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ONTOLOGY REPORT - ANNOTATIONS

Term:spinal cord motor neuron differentiation
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Accession:GO:0021522 term browser browse the term
Definition:The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.

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spinal cord motor neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABT1 activator of basal transcription 1 acts_upstream_of_or_within ISO (PMID:19299493) MGI PMID:19299493 NCBI chr17:45,617,425...45,619,634
Ensembl chr17:45,616,617...45,619,681 		JBrowse link
G CACNA1A calcium voltage-gated channel subunit alpha1 A acts_upstream_of_or_within ISO (PMID:17156092) MGI PMID:17156092 NCBI chr 6:11,883,353...12,307,023 JBrowse link
G CLN8 CLN8 transmembrane ER and ERGIC protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:2061715) Ensembl
MGI		 PMID:2061715 GO_REF:0000107 NCBI chr 8:1,424,402...1,445,505
Ensembl chr 8:1,433,953...1,445,021 		JBrowse link
G DICER1 dicer 1, ribonuclease III acts_upstream_of_or_within ISO (PMID:21338882) MGI PMID:21338882 NCBI chr24:72,915,550...72,986,658
Ensembl chr24:72,915,499...72,963,006 		JBrowse link
G DYNC2H1 dynein cytoplasmic 2 heavy chain 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21552265) Ensembl
MGI		 PMID:21552265 GO_REF:0000107 NCBI chr 1:94,484,090...94,849,960
Ensembl chr 1:94,484,512...94,849,581 		JBrowse link
G GBX1 gastrulation brain homeobox 1 acts_upstream_of_or_within ISO (PMID:23418536) MGI PMID:23418536 NCBI chr21:119,331,203...119,354,622 JBrowse link
G GBX1 gastrulation brain homeobox 1 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr21:119,331,772...119,352,076 JBrowse link
G GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 acts_upstream_of_or_within ISO (PMID:21943603) MGI PMID:21943603 NCBI chr 1:66,665,496...66,755,712
Ensembl chr 1:66,664,914...66,755,692 		JBrowse link
G GIGYF2 GRB10 interacting GYF protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19744960) Ensembl
MGI		 PMID:19744960 GO_REF:0000107 NCBI chr10:118,720,668...118,883,299
Ensembl chr10:118,720,690...118,874,162 		JBrowse link
G GLI2 GLI family zinc finger 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:21552265) MGI
Ensembl		 PMID:21552265 GO_REF:0000107 NCBI chr10:9,302,890...9,561,287
Ensembl chr10:9,304,645...9,369,115 		JBrowse link
G GLI3 GLI family zinc finger 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21552265) Ensembl
MGI		 PMID:21552265 GO_REF:0000107 NCBI chr21:16,386,700...16,665,648
Ensembl chr21:16,549,789...16,662,238 		JBrowse link
G IFT172 intraflagellar transport 172 acts_upstream_of_or_within ISO (PMID:21552265) MGI PMID:21552265 NCBI chr14:80,130,436...80,171,259 JBrowse link
G IFT172 intraflagellar transport 172 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr14:80,138,354...80,171,200 JBrowse link
G IGHMBP2 immunoglobulin mu DNA binding protein 2 acts_upstream_of_or_within ISO (PMID:19299493) MGI PMID:19299493 NCBI chr 1:5,619,138...5,655,033
Ensembl chr 1:5,619,425...5,655,737 		JBrowse link
G ISL1 ISL LIM homeobox 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:8565076) MGI
Ensembl		 PMID:8565076 GO_REF:0000107 NCBI chr 4:47,665,861...47,678,631
Ensembl chr 4:47,666,536...47,677,552 		JBrowse link
G LBX1 ladybird homeobox 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15769945) Ensembl
MGI		 PMID:15769945 GO_REF:0000107 NCBI chr 9:94,247,931...94,251,092
Ensembl chr 9:94,249,000...94,250,545 		JBrowse link
G LMO4 LIM domain only 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19666821) Ensembl
MGI		 PMID:19666821 GO_REF:0000107 NCBI chr20:46,105,755...46,126,291
Ensembl chr20:46,105,699...46,126,399 		JBrowse link
G LOC103219825 protein patched homolog 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:21552265) MGI
Ensembl		 PMID:21552265 GO_REF:0000107 NCBI chr12:107,580,895...107,656,443
Ensembl chr12:107,590,663...107,652,985 		JBrowse link
G MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 involved_in ISO PMID:15019943 HGNC-UCL PMID:15019943 RGD:8554528 NCBI chr24:23,853,710...24,705,276
Ensembl chr24:23,856,533...24,318,531 		JBrowse link
G NFE2L1 NFE2 like bZIP transcription factor 1 acts_upstream_of_or_within ISO (PMID:21554501) MGI PMID:21554501 NCBI chr16:68,449,601...68,463,030
Ensembl chr16:68,449,898...68,461,190 		JBrowse link
G NKX2-2 NK2 homeobox 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10217145) Ensembl
MGI		 PMID:10217145 GO_REF:0000107 NCBI chr 2:50,499,802...50,511,309
Ensembl chr 2:50,500,691...50,502,438 		JBrowse link
G OLIG2 oligodendrocyte transcription factor 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21338882) Ensembl
MGI		 PMID:21338882 GO_REF:0000107 NCBI chr 2:59,151,151...59,161,253
Ensembl chr 2:59,152,487...59,153,458 		JBrowse link
G OLIG3 oligodendrocyte transcription factor 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15769945)
(PMID:15674731)		 Ensembl
MGI		 PMID:15674731 PMID:15769945 GO_REF:0000107 NCBI chr13:35,925,356...35,926,211
Ensembl chr13:35,925,373...35,926,194 		JBrowse link
G SCYL1 SCY1 like pseudokinase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:29437892) Ensembl
MGI		 PMID:29437892 GO_REF:0000107 NCBI chr 1:8,700,828...8,714,571
Ensembl chr 1:8,700,973...8,714,763 		JBrowse link
G SCYL3 SCY1 like pseudokinase 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:29437892) Ensembl
MGI		 PMID:29437892 GO_REF:0000107 NCBI chr25:59,157,208...59,215,074
Ensembl chr25:59,156,992...59,198,614 		JBrowse link
G SHH sonic hedgehog signaling molecule involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21552265) Ensembl
MGI		 PMID:21552265 GO_REF:0000107 NCBI chr21:123,929,937...123,942,451
Ensembl chr21:123,932,900...123,942,395 		JBrowse link
medial motor column neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LHX3 LIM homeobox 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:9865699) MGI
Ensembl		 PMID:9865699 GO_REF:0000107 NCBI chr12:1,997,437...2,007,473
Ensembl chr12:2,000,638...2,006,430 		JBrowse link
G LHX4 LIM homeobox 4 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:9865699) MGI
Ensembl		 PMID:9865699 GO_REF:0000107 NCBI chr25:49,102,819...49,148,193
Ensembl chr25:49,103,349...49,147,752 		JBrowse link
smoothened signaling pathway involved in spinal cord motor neuron cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GLI2 GLI family zinc finger 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:15215207) MGI
Ensembl		 PMID:15215207 GO_REF:0000107 NCBI chr10:9,302,890...9,561,287
Ensembl chr10:9,304,645...9,369,115 		JBrowse link
G GLI3 GLI family zinc finger 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15215207) Ensembl
MGI		 PMID:15215207 GO_REF:0000107 NCBI chr21:16,386,700...16,665,648
Ensembl chr21:16,549,789...16,662,238 		JBrowse link
G SUFU SUFU negative regulator of hedgehog signaling involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19684112) Ensembl
MGI		 PMID:19684112 GO_REF:0000107 NCBI chr 9:95,532,228...95,660,594
Ensembl chr 9:95,532,242...95,657,290 		JBrowse link
somatic motor neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLN8 CLN8 transmembrane ER and ERGIC protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21052544) Ensembl
MGI		 PMID:21052544 GO_REF:0000107 NCBI chr 8:1,424,402...1,445,505
Ensembl chr 8:1,433,953...1,445,021 		JBrowse link
G PHOX2A paired like homeobox 2A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16319924) Ensembl
MGI		 PMID:16319924 GO_REF:0000107 NCBI chr 1:63,459,031...63,464,674
Ensembl chr 1:63,459,719...63,463,894 		JBrowse link
G TCTN1 tectonic family member 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16357211) Ensembl
MGI		 PMID:16357211 GO_REF:0000107 NCBI chr11:105,855,138...105,898,764
Ensembl chr11:105,855,288...105,891,093 		JBrowse link
spinal cord motor neuron cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HOXC10 homeobox C10 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18065432) Ensembl
MGI		 PMID:18065432 GO_REF:0000107 NCBI chr11:50,092,230...50,100,934
Ensembl chr11:50,095,810...50,100,940 		JBrowse link
G HOXD10 homeobox D10 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:18065432) MGI
Ensembl		 PMID:18065432 GO_REF:0000107 NCBI chr10:61,686,868...61,694,965
Ensembl chr10:61,691,797...61,694,415 		JBrowse link
G ISL1 ISL LIM homeobox 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:19666821) MGI
Ensembl		 PMID:19666821 GO_REF:0000107 NCBI chr 4:47,665,861...47,678,631
Ensembl chr 4:47,666,536...47,677,552 		JBrowse link
G ISL2 ISL LIM homeobox 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:19666821) MGI
Ensembl		 PMID:19666821 GO_REF:0000107 NCBI chr26:6,940,218...6,946,007
Ensembl chr26:6,940,850...6,945,786 		JBrowse link
G LHX3 LIM homeobox 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:19666821) MGI
Ensembl		 PMID:19666821 GO_REF:0000107 NCBI chr12:1,997,437...2,007,473
Ensembl chr12:2,000,638...2,006,430 		JBrowse link
G LMO4 LIM domain only 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:46,105,755...46,126,291
Ensembl chr20:46,105,699...46,126,399 		JBrowse link
G MNX1 motor neuron and pancreas homeobox 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10482234) InterPro
TreeGrafter
MGI		 PMID:10482234 GO_REF:0000002 GO_REF:0000118 NCBI chr21:125,132,517...125,138,520
Ensembl chr21:125,133,194...125,138,217 		JBrowse link
G OLIG3 oligodendrocyte transcription factor 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15769945) Ensembl
MGI		 PMID:15769945 GO_REF:0000107 NCBI chr13:35,925,356...35,926,211
Ensembl chr13:35,925,373...35,926,194 		JBrowse link
visceral motor neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ISL1 ISL LIM homeobox 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:14766174) MGI
Ensembl		 PMID:14766174 GO_REF:0000107 NCBI chr 4:47,665,861...47,678,631
Ensembl chr 4:47,666,536...47,677,552 		JBrowse link
G ISL2 ISL LIM homeobox 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:14766174) MGI
Ensembl		 PMID:14766174 GO_REF:0000107 NCBI chr26:6,940,218...6,946,007
Ensembl chr26:6,940,850...6,945,786 		JBrowse link
G TBX20 T-box transcription factor 20 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:23,166,020...23,222,416
Ensembl chr21:23,166,109...23,224,657 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17043
    developmental process 6815
      anatomical structure development 6397
        ventral spinal cord development 53
          spinal cord motor neuron differentiation 36
            lateral motor column neuron differentiation 0
            somatic motor neuron differentiation + 5
            spinal cord motor neuron cell fate specification + 11
            visceral motor neuron differentiation 3
Path 2
Term Annotations click to browse term
  biological_process 17043
    developmental process 6815
      anatomical structure development 6397
        multicellular organism development 5149
          system development 4462
            nervous system development 2796
              neurogenesis 2059
                generation of neurons 1783
                  neuron differentiation 1700
                    central nervous system neuron differentiation 251
                      spinal cord motor neuron differentiation 36
                        lateral motor column neuron differentiation 0
                        somatic motor neuron differentiation + 5
                        spinal cord motor neuron cell fate specification + 11
                        visceral motor neuron differentiation 3
paths to the root