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ONTOLOGY REPORT - ANNOTATIONS

Term:somatic diversification of immune receptors
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Accession:GO:0002200 term browser browse the term
Definition:The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences.
Comment:Note that this process covers somatic recombination, gene conversion, hypermutation, N-region addition, and alternate splicing processes of immune receptor diversification.


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immunoglobulin heavy chain V-D-J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Polb DNA polymerase beta acts_upstream_of_or_within ISO
IEA 		MGI:5427084 (PMID:24388753)
GO_REF:0000107 		RGD
Ensembl		 PMID:24388753 GO_REF:0000107 NCBI chr16:69,379,438...69,402,710
Ensembl chr16:69,379,400...69,404,812 		JBrowse link
G Yy1 YY1 transcription factor involved_in ISO
IEA 		MGI:3624790 (PMID:23531880)
GO_REF:0000107 		RGD
Ensembl		 PMID:23531880 GO_REF:0000107 NCBI chr 6:133,471,615...133,500,875
Ensembl chr 6:127,707,596...127,732,747 		JBrowse link
immunoglobulin V(D)J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyren cell cycle regulator of NHEJ involved_in ISS
ISO 		GO_REF:0000024
(PMID:30017584), (PMID:31795137) 		UniProt
RGD		 PMID:30017584 PMID:31795137 GO_REF:0000024 NCBI chr 4:63,547,311...63,553,394
Ensembl chr 4:63,547,335...63,551,602 		JBrowse link
G Foxp1 forkhead box P1 acts_upstream_of_or_within ISO MGI:3711150 (PMID:16819554) RGD PMID:16819554 NCBI chr 4:133,117,346...133,808,647
Ensembl chr 4:131,564,756...132,112,258 		JBrowse link
G Lig4 DNA ligase 4 involved_in
acts_upstream_of_or_within 		IBA
ISO 		GO_REF:0000033
MGI:1857732 (PMID:9823897) 		GO_Central
RGD		 PMID:9823897 GO_REF:0000033 NCBI chr16:86,220,345...86,228,930
Ensembl chr16:79,518,312...79,527,040 		JBrowse link
G Nhej1 nonhomologous end-joining factor 1 involved_in ISO
IEA
ISS 		(PMID:20558749)
GO_REF:0000107
GO_REF:0000024 		RGD
Ensembl
UniProt		 PMID:20558749 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:83,974,995...84,071,161
Ensembl chr 9:76,526,324...76,622,444 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit involved_in
acts_upstream_of_or_within 		IBA
IEA
ISO 		GO_REF:0000033
GO_REF:0000107
MGI:2383951 (PMID:9768755) 		GO_Central
Ensembl
RGD		 PMID:9768755 GO_REF:0000033 GO_REF:0000107 NCBI chr11:98,544,952...98,762,499
Ensembl chr11:85,040,792...85,257,952 		JBrowse link
G Tcf3 transcription factor 3 acts_upstream_of_or_within
involved_in 		ISO
IEA
IBA 		(PMID:16428437)
GO_REF:0000107
MGI:2178112 (PMID:16428437)
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:16428437 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:9,931,251...9,952,994
Ensembl chr 7:9,280,571...9,302,314 		JBrowse link
G Xrcc4 X-ray repair cross complementing 4 involved_in
acts_upstream_of_or_within 		IBA
ISO 		GO_REF:0000033
MGI:1926771 (PMID:9875844) 		GO_Central
RGD		 PMID:9875844 GO_REF:0000033 NCBI chr 2:22,686,506...22,932,929
Ensembl chr 2:20,951,200...21,197,808 		JBrowse link
isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aicda activation-induced cytidine deaminase acts_upstream_of_or_within
involved_in 		ISO (PMID:17713479)
(PMID:21518874) 		RGD PMID:17713479 PMID:21518874 NCBI chr 4:157,446,120...157,455,958
Ensembl chr 4:155,774,132...155,783,972 		JBrowse link
G Atad5 ATPase family, AAA domain containing 5 acts_upstream_of ISO
IEA 		MGI:4127920 (PMID:25404367)
GO_REF:0000107 		RGD
Ensembl		 PMID:25404367 GO_REF:0000107 NCBI chr10:65,568,569...65,616,379
Ensembl chr10:65,070,689...65,117,845 		JBrowse link
G Batf basic leucine zipper ATF-like transcription factor involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:20421391), (PMID:21572431) 		UniProt
Ensembl
RGD		 PMID:20421391 PMID:21572431 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:111,084,717...111,107,052
Ensembl chr 6:105,353,715...105,376,051 		JBrowse link
G Cd40lg CD40 ligand involved_in IEA
ISO 		GO_REF:0000107
(PMID:7529792) 		Ensembl
RGD		 PMID:7529792 GO_REF:0000107 NCBI chr  X:140,164,341...140,176,057
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit acts_upstream_of_or_within ISO MGI:2183944 (PMID:15280420) RGD PMID:15280420 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963 		JBrowse link
G Exo1 exonuclease 1 acts_upstream_of_or_within ISO
IEA 		MGI:2653925 (PMID:14716311)
GO_REF:0000107 		RGD
Ensembl		 PMID:14716311 GO_REF:0000107 NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654 		JBrowse link
G Exosc3 exosome component 3 involved_in ISO
IEA 		(PMID:21255825)
GO_REF:0000107 		RGD
Ensembl		 PMID:21255825 GO_REF:0000107 NCBI chr 5:64,369,495...64,374,711
Ensembl chr 5:59,573,886...59,579,060 		JBrowse link
G Exosc6 exosome component 6 involved_in ISO
IEA 		(PMID:21255825)
GO_REF:0000107 		RGD
Ensembl		 PMID:21255825 GO_REF:0000107 NCBI chr19:39,022,171...39,023,585
Ensembl chr19:39,022,183...39,023,515 		JBrowse link
G Lig4 DNA ligase 4 acts_upstream_of_or_within ISO MGI:1857732 (PMID:17713479) RGD PMID:17713479 NCBI chr16:86,220,345...86,228,930
Ensembl chr16:79,518,312...79,527,040 		JBrowse link
G Mlh1 mutL homolog 1 acts_upstream_of_or_within ISO
IEA 		MGI:1857946 (PMID:12743174)
GO_REF:0000107 		RGD
Ensembl		 PMID:12743174 GO_REF:0000107 NCBI chr 8:120,074,871...120,112,109
Ensembl chr 8:111,196,468...111,233,617 		JBrowse link
G Msh2 mutS homolog 2 acts_upstream_of_or_within ISO
IEA 		MGI:1857940|MGI:2151801 (PMID:10430621), (PMID:12743174)
GO_REF:0000107 		RGD
Ensembl		 PMID:10430621 PMID:12743174 GO_REF:0000107 NCBI chr 6:12,567,368...12,626,534
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Msh6 mutS homolog 6 acts_upstream_of_or_within ISO
IEA 		MGI:109352|MGI:3653701 (PMID:16618598), (PMID:17015724)
GO_REF:0000107 		RGD
Ensembl		 PMID:16618598 PMID:17015724 GO_REF:0000107 NCBI chr 6:12,316,190...12,333,505
Ensembl chr 6:6,562,632...6,579,956 		JBrowse link
G Nbn nibrin involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:15668383)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:15668383 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:29,459,574...29,494,152
Ensembl chr 5:29,459,457...29,494,150 		JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in ISO MGI:3046930|MGI:5501251 (PMID:25124037), (PMID:31182790) RGD PMID:25124037 PMID:31182790 NCBI chr11:58,251,720...58,279,767
Ensembl chr11:44,782,676...44,810,723 		JBrowse link
G Pcyt1a phosphate cytidylyltransferase 1A, choline involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:19139091) 		UniProt
Ensembl
RGD		 PMID:19139091 GO_REF:0000024 GO_REF:0000107 NCBI chr11:81,818,914...81,862,623
Ensembl chr11:68,313,882...68,357,357 		JBrowse link
G Rnf168 ring finger protein 168 involved_in ISS
ISO 		GO_REF:0000024
(PMID:20080757) 		UniProt
RGD		 PMID:20080757 GO_REF:0000024 NCBI chr11:68,486,313...68,508,296
Ensembl chr11:68,486,321...68,508,277 		JBrowse link
G Rnf8 ring finger protein 8 involved_in ISS
ISO 		GO_REF:0000024
(PMID:20080757) 		UniProt
RGD		 PMID:20080757 GO_REF:0000024 NCBI chr20:7,682,258...7,710,448
Ensembl chr20:7,682,322...7,708,491 		JBrowse link
G Sanbr SANT and BTB domain regulator of CSR involved_in ISS
IBA
ISO
IEA 		GO_REF:0000024
GO_REF:0000033
(PMID:33831416)
GO_REF:0000107 		UniProt
GO_Central
RGD
Ensembl		 PMID:33831416 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr14:97,516,652...97,585,955
Ensembl chr14:97,516,413...97,581,346 		JBrowse link
G Swap70 switching B-cell complex subunit SWAP70 acts_upstream_of_or_within ISO
IEA 		(PMID:9642267)
GO_REF:0000107 		RGD
Ensembl		 PMID:9642267 GO_REF:0000107 NCBI chr 1:164,267,588...164,328,796
Ensembl chr 1:164,267,609...164,328,794 		JBrowse link
G Ung uracil-DNA glycosylase acts_upstream_of_or_within ISO MGI:1343961 (PMID:17015724) RGD PMID:17015724 NCBI chr12:48,145,838...48,154,789
Ensembl chr12:42,485,276...42,494,206 		JBrowse link
G Xrcc4 X-ray repair cross complementing 4 acts_upstream_of_or_within ISO MGI:1926771|MGI:3047571|MGI:3641440 (PMID:17713479) RGD PMID:17713479 NCBI chr 2:22,686,506...22,932,929
Ensembl chr 2:20,951,200...21,197,808 		JBrowse link
isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr6 C-C motif chemokine receptor 6 involved_in ISO
IEA 		(PMID:27174992)
GO_REF:0000107 		RGD
Ensembl		 PMID:27174992 GO_REF:0000107 NCBI chr 1:55,022,037...55,055,857
Ensembl chr 1:52,474,168...52,498,603 		JBrowse link
isotype switching to IgD isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fdcsp follicular dendritic cell secreted protein acts_upstream_of_positive_effect ISO MGI:7719862 (PMID:17548624) RGD PMID:17548624 NCBI chr14:20,169,691...20,173,983
Ensembl chr14:20,169,691...20,173,983 		JBrowse link
isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6, transcription repressor acts_upstream_of ISO
IEA 		MGI:103034|MGI:2158438 (PMID:10490661)
GO_REF:0000107 		RGD
Ensembl		 PMID:10490661 GO_REF:0000107 NCBI chr11:90,358,753...90,382,049
Ensembl chr11:76,854,090...76,877,389 		JBrowse link
G Fdcsp follicular dendritic cell secreted protein acts_upstream_of_or_within_negative_effect ISO MGI:7719862 (PMID:17548624) RGD PMID:17548624 NCBI chr14:20,169,691...20,173,983
Ensembl chr14:20,169,691...20,173,983 		JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of ISO
IEA 		MGI:3696705 (PMID:16275384)
GO_REF:0000107 		RGD
Ensembl		 PMID:16275384 GO_REF:0000107 NCBI chr  X:17,580,380...17,601,181
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Il4 interleukin 4 acts_upstream_of ISO (PMID:14988498) RGD PMID:14988498 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 acts_upstream_of ISO MGI:107187 (PMID:10490661) RGD PMID:10490661 NCBI chr 7:65,365,505...65,382,825
Ensembl chr 7:63,479,642...63,498,495 		JBrowse link
isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fdcsp follicular dendritic cell secreted protein acts_upstream_of_or_within_negative_effect ISO MGI:7719862 (PMID:17548624) RGD PMID:17548624 NCBI chr14:20,169,691...20,173,983
Ensembl chr14:20,169,691...20,173,983 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 involved_in ISO (PMID:16148103) RGD PMID:16148103 NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:56,579,201...56,589,662 		JBrowse link
G Il4 interleukin 4 acts_upstream_of ISO (PMID:14988498) RGD PMID:14988498 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
negative regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Parp3 poly (ADP-ribose) polymerase family, member 3 involved_in ISO
IEA 		(PMID:26000965)
GO_REF:0000107 		RGD
Ensembl		 PMID:26000965 GO_REF:0000107 NCBI chr 8:107,111,010...107,117,073
Ensembl chr 8:107,111,012...107,116,782 		JBrowse link
negative regulation of isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fdcsp follicular dendritic cell secreted protein involved_in ISO MGI:6723808|MGI:7719862 (PMID:24399151) RGD PMID:24399151 NCBI chr14:20,169,691...20,173,983
Ensembl chr14:20,169,691...20,173,983 		JBrowse link
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6, transcription repressor acts_upstream_of_or_within ISO
IEA 		MGI:103034|MGI:2158438 (PMID:10490661)
GO_REF:0000107 		RGD
Ensembl		 PMID:10490661 GO_REF:0000107 NCBI chr11:90,358,753...90,382,049
Ensembl chr11:76,854,090...76,877,389 		JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO
IEA 		MGI:3696705 (PMID:16275384)
GO_REF:0000107 		RGD
Ensembl		 PMID:16275384 GO_REF:0000107 NCBI chr  X:17,580,380...17,601,181
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 acts_upstream_of_or_within ISO
IEA 		MGI:3695433 (PMID:17137798)
GO_REF:0000107 		RGD
Ensembl		 PMID:17137798 GO_REF:0000107 NCBI chr18:30,516,931...30,567,199
Ensembl chr18:30,250,613...30,322,311 		JBrowse link
positive regulation of interleukin-4-dependent isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnfsf4 TNF superfamily member 4 involved_in ISO
IEA 		(PMID:12496423)
GO_REF:0000107 		RGD
Ensembl		 PMID:12496423 GO_REF:0000107 NCBI chr13:76,256,654...76,280,133
Ensembl chr13:73,723,329...73,746,788 		JBrowse link
positive regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Exosc3 exosome component 3 acts_upstream_of_or_within ISO
IEA 		(PMID:21255825)
GO_REF:0000107 		RGD
Ensembl		 PMID:21255825 GO_REF:0000107 NCBI chr 5:64,369,495...64,374,711
Ensembl chr 5:59,573,886...59,579,060 		JBrowse link
G Exosc6 exosome component 6 acts_upstream_of_or_within ISO
IEA 		(PMID:21255825)
GO_REF:0000107 		RGD
Ensembl		 PMID:21255825 GO_REF:0000107 NCBI chr19:39,022,171...39,023,585
Ensembl chr19:39,022,183...39,023,515 		JBrowse link
G Hmces 5-hydroxymethylcytosine binding, ES cell specific involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:31806351) 		UniProt
Ensembl
RGD		 PMID:31806351 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:120,392,812...120,415,616
Ensembl chr 4:120,366,542...120,415,616 		JBrowse link
G Kmt5b lysine methyltransferase 5B involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:28114273) 		UniProt
Ensembl
RGD		 PMID:28114273 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:201,000,444...201,049,819
Ensembl chr 1:201,000,444...201,049,819 		JBrowse link
G Kmt5c lysine methyltransferase 5C involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:28114273) 		UniProt
Ensembl
RGD		 PMID:28114273 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:69,099,531...69,107,145
Ensembl chr 1:69,099,539...69,107,145 		JBrowse link
G Mad2l2 mitotic arrest deficient 2 like 2 involved_in ISO (PMID:29656893) RGD PMID:29656893 NCBI chr 5:163,846,678...163,859,851
Ensembl chr 5:158,563,567...158,576,693 		JBrowse link
G Paxip1 PAX interacting protein 1 involved_in ISO (PMID:20671152) RGD PMID:20671152 NCBI chr 4:7,525,132...7,576,659
Ensembl chr 4:7,525,004...7,576,548 		JBrowse link
G Rif1 replication timing regulatory factor 1 involved_in ISO
IEA 		(PMID:23306439), (PMID:23333305), (PMID:23333306)
GO_REF:0000107 		RGD
Ensembl		 PMID:23306439 PMID:23333305 PMID:23333306 GO_REF:0000107 NCBI chr 3:36,554,689...36,607,961
Ensembl chr 3:36,554,697...36,603,617 		JBrowse link
G Shld1 shieldin complex subunit 1 involved_in ISO
IBA 		(PMID:29656893)
GO_REF:0000033 		RGD
GO_Central		 PMID:29656893 GO_REF:0000033 NCBI chr 3:140,391,611...140,462,273
Ensembl chr 3:119,938,833...120,009,550 		JBrowse link
G Shld2 shieldin complex subunit 2 involved_in ISO (PMID:29656893) RGD PMID:29656893 NCBI chr16:9,544,940...9,640,323
Ensembl chr16:9,548,660...9,639,965 		JBrowse link
G Shld3 shieldin complex subunit 3 involved_in ISO
IEA
IBA 		(PMID:29656893)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:29656893 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:35,297,255...35,302,071
Ensembl chr 2:35,295,859...35,302,346 		JBrowse link
G Tfrc transferrin receptor involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:26642240) 		UniProt
Ensembl
RGD		 PMID:26642240 GO_REF:0000024 GO_REF:0000107 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 involved_in ISO
IEA 		(PMID:23345425), (PMID:23760478)
GO_REF:0000107
(PMID:15077110), (PMID:15159415) 		RGD
Ensembl		 PMID:15077110 PMID:15159415 PMID:23345425 PMID:23760478 GO_REF:0000107 NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822 		JBrowse link
positive regulation of isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mlh1 mutL homolog 1 involved_in IEA
ISO 		GO_REF:0000107
(PMID:10430621) 		Ensembl
RGD		 PMID:10430621 GO_REF:0000107 NCBI chr 8:120,074,871...120,112,109
Ensembl chr 8:111,196,468...111,233,617 		JBrowse link
G Msh2 mutS homolog 2 involved_in IEA
ISO 		GO_REF:0000107
(PMID:10430621) 		Ensembl
RGD		 PMID:10430621 GO_REF:0000107 NCBI chr 6:12,567,368...12,626,534
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Nsd2 nuclear receptor binding SET domain protein 2 acts_upstream_of_or_within ISO
IEA 		(PMID:23241889)
GO_REF:0000107 		RGD
Ensembl		 PMID:23241889 GO_REF:0000107 NCBI chr14:76,833,179...76,911,304
Ensembl chr14:76,835,637...76,913,641 		JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component involved_in ISO
IEA 		UniProtKB:Q9JK91 (PMID:10430621)
GO_REF:0000107 		RGD
Ensembl		 PMID:10430621 GO_REF:0000107 NCBI chr12:15,790,478...15,814,790
Ensembl chr12:10,676,764...10,701,066 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in
acts_upstream_of_or_within 		ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:14988498) 		AgBase
Ensembl
RGD		 PMID:14988498 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnfsf13 TNF superfamily member 13 acts_upstream_of_or_within
involved_in 		ISO
IBA 		(PMID:14988498)
MGI:3038886 (PMID:14988498)
GO_REF:0000033 		RGD
GO_Central		 PMID:14988498 GO_REF:0000033 NCBI chr10:54,898,805...54,901,815
Ensembl chr10:54,400,065...54,403,042 		JBrowse link
positive regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clcf1 cardiotrophin-like cytokine factor 1 involved_in ISO (PMID:12023368) RGD PMID:12023368 NCBI chr 1:210,937,763...210,947,064
Ensembl chr 1:201,507,859...201,517,605 		JBrowse link
G Il4 interleukin 4 acts_upstream_of_or_within ISO (PMID:14988498) RGD PMID:14988498 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 acts_upstream_of_or_within ISO MGI:107187 (PMID:10490661) RGD PMID:10490661 NCBI chr 7:65,365,505...65,382,825
Ensembl chr 7:63,479,642...63,498,495 		JBrowse link
positive regulation of isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atad5 ATPase family, AAA domain containing 5 acts_upstream_of_or_within ISO
IEA 		MGI:4127920 (PMID:25404367)
GO_REF:0000107 		RGD
Ensembl		 PMID:25404367 GO_REF:0000107 NCBI chr10:65,568,569...65,616,379
Ensembl chr10:65,070,689...65,117,845 		JBrowse link
G Cd28 Cd28 molecule acts_upstream_of_or_within ISO MGI:1857150 (PMID:7688139) RGD PMID:7688139 NCBI chr 9:69,660,316...69,689,192
Ensembl chr 9:62,166,192...62,194,685 		JBrowse link
G Cd40 CD40 molecule acts_upstream_of_or_within ISO (PMID:12882831) RGD PMID:12882831 NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Ifng interferon gamma acts_upstream_of_or_within ISO (PMID:12882831) RGD PMID:12882831 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il2 interleukin 2 acts_upstream_of_or_within ISO MGI:1857191 (PMID:1830926) RGD PMID:1830926 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il4 interleukin 4 acts_upstream_of_or_within ISO (PMID:12882831), (PMID:14988498) RGD PMID:12882831 PMID:14988498 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Mlh1 mutL homolog 1 involved_in IEA
ISO 		GO_REF:0000107
(PMID:10430621) 		Ensembl
RGD		 PMID:10430621 GO_REF:0000107 NCBI chr 8:120,074,871...120,112,109
Ensembl chr 8:111,196,468...111,233,617 		JBrowse link
G Msh2 mutS homolog 2 involved_in IEA
ISO 		GO_REF:0000107
(PMID:10430621) 		Ensembl
RGD		 PMID:10430621 GO_REF:0000107 NCBI chr 6:12,567,368...12,626,534
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Pagr1 Paxip1-associated glutamate-rich protein 1 involved_in ISO (PMID:26744420) RGD PMID:26744420 NCBI chr 1:191,053,228...191,055,554 JBrowse link
G Paxip1 PAX interacting protein 1 involved_in ISO (PMID:26744420) RGD PMID:26744420 NCBI chr 4:7,525,132...7,576,659
Ensembl chr 4:7,525,004...7,576,548 		JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component involved_in ISO
IEA 		UniProtKB:Q9JK91 (PMID:10430621)
GO_REF:0000107 		RGD
Ensembl		 PMID:10430621 GO_REF:0000107 NCBI chr12:15,790,478...15,814,790
Ensembl chr12:10,676,764...10,701,066 		JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C acts_upstream_of_or_within ISO MGI:2181288 (PMID:9015183) RGD PMID:9015183 NCBI chr13:52,147,717...52,259,810
Ensembl chr13:49,596,193...49,708,692 		JBrowse link
G Tbx21 T-box transcription factor 21 acts_upstream_of_or_within ISO
IEA 		MGI:2180194 (PMID:12882831)
GO_REF:0000107 		RGD
Ensembl		 PMID:12882831 GO_REF:0000107 NCBI chr10:82,578,751...82,595,253
Ensembl chr10:82,082,322...82,098,831 		JBrowse link
regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aplf aprataxin and PNKP like factor acts_upstream_of_or_within ISO
IEA 		MGI:4128102 (PMID:21211721)
GO_REF:0000107 		RGD
Ensembl		 PMID:21211721 GO_REF:0000107 NCBI chr 4:120,070,471...120,122,656
Ensembl chr 4:120,070,471...120,122,633 		JBrowse link
G Mir181b1 microRNA 181b-1 acts_upstream_of_or_within ISO (PMID:18762567) RGD PMID:18762567 NCBI chr13:49,485,688...49,485,797
Ensembl chr13:49,485,688...49,485,797 		JBrowse link
G Mir181b2 microRNA 181b-2 acts_upstream_of_or_within ISO (PMID:18762567) RGD PMID:18762567 NCBI chr 3:22,616,948...22,617,035
Ensembl chr 3:22,616,948...22,617,035 		JBrowse link
G Supt6h SPT6 homolog, histone chaperone and transcription elongation factor involved_in ISO
IEA 		(PMID:21518874)
GO_REF:0000107 		RGD
Ensembl		 PMID:21518874 GO_REF:0000107 NCBI chr10:63,103,920...63,140,780
Ensembl chr10:63,103,921...63,140,780 		JBrowse link
regulation of isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO
IEA 		MGI:3696705 (PMID:16275384)
GO_REF:0000107 		RGD
Ensembl		 PMID:16275384 GO_REF:0000107 NCBI chr  X:17,580,380...17,601,181
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Il27ra interleukin 27 receptor subunit alpha acts_upstream_of_or_within ISO
IEA 		MGI:3525439 (PMID:11057672)
GO_REF:0000107 		RGD
Ensembl		 PMID:11057672 GO_REF:0000107 NCBI chr19:24,109,963...24,121,977
Ensembl chr19:24,109,972...24,121,938 		JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 acts_upstream_of_or_within ISO
IEA 		MGI:3695433 (PMID:17137798)
GO_REF:0000107 		RGD
Ensembl		 PMID:17137798 GO_REF:0000107 NCBI chr18:30,516,931...30,567,199
Ensembl chr18:30,250,613...30,322,311 		JBrowse link
G Slc15a4 solute carrier family 15 member 4 involved_in IEA
ISO
ISS 		GO_REF:0000107
(PMID:25310967)
GO_REF:0000024 		Ensembl
RGD
UniProt		 PMID:25310967 GO_REF:0000024 GO_REF:0000107 NCBI chr12:29,048,634...29,082,480
Ensembl chr12:29,063,015...29,082,480 		JBrowse link
somatic diversification of immune receptors via somatic mutation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adar adenosine deaminase, RNA-specific acts_upstream_of_or_within ISO
IEA 		(PMID:23209284)
GO_REF:0000107 		RGD
Ensembl		 PMID:23209284 GO_REF:0000107 NCBI chr 2:175,138,391...175,178,280
Ensembl chr 2:175,138,403...175,178,282 		JBrowse link
somatic diversification of immunoglobulins term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aicda activation-induced cytidine deaminase involved_in ISO (PMID:18722174) RGD PMID:18722174 NCBI chr 4:157,446,120...157,455,958
Ensembl chr 4:155,774,132...155,783,972 		JBrowse link
G Ctnnbl1 catenin, beta like 1 involved_in ISO
IEA 		(PMID:18722174)
GO_REF:0000107 		RGD
Ensembl		 PMID:18722174 GO_REF:0000107 NCBI chr 3:146,387,940...146,548,987
Ensembl chr 3:146,387,889...146,548,987 		JBrowse link
G Polb DNA polymerase beta acts_upstream_of_or_within ISO
IEA 		MGI:5427084 (PMID:24388753)
GO_REF:0000107 		RGD
Ensembl		 PMID:24388753 GO_REF:0000107 NCBI chr16:69,379,438...69,402,710
Ensembl chr16:69,379,400...69,404,812 		JBrowse link
somatic hypermutation of immunoglobulin genes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aicda activation-induced cytidine deaminase involved_in ISO (PMID:21518874) RGD PMID:21518874 NCBI chr 4:157,446,120...157,455,958
Ensembl chr 4:155,774,132...155,783,972 		JBrowse link
G Exo1 exonuclease 1 acts_upstream_of_or_within ISO
IEA 		MGI:2653925 (PMID:14716311)
GO_REF:0000107 		RGD
Ensembl		 PMID:14716311 GO_REF:0000107 NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654 		JBrowse link
G Hmces 5-hydroxymethylcytosine binding, ES cell specific involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:35450882) 		UniProt
Ensembl
RGD		 PMID:35450882 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:120,392,812...120,415,616
Ensembl chr 4:120,366,542...120,415,616 		JBrowse link
G Mcm3ap minichromosome maintenance complex component 3 associated protein involved_in ISO
IEA 		(PMID:23652018)
GO_REF:0000107 		RGD
Ensembl		 PMID:23652018 GO_REF:0000107 NCBI chr20:12,127,570...12,165,165
Ensembl chr20:12,127,570...12,165,165 		JBrowse link
G Mlh1 mutL homolog 1 involved_in
acts_upstream_of_or_within 		IBA
IEA
ISO 		GO_REF:0000033
GO_REF:0000107
MGI:1857946 (PMID:10092760), (PMID:10429667) 		GO_Central
Ensembl
RGD		 PMID:10092760 PMID:10429667 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:120,074,871...120,112,109
Ensembl chr 8:111,196,468...111,233,617 		JBrowse link
G Msh2 mutS homolog 2 acts_upstream_of_or_within
NOT|acts_upstream_of_or_within 		ISO
IEA 		MGI:109352|MGI:1857940|MGI:1858055|MGI:2680817 (PMID:14568978), (PMID:15494304), (PMID:9607916), (PMID:9697842), (PMID:9697843)
GO_REF:0000107
MGI:1858055 (PMID:9607915) 		RGD
Ensembl		 PMID:9607915 PMID:9607916 PMID:9697842 PMID:9697843 PMID:14568978 More... GO_REF:0000107 NCBI chr 6:12,567,368...12,626,534
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Msh3 mutS homolog 3 NOT|acts_upstream_of_or_within ISO MGI:1858056 (PMID:10662804) RGD PMID:10662804 NCBI chr 2:25,179,400...25,320,857 JBrowse link
G Msh6 mutS homolog 6 acts_upstream_of_or_within ISO
IEA 		MGI:1858014|MGI:3653701 (PMID:10662804), (PMID:15238604), (PMID:16618598), (PMID:17015724)
GO_REF:0000107 		RGD
Ensembl		 PMID:10662804 PMID:15238604 PMID:16618598 PMID:17015724 GO_REF:0000107 NCBI chr 6:12,316,190...12,333,505
Ensembl chr 6:6,562,632...6,579,956 		JBrowse link
G Nuggc nuclear GTPase, germinal center associated acts_upstream_of_or_within ISO
IEA 		MGI:5449552 (PMID:22833677)
GO_REF:0000107 		RGD
Ensembl		 PMID:22833677 GO_REF:0000107 NCBI chr15:39,821,851...39,866,122
Ensembl chr15:39,821,855...39,866,122 		JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component involved_in
acts_upstream_of_or_within 		IBA
IEA
ISO 		GO_REF:0000033
GO_REF:0000107
(PMID:9618520)
MGI:1857947 (PMID:10429667) 		GO_Central
Ensembl
RGD		 PMID:9618520 PMID:10429667 GO_REF:0000033 GO_REF:0000107 NCBI chr12:15,790,478...15,814,790
Ensembl chr12:10,676,764...10,701,066 		JBrowse link
G Polb DNA polymerase beta acts_upstream_of_or_within ISO
IEA 		MGI:5427084 (PMID:24388753)
GO_REF:0000107 		RGD
Ensembl		 PMID:24388753 GO_REF:0000107 NCBI chr16:69,379,438...69,402,710
Ensembl chr16:69,379,400...69,404,812 		JBrowse link
G Polm DNA polymerase mu acts_upstream_of_or_within ISO
IEA 		MGI:2179233 (PMID:15789338)
GO_REF:0000107 		RGD
Ensembl		 PMID:15789338 GO_REF:0000107 NCBI chr14:84,921,039...84,930,649
Ensembl chr14:80,706,345...80,717,086 		JBrowse link
G Polq DNA polymerase theta involved_in ISO
IEA 		(PMID:16172387), (PMID:16222339), (PMID:16890500)
GO_REF:0000107 		RGD
Ensembl		 PMID:16172387 PMID:16222339 PMID:16890500 GO_REF:0000107 NCBI chr11:63,673,796...63,775,905
Ensembl chr11:63,673,816...63,775,878 		JBrowse link
G Samhd1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 involved_in ISO
IEA 		(PMID:29669924)
GO_REF:0000107 		RGD
Ensembl		 PMID:29669924 GO_REF:0000107 NCBI chr 3:145,761,549...145,794,420
Ensembl chr 3:145,761,558...145,794,386 		JBrowse link
G Ung uracil-DNA glycosylase acts_upstream_of_or_within ISO MGI:101816|MGI:2182610 (PMID:15494304), (PMID:17015724) RGD PMID:15494304 PMID:17015724 NCBI chr12:48,145,838...48,154,789
Ensembl chr12:42,485,276...42,494,206 		JBrowse link
somatic recombination of immunoglobulin gene segments term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mlh1 mutL homolog 1 acts_upstream_of_or_within ISO
IEA 		MGI:1857946 (PMID:11828012)
GO_REF:0000107 		RGD
Ensembl		 PMID:11828012 GO_REF:0000107 NCBI chr 8:120,074,871...120,112,109
Ensembl chr 8:111,196,468...111,233,617 		JBrowse link
G Msh2 mutS homolog 2 acts_upstream_of_or_within ISO
IEA 		MGI:109352|MGI:1857940|MGI:2151801|MGI:2680817 (PMID:11828012), (PMID:14563316), (PMID:14568978), (PMID:15494304), (PMID:15955838)
GO_REF:0000107 		RGD
Ensembl		 PMID:11828012 PMID:14563316 PMID:14568978 PMID:15494304 PMID:15955838 GO_REF:0000107 NCBI chr 6:12,567,368...12,626,534
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Msh3 mutS homolog 3 acts_upstream_of_or_within ISO MGI:1858056 (PMID:15238604) RGD PMID:15238604 NCBI chr 2:25,179,400...25,320,857 JBrowse link
G Msh6 mutS homolog 6 acts_upstream_of_or_within ISO
IEA 		MGI:1858014 (PMID:15238604)
GO_REF:0000107 		RGD
Ensembl		 PMID:15238604 GO_REF:0000107 NCBI chr 6:12,316,190...12,333,505
Ensembl chr 6:6,562,632...6,579,956 		JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component acts_upstream_of_or_within ISO
IEA 		MGI:1857947 (PMID:11828012)
GO_REF:0000107 		RGD
Ensembl		 PMID:11828012 GO_REF:0000107 NCBI chr12:15,790,478...15,814,790
Ensembl chr12:10,676,764...10,701,066 		JBrowse link
G Ung uracil-DNA glycosylase acts_upstream_of_or_within ISO MGI:101816|MGI:2182610 (PMID:15494304) RGD PMID:15494304 NCBI chr12:48,145,838...48,154,789
Ensembl chr12:42,485,276...42,494,206 		JBrowse link
somatic recombination of immunoglobulin genes involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mlh1 mutL homolog 1 acts_upstream_of_or_within ISO
IEA 		MGI:101816 (PMID:12743174)
GO_REF:0000107 		RGD
Ensembl		 PMID:12743174 GO_REF:0000107 NCBI chr 8:120,074,871...120,112,109
Ensembl chr 8:111,196,468...111,233,617 		JBrowse link
G Msh2 mutS homolog 2 involved_in
acts_upstream_of_or_within 		IBA
IEA
ISO 		GO_REF:0000033
GO_REF:0000107
MGI:101938 (PMID:12743174) 		GO_Central
Ensembl
RGD		 PMID:12743174 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:12,567,368...12,626,534
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
T cell receptor V(D)J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl11b BCL11 transcription factor B acts_upstream_of_or_within ISO
IEA 		MGI:2663971 (PMID:12717433)
GO_REF:0000107 		RGD
Ensembl		 PMID:12717433 GO_REF:0000107 NCBI chr 6:132,598,968...132,692,123
Ensembl chr 6:126,834,531...126,928,224 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 acts_upstream_of_or_within ISO
IEA 		MGI:98507 (PMID:9462507)
GO_REF:0000107 		RGD
Ensembl		 PMID:9462507 GO_REF:0000107 NCBI chr 2:222,340,541...222,453,931
Ensembl chr 2:219,666,592...219,779,794 		JBrowse link
G Lig4 DNA ligase 4 acts_upstream_of_or_within ISO MGI:1857732 (PMID:10911993) RGD PMID:10911993 NCBI chr16:86,220,345...86,228,930
Ensembl chr16:79,518,312...79,527,040 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit acts_upstream_of_or_within ISO
IEA 		MGI:2383951 (PMID:9768755)
GO_REF:0000107 		RGD
Ensembl		 PMID:9768755 GO_REF:0000107 NCBI chr11:98,544,952...98,762,499
Ensembl chr11:85,040,792...85,257,952 		JBrowse link
G Tcf7 transcription factor 7 acts_upstream_of_or_within ISO MGI:96770 (PMID:9462507) RGD PMID:9462507 NCBI chr10:36,924,363...36,954,279
Ensembl chr10:36,423,445...36,453,535 		JBrowse link
V(D)J recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase acts_upstream_of_or_within ISO MGI:104779 (PMID:23836881) RGD PMID:23836881 NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Dcaf1 DDB1 and CUL4 associated factor 1 involved_in ISO (PMID:22157821) RGD PMID:22157821 NCBI chr 8:116,344,927...116,419,329
Ensembl chr 8:107,474,312...107,540,627 		JBrowse link
G Dclre1c DNA cross-link repair 1C acts_upstream_of_or_within ISO (PMID:23836881) RGD PMID:23836881 NCBI chr17:79,684,988...79,718,399
Ensembl chr17:74,776,935...74,809,186 		JBrowse link
G Hmgb1 high mobility group box 1 involved_in ISO (PMID:9166431) RGD PMID:9166431 NCBI chr12:11,009,236...11,015,941
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Lig1 DNA ligase 1 NOT|involved_in ISO (PMID:9809069) RGD PMID:9809069 NCBI chr 1:74,165,688...74,204,400
Ensembl chr 1:74,165,842...74,204,413 		JBrowse link
G Lig3 DNA ligase 3 NOT|involved_in ISO (PMID:9809069) RGD PMID:9809069 NCBI chr10:67,717,808...67,741,141
Ensembl chr10:67,717,812...67,798,414 		JBrowse link
G Lig4 DNA ligase 4 involved_in
acts_upstream_of_or_within 		ISO (PMID:9809069)
MGI:1857732 (PMID:10716994), (PMID:15194694) 		RGD PMID:9809069 PMID:10716994 PMID:15194694 NCBI chr16:86,220,345...86,228,930
Ensembl chr16:79,518,312...79,527,040 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit acts_upstream_of_or_within ISO
IEA 		MGI:107202 (PMID:23836881)
GO_REF:0000107 		RGD
Ensembl		 PMID:23836881 GO_REF:0000107 NCBI chr11:98,544,952...98,762,499
Ensembl chr11:85,040,792...85,257,952 		JBrowse link
G Rag1 recombination activating 1 involved_in
acts_upstream_of_or_within 		ISO
IEA
IBA 		(PMID:14670978)
GO_REF:0000107
GO_REF:0000002
GO_REF:0000104
(PMID:10601033), (PMID:1547488), (PMID:20122409), (PMID:8284210)
MGI:97849 (PMID:2360047)
GO_REF:0000033 		RGD
Ensembl
InterPro
UniProt
GO_Central		 PMID:1547488 PMID:2360047 PMID:8284210 PMID:10601033 PMID:14670978 More... GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 NCBI chr 3:108,372,087...108,383,184
Ensembl chr 3:87,917,004...87,928,291 		JBrowse link
G Rag2 recombination activating 2 involved_in
acts_upstream_of_or_within 		IBA
IEA
ISO 		GO_REF:0000033
GO_REF:0000107
(PMID:1547488), (PMID:18033247)
MGI:97848 (PMID:2360047) 		GO_Central
Ensembl
RGD		 PMID:1547488 PMID:2360047 PMID:18033247 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:108,357,399...108,367,186
Ensembl chr 3:87,902,238...87,911,066 		JBrowse link
G Xrcc4 X-ray repair cross complementing 4 acts_upstream_of_or_within ISO MGI:1926771 (PMID:10716994), (PMID:15194694) RGD PMID:10716994 PMID:15194694 NCBI chr 2:22,686,506...22,932,929
Ensembl chr 2:20,951,200...21,197,808 		JBrowse link
G Xrcc6 X-ray repair cross complementing 6 acts_upstream_of_or_within ISO MGI:2179954 (PMID:10716994) RGD PMID:10716994 NCBI chr 7:115,423,026...115,443,884
Ensembl chr 7:113,543,057...113,563,762 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20543
    immune system process 3132
      somatic diversification of immune receptors 87
        somatic diversification of DSCAM-based immune receptors 0
        somatic diversification of FREP-based immune receptors 0
        somatic diversification of T cell receptor genes + 5
        somatic diversification of immune receptors by N region addition + 0
        somatic diversification of immune receptors via alternate splicing + 0
        somatic diversification of immune receptors via gene conversion + 0
        somatic diversification of immune receptors via germline recombination within a single locus + 80
        somatic diversification of immune receptors via somatic mutation + 16
        somatic diversification of immunoglobulins + 74
        somatic diversification of variable lymphocyte receptors of jawless fish 0
Path 2
Term Annotations click to browse term
  biological_process 20543
    developmental process 7160
      anatomical structure development 6656
        multicellular organism development 5362
          system development 4644
            immune system development 241
              somatic diversification of immune receptors 87
                somatic diversification of DSCAM-based immune receptors 0
                somatic diversification of FREP-based immune receptors 0
                somatic diversification of T cell receptor genes + 5
                somatic diversification of immune receptors by N region addition + 0
                somatic diversification of immune receptors via alternate splicing + 0
                somatic diversification of immune receptors via gene conversion + 0
                somatic diversification of immune receptors via germline recombination within a single locus + 80
                somatic diversification of immune receptors via somatic mutation + 16
                somatic diversification of immunoglobulins + 74
                somatic diversification of variable lymphocyte receptors of jawless fish 0
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