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ONTOLOGY REPORT - ANNOTATIONS

Term:somatic diversification of immune receptors
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Accession:GO:0002200 term browser browse the term
Definition:The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences.
Comment:Note that this process covers somatic recombination, gene conversion, hypermutation, N-region addition, and alternate splicing processes of immune receptor diversification.


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immunoglobulin heavy chain V-D-J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Polb DNA polymerase beta acts_upstream_of_or_within ISO MGI:5427084 (MGI:5553198|PMID:24388753) RGD PMID:24388753 MGI:5553198 NCBI chr16:69,379,438...69,402,710
Ensembl chr16:69,379,400...69,404,812 		JBrowse link
G Yy1 YY1 transcription factor involved_in ISO MGI:3624790 (MGI:5484711|PMID:23531880) RGD PMID:23531880 MGI:5484711 NCBI chr 6:127,706,739...127,731,907
Ensembl chr 6:127,707,596...127,732,747 		JBrowse link
immunoglobulin V(D)J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyren cell cycle regulator of NHEJ involved_in ISS
ISO		 GO_REF:0000024
(MGI:6202149|PMID:30017584), (MGI:6716972|PMID:31795137)		 UniProt
RGD		 PMID:30017584 PMID:31795137 GO_REF:0000024 MGI:6202149 MGI:6716972 NCBI chr 4:63,547,311...63,553,394
Ensembl chr 4:63,547,335...63,551,602 		JBrowse link
G Foxp1 forkhead box P1 acts_upstream_of_or_within ISO MGI:3711150 (MGI:3662963|PMID:16819554) RGD PMID:16819554 MGI:3662963 NCBI chr 4:131,559,599...132,155,092
Ensembl chr 4:131,564,756...132,112,258 		JBrowse link
G Lig4 DNA ligase 4 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
MGI:1857732 (MGI:1312981|PMID:9823897)		 RGD PMID:9823897 PMID:21873635 MGI:1312981, RGD:13792537 NCBI chr16:79,518,393...79,526,956
Ensembl chr16:79,518,312...79,527,040 		JBrowse link
G Nhej1 nonhomologous end-joining factor 1 involved_in ISO
ISS		 (PMID:20558749)
GO_REF:0000024		 RGD
UniProt		 PMID:20558749 GO_REF:0000024 NCBI chr 9:76,526,322...76,622,488
Ensembl chr 9:76,526,324...76,622,444 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
MGI:2383951 (MGI:1290043|PMID:9768755)		 RGD PMID:9768755 PMID:21873635 MGI:1290043, RGD:13792537 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952 		JBrowse link
G Tcf3 transcription factor 3 involved_in
acts_upstream_of_or_within		 IBA
IEA
ISO		 PMID:21873635
GO_REF:0000107
(PMID:16428437)
MGI:2178112 (MGI:3615721|PMID:16428437)		 Ensembl
RGD		 PMID:16428437 PMID:21873635 GO_REF:0000107 MGI:3615721, RGD:13792537 NCBI chr 7:9,280,571...9,302,315
Ensembl chr 7:9,280,571...9,302,314 		JBrowse link
G Xrcc4 X-ray repair cross complementing 4 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
MGI:1926771 (MGI:1913213|PMID:9875844)		 RGD PMID:9875844 PMID:21873635 MGI:1913213, RGD:13792537 NCBI chr 2:20,948,464...21,197,705
Ensembl chr 2:20,951,200...21,197,808 		JBrowse link
isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aicda activation-induced cytidine deaminase involved_in
acts_upstream_of_or_within		 ISO (MGI:5004983|PMID:21518874)
(MGI:3761960|PMID:17713479)		 RGD PMID:17713479 PMID:21518874 MGI:3761960 MGI:5004983 NCBI chr 4:155,774,132...155,783,972
Ensembl chr 4:155,774,132...155,783,972 		JBrowse link
G Atad5 ATPase family, AAA domain containing 5 acts_upstream_of ISO MGI:4127920 (MGI:5763555|PMID:25404367) RGD PMID:25404367 MGI:5763555 NCBI chr10:65,070,682...65,118,489
Ensembl chr10:65,070,689...65,117,845 		JBrowse link
G Batf basic leucine zipper ATF-like transcription factor involved_in ISS
ISO		 GO_REF:0000024
(MGI:4456325|PMID:20421391), (MGI:5004732|PMID:21572431)		 UniProt
RGD		 PMID:20421391 PMID:21572431 GO_REF:0000024 MGI:4456325 MGI:5004732 NCBI chr 6:105,353,715...105,376,051
Ensembl chr 6:105,353,715...105,376,051 		JBrowse link
G Cd40lg CD40 ligand involved_in IEA
ISO		 GO_REF:0000107
(MGI:3687427|PMID:7529792)		 Ensembl
RGD		 PMID:7529792 GO_REF:0000107 MGI:3687427 NCBI chr  X:135,127,119...135,138,302
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit acts_upstream_of_or_within ISO MGI:2183944 (MGI:3052883|PMID:15280420) RGD PMID:15280420 MGI:3052883 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963 		JBrowse link
G Exo1 exonuclease 1 acts_upstream_of_or_within ISO MGI:2653925 (MGI:3028407|PMID:14716311) RGD PMID:14716311 MGI:3028407 NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654 		JBrowse link
G Exosc3 exosome component 3 involved_in ISO (MGI:5009766|PMID:21255825) RGD PMID:21255825 MGI:5009766 NCBI chr 5:59,573,849...59,579,065
Ensembl chr 5:59,573,886...59,579,060 		JBrowse link
G Exosc6 exosome component 6 involved_in ISO (MGI:5009766|PMID:21255825) RGD PMID:21255825 MGI:5009766 NCBI chr19:39,021,308...39,023,535
Ensembl chr19:39,022,183...39,023,515 		JBrowse link
G Lig4 DNA ligase 4 acts_upstream_of_or_within ISO MGI:1857732 (MGI:3761960|PMID:17713479) RGD PMID:17713479 MGI:3761960 NCBI chr16:79,518,393...79,526,956
Ensembl chr16:79,518,312...79,527,040 		JBrowse link
G Mlh1 mutL homolog 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1857946 (MGI:2662086|PMID:12743174)		 Ensembl
RGD		 PMID:12743174 GO_REF:0000107 MGI:2662086 NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617 		JBrowse link
G Msh2 mutS homolog 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1857940|MGI:2151801 (MGI:1342394|PMID:10430621), (MGI:2662086|PMID:12743174)		 Ensembl
RGD		 PMID:10430621 PMID:12743174 GO_REF:0000107 MGI:1342394 MGI:2662086 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Msh6 mutS homolog 6 acts_upstream_of_or_within ISO MGI:109352|MGI:3653701 (MGI:3641510|PMID:16618598), (MGI:3723381|PMID:17015724) RGD PMID:16618598 PMID:17015724 MGI:3641510 MGI:3723381 NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956 		JBrowse link
G Nbn nibrin involved_in ISS
ISO
IEA		 GO_REF:0000024
(MGI:3529405|PMID:15668383)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:15668383 GO_REF:0000024 GO_REF:0000107 MGI:3529405 NCBI chr 5:29,459,574...29,494,152
Ensembl chr 5:29,459,457...29,494,150 		JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in ISO MGI:5501251 (MGI:5613038|PMID:25124037)
MGI:3046930|MGI:5501251 (MGI:5613038|PMID:25124037), (MGI:6357443|PMID:31182790)		 RGD PMID:25124037 PMID:31182790 MGI:5613038 MGI:6357443 NCBI chr11:44,782,676...44,810,723
Ensembl chr11:44,782,676...44,810,723 		JBrowse link
G Rnf168 ring finger protein 168 involved_in ISS
ISO		 GO_REF:0000024
(MGI:4420833|PMID:20080757)		 UniProt
RGD		 PMID:20080757 GO_REF:0000024 MGI:4420833 NCBI chr11:68,486,313...68,508,296
Ensembl chr11:68,486,321...68,508,277 		JBrowse link
G Rnf8 ring finger protein 8 involved_in ISS
ISO		 GO_REF:0000024
(MGI:4420833|PMID:20080757)		 UniProt
RGD		 PMID:20080757 GO_REF:0000024 MGI:4420833 NCBI chr20:7,682,258...7,710,448
Ensembl chr20:7,682,322...7,708,491 		JBrowse link
G Sanbr SANT and BTB domain regulator of CSR involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:6707280|PMID:33831416)		 UniProt
Ensembl
RGD		 PMID:33831416 GO_REF:0000024 GO_REF:0000107 MGI:6707280 NCBI chr14:97,516,652...97,585,955
Ensembl chr14:97,516,413...97,581,346 		JBrowse link
G Swap70 switching B-cell complex subunit SWAP70 acts_upstream_of_or_within ISO (MGI:1270060|PMID:9642267) RGD PMID:9642267 MGI:1270060 NCBI chr 1:164,267,588...164,328,796
Ensembl chr 1:164,267,609...164,328,794 		JBrowse link
G Ung uracil-DNA glycosylase acts_upstream_of_or_within ISO MGI:1343961 (MGI:3723381|PMID:17015724) RGD PMID:17015724 MGI:3723381 NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206 		JBrowse link
G Xrcc4 X-ray repair cross complementing 4 acts_upstream_of_or_within ISO MGI:1926771|MGI:3047571|MGI:3641440 (MGI:3761960|PMID:17713479) RGD PMID:17713479 MGI:3761960 NCBI chr 2:20,948,464...21,197,705
Ensembl chr 2:20,951,200...21,197,808 		JBrowse link
isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr6 C-C motif chemokine receptor 6 involved_in ISO (MGI:5787846|PMID:27174992) RGD PMID:27174992 MGI:5787846 NCBI chr 1:52,474,477...52,508,301
Ensembl chr 1:52,474,168...52,498,603 		JBrowse link
isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6, transcription repressor acts_upstream_of ISO MGI:103034|MGI:2158438 (MGI:1345885|PMID:10490661) RGD PMID:10490661 MGI:1345885 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389 		JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of ISO MGI:3696705 (MGI:3695768|PMID:16275384) RGD PMID:16275384 MGI:3695768 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Il4 interleukin 4 acts_upstream_of ISO (MGI:3037416|PMID:14988498) RGD PMID:14988498 MGI:3037416 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 acts_upstream_of ISO MGI:107187 (MGI:1345885|PMID:10490661) RGD PMID:10490661 MGI:1345885 NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495 		JBrowse link
isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hspd1 heat shock protein family D (Hsp60) member 1 involved_in ISO (PMID:16148103) RGD PMID:16148103 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662 		JBrowse link
G Il4 interleukin 4 acts_upstream_of ISO (MGI:3037416|PMID:14988498) RGD PMID:14988498 MGI:3037416 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
negative regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Parp3 poly (ADP-ribose) polymerase family, member 3 involved_in ISO (MGI:6214451|PMID:26000965) RGD PMID:26000965 MGI:6214451 NCBI chr 8:107,111,010...107,117,073
Ensembl chr 8:107,111,012...107,116,782 		JBrowse link
negative regulation of isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Da2-19 uncharacterized LOC302729 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr  X:44,820,693...44,837,935
Ensembl chr  X:44,820,820...44,837,934 		JBrowse link
G Thoc1 THO complex subunit 1 involved_in ISO (MGI:5520039|PMID:22144908) RGD PMID:22144908 MGI:5520039 NCBI chr18:983,606...1,020,379
Ensembl chr18:983,824...1,019,114 		JBrowse link
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6, transcription repressor acts_upstream_of_or_within ISO MGI:103034|MGI:2158438 (MGI:1345885|PMID:10490661) RGD PMID:10490661 MGI:1345885 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389 		JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO MGI:3696705 (MGI:3695768|PMID:16275384) RGD PMID:16275384 MGI:3695768 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 acts_upstream_of_or_within ISO MGI:3695433 (MGI:3694584|PMID:17137798) RGD PMID:17137798 MGI:3694584 NCBI chr18:30,265,808...30,316,068
Ensembl chr18:30,250,613...30,322,311 		JBrowse link
positive regulation of interleukin-4-dependent isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnfsf4 TNF superfamily member 4 involved_in ISO (MGI:3763508|PMID:12496423) RGD PMID:12496423 MGI:3763508 NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788 		JBrowse link
positive regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Exosc3 exosome component 3 acts_upstream_of_or_within ISO (MGI:5009766|PMID:21255825) RGD PMID:21255825 MGI:5009766 NCBI chr 5:59,573,849...59,579,065
Ensembl chr 5:59,573,886...59,579,060 		JBrowse link
G Exosc6 exosome component 6 acts_upstream_of_or_within ISO (MGI:5009766|PMID:21255825) RGD PMID:21255825 MGI:5009766 NCBI chr19:39,021,308...39,023,535
Ensembl chr19:39,022,183...39,023,515 		JBrowse link
G Hmces 5-hydroxymethylcytosine binding, ES cell specific involved_in ISS
ISO		 GO_REF:0000024
(MGI:6393148|PMID:31806351)		 UniProt
RGD		 PMID:31806351 GO_REF:0000024 MGI:6393148 NCBI chr 4:120,392,812...120,415,616
Ensembl chr 4:120,366,542...120,415,616 		JBrowse link
G Kmt5b lysine methyltransferase 5B involved_in ISS
ISO		 GO_REF:0000024
(MGI:6370097|PMID:28114273)		 UniProt
RGD		 PMID:28114273 GO_REF:0000024 MGI:6370097 NCBI chr 1:201,000,444...201,049,819
Ensembl chr 1:201,000,444...201,049,819 		JBrowse link
G Kmt5c lysine methyltransferase 5C involved_in ISO
ISS		 (MGI:6370097|PMID:28114273)
GO_REF:0000024		 RGD
UniProt		 PMID:28114273 GO_REF:0000024 MGI:6370097 NCBI chr 1:69,099,531...69,107,145
Ensembl chr 1:69,099,539...69,107,145 		JBrowse link
G Mad2l2 mitotic arrest deficient 2 like 2 involved_in ISO (PMID:29656893) RGD PMID:29656893 NCBI chr 5:158,563,545...158,576,698
Ensembl chr 5:158,563,567...158,576,693 		JBrowse link
G Paxip1 PAX interacting protein 1 involved_in ISO (MGI:4821506|PMID:20671152) RGD PMID:20671152 MGI:4821506 NCBI chr 4:7,524,887...7,576,663
Ensembl chr 4:7,525,004...7,576,548 		JBrowse link
G Rif1 replication timing regulatory factor 1 involved_in ISO (MGI:5468036|PMID:23306439), (MGI:5476381|PMID:23333305), (MGI:5490831|PMID:23333306) RGD PMID:23306439 PMID:23333305 PMID:23333306 MGI:5468036 MGI:5476381 MGI:5490831 NCBI chr 3:36,554,689...36,607,961
Ensembl chr 3:36,554,697...36,603,617 		JBrowse link
G Shld1 shieldin complex subunit 1 involved_in ISO
IBA		 (PMID:29656893)
PMID:21873635		 RGD PMID:29656893 PMID:21873635 RGD:13792537 NCBI chr 3:119,938,695...120,011,068
Ensembl chr 3:119,938,833...120,009,550 		JBrowse link
G Shld2 shieldin complex subunit 2 involved_in ISO (PMID:29656893) RGD PMID:29656893 NCBI chr16:9,544,940...9,640,323
Ensembl chr16:9,548,660...9,639,965 		JBrowse link
G Shld3 shieldin complex subunit 3 involved_in ISO (PMID:29656893) RGD PMID:29656893 NCBI chr 2:35,294,956...35,301,865
Ensembl chr 2:35,295,859...35,302,346 		JBrowse link
G Tfrc transferrin receptor involved_in ISS
ISO		 GO_REF:0000024
(PMID:26642240)		 UniProt
RGD		 PMID:26642240 GO_REF:0000024 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 involved_in ISO (PMID:23345425), (PMID:23760478)
(MGI:3041657|PMID:15077110), (MGI:3046005|PMID:15159415)		 RGD PMID:15077110 PMID:15159415 PMID:23345425 PMID:23760478 MGI:3041657 MGI:3046005 NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822 		JBrowse link
positive regulation of isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mlh1 mutL homolog 1 involved_in IEA
ISO		 GO_REF:0000107
(MGI:1342394|PMID:10430621)		 Ensembl
RGD		 PMID:10430621 GO_REF:0000107 MGI:1342394 NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617 		JBrowse link
G Msh2 mutS homolog 2 involved_in IEA
ISO		 GO_REF:0000107
(MGI:1342394|PMID:10430621)		 Ensembl
RGD		 PMID:10430621 GO_REF:0000107 MGI:1342394 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Nsd2 nuclear receptor binding SET domain protein 2 acts_upstream_of_or_within ISO (MGI:5462481|PMID:23241889) RGD PMID:23241889 MGI:5462481 NCBI chr14:76,833,194...76,911,304
Ensembl chr14:76,835,637...76,913,641 		JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component involved_in ISO UniProtKB:Q9JK91 (MGI:1342394|PMID:10430621) RGD PMID:10430621 MGI:1342394 NCBI chr12:10,676,819...10,701,161
Ensembl chr12:10,676,764...10,701,066 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in
acts_upstream_of_or_within		 ISS
ISO		 GO_REF:0000024
(PMID:14988498)		 AgBase
RGD		 PMID:14988498 GO_REF:0000024 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnfsf13 TNF superfamily member 13 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(PMID:14988498)
MGI:3038886 (MGI:3037416|PMID:14988498)		 RGD PMID:14988498 PMID:21873635 MGI:3037416, RGD:13792537 NCBI chr10:54,400,054...54,403,723
Ensembl chr10:54,400,065...54,403,042 		JBrowse link
positive regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clcf1 cardiotrophin-like cytokine factor 1 involved_in ISO (MGI:3777853|PMID:12023368) RGD PMID:12023368 MGI:3777853 NCBI chr 1:201,507,763...201,517,607
Ensembl chr 1:201,507,859...201,517,605 		JBrowse link
G Il4 interleukin 4 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(MGI:3037416|PMID:14988498)		 RGD PMID:14988498 PMID:21873635 MGI:3037416, RGD:13792537 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 acts_upstream_of_or_within ISO MGI:107187 (MGI:1345885|PMID:10490661) RGD PMID:10490661 MGI:1345885 NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495 		JBrowse link
positive regulation of isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atad5 ATPase family, AAA domain containing 5 acts_upstream_of_or_within ISO MGI:4127920 (MGI:5763555|PMID:25404367) RGD PMID:25404367 MGI:5763555 NCBI chr10:65,070,682...65,118,489
Ensembl chr10:65,070,689...65,117,845 		JBrowse link
G Cd28 Cd28 molecule acts_upstream_of_or_within ISO MGI:1857150 (MGI:62368|PMID:7688139) RGD PMID:7688139 MGI:62368 NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685 		JBrowse link
G Cd40 CD40 molecule involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(MGI:2670820|PMID:12882831)		 RGD PMID:12882831 PMID:21873635 MGI:2670820, RGD:13792537 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Ifng interferon gamma acts_upstream_of_or_within ISO (MGI:2670820|PMID:12882831) RGD PMID:12882831 MGI:2670820 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il2 interleukin 2 acts_upstream_of_or_within ISO MGI:1857191 (MGI:87443|PMID:1830926) RGD PMID:1830926 MGI:87443 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il4 interleukin 4 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(MGI:2670820|PMID:12882831), (MGI:3037416|PMID:14988498)		 RGD PMID:12882831 PMID:14988498 PMID:21873635 MGI:2670820 MGI:3037416, RGD:13792537 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Mlh1 mutL homolog 1 involved_in IEA
ISO		 GO_REF:0000107
(MGI:1342394|PMID:10430621)		 Ensembl
RGD		 PMID:10430621 GO_REF:0000107 MGI:1342394 NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617 		JBrowse link
G Msh2 mutS homolog 2 involved_in IEA
ISO		 GO_REF:0000107
(MGI:1342394|PMID:10430621)		 Ensembl
RGD		 PMID:10430621 GO_REF:0000107 MGI:1342394 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Pagr1 Paxip1-associated glutamate-rich protein 1 involved_in ISO (MGI:5752090|PMID:26744420) RGD PMID:26744420 MGI:5752090 NCBI chr 1:181,622,708...181,624,996 JBrowse link
G Paxip1 PAX interacting protein 1 involved_in ISO (MGI:5752090|PMID:26744420) RGD PMID:26744420 MGI:5752090 NCBI chr 4:7,524,887...7,576,663
Ensembl chr 4:7,525,004...7,576,548 		JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component involved_in ISO UniProtKB:Q9JK91 (MGI:1342394|PMID:10430621) RGD PMID:10430621 MGI:1342394 NCBI chr12:10,676,819...10,701,161
Ensembl chr12:10,676,764...10,701,066 		JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C acts_upstream_of_or_within ISO MGI:2181288 (MGI:85031|PMID:9015183) RGD PMID:9015183 MGI:85031 NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692 		JBrowse link
G Tbx21 T-box transcription factor 21 acts_upstream_of_or_within ISO MGI:2180194 (MGI:2670820|PMID:12882831) RGD PMID:12882831 MGI:2670820 NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831 		JBrowse link
regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aplf aprataxin and PNKP like factor acts_upstream_of_or_within ISO MGI:4128102 (MGI:4887518|PMID:21211721) RGD PMID:21211721 MGI:4887518 NCBI chr 4:120,070,471...120,122,656
Ensembl chr 4:120,070,471...120,122,633 		JBrowse link
G Mir181b1 microRNA 181b-1 acts_upstream_of_or_within ISO (MGI:3817382|PMID:18762567) RGD PMID:18762567 MGI:3817382 NCBI chr13:49,485,688...49,485,797
Ensembl chr13:49,485,688...49,485,797 		JBrowse link
G Mir181b2 microRNA 181b-2 acts_upstream_of_or_within ISO (MGI:3817382|PMID:18762567) RGD PMID:18762567 MGI:3817382 NCBI chr 3:22,616,948...22,617,035
Ensembl chr 3:22,616,948...22,617,035 		JBrowse link
G Supt6h SPT6 homolog, histone chaperone and transcription elongation factor involved_in ISO (MGI:5004983|PMID:21518874) RGD PMID:21518874 MGI:5004983 NCBI chr10:63,103,920...63,140,780
Ensembl chr10:63,103,921...63,140,780 		JBrowse link
regulation of isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO MGI:3696705 (MGI:3695768|PMID:16275384) RGD PMID:16275384 MGI:3695768 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Il27ra interleukin 27 receptor subunit alpha acts_upstream_of_or_within ISO MGI:3525439 (MGI:1926579|PMID:11057672) RGD PMID:11057672 MGI:1926579 NCBI chr19:24,109,698...24,121,977
Ensembl chr19:24,109,972...24,121,938 		JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 acts_upstream_of_or_within ISO MGI:3695433 (MGI:3694584|PMID:17137798) RGD PMID:17137798 MGI:3694584 NCBI chr18:30,265,808...30,316,068
Ensembl chr18:30,250,613...30,322,311 		JBrowse link
G Slc15a4 solute carrier family 15 member 4 involved_in IEA
ISO
ISS		 GO_REF:0000107
(MGI:5649169|PMID:25310967)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:25310967 GO_REF:0000024 GO_REF:0000107 MGI:5649169 NCBI chr12:29,048,634...29,082,480
Ensembl chr12:29,063,015...29,082,480 		JBrowse link
somatic diversification of immune receptors via somatic mutation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adar adenosine deaminase, RNA-specific acts_upstream_of_or_within ISO (MGI:5469797|PMID:23209284) RGD PMID:23209284 MGI:5469797 NCBI chr 2:175,138,391...175,178,280
Ensembl chr 2:175,138,403...175,178,282 		JBrowse link
somatic diversification of immunoglobulins term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aicda activation-induced cytidine deaminase involved_in ISO (PMID:18722174) RGD PMID:18722174 NCBI chr 4:155,774,132...155,783,972
Ensembl chr 4:155,774,132...155,783,972 		JBrowse link
G Ctnnbl1 catenin, beta like 1 involved_in ISO (PMID:18722174) RGD PMID:18722174 NCBI chr 3:146,387,940...146,548,987
Ensembl chr 3:146,387,889...146,548,987 		JBrowse link
G Polb DNA polymerase beta acts_upstream_of_or_within ISO MGI:5427084 (MGI:5553198|PMID:24388753) RGD PMID:24388753 MGI:5553198 NCBI chr16:69,379,438...69,402,710
Ensembl chr16:69,379,400...69,404,812 		JBrowse link
somatic hypermutation of immunoglobulin genes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aicda activation-induced cytidine deaminase involved_in ISO (PMID:21518874) RGD PMID:21518874 NCBI chr 4:155,774,132...155,783,972
Ensembl chr 4:155,774,132...155,783,972 		JBrowse link
G Exo1 exonuclease 1 acts_upstream_of_or_within ISO MGI:2653925 (MGI:3028407|PMID:14716311) RGD PMID:14716311 MGI:3028407 NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654 		JBrowse link
G Mcm3ap minichromosome maintenance complex component 3 associated protein involved_in ISO (PMID:23652018) RGD PMID:23652018 NCBI chr20:12,127,570...12,165,165
Ensembl chr20:12,127,570...12,165,165 		JBrowse link
G Mlh1 mutL homolog 1 involved_in
acts_upstream_of_or_within		 IBA
ISO
IEA		 PMID:21873635
MGI:1857946 (MGI:1332749|PMID:10092760), (MGI:3691360|PMID:10429667)
GO_REF:0000107		 RGD
Ensembl		 PMID:10092760 PMID:10429667 PMID:21873635 GO_REF:0000107 MGI:1332749 MGI:3691360, RGD:13792537 NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617 		JBrowse link
G Msh2 mutS homolog 2 involved_in
NOT|acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1858055 (MGI:1261398|PMID:9607915)
MGI:109352|MGI:1857940|MGI:1858055|MGI:2680817 (MGI:1275866|PMID:9697842), (MGI:1275867|PMID:9697843), (MGI:2679186|PMID:14568978), (MGI:3513244|PMID:15494304), (MGI:3641481|PMID:9607916)		 Ensembl
RGD		 PMID:9607915 PMID:9607916 PMID:9697842 PMID:9697843 PMID:14568978 More... GO_REF:0000107 MGI:1261398 MGI:1275866 MGI:1275867 MGI:2679186 MGI:3513244 MGI:3641481 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Msh3 mutS homolog 3 NOT|acts_upstream_of_or_within ISO MGI:1858056 (MGI:1353126|PMID:10662804) RGD PMID:10662804 MGI:1353126 NCBI chr 2:23,444,326...23,585,777 JBrowse link
G Msh6 mutS homolog 6 acts_upstream_of_or_within ISO MGI:1858014|MGI:3653701 (MGI:1353126|PMID:10662804), (MGI:3046392|PMID:15238604), (MGI:3641510|PMID:16618598), (MGI:3723381|PMID:17015724) RGD PMID:10662804 PMID:15238604 PMID:16618598 PMID:17015724 MGI:1353126 MGI:3046392 MGI:3641510 MGI:3723381 NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956 		JBrowse link
G Nuggc nuclear GTPase, germinal center associated acts_upstream_of_or_within ISO MGI:5449552 (MGI:5448793|PMID:22833677) RGD PMID:22833677 MGI:5448793 NCBI chr15:39,821,851...39,866,122
Ensembl chr15:39,821,855...39,866,122 		JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(MGI:1261707|PMID:9618520)
MGI:1857947 (MGI:3691360|PMID:10429667)		 RGD PMID:9618520 PMID:10429667 PMID:21873635 MGI:1261707 MGI:3691360, RGD:13792537 NCBI chr12:10,676,819...10,701,161
Ensembl chr12:10,676,764...10,701,066 		JBrowse link
G Polb DNA polymerase beta acts_upstream_of_or_within ISO MGI:5427084 (MGI:5553198|PMID:24388753) RGD PMID:24388753 MGI:5553198 NCBI chr16:69,379,438...69,402,710
Ensembl chr16:69,379,400...69,404,812 		JBrowse link
G Polm DNA polymerase mu acts_upstream_of_or_within ISO MGI:2179233 (MGI:3576407|PMID:15789338) RGD PMID:15789338 MGI:3576407 NCBI chr14:80,707,075...80,716,677
Ensembl chr14:80,706,345...80,717,086 		JBrowse link
G Polq DNA polymerase theta involved_in ISO (MGI:3603978|PMID:16172387), (MGI:3609287|PMID:16222339), (MGI:3692678|PMID:16890500) RGD PMID:16172387 PMID:16222339 PMID:16890500 MGI:3603978 MGI:3609287 MGI:3692678 NCBI chr11:63,673,796...63,775,905
Ensembl chr11:63,673,816...63,775,878 		JBrowse link
G Samhd1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 involved_in ISO (MGI:6157199|PMID:29669924) RGD PMID:29669924 MGI:6157199 NCBI chr 3:145,761,549...145,794,420
Ensembl chr 3:145,761,558...145,794,386 		JBrowse link
G Ung uracil-DNA glycosylase acts_upstream_of_or_within ISO MGI:101816|MGI:2182610 (MGI:3513244|PMID:15494304), (MGI:3723381|PMID:17015724) RGD PMID:15494304 PMID:17015724 MGI:3513244 MGI:3723381 NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206 		JBrowse link
somatic recombination of immunoglobulin gene segments term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mlh1 mutL homolog 1 acts_upstream_of_or_within ISO MGI:1857946 (MGI:3722579|PMID:11828012) RGD PMID:11828012 MGI:3722579 NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617 		JBrowse link
G Msh2 mutS homolog 2 acts_upstream_of_or_within ISO MGI:109352|MGI:1857940|MGI:2151801|MGI:2680817 (MGI:2679186|PMID:14568978), (MGI:3513244|PMID:15494304), (MGI:3581477|PMID:15955838), (MGI:3582380|PMID:14563316), (MGI:3722579|PMID:11828012) RGD PMID:11828012 PMID:14563316 PMID:14568978 PMID:15494304 PMID:15955838 MGI:2679186 MGI:3513244 MGI:3581477 MGI:3582380 MGI:3722579 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Msh3 mutS homolog 3 acts_upstream_of_or_within ISO MGI:1858056 (MGI:3046392|PMID:15238604) RGD PMID:15238604 MGI:3046392 NCBI chr 2:23,444,326...23,585,777 JBrowse link
G Msh6 mutS homolog 6 acts_upstream_of_or_within ISO MGI:1858014 (MGI:3046392|PMID:15238604) RGD PMID:15238604 MGI:3046392 NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956 		JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component acts_upstream_of_or_within ISO MGI:1857947 (MGI:3722579|PMID:11828012) RGD PMID:11828012 MGI:3722579 NCBI chr12:10,676,819...10,701,161
Ensembl chr12:10,676,764...10,701,066 		JBrowse link
G Ung uracil-DNA glycosylase acts_upstream_of_or_within ISO MGI:101816|MGI:2182610 (MGI:3513244|PMID:15494304) RGD PMID:15494304 MGI:3513244 NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206 		JBrowse link
somatic recombination of immunoglobulin genes involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mlh1 mutL homolog 1 acts_upstream_of_or_within ISO MGI:101816 (MGI:2662086|PMID:12743174) RGD PMID:12743174 MGI:2662086 NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617 		JBrowse link
G Msh2 mutS homolog 2 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
MGI:101938 (MGI:2662086|PMID:12743174)		 RGD PMID:12743174 PMID:21873635 MGI:2662086, RGD:13792537 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
T cell receptor V(D)J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl11b BCL11 transcription factor B acts_upstream_of_or_within ISO MGI:2663971 (MGI:2662810|PMID:12717433) RGD PMID:12717433 MGI:2662810 NCBI chr 6:126,834,531...126,927,720
Ensembl chr 6:126,834,531...126,928,224 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 acts_upstream_of_or_within ISO MGI:98507 (MGI:3640275|PMID:9462507) RGD PMID:9462507 MGI:3640275 NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794 		JBrowse link
G Lig4 DNA ligase 4 acts_upstream_of_or_within ISO MGI:1857732 (MGI:1860400|PMID:10911993) RGD PMID:10911993 MGI:1860400 NCBI chr16:79,518,393...79,526,956
Ensembl chr16:79,518,312...79,527,040 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit acts_upstream_of_or_within ISO MGI:2383951 (MGI:1290043|PMID:9768755) RGD PMID:9768755 MGI:1290043 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952 		JBrowse link
G Tcf7 transcription factor 7 acts_upstream_of_or_within ISO MGI:96770 (MGI:3640275|PMID:9462507) RGD PMID:9462507 MGI:3640275 NCBI chr10:36,423,443...36,454,350
Ensembl chr10:36,423,445...36,453,535 		JBrowse link
V(D)J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase acts_upstream_of_or_within ISO MGI:104779 (MGI:5543316|PMID:23836881) RGD PMID:23836881 MGI:5543316 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Dcaf1 DDB1 and CUL4 associated factor 1 involved_in ISO (MGI:5314150|PMID:22157821) RGD PMID:22157821 MGI:5314150 NCBI chr 8:107,466,229...107,540,633
Ensembl chr 8:107,474,312...107,540,627 		JBrowse link
G Dclre1c DNA cross-link repair 1C acts_upstream_of_or_within ISO (MGI:5543316|PMID:23836881) RGD PMID:23836881 MGI:5543316 NCBI chr17:74,775,828...74,810,089
Ensembl chr17:74,776,935...74,809,186 		JBrowse link
G Hmgb1 high mobility group box 1 involved_in ISO (PMID:9166431) RGD PMID:9166431 NCBI chr12:5,973,062...5,978,565
Ensembl chr12:5,901,586...5,978,565 		JBrowse link
G Lig1 DNA ligase 1 NOT|involved_in ISO (PMID:9809069) RGD PMID:9809069 NCBI chr 1:74,165,688...74,204,400
Ensembl chr 1:74,165,842...74,204,413 		JBrowse link
G Lig3 DNA ligase 3 NOT|involved_in ISO (PMID:9809069) RGD PMID:9809069 NCBI chr10:67,717,796...67,741,141
Ensembl chr10:67,717,812...67,798,414 		JBrowse link
G Lig4 DNA ligase 4 involved_in
acts_upstream_of_or_within		 ISO (PMID:9809069)
MGI:1857732 (MGI:3052572|PMID:15194694), (MGI:3641390|PMID:10716994)		 RGD PMID:9809069 PMID:10716994 PMID:15194694 MGI:3052572 MGI:3641390 NCBI chr16:79,518,393...79,526,956
Ensembl chr16:79,518,312...79,527,040 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit acts_upstream_of_or_within ISO MGI:107202 (MGI:5543316|PMID:23836881) RGD PMID:23836881 MGI:5543316 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952 		JBrowse link
G Rag1 recombination activating 1 involved_in
acts_upstream_of_or_within		 ISO
IBA		 (PMID:14670978)
PMID:21873635
MGI:97849 (MGI:59028|PMID:2360047)
(MGI:4441018|PMID:20122409), (MGI:4441148|PMID:10601033), (MGI:50458|PMID:1547488), (MGI:64624|PMID:8284210)		 RGD PMID:1547488 PMID:2360047 PMID:8284210 PMID:10601033 PMID:14670978 More... MGI:4441018 MGI:4441148 MGI:50458 MGI:59028 MGI:64624, RGD:13792537 NCBI chr 3:87,917,061...87,928,158
Ensembl chr 3:87,917,004...87,928,291 		JBrowse link
G Rag2 recombination activating 2 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(MGI:4441252|PMID:18033247), (MGI:50458|PMID:1547488)
MGI:97848 (MGI:59028|PMID:2360047)		 RGD PMID:1547488 PMID:2360047 PMID:18033247 PMID:21873635 MGI:4441252 MGI:50458 MGI:59028, RGD:13792537 NCBI chr 3:87,902,373...87,910,227
Ensembl chr 3:87,902,238...87,911,066 		JBrowse link
G Xrcc4 X-ray repair cross complementing 4 acts_upstream_of_or_within ISO MGI:1926771 (MGI:3641390|PMID:10716994) RGD PMID:10716994 MGI:3641390 NCBI chr 2:20,948,464...21,197,705
Ensembl chr 2:20,951,200...21,197,808 		JBrowse link
G Xrcc6 X-ray repair cross complementing 6 acts_upstream_of_or_within ISO MGI:2179954 (MGI:3641390|PMID:10716994) RGD PMID:10716994 MGI:3641390 NCBI chr 7:113,542,992...113,563,762
Ensembl chr 7:113,543,057...113,563,762 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19898
    immune system process 2579
      somatic diversification of immune receptors 87
        somatic diversification of DSCAM-based immune receptors 0
        somatic diversification of FREP-based immune receptors 0
        somatic diversification of T cell receptor genes + 5
        somatic diversification of immune receptors by N region addition + 0
        somatic diversification of immune receptors via alternate splicing + 0
        somatic diversification of immune receptors via gene conversion + 0
        somatic diversification of immune receptors via germline recombination within a single locus + 80
        somatic diversification of immune receptors via somatic mutation + 15
        somatic diversification of immunoglobulins + 74
        somatic diversification of variable lymphocyte receptors of jawless fish 0
Path 2
Term Annotations click to browse term
  biological_process 19898
    developmental process 7021
      anatomical structure development 6456
        multicellular organism development 5242
          system development 4503
            immune system development 237
              somatic diversification of immune receptors 87
                somatic diversification of DSCAM-based immune receptors 0
                somatic diversification of FREP-based immune receptors 0
                somatic diversification of T cell receptor genes + 5
                somatic diversification of immune receptors by N region addition + 0
                somatic diversification of immune receptors via alternate splicing + 0
                somatic diversification of immune receptors via gene conversion + 0
                somatic diversification of immune receptors via germline recombination within a single locus + 80
                somatic diversification of immune receptors via somatic mutation + 15
                somatic diversification of immunoglobulins + 74
                somatic diversification of variable lymphocyte receptors of jawless fish 0
paths to the root