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Ontology Browser

nuclear exosome (RNase complex) (GO:0000176)
Annotations: Rat: (15) Mouse: (15) Human: (16) Chinchilla: (9) Bonobo: (9) Dog: (14) Squirrel: (9) Pig: (15)
Parent Terms Term With Siblings Child Terms
nuclear lumen +     
cytoplasmic exosome (RNase complex) +   
nuclear chromosome +   
nuclear exosome (RNase complex) +   
A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.
nuclear periphery +   
nuclear proteasome complex +   
nucleolus +   
nucleolus-like body 
nucleoplasm +   
perinucleolar compartment  

Exact Synonyms: eukaryotic exosome multienzyme ribonuclease complex ;   nuclear exosome (ribonuclease complex) ;   nuclear exosome multienzyme ribonuclease complex
Definition Sources: PMID:17174896, PMID:20531386, PMID:26726035

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.