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ONTOLOGY REPORT - ANNOTATIONS

Term:nuclear exosome (RNase complex)
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Accession:GO:0000176 term browser browse the term
Definition:A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.
Synonyms:exact_synonym: eukaryotic exosome multienzyme ribonuclease complex;   nuclear exosome (ribonuclease complex);   nuclear exosome multienzyme ribonuclease complex


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nuclear exosome (RNase complex) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dis3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease part_of ISO
IBA		 (PMID:20531386)
GO_REF:0000033		 RGD
GO_Central		 PMID:20531386 GO_REF:0000033 NCBI chr15:75,820,040...75,850,450
Ensembl chr15:75,823,436...75,850,642 		JBrowse link
G Exosc1 exosome component 1 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:240,734,777...240,745,431
Ensembl chr 1:240,734,773...240,745,438 		JBrowse link
G Exosc10 exosome component 10 part_of ISO
IEA
IBA		 (PMID:26166824)
GO_REF:0000002
GO_REF:0000033		 RGD
InterPro
GO_Central		 PMID:26166824 GO_REF:0000002 GO_REF:0000033 NCBI chr 5:158,995,313...159,018,940
Ensembl chr 5:158,995,313...159,018,940 		JBrowse link
G Exosc2 exosome component 2 part_of ISO
IBA		 (PMID:26166824)
GO_REF:0000033		 RGD
GO_Central		 PMID:26166824 GO_REF:0000033 NCBI chr 3:14,962,930...14,973,645
Ensembl chr 3:14,962,917...14,973,575 		JBrowse link
G Exosc3 exosome component 3 part_of ISO
IBA		 (PMID:11110791)
GO_REF:0000033		 RGD
GO_Central		 PMID:11110791 GO_REF:0000033 NCBI chr 5:59,573,849...59,579,065
Ensembl chr 5:59,573,886...59,579,060 		JBrowse link
G Exosc4 exosome component 4 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:108,047,831...108,050,573
Ensembl chr 7:108,047,831...108,050,573 		JBrowse link
G Exosc5 exosome component 5 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:81,168,128...81,177,266
Ensembl chr 1:81,166,023...81,177,265 		JBrowse link
G Exosc6 exosome component 6 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:39,022,171...39,023,585
Ensembl chr19:39,022,183...39,023,515 		JBrowse link
G Exosc7 exosome component 7 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:122,773,607...122,798,943
Ensembl chr 8:122,773,591...122,799,270 		JBrowse link
G Exosc8 exosome component 8 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:138,930,405...138,937,009
Ensembl chr 2:138,930,405...138,936,928 		JBrowse link
G Exosc9 exosome component 9 part_of ISO
IBA		 (PMID:22791713)
GO_REF:0000033		 RGD
GO_Central		 PMID:22791713 GO_REF:0000033 NCBI chr 2:119,416,028...119,426,981
Ensembl chr 2:119,388,715...119,427,051 		JBrowse link
G Mphosph6 M phase phosphoprotein 6 located_in ISO (PMID:26166824) RGD PMID:26166824 NCBI chr19:45,860,152...45,870,117
Ensembl chr19:45,860,154...45,870,170 		JBrowse link
G Mtrex Mtr4 exosome RNA helicase located_in ISO (PMID:26166824) RGD PMID:26166824 NCBI chr 2:44,500,326...44,560,624
Ensembl chr 2:44,461,444...44,560,627 		JBrowse link
G Nvl nuclear VCP-like located_in ISO (PMID:26166824) RGD PMID:26166824 NCBI chr13:92,851,023...92,906,749
Ensembl chr13:92,853,650...92,906,049 		JBrowse link
G Wdr74 WD repeat domain 74 located_in ISO (PMID:26456651) RGD PMID:26456651 NCBI chr 1:205,631,769...205,636,558
Ensembl chr 1:205,631,824...205,636,563 		JBrowse link
G Zfc3h1 zinc finger, C3H1-type containing part_of ISO (PMID:27871484) RGD PMID:27871484 NCBI chr 7:51,008,251...51,064,666
Ensembl chr 7:51,007,984...51,064,661 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20969
    protein-containing complex 6600
      nuclear protein-containing complex 1301
        nuclear exosome (RNase complex) 16
          nucleolar exosome (RNase complex) 0
Path 2
Term Annotations click to browse term
  cellular_component 20969
    cellular anatomical structure 20768
      organelle 14065
        membrane-bounded organelle 12645
          intracellular membrane-bounded organelle 12095
            nucleus 7521
              nuclear lumen 4106
                nuclear exosome (RNase complex) 16
                  nucleolar exosome (RNase complex) 0
paths to the root