Lrrc8d (leucine rich repeat containing 8 VRAC subunit D)

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Gene: Lrrc8d (leucine rich repeat containing 8 VRAC subunit D) Rattus norvegicus

Analyze

Symbol:

Lrrc8d

Name:

leucine rich repeat containing 8 VRAC subunit D

RGD ID:

1309601

Description:

Contributes to volume-sensitive anion channel activity. Involved in aspartate transmembrane transport; cellular response to osmotic stress; and taurine transport. Part of ion channel complex. Orthologous to human LRRC8D (leucine rich repeat containing 8 VRAC subunit D); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

leucine rich repeat containing 5; leucine rich repeat containing 8 family, member D; leucine rich repeat containing 8D; leucine-rich repeat-containing 5; leucine-rich repeat-containing protein 5; leucine-rich repeat-containing protein 8D; LOC305131; Lrrc5; MGC93739; volume-regulated anion channel subunit LRRC8D

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	14	4,029,971 - 4,134,922 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	4,029,473 - 4,135,877 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	4,031,137 - 4,046,274 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	14	5,331,273 - 5,346,414 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	14	4,034,927 - 4,050,056 (-)	NCBI	Rnor_WKY
Rnor_6.0	14	5,085,606 - 5,194,808 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	5,086,054 - 5,101,177 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	5,077,476 - 5,157,358 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	5,104,878 - 5,120,038 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	5,104,878 - 5,120,038 (-)	NCBI
Celera	14	4,193,278 - 4,208,420 (-)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (ISO)

1,4-dichlorobenzene (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-diaminotoluene (ISO)

2,6-dinitrotoluene (EXP)

3-methylcholanthrene (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

avobenzone (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (EXP)

chlorpyrifos (ISO)

choline (ISO)

cobalt dichloride (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

diazinon (ISO)

dibutyl phthalate (ISO)

dioxygen (ISO)

doxorubicin (ISO)

epoxiconazole (ISO)

ethanol (ISO)

fenthion (ISO)

fipronil (EXP)

fluoranthene (ISO)

flutamide (EXP)

folic acid (ISO)

fulvestrant (ISO)

glafenine (EXP)

hypochlorous acid (ISO)

L-methionine (ISO)

leflunomide (ISO)

methapyrilene (ISO)

methidathion (ISO)

methyl methanesulfonate (ISO)

oxaliplatin (EXP)

paracetamol (ISO)

perfluorononanoic acid (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

progesterone (ISO)

prothioconazole (ISO)

quercetin (ISO)

resorcinol (ISO)

rotenone (ISO)

silicon dioxide (ISO)

sunitinib (ISO)

temozolomide (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

trichloroethene (EXP)

tungsten (ISO)

tunicamycin (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

aspartate transmembrane transport (IEA,IMP,ISO,ISS)

cellular response to osmotic stress (IEA,IMP,ISO,ISS)

cyclic-GMP-AMP transmembrane import across plasma membrane (ISO,ISS)

intracellular glucose homeostasis (IEA,ISO,ISS)

monoatomic anion transmembrane transport (IEA,ISO,ISS)

protein hexamerization (IEA,ISO,ISS)

taurine transport (IEA,IMP,ISO,ISS)

Cellular Component

cytoplasm (IEA,ISO,ISS)

endoplasmic reticulum membrane (IEA)

membrane (ISO,ISS)

monoatomic ion channel complex (IEA,IMP,ISO,ISS)

plasma membrane (IEA,ISO,ISS)

Molecular Function

protein binding (ISO)

volume-sensitive anion channel activity (IEA,IMP,ISO,ISS)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Molecular composition and heterogeneity of the LRRC8-containing swelling-activated osmolyte channels in primary rat astrocytes.	Schober AL, etal., J Physiol. 2017 Nov 15;595(22):6939-6951. doi: 10.1113/JP275053. Epub 2017 Sep 12.

Additional References at PubMed

PMID:12477932	PMID:15489334	PMID:19946888	PMID:24790029	PMID:26824658	PMID:28193731

Genomics

Comparative Map Data

Lrrc8d
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	14	4,029,971 - 4,134,922 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	4,029,473 - 4,135,877 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	4,031,137 - 4,046,274 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	14	5,331,273 - 5,346,414 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	14	4,034,927 - 4,050,056 (-)	NCBI	Rnor_WKY
Rnor_6.0	14	5,085,606 - 5,194,808 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	5,086,054 - 5,101,177 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	5,077,476 - 5,157,358 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	5,104,878 - 5,120,038 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	5,104,878 - 5,120,038 (-)	NCBI
Celera	14	4,193,278 - 4,208,420 (-)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

LRRC8D
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	89,821,032 - 89,936,611 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	1	89,821,014 - 89,936,611 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	90,286,591 - 90,402,170 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	90,060,101 - 90,174,148 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	89,999,533 - 90,113,580	NCBI
Celera	1	88,532,275 - 88,647,680 (+)	NCBI		Celera
Cytogenetic Map	1	p22.2	NCBI
HuRef	1	88,403,943 - 88,519,276 (+)	NCBI		HuRef
CHM1_1	1	90,401,923 - 90,517,356 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	89,664,271 - 89,779,829 (+)	NCBI		T2T-CHM13v2.0

Lrrc8d
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	105,847,829 - 105,963,081 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	105,847,835 - 105,980,302 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	105,699,963 - 105,815,215 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	105,699,969 - 105,832,436 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	106,128,988 - 106,244,234 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	105,934,781 - 106,055,512 (+)	NCBI		MGSCv36	mm8
Celera	5	102,815,568 - 102,929,479 (+)	NCBI		Celera
Cytogenetic Map	5	E5	NCBI

Lrrc8d
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955423	4,237,651 - 4,240,227 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955423	4,237,263 - 4,360,352 (-)	NCBI	ChiLan1.0	ChiLan1.0

LRRC8D
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	1	91,232,146 - 91,346,539 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
Mhudiblu_PPA_v0	1	92,481,871 - 92,606,922 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

LRRC8D
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	58,692,352 - 58,805,004 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	58,692,792 - 58,695,368 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	61,401,528 - 61,514,644 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0 Ensembl	6	59,086,746 - 59,111,772 (-)	Ensembl		ROS_Cfam_1.0 Ensembl

Lrrc8d
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	99,984,575 - 100,097,562 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936537	8,850,411 - 8,963,448 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936537	8,850,411 - 8,963,601 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LRRC8D
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	126,766,211 - 126,874,275 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	126,751,720 - 126,883,344 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	138,807,385 - 138,915,877 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LRRC8D
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	43,542,451 - 43,659,465 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	43,542,806 - 43,545,382 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	74,274,555 - 74,391,546 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lrrc8d
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624742	7,822,880 - 7,946,087 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624742	7,822,880 - 7,947,731 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Lrrc8d
893 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	47
Count of miRNA genes:	41
Interacting mature miRNAs:	45
Transcripts:	ENSRNOT00000002888
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2300159	Bmd61	Bone mineral density QTL 61	5.3	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	26541967	Rat
2300183	Bmd60	Bone mineral density QTL 60	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	26541967	Rat
619619	Rf4	Renal disease susceptibility QTL 4	4.1	0.002	urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	14	1	32754612	Rat
634352	Apr6	Acute phase response QTL 6	3.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	14	1	41131407	Rat
71115	Niddm15	Non-insulin dependent diabetes mellitus QTL 15	4.8		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	14	1217606	11030812	Rat
70204	Niddm20	Non-insulin dependent diabetes mellitus QTL 20	5.1	0.000008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	1217606	16960180	Rat
724541	Niddm53	Non-insulin dependent diabetes mellitus QTL 53		0.001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	3813074	9088978	Rat
2293089	Iddm31	Insulin dependent diabetes mellitus QTL 31	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	3813074	18274691	Rat
2293089	Iddm31	Insulin dependent diabetes mellitus QTL 31	4.7		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	14	3813074	18274691	Rat
1300114	Srn2	Serum renin concentration QTL 2	3.27		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	14	3813074	21217635	Rat
70195	Mcs8	Mammary carcinoma susceptibility QTL 8	4.28		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	14	3813074	24531477	Rat
1331740	Bw26	Body weight QTL 26	3.028		body mass (VT:0001259)	body weight (CMO:0000012)	14	3813074	30767156	Rat

Markers in Region

D14Rat54

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	4,041,872 - 4,042,062 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	5,097,667 - 5,097,856	NCBI	Rnor6.0
Rnor_5.0	14	5,089,537 - 5,089,726	UniSTS	Rnor5.0
RGSC_v3.4	14	5,116,492 - 5,116,681	UniSTS	RGSC3.4
RGSC_v3.4	14	5,116,491 - 5,116,681	RGD	RGSC3.4
RGSC_v3.1	14	5,116,492 - 5,116,681	RGD
Celera	14	4,204,900 - 4,205,089	UniSTS
RH 3.4 Map	14	79.2	RGD
RH 3.4 Map	14	79.2	UniSTS
RH 2.0 Map	14	105.5	RGD
SHRSP x BN Map	14	2.29	RGD
FHH x ACI Map	14	1.33	RGD
Cytogenetic Map	14	p22	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	26	57	41	19	41			74	35	35	11
Low		17					8	11			6		8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001008338	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006250556	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017599156	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017599157	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017599158	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017599159	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017599160	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091810	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC085783	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474022	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000247	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000002888 ⟹ ENSRNOP00000002888

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	4,030,260 - 4,045,384 (-)	Ensembl
Rnor_6.0 Ensembl	14	5,086,054 - 5,101,177 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000094660 ⟹ ENSRNOP00000096115

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	4,029,721 - 4,135,877 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000105738 ⟹ ENSRNOP00000091428

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	4,029,854 - 4,106,975 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000106093 ⟹ ENSRNOP00000081098

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	4,029,854 - 4,118,076 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000109682 ⟹ ENSRNOP00000090251

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	4,029,812 - 4,129,314 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000112887 ⟹ ENSRNOP00000087579

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	4,029,812 - 4,135,626 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000117756 ⟹ ENSRNOP00000092059

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	4,029,473 - 4,134,929 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000118999 ⟹ ENSRNOP00000096292

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	4,029,473 - 4,134,803 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000119904 ⟹ ENSRNOP00000078114

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	4,029,473 - 4,134,957 (-)	Ensembl

RefSeq Acc Id:

NM_001008338 ⟹ NP_001008339

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	14	4,030,259 - 4,045,384 (-)	NCBI
Rnor_6.0	14	5,086,053 - 5,101,177 (-)	NCBI
Rnor_5.0	14	5,077,476 - 5,157,358 (-)	NCBI
RGSC_v3.4	14	5,104,878 - 5,120,038 (-)	RGD
Celera	14	4,193,278 - 4,208,420 (-)	RGD

Sequence:

show sequence

ACGAAGGTGACTGCAGGTCCGTCCCTATTCAGGCATCGTCTCCCACATGAGGGATCTAAGGCTC
GGAGACATTAGGTGACCTTGCCTTAGACCCGGCAGCAGTCTATGTAGACTCACGGCAAGAATTA
TGCTGGGACTCTCCTCCTCCTGCTGGAAATTGAGCTTGGATCATGGGAATGTTTACCCTTGCGG
AAGTTGCTTCACTTAATGACATTCAGCCAACTTACCGAATCCTGAAGCCATGGTGGGACGTGTT
TATGGATTACCTGGCGGTTGTTATGCTGATGGTAGCCATCTTTGCAGGGACCATGCAACTTACC
AAAGATCAGGTGGTCTGTTTGCCAGTGTTGCCGTCGCCTGCAAATTCAAAGGCGCACACACCAC
CCGGGAATGCTGACGTCACCACTGAAGTCCCCAAGATGGAGACAGCCACACCCCAAGACCAAAA
CGGGCAGACGACGAATGACATTGCCTTTGGCACATCTGCTGTGACGCCTGACATACCTCTCCAA
GCCACCTATTCACACGCAGAGTCCACCTTTCCCAGTCAGGAGACGAAGAAGGAGAAGAGAGACC
CCACGGGCCGCAAAACCAACTTGGATTTTCAGCAGTACGTATTTATCAATCAGATGTGCTACCA
TCTGGCCCTTCCTTGGTATTCCAAGTACTTTCCATACCTTGCCCTTATACACACCATCATCCTT
ATGGTCAGTAGCAACTTTTGGTTCAAATATCCCAAAACGTGCTCCAAGGTTGAGCATTTTGTTT
CAATATTAGGAAAGTGTTTCGAATCTCCCTGGACTACTAAAGCGCTGTCCGAGACAGCCTGTGA
GGACTCTGAGGAGAACAAGCAGCGGATAACGGGCGCCCAGACCCTACCGAAGCACGTGTCCACC
AGCAGCGATGAGGGGAGCCCCAGCGCCAGCACCCCCATGATCAACAAAACGGGCTTCAAGTTCT
CAGCTGAAAAGCCGGTGATCGAAGTTCCCAGCATGACGATCCTGGACAAGAAGGACGGGGAGCA
GGCCAAAGCCCTGTTTGAGAAGGTGAGGAAATTTCGTGCCCATGTGGAAGACAGTGACTTGATC
TACAAGCTCTACGTGGTCCAGACCCTCATCAAGACCGCCAAGTTCATTTTTATCCTCTGCTACA
CTGCAAACTTTGTCAACGCCATCAGCTTCGAGCATGTCTGCAAGCCAAAAGTCGAGCACCTCAC
GGGGTACGAGGTGTTCGAGTGCACTCACAATATGGCCTACATGTTGAAGAAACTGCTCATCAGC
TACATCTCCATCATCTGTGTCTATGGCTTCATCTGCCTCTACACTCTCTTCTGGCTGTTCAGGA
TCCCTCTGAAGGAATATTCCTTTGAGAAAGTCCGAGAGGAAAGCAGCTTCAGCGACATCCCGGA
TGTCAAGAACGACTTCGCGTTCCTCCTGCACATGGTCGACCAGTACGACCAGCTCTATTCCAAG
CGTTTTGGTGTCTTCTTATCTGAAGTCAGTGAAAACAAACTGAGGGAAATCAGCCTGAACCATG
AGTGGACTTTCGAGAAACTCAGGCAGCACGTGTCTCGCAACGCCCAGGACAAGCAGGAGCTGCA
CTTGTTCATGCTGTCAGGGGTGCCCGACGCTGTCTTTGACCTCACGGACCTGGATGTGCTAAAA
CTTGAACTGATTCCCGAAGCAAAAATTCCTGCCAAGATCTCTCAGATGACGAACCTTCAAGAAC
TCCACCTCTGCCACTGCCCTGCCAAGGTGGAGCAGACCGCCTTTAGCTTTCTTCGCGATCACTT
GAGATGCCTTCATGTGAAGTTCACTGACGTGGCTGAAATCCCTGCCTGGGTGTATTTGCTCAAA
AACCTGCGGGAGCTGTACTTGATAGGCAACTTGAACTCAGAGAACAATAAGATGATCGGGCTGG
AGTCTCTGCGAGAGCTGCGGCACCTTAAGATCCTCCACGTGAAGAGTAACCTGACCAAAGTTCC
CTCCAACATAACTGACGTGGCTCCTCACCTCACCAAGCTCGTCATCCACAATGACGGCACCAAG
CTCTTGGTGCTCAACAGCCTGAAGAAGATGATGAACGTTGCCGAGCTAGAGCTGCAGAACTGTG
AGCTGGAGAGGATTCCACACGCCATTTTCAGCCTTTCTAACTTGCAGGAGCTGGACCTGAAGTC
CAACAGCATCCGCACGATCGAGGAGATCATCAGTTTCCAACACCTGAAGCGACTGACTTGCTTG
AAATTGTGGCACAATAAAATTGTGGCCATTCCTCCCTCCATTACCCACGTCAAGAACCTGGAGT
CCCTCTACTTCTCCAACAACAAGCTCGAGTCCTTACCGGTGGCAGTGTTTAGTTTACAGAAACT
CAGATGCTTAGATGTCAGCTATAACAACATTTCCACGATCCCCATAGAGATAGGTTTGCTTCAG
AACCTGCAGCATTTGCACATCACAGGGAACAAAGTGGACGTTCTGCCAAAACAGTTGTTTAAGT
GCGTGAAGTTGAGGACTTTGAACCTGGGGCAGAACTGCATCGCCTCCCTGCCTGAGAAGATCAG
TCAGCTGTCCCAGCTCACTCAGCTGGAGCTGAAGGGCAACTGTCTCGACCGCCTGCCAGCCCAG
CTGGGCCAGTGTCGGATGCTCAAGAAAAGCGGGCTTGTTGTAGAAGACCAACTGTTTGACACGC
TGCCACTGGAAGTCAAAGAGGCATTGAATCAAGACGTAAATGTCCCCTTTGCGAACGGGATTTG
AACCAAGCGAACGCGGGCACGTCCGCGTGCGGGGATACCTTCCTAGATTGCAGATGCTCACTTG
CAAGTTATTACAAGATAATGCATTTTAGGAGTAGATAAGCCCTTTAAGCAGAACGCGGCGCACG
GAGGCTGGTAGCAGACGAAACCGAATGTTCGATGTTTGTAGCGTTTTTAAGTCACTCATTTCCA
AATCTTTTCTTTCCTGTTCGTTTGTTTGAGGTTTTTTTTGTTTTTGTTTTATTGTTCTTCTTCT
GGGGAAAGGGAAGGAAAAAGAAAATCACAGTCACTGATCTCAGTTCTTTTTAAAATTGTAAGTT
GGATGCGGCTGCTGGCTGAATGTTTACACATTGCTTGCCTGCTAAAGTAAATGATTAAATTGAC
TTTCTTCTTACTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039091810 ⟹ XP_038947738

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	14	4,029,971 - 4,134,922 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001008339	(Get FASTA)	NCBI Sequence Viewer
	XP_038947738	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH85783	(Get FASTA)	NCBI Sequence Viewer
	EDL99470	(Get FASTA)	NCBI Sequence Viewer
	Q5U308	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001008339 ⟸ NM_001008338

- UniProtKB:

Q5U308 (UniProtKB/Swiss-Prot), A0A0H2UHA3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGMFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPSPA
NSKAHTPPGNADVTTEVPKMETATPQDQNGQTTNDIAFGTSAVTPDIPLQATYSHAESTFPSQE
TKKEKRDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSSNFWFKYPKTC
SKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVSTSSDEGSPSASTPMI
NKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVEDSDLIYKLYVVQTLIKTAK
FIFILCYTANFVNAISFEHVCKPKVEHLTGYEVFECTHNMAYMLKKLLISYISIICVYGFICLY
TLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLLHMVDQYDQLYSKRFGVFLSEVSENKL
REISLNHEWTFEKLRQHVSRNAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKIS
QMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSE
NNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVA
ELELQNCELERIPHAIFSLSNLQELDLKSNSIRTIEEIISFQHLKRLTCLKLWHNKIVAIPPSI
THVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISTIPIEIGLLQNLQHLHITGNKVDV
LPKQLFKCVKLRTLNLGQNCIASLPEKISQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVV
EDQLFDTLPLEVKEALNQDVNVPFANGI

hide sequence

RefSeq Acc Id:

ENSRNOP00000002888 ⟸ ENSRNOT00000002888

RefSeq Acc Id:	XP_038947738 ⟸ XM_039091810
- Peptide Label:	isoform X1
- UniProtKB:	Q5U308 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:

ENSRNOP00000090251 ⟸ ENSRNOT00000109682

RefSeq Acc Id:

ENSRNOP00000092059 ⟸ ENSRNOT00000117756

RefSeq Acc Id:

ENSRNOP00000078114 ⟸ ENSRNOT00000119904

RefSeq Acc Id:

ENSRNOP00000081098 ⟸ ENSRNOT00000106093

RefSeq Acc Id:

ENSRNOP00000096115 ⟸ ENSRNOT00000094660

RefSeq Acc Id:

ENSRNOP00000087579 ⟸ ENSRNOT00000112887

RefSeq Acc Id:

ENSRNOP00000091428 ⟸ ENSRNOT00000105738

RefSeq Acc Id:

ENSRNOP00000096292 ⟸ ENSRNOT00000118999

Protein Domains

LRRC8 pannexin-like TM region

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5U308-F1-model_v2	AlphaFold	Q5U308	1-858	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309601	AgrOrtholog
BioCyc Gene	G2FUF-16554	BioCyc
Ensembl Genes	ENSRNOG00000002121	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000002888	ENTREZGENE
	ENSRNOP00000002888.4	UniProtKB/TrEMBL
	ENSRNOP00000078114	ENTREZGENE
	ENSRNOP00000078114.1	UniProtKB/Swiss-Prot
	ENSRNOP00000081098.1	UniProtKB/Swiss-Prot
	ENSRNOP00000087579.1	UniProtKB/Swiss-Prot
	ENSRNOP00000090251.1	UniProtKB/Swiss-Prot
	ENSRNOP00000091428.1	UniProtKB/Swiss-Prot
	ENSRNOP00000092059.1	UniProtKB/Swiss-Prot
	ENSRNOP00000096115.1	UniProtKB/Swiss-Prot
	ENSRNOP00000096292.1	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000002888	ENTREZGENE
	ENSRNOT00000002888.5	UniProtKB/TrEMBL
	ENSRNOT00000094660.1	UniProtKB/Swiss-Prot
	ENSRNOT00000105738.1	UniProtKB/Swiss-Prot
	ENSRNOT00000106093.1	UniProtKB/Swiss-Prot
	ENSRNOT00000109682.1	UniProtKB/Swiss-Prot
	ENSRNOT00000112887.1	UniProtKB/Swiss-Prot
	ENSRNOT00000117756.1	UniProtKB/Swiss-Prot
	ENSRNOT00000118999.1	UniProtKB/Swiss-Prot
	ENSRNOT00000119904	ENTREZGENE
	ENSRNOT00000119904.1	UniProtKB/Swiss-Prot
Gene3D-CATH	3.80.10.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7107805	IMAGE-MGC_LOAD
InterPro	Leu-rich_rpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Leu-rich_rpt_typical-subtyp	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LRR_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LRRC8_Pannexin-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:305131	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:93739	IMAGE-MGC_LOAD
NCBI Gene	305131	ENTREZGENE
PANTHER	PTHR48051	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	VOLUME-REGULATED ANION CHANNEL SUBUNIT LRRC8C-LIKE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	LRR_8	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Pannexin_like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Lrrc8d	PhenoGen
PROSITE	LRR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	LRR_SD22	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LRR_TYP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	L domain-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0H2UHA3	ENTREZGENE, UniProtKB/TrEMBL
	LRC8D_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-08-16	Lrrc8d	leucine rich repeat containing 8 VRAC subunit D	Lrrc8d	leucine rich repeat containing 8 family, member D	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-18	Lrrc8d	leucine rich repeat containing 8 family, member D	Lrrc8d	leucine rich repeat containing 8D	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-06	Lrrc8d	leucine rich repeat containing 8D	Lrrc8d	leucine rich repeat containing 8 family, member D	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Lrrc8d	leucine rich repeat containing 8 family, member D	Lrrc5	leucine-rich repeat-containing 5	Symbol and Name updated	1299863	APPROVED
2005-12-06	Lrrc5	leucine-rich repeat-containing 5	Lrrc5_predicted	leucine-rich repeat-containing 5 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Lrrc5_predicted	leucine-rich repeat-containing 5 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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