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ONTOLOGY REPORT - ANNOTATIONS

Term:volume-sensitive anion channel activity
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Accession:GO:0005225 term browser browse the term
Definition:Enables the transmembrane transfer of a monoatomic anion by a volume-sensitive channel. A volume-sensitive channel is a channel that responds to changes in the volume of a cell.
Synonyms:broad_synonym: volume-regulated channel
 xref: reactome:R-HSA-8941543 "VRAC heteromer transports I-, Cl- from cytosol to extracellular region"


show annotations for term's descendants           Sort by:
volume-sensitive anion channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrrc8a leucine rich repeat containing 8 VRAC subunit A enables ISO
ISS
IMP		 (PMID:26824658), (PMID:29769723), (PMID:30095067), (PMID:33139539)
GO_REF:0000024
PMID:28833202		 RGD
UniProt		 PMID:26824658 PMID:29769723 PMID:30095067 PMID:33139539 PMID:28833202 GO_REF:0000024, RGD:13673739 NCBI chr 3:13,509,577...13,537,174
Ensembl chr 3:13,510,513...13,536,202 		JBrowse link
G Lrrc8b leucine rich repeat containing 8 VRAC subunit B contributes_to ISO (PMID:28193731) RGD PMID:28193731 NCBI chr14:4,350,462...4,416,336
Ensembl chr14:4,354,508...4,416,311 		JBrowse link
G Lrrc8c leucine rich repeat containing 8 VRAC subunit C contributes_to
enables		 ISS
ISO
IMP		 GO_REF:0000024
(PMID:26824658)
(MGI:6162376|PMID:29769723)
PMID:28833202		 UniProt
RGD		 PMID:26824658 PMID:29769723 PMID:28833202 GO_REF:0000024 MGI:6162376, RGD:13673739 NCBI chr14:4,223,901...4,315,590
Ensembl chr14:4,227,832...4,315,249 		JBrowse link
G Lrrc8d leucine rich repeat containing 8 VRAC subunit D contributes_to
enables		 ISS
ISO
IEA
IMP		 GO_REF:0000024
(MGI:6160993|PMID:29773801)
GO_REF:0000107
(PMID:26824658), (PMID:32415200)
(PMID:28193731)
PMID:28833202		 UniProt
RGD
Ensembl		 PMID:26824658 PMID:28193731 PMID:29773801 PMID:32415200 PMID:28833202 GO_REF:0000024 GO_REF:0000107 MGI:6160993, RGD:13673739 NCBI chr14:4,029,971...4,134,922
Ensembl chr14:4,029,473...4,135,877 		JBrowse link
G Lrrc8e leucine rich repeat containing 8 VRAC subunit E contributes_to
enables		 ISO
ISS		 (PMID:28193731)
GO_REF:0000024
(PMID:26824658), (PMID:33139539)		 RGD
UniProt		 PMID:26824658 PMID:28193731 PMID:33139539 GO_REF:0000024 NCBI chr12:2,578,240...2,589,407
Ensembl chr12:2,578,315...2,589,412 		JBrowse link
G Ttyh1 tweety family member 1 NOT|enables ISO (PMID:34385445) RGD PMID:34385445 NCBI chr 1:70,053,312...70,071,872
Ensembl chr 1:70,053,324...70,071,845 		JBrowse link
G Ttyh2 tweety family member 2 NOT|enables ISO (PMID:34385445)
(MGI:7581107|PMID:34824283)		 RGD PMID:34385445 PMID:34824283 MGI:7581107 NCBI chr10:99,709,063...99,753,449
Ensembl chr10:99,709,007...99,753,444 		JBrowse link
G Ttyh3 tweety family member 3 NOT|enables ISO (PMID:34385445) RGD PMID:34385445 NCBI chr12:13,996,831...14,025,457
Ensembl chr12:13,997,045...14,025,459 		JBrowse link
volume-sensitive chloride channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clcn2 chloride voltage-gated channel 2 enables IMP PMID:1334533 UniProt PMID:1334533 RGD:405650350 NCBI chr11:80,197,741...80,211,657
Ensembl chr11:80,198,153...80,211,657 		JBrowse link
G Clcn3 chloride voltage-gated channel 3 enables
NOT|enables		 ISO
IEA		 (PMID:12183454)
GO_REF:0000107
MGI:2183297 (PMID:11182090)		 RGD
Ensembl		 PMID:11182090 PMID:12183454 GO_REF:0000107 NCBI chr16:29,127,152...29,200,133
Ensembl chr16:29,127,419...29,200,119 		JBrowse link
G Ttyh1 tweety family member 1 enables ISO
IBA
ISS		 (PMID:16219661)
GO_REF:0000033
GO_REF:0000024
(MGI:7581104|PMID:31138989)		 RGD
GO_Central
UniProt		 PMID:16219661 PMID:31138989 GO_REF:0000024 GO_REF:0000033 MGI:7581104 NCBI chr 1:70,053,312...70,071,872
Ensembl chr 1:70,053,324...70,071,845 		JBrowse link
G Ttyh2 tweety family member 2 enables IBA
ISO		 GO_REF:0000033
(MGI:7581104|PMID:31138989)		 GO_Central
RGD		 PMID:31138989 GO_REF:0000033 MGI:7581104 NCBI chr10:99,709,063...99,753,449
Ensembl chr10:99,709,007...99,753,444 		JBrowse link
G Ttyh3 tweety family member 3 enables IBA
ISO		 GO_REF:0000033
(MGI:7581104|PMID:31138989)		 GO_Central
RGD		 PMID:31138989 GO_REF:0000033 MGI:7581104 NCBI chr12:13,996,831...14,025,457
Ensembl chr12:13,997,045...14,025,459 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20483
    transporter activity 1237
      transmembrane transporter activity 1143
        monoatomic ion transmembrane transporter activity 759
          monoatomic ion channel activity 448
            monoatomic anion channel activity 99
              volume-sensitive anion channel activity 10
                volume-sensitive chloride channel activity 5
Path 2
Term Annotations click to browse term
  molecular_function 20483
    transporter activity 1237
      transmembrane transporter activity 1143
        passive transmembrane transporter activity 507
          channel activity 507
            monoatomic ion channel activity 448
              monoatomic anion channel activity 99
                volume-sensitive anion channel activity 10
                  volume-sensitive chloride channel activity 5
paths to the root