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ONTOLOGY REPORT - ANNOTATIONS

Term:NAD+-protein poly-ADP-ribosyltransferase activity
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Accession:GO:0003950 term browser browse the term
Definition:Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
Synonyms:exact_synonym: NAD ADP-ribosyltransferase activity
 related_synonym: ADP-ribosyltransferase (polymerizing) activity;   NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity;   poly(ADP-ribose) synthase activity;   poly(ADP-ribose) synthetase activity;   poly(ADP-ribose)polymerase activity;   poly(adenosine diphosphate ribose) polymerase activity
 xref: EC:2.4.2.30;   MetaCyc:NAD+-ADP-RIBOSYLTRANSFERASE-RXN;   Reactome:R-HSA-9686061 "Nucleoprotein is ADP-ribosylated";   Reactome:R-HSA-9729279 "Nucleoprotein is ADP-ribosylated";   reactome:R-HSA-2187325 "PARP1 ADP-ribosylates SMAD3 and SMAD4";   reactome:R-HSA-3640858 "Tankyrase ADP-ribosylates AXIN";   reactome:R-HSA-5651723 "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate";   reactome:R-HSA-5687653 "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate";   reactome:R-HSA-5688276 "SIRT4 transfers ADPRib to GLUD";   reactome:R-HSA-8938073 "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation)";   reactome:R-HSA-8948800 "TNKS and TNKS2 PARylate PTEN"


show annotations for term's descendants           Sort by:
NAD+-protein poly-ADP-ribosyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Art1 ADP-ribosyltransferase 1 enables IBA
ISO		 GO_REF:0000033
(PMID:11587854), (PMID:8703012), (PMID:9052744)		 GO_Central
RGD		 PMID:8703012 PMID:9052744 PMID:11587854 GO_REF:0000033 NCBI chr 1:156,478,096...156,487,172
Ensembl chr 1:156,482,621...156,487,172 		JBrowse link
G Art2b ADP-ribosyltransferase 2b enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:155,956,601...155,974,252
Ensembl chr 1:155,956,603...155,974,253 		JBrowse link
G Art3 ADP-ribosyltransferase 3 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:15,637,230...15,719,442
Ensembl chr14:15,637,237...15,665,407 		JBrowse link
G Art4 ADP-ribosyltransferase 4 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:169,740,331...169,751,571
Ensembl chr 4:169,740,331...169,750,665 		JBrowse link
G Art5 ADP-ribosyltransferase 5 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:156,473,362...156,483,324
Ensembl chr 1:156,473,362...156,483,324 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 enables IDA
ISO
IBA
IMP		 (PMID:22736760), (PMID:24449909), (PMID:28991266)
GO_REF:0000033
(PMID:16107709), (PMID:17396150), (PMID:18055453), (PMID:19470756), (PMID:19764761), (PMID:20388712), (PMID:22504299), (PMID:23275542), (PMID:26626479), (PMID:26626480), (PMID:28190768), (PMID:30104678), (PMID:32028527), (PMID:32241924), (PMID:32358582), (PMID:33186521), (PMID:33683197), (PMID:34732825), (PMID:34795260), (PMID:35219381), (PMID:7852410)
PMID:22073128		 RGD
GO_Central		 PMID:7852410 PMID:16107709 PMID:17396150 PMID:18055453 PMID:19470756 More... GO_REF:0000033, RGD:1601079, RGD:1601082, RGD:8554355 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Parp10 poly (ADP-ribose) polymerase family, member 10 enables ISO
IBA		 (PMID:23473667), (PMID:23575687)
GO_REF:0000033		 RGD
GO_Central		 PMID:23473667 PMID:23575687 GO_REF:0000033 NCBI chr 7:107,949,031...107,958,377
Ensembl chr 7:107,949,043...107,958,304 		JBrowse link
G Parp11 poly (ADP-ribose) polymerase family, member 11 enables ISO
IBA		 (PMID:25673562)
GO_REF:0000033		 RGD
GO_Central		 PMID:25673562 GO_REF:0000033 NCBI chr 4:160,298,040...160,344,369
Ensembl chr 4:160,304,905...160,341,946 		JBrowse link
G Parp12 poly (ADP-ribose) polymerase family, member 12 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:67,826,548...67,885,356
Ensembl chr 4:67,839,237...67,883,685 		JBrowse link
G Parp14 poly (ADP-ribose) polymerase family, member 14 enables ISO
IBA		 (PMID:16061477)
GO_REF:0000033
(PMID:27796300)		 RGD
GO_Central		 PMID:16061477 PMID:27796300 GO_REF:0000033 NCBI chr11:64,902,848...64,934,916
Ensembl chr11:64,902,785...64,934,916 		JBrowse link
G Parp16 poly (ADP-ribose) polymerase family, member 16 enables IEA
IBA
ISO		 GO_REF:0000104
GO_REF:0000033
(PMID:22701565), (PMID:23103912)		 UniProt
GO_Central
RGD		 PMID:22701565 PMID:23103912 GO_REF:0000033 GO_REF:0000104 NCBI chr 8:65,731,152...65,749,438
Ensembl chr 8:65,727,706...65,749,433 		JBrowse link
G Parp2 poly (ADP-ribose) polymerase 2 enables ISO
IBA		 (PMID:30104678), (PMID:32028527), (PMID:32939087), (PMID:34732825), (PMID:34795260)
(PMID:10364231), (PMID:12065591)
GO_REF:0000033		 RGD
GO_Central		 PMID:10364231 PMID:12065591 PMID:30104678 PMID:32028527 PMID:32939087 More... GO_REF:0000033 NCBI chr15:24,034,069...24,044,340
Ensembl chr15:24,034,106...24,044,338 		JBrowse link
G Parp3 poly (ADP-ribose) polymerase family, member 3 enables ISO
IBA		 (PMID:21211721), (PMID:21270334)
GO_REF:0000033		 RGD
GO_Central		 PMID:21211721 PMID:21270334 GO_REF:0000033 NCBI chr 8:107,111,010...107,117,073
Ensembl chr 8:107,111,012...107,116,782 		JBrowse link
G Parp4 poly (ADP-ribose) polymerase family, member 4 enables ISO (PMID:10477748) RGD PMID:10477748 NCBI chr15:30,690,503...30,792,868
Ensembl chr15:30,686,613...30,828,810 		JBrowse link
G Parp6 poly (ADP-ribose) polymerase family, member 6 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:60,016,594...60,049,108
Ensembl chr 8:60,016,877...60,049,108 		JBrowse link
G Parp8 poly (ADP-ribose) polymerase family, member 8 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:48,679,405...48,848,700
Ensembl chr 2:48,679,436...48,849,253 		JBrowse link
G Parp9 poly (ADP-ribose) polymerase family, member 9 NOT|enables ISO
IBA		 (PMID:16061477)
GO_REF:0000033
(PMID:23230272)		 RGD
GO_Central		 PMID:16061477 PMID:23230272 GO_REF:0000033 NCBI chr11:64,780,977...64,814,995
Ensembl chr11:64,780,981...64,815,455 		JBrowse link
G Sirt2 sirtuin 2 enables ISO
IEA		 (PMID:10381378)
GO_REF:0000107		 RGD
Ensembl		 PMID:10381378 GO_REF:0000107 NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975 		JBrowse link
G Sirt4 sirtuin 4 enables ISO (PMID:16959573), (PMID:17715127)
(PMID:23663782)		 RGD PMID:16959573 PMID:17715127 PMID:23663782 NCBI chr12:41,125,533...41,139,440
Ensembl chr12:41,131,262...41,139,439 		JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase enables ISO
IBA		 (PMID:23275542)
GO_REF:0000033		 RGD
GO_Central		 PMID:23275542 GO_REF:0000033 NCBI chr 2:149,753,682...149,780,327
Ensembl chr 2:149,753,682...149,780,327 		JBrowse link
G Tnks tankyrase enables ISO
IBA		 (PMID:11854288), (PMID:16076287), (PMID:19759537), (PMID:21270334), (PMID:21478859), (PMID:22864114), (PMID:9822378)
GO_REF:0000033		 RGD
GO_Central		 PMID:9822378 PMID:11854288 PMID:16076287 PMID:19759537 PMID:21270334 More... GO_REF:0000033 NCBI chr16:57,223,174...57,370,740
Ensembl chr16:57,225,094...57,366,260 		JBrowse link
G Tnks2 tankyrase 2 enables ISO
IBA		 (PMID:19759537), (PMID:21478859)
GO_REF:0000033		 RGD
GO_Central		 PMID:19759537 PMID:21478859 GO_REF:0000033 NCBI chr 1:234,567,888...234,621,079
Ensembl chr 1:234,567,858...234,621,079 		JBrowse link
G Zc3hav1 zinc finger CCCH-type containing, antiviral 1 NOT|enables ISO
IEA		 (PMID:25635049)
GO_REF:0000002		 RGD
InterPro		 PMID:25635049 GO_REF:0000002 NCBI chr 4:67,012,129...67,062,428
Ensembl chr 4:67,012,185...67,062,428 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20811
    catalytic activity 6119
      catalytic activity, acting on a protein 2576
        NAD+-protein ADP-ribosyltransferase activity 25
          NAD+-protein poly-ADP-ribosyltransferase activity 23
Path 2
Term Annotations click to browse term
  molecular_function 20811
    catalytic activity 6119
      transferase activity 2465
        glycosyltransferase activity 285
          pentosyltransferase activity 52
            NAD+-protein ADP-ribosyltransferase activity 25
              NAD+-protein poly-ADP-ribosyltransferase activity 23
paths to the root