119,210...82,171,480 		JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component ISO UniProtKB:Q9JK91 (MGI:1342394|PMID:10430621) RGD PMID:10430621 MGI:1342394 NCBI chr12:12,714,394...12,738,654
Ensembl chr12:12,714,394...12,738,641 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in ISO
ISS		 (PMID:14988498)
GO_REF:0000024		 RGD
AgBase		 PMID:14988498 GO_REF:0000024 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Tnfsf13 TNF superfamily member 13 involved_in ISO
IBA		 (PMID:14988498)
PMID:21873635
MGI:3038886 (MGI:3037416|PMID:14988498)		 RGD PMID:14988498, PMID:21873635, PMID:21873635 MGI:3037416, RGD:13792537, RGD:13792537 NCBI chr10:56,286,964...56,290,680
Ensembl chr10:56,286,887...56,289,952 		JBrowse link
positive regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clcf1 cardiotrophin-like cytokine factor 1 ISO (MGI:3777853|PMID:12023368) RGD PMID:12023368 MGI:3777853 NCBI chr 1:219,468,866...219,472,445
Ensembl chr 1:219,468,675...219,472,654 		JBrowse link
G Il4 interleukin 4 involved_in ISO
IBA		 (MGI:3037416|PMID:14988498)
PMID:21873635		 RGD PMID:14988498, PMID:21873635, PMID:21873635 MGI:3037416, RGD:13792537, RGD:13792537 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 ISO MGI:107187 (MGI:1345885|PMID:10490661) RGD PMID:10490661 MGI:1345885 NCBI chr 7:70,946,228...70,963,542
Ensembl chr 7:70,946,228...70,964,484 		JBrowse link
positive regulation of isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atad5 ATPase family, AAA domain containing 5 ISO MGI:4127920 (MGI:5763555|PMID:25404367) RGD PMID:25404367 MGI:5763555 NCBI chr10:67,427,042...67,475,825
Ensembl chr10:67,427,066...67,473,649 		JBrowse link
G Cd28 Cd28 molecule IEA
ISO		 GO_REF:0000107
MGI:1857150 (MGI:62368|PMID:7688139)		 Ensembl
RGD		 PMID:7688139 GO_REF:0000107 MGI:62368 NCBI chr 9:67,546,408...67,573,858
Ensembl chr 9:67,546,408...67,571,871 		JBrowse link
G Cd40 CD40 molecule involved_in ISO
IBA		 (MGI:2670820|PMID:12882831)
PMID:21873635		 RGD PMID:12882831, PMID:21873635, PMID:21873635 MGI:2670820, RGD:13792537, RGD:13792537 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704 		JBrowse link
G Ifng interferon gamma ISO (MGI:2670820|PMID:12882831) RGD PMID:12882831 MGI:2670820 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Il2 interleukin 2 ISO MGI:1857191 (MGI:87443|PMID:1830926) RGD PMID:1830926 MGI:87443 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854 		JBrowse link
G Il4 interleukin 4 involved_in ISO
IBA		 (MGI:2670820|PMID:12882831), (MGI:3037416|PMID:14988498)
PMID:21873635		 RGD PMID:12882831 PMID:14988498, PMID:21873635, PMID:21873635 MGI:2670820 MGI:3037416, RGD:13792537, RGD:13792537 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531 		JBrowse link
G Mlh1 mutL homolog 1 involved_in IEA
ISO		 GO_REF:0000107
(MGI:1342394|PMID:10430621)		 Ensembl
RGD		 PMID:10430621 GO_REF:0000107 MGI:1342394 NCBI chr 8:119,486,655...119,523,716
Ensembl chr 8:119,486,691...119,523,964 		JBrowse link
G Msh2 mutS homolog 2 involved_in IEA
ISO		 GO_REF:0000107
(MGI:1342394|PMID:10430621)		 Ensembl
RGD		 PMID:10430621 GO_REF:0000107 MGI:1342394 NCBI chr 6:11,215,951...11,274,916
Ensembl chr 6:11,215,963...11,274,932 		JBrowse link
G Pagr1 Paxip1-associated glutamate-rich protein 1 ISO (MGI:5752090|PMID:26744420) RGD PMID:26744420 MGI:5752090 NCBI chr 1:198,448,790...198,451,078
Ensembl chr 1:198,449,040...198,450,688 		JBrowse link
G Paxip1 PAX interacting protein 1 ISO (MGI:5752090|PMID:26744420) RGD PMID:26744420 MGI:5752090 NCBI chr 4:3,956,931...4,008,326
Ensembl chr 4:3,959,640...4,008,326 		JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component ISO UniProtKB:Q9JK91 (MGI:1342394|PMID:10430621) RGD PMID:10430621 MGI:1342394 NCBI chr12:12,714,394...12,738,654
Ensembl chr12:12,714,394...12,738,641 		JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C ISO MGI:2181288 (MGI:85031|PMID:9015183) RGD PMID:9015183 MGI:85031 NCBI chr13:55,061,561...55,174,150
Ensembl chr13:55,061,562...55,173,692 		JBrowse link
G Tbx21 T-box transcription factor 21 ISO MGI:2180194 (MGI:2670820|PMID:12882831) RGD PMID:12882831 MGI:2670820 NCBI chr10:85,032,799...85,049,331
Ensembl chr10:85,032,799...85,049,331 		JBrowse link
regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aplf aprataxin and PNKP like factor ISO MGI:4128102 (MGI:4887518|PMID:21211721) RGD PMID:21211721 MGI:4887518 NCBI chr 4:119,514,822...119,568,764
Ensembl chr 4:119,514,840...119,568,736 		JBrowse link
G Mir181b1 microRNA 181b-1 ISO (MGI:3817382|PMID:18762567) RGD PMID:18762567 MGI:3817382 NCBI chr13:54,952,903...54,953,012
Ensembl chr13:54,952,903...54,953,012 		JBrowse link
G Mir181b2 microRNA 181b-2 ISO (MGI:3817382|PMID:18762567) RGD PMID:18762567 MGI:3817382 NCBI chr 3:23,151,455...23,151,542
Ensembl chr 3:23,151,455...23,151,542 		JBrowse link
G Supt6h SPT6 homolog, histone chaperone and transcription elongation factor ISO (MGI:5004983|PMID:21518874) RGD PMID:21518874 MGI:5004983 NCBI chr10:65,470,470...65,507,581
Ensembl chr10:65,470,471...65,507,581 		JBrowse link
regulation of isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 ISO MGI:3696705 (MGI:3695768|PMID:16275384) RGD PMID:16275384 MGI:3695768 NCBI chr  X:15,753,175...15,768,648
Ensembl chr  X:15,753,175...15,768,522 		JBrowse link
G Il27ra interleukin 27 receptor subunit alpha ISO MGI:3525439 (MGI:1926579|PMID:11057672) RGD PMID:11057672 MGI:1926579 NCBI chr19:25,151,835...25,163,995
Ensembl chr19:25,149,897...25,164,086 		JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 ISO MGI:3695433 (MGI:3694584|PMID:17137798) RGD PMID:17137798 MGI:3694584 NCBI chr18:31,574,759...31,625,286
Ensembl chr18:31,574,821...31,625,274 		JBrowse link
G Slc15a4 solute carrier family 15 member 4 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:5649169|PMID:25310967)		 UniProt
Ensembl
RGD		 PMID:25310967 GO_REF:0000024 GO_REF:0000107 MGI:5649169 NCBI chr12:32,753,824...32,773,277
Ensembl chr12:32,753,824...32,773,277 		JBrowse link
somatic diversification of immune receptors via somatic mutation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adar adenosine deaminase, RNA-specific involved_in IEA
ISO		 GO_REF:0000107
(MGI:5469797|PMID:23209284)		 Ensembl
RGD		 PMID:23209284 GO_REF:0000107 MGI:5469797 NCBI chr 2:189,045,551...189,085,448
Ensembl chr 2:189,062,443...189,083,236 		JBrowse link
somatic diversification of immunoglobulins term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aicda activation-induced cytidine deaminase involved_in ISO (PMID:18722174) RGD PMID:18722174 NCBI chr 4:155,359,909...155,371,104
Ensembl chr 4:155,359,921...155,369,671 		JBrowse link
G Ctnnbl1 catenin, beta like 1 involved_in ISO (PMID:18722174) RGD PMID:18722174 NCBI chr 3:154,212,245...154,373,170
Ensembl chr 3:154,212,202...154,373,169 		JBrowse link
G Polb DNA polymerase beta ISO MGI:5427084 (MGI:5553198|PMID:24388753) RGD PMID:24388753 MGI:5553198 NCBI chr16:74,237,001...74,260,272
Ensembl chr16:74,237,001...74,260,271 		JBrowse link
somatic hypermutation of immunoglobulin genes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aicda activation-induced cytidine deaminase involved_in ISO (PMID:21518874) RGD PMID:21518874 NCBI chr 4:155,359,909...155,371,104
Ensembl chr 4:155,359,921...155,369,671 		JBrowse link
G Exo1 exonuclease 1 ISO MGI:2653925 (MGI:3028407|PMID:14716311) RGD PMID:14716311 MGI:3028407 NCBI chr13:93,936,989...93,962,749
Ensembl chr13:93,939,022...93,960,342 		JBrowse link
G Mcm3ap minichromosome maintenance complex component 3 associated protein involved_in ISO (PMID:23652018) RGD PMID:23652018 NCBI chr20:12,879,304...12,917,069
Ensembl chr20:12,879,278...12,917,039 		JBrowse link
G Mlh1 mutL homolog 1 involved_in IEA
IBA
ISO		 GO_REF:0000107
PMID:21873635
MGI:1857946 (MGI:1332749|PMID:10092760), (MGI:3691360|PMID:10429667)		 Ensembl
RGD		 PMID:10092760 PMID:10429667, PMID:21873635, PMID:21873635 GO_REF:0000107 MGI:1332749 MGI:3691360, RGD:13792537, RGD:13792537 NCBI chr 8:119,486,655...119,523,716
Ensembl chr 8:119,486,691...119,523,964 		JBrowse link
G Msh2 mutS homolog 2 involved_in
NOT		 IEA
ISO		 GO_REF:0000107
MGI:109352|MGI:1857940|MGI:1858055|MGI:2680817 (MGI:1275866|PMID:9697842), (MGI:1275867|PMID:9697843), (MGI:2679186|PMID:14568978), (MGI:3513244|PMID:15494304), (MGI:3641481|PMID:9607916)
MGI:1858055 (MGI:1261398|PMID:9607915)		 Ensembl
RGD		 PMID:9607915 PMID:9607916 PMID:9697842 PMID:9697843 PMID:14568978 PMID:15494304 GO_REF:0000107 MGI:1261398 MGI:1275866 MGI:1275867 MGI:2679186 MGI:3513244 MGI:3641481 NCBI chr 6:11,215,951...11,274,916
Ensembl chr 6:11,215,963...11,274,932 		JBrowse link
G Msh3 mutS homolog 3 NOT ISO MGI:1858056 (MGI:1353126|PMID:10662804) RGD PMID:10662804 MGI:1353126 NCBI chr 2:21,790,048...21,931,791
Ensembl chr 2:21,790,044...21,931,720 		JBrowse link
G Msh6 mutS homolog 6 involved_in ISO
IBA		 MGI:1858014|MGI:3653701 (MGI:1353126|PMID:10662804), (MGI:3046392|PMID:15238604), (MGI:3641510|PMID:16618598), (MGI:3723381|PMID:17015724)
PMID:21873635		 RGD PMID:10662804 PMID:15238604 PMID:16618598 PMID:17015724, PMID:21873635, PMID:21873635 MGI:1353126 MGI:3046392 MGI:3641510 MGI:3723381, RGD:13792537, RGD:13792537 NCBI chr 6:11,644,565...11,662,389
Ensembl chr 6:11,644,578...11,662,499 		JBrowse link
G Nuggc nuclear GTPase, germinal center associated ISO MGI:5449552 (MGI:5448793|PMID:22833677) RGD PMID:22833677 MGI:5448793 NCBI chr15:49,011,951...49,055,246
Ensembl chr15:49,010,492...49,055,237 		JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component involved_in ISO
IBA		 MGI:1857947 (MGI:1261707|PMID:9618520), (MGI:3691360|PMID:10429667)
PMID:21873635		 RGD PMID:9618520 PMID:10429667, PMID:21873635, PMID:21873635 MGI:1261707 MGI:3691360, RGD:13792537, RGD:13792537 NCBI chr12:12,714,394...12,738,654
Ensembl chr12:12,714,394...12,738,641 		JBrowse link
G Polb DNA polymerase beta ISO MGI:5427084 (MGI:5553198|PMID:24388753) RGD PMID:24388753 MGI:5553198 NCBI chr16:74,237,001...74,260,272
Ensembl chr16:74,237,001...74,260,271 		JBrowse link
G Polm DNA polymerase mu ISO MGI:2179233 (MGI:3576407|PMID:15789338) RGD PMID:15789338 MGI:3576407 NCBI chr14:86,069,378...86,079,327
Ensembl chr14:86,069,016...86,078,954 		JBrowse link
G Polq DNA polymerase theta ISO (MGI:3603978|PMID:16172387), (MGI:3609287|PMID:16222339), (MGI:3692678|PMID:16890500) RGD PMID:16172387 PMID:16222339 PMID:16890500 MGI:3603978 MGI:3609287 MGI:3692678 NCBI chr11:66,585,860...66,695,369
Ensembl chr11:66,585,881...66,695,353 		JBrowse link
G Samhd1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 ISO (MGI:6157199|PMID:29669924) RGD PMID:29669924 MGI:6157199 NCBI chr 3:153,210,829...153,250,705
Ensembl chr 3:153,210,829...153,250,641 		JBrowse link
G Ung uracil-DNA glycosylase ISO MGI:101816|MGI:2182610 (MGI:3513244|PMID:15494304), (MGI:3723381|PMID:17015724) RGD PMID:15494304 PMID:17015724 MGI:3513244 MGI:3723381 NCBI chr12:48,246,593...48,255,547
Ensembl chr12:48,246,569...48,254,822 		JBrowse link
somatic recombination of immunoglobulin gene segments term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mlh1 mutL homolog 1 ISO MGI:1857946 (MGI:3722579|PMID:11828012) RGD PMID:11828012 MGI:3722579 NCBI chr 8:119,486,655...119,523,716
Ensembl chr 8:119,486,691...119,523,964 		JBrowse link
G Msh2 mutS homolog 2 ISO MGI:109352|MGI:1857940|MGI:2151801|MGI:2680817 (MGI:2679186|PMID:14568978), (MGI:3513244|PMID:15494304), (MGI:3581477|PMID:15955838), (MGI:3582380|PMID:14563316), (MGI:3722579|PMID:11828012) RGD PMID:11828012 PMID:14563316 PMID:14568978 PMID:15494304 PMID:15955838 MGI:2679186 MGI:3513244 MGI:3581477 MGI:3582380 MGI:3722579 NCBI chr 6:11,215,951...11,274,916
Ensembl chr 6:11,215,963...11,274,932 		JBrowse link
G Msh3 mutS homolog 3 involved_in ISO
IBA		 MGI:1858056 (MGI:3046392|PMID:15238604)
PMID:21873635		 RGD PMID:15238604, PMID:21873635, PMID:21873635 MGI:3046392, RGD:13792537, RGD:13792537 NCBI chr 2:21,790,048...21,931,791
Ensembl chr 2:21,790,044...21,931,720 		JBrowse link
G Msh6 mutS homolog 6 involved_in ISO
IBA		 MGI:1858014 (MGI:3046392|PMID:15238604)
PMID:21873635		 RGD PMID:15238604, PMID:21873635, PMID:21873635 MGI:3046392, RGD:13792537, RGD:13792537 NCBI chr 6:11,644,565...11,662,389
Ensembl chr 6:11,644,578...11,662,499 		JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component ISO MGI:1857947 (MGI:3722579|PMID:11828012) RGD PMID:11828012 MGI:3722579 NCBI chr12:12,714,394...12,738,654
Ensembl chr12:12,714,394...12,738,641 		JBrowse link
G Ung uracil-DNA glycosylase ISO MGI:101816|MGI:2182610 (MGI:3513244|PMID:15494304) RGD PMID:15494304 MGI:3513244 NCBI chr12:48,246,593...48,255,547
Ensembl chr12:48,246,569...48,254,822 		JBrowse link
somatic recombination of immunoglobulin genes involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mlh1 mutL homolog 1 ISO MGI:101816 (MGI:2662086|PMID:12743174) RGD PMID:12743174 MGI:2662086 NCBI chr 8:119,486,655...119,523,716
Ensembl chr 8:119,486,691...119,523,964 		JBrowse link
G Msh2 mutS homolog 2 involved_in ISO
IBA		 MGI:101938 (MGI:2662086|PMID:12743174)
PMID:21873635		 RGD PMID:12743174, PMID:21873635, PMID:21873635 MGI:2662086, RGD:13792537, RGD:13792537 NCBI chr 6:11,215,951...11,274,916
Ensembl chr 6:11,215,963...11,274,932 		JBrowse link
T cell receptor V(D)J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl11b BAF chromatin remodeling complex subunit BCL11B ISO MGI:2663971 (MGI:2662810|PMID:12717433) RGD PMID:12717433 MGI:2662810 NCBI chr 6:131,834,097...131,927,251
Ensembl chr 6:131,834,097...131,926,272 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 involved_in IEA
ISO		 GO_REF:0000107
MGI:98507 (MGI:3640275|PMID:9462507)		 Ensembl
RGD		 PMID:9462507 GO_REF:0000107 MGI:3640275 NCBI chr 2:236,232,115...236,345,061
Ensembl chr 2:236,233,239...236,345,056 		JBrowse link
G Lig4 DNA ligase 4 ISO MGI:1857732 (MGI:1860400|PMID:10911993) RGD PMID:10911993 MGI:1860400 NCBI chr16:85,331,771...85,339,496
Ensembl chr16:85,331,866...85,337,769 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit ISO MGI:2383951 (MGI:1290043|PMID:9768755) RGD PMID:9768755 MGI:1290043 NCBI chr11:89,293,547...89,510,948
Ensembl chr11:89,293,696...89,510,871 		JBrowse link
G Tcf7 transcription factor 7 ISO MGI:96770 (MGI:3640275|PMID:9462507) RGD PMID:9462507 MGI:3640275 NCBI chr10:37,616,033...37,646,027
Ensembl chr10:37,617,279...37,645,802 		JBrowse link
V(D)J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase ISO MGI:104779 (MGI:5543316|PMID:23836881) RGD PMID:23836881 MGI:5543316 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045 		JBrowse link
G Dcaf1 DDB1 and CUL4 associated factor 1 ISO (MGI:5314150|PMID:22157821) RGD PMID:22157821 MGI:5314150 NCBI chr 8:115,538,365...115,615,282
Ensembl chr 8:115,546,712...115,615,282 		JBrowse link
G Dclre1c DNA cross-link repair 1C ISO (MGI:5543316|PMID:23836881) RGD PMID:23836881 MGI:5543316 NCBI chr17:78,782,512...78,812,140
Ensembl chr17:78,783,437...78,812,111 		JBrowse link
G Hmgb1 high mobility group box 1 involved_in ISO (PMID:9166431) RGD PMID:9166431 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237 		JBrowse link
G Lig1 DNA ligase 1 NOT
NOT|involved_in		 ISO (PMID:9809069) RGD PMID:9809069 NCBI chr 1:75,356,212...75,394,757
Ensembl chr 1:75,356,220...75,394,758 		JBrowse link
G Lig3 DNA ligase 3 NOT
NOT|involved_in		 ISO (PMID:9809069) RGD PMID:9809069 NCBI chr10:70,134,734...70,158,051
Ensembl chr10:70,134,729...70,158,055 		JBrowse link
G Lig4 DNA ligase 4 involved_in ISO (PMID:9809069)
MGI:1857732 (MGI:3052572|PMID:15194694), (MGI:3641390|PMID:10716994)		 RGD PMID:9809069 PMID:10716994 PMID:15194694 MGI:3052572 MGI:3641390 NCBI chr16:85,331,771...85,339,496
Ensembl chr16:85,331,866...85,337,769 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit ISO MGI:107202 (MGI:5543316|PMID:23836881) RGD PMID:23836881 MGI:5543316 NCBI chr11:89,293,547...89,510,948
Ensembl chr11:89,293,696...89,510,871 		JBrowse link
G Rag1 recombination activating 1 involved_in ISO
IBA		 (PMID:14670978)
PMID:21873635
MGI:97849 (MGI:4441018|PMID:20122409), (MGI:4441148|PMID:10601033), (MGI:50458|PMID:1547488), (MGI:59028|PMID:2360047), (MGI:64624|PMID:8284210)		 RGD PMID:1547488 PMID:2360047 PMID:8284210 PMID:10601033 PMID:14670978 PMID:20122409, PMID:21873635, PMID:21873635 MGI:4441018 MGI:4441148 MGI:50458 MGI:59028 MGI:64624, RGD:13792537, RGD:13792537 NCBI chr 3:91,206,394...91,217,491
Ensembl chr 3:91,206,394...91,217,491 		JBrowse link
G Rag2 recombination activating 2 involved_in ISO
IBA		 MGI:97848 (MGI:4441252|PMID:18033247), (MGI:50458|PMID:1547488), (MGI:59028|PMID:2360047)
PMID:21873635		 RGD PMID:1547488 PMID:2360047 PMID:18033247, PMID:21873635, PMID:21873635 MGI:4441252 MGI:50458 MGI:59028, RGD:13792537, RGD:13792537 NCBI chr 3:91,191,837...91,200,134
Ensembl chr 3:91,191,837...91,200,134 		JBrowse link
G Xrcc4 X-ray repair cross complementing 4 ISO MGI:1926771 (MGI:3641390|PMID:10716994) RGD PMID:10716994 MGI:3641390 NCBI chr 2:18,674,496...18,927,463
Ensembl chr 2:18,677,220...18,927,365 		JBrowse link
G Xrcc6 X-ray repair cross complementing 6 ISO MGI:2179954 (MGI:3641390|PMID:10716994) RGD PMID:10716994 MGI:3641390 NCBI chr 7:123,259,881...123,280,613
Ensembl chr 7:123,259,761...123,280,612 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20078
    immune system process 2843
      somatic diversification of immune receptors 83
        somatic diversification of DSCAM-based immune receptors 0
        somatic diversification of FREP-based immune receptors 0
        somatic diversification of T cell receptor genes + 5
        somatic diversification of immune receptors by N region addition + 0
        somatic diversification of immune receptors via alternate splicing + 0
        somatic diversification of immune receptors via gene conversion + 0
        somatic diversification of immune receptors via germline recombination within a single locus + 76
        somatic diversification of immune receptors via somatic mutation + 15
        somatic diversification of immunoglobulins + 70
        somatic diversification of variable lymphocyte receptors of jawless fish 0
Path 2
Term Annotations click to browse term
  biological_process 20078
    developmental process 6848
      anatomical structure development 6308
        multicellular organism development 5783
          system development 5311
            immune system development 1088
              somatic diversification of immune receptors 83
                somatic diversification of DSCAM-based immune receptors 0
                somatic diversification of FREP-based immune receptors 0
                somatic diversification of T cell receptor genes + 5
                somatic diversification of immune receptors by N region addition + 0
                somatic diversification of immune receptors via alternate splicing + 0
                somatic diversification of immune receptors via gene conversion + 0
                somatic diversification of immune receptors via germline recombination within a single locus + 76
                somatic diversification of immune receptors via somatic mutation + 15
                somatic diversification of immunoglobulins + 70
                somatic diversification of variable lymphocyte receptors of jawless fish 0
paths to the root