Wdr74 (WD repeat domain 74) - Rat Genome Database

Name: Wdr74
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Wdr74 (WD repeat domain 74) Rattus norvegicus

Analyze

Symbol:

Wdr74

Name:

WD repeat domain 74

RGD ID:

1582881

Description:

Predicted to be involved in rRNA processing and ribosomal large subunit biogenesis. Predicted to act upstream of or within RNA metabolic process and blastocyst formation. Predicted to be located in nucleoplasm. Predicted to be part of preribosome, large subunit precursor. Predicted to be active in nucleolus. Orthologous to human WDR74 (WD repeat domain 74); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC690229; similar to WD repeat domain 74; WD repeat-containing protein 74

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	WDR74 (WD repeat domain 74)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Wdr74 (WD repeat domain 74)	HGNC	EggNOG, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Wdr74 (WD repeat domain 74)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	WDR74 (WD repeat domain 74)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	WDR74 (WD repeat domain 74)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Wdr74 (WD repeat domain 74)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	WDR74 (WD repeat domain 74)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	WDR74 (WD repeat domain 74)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Wdr74 (WD repeat domain 74)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Wdr74 (WD repeat domain 74)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	WDR74 (WD repeat domain 74)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	wdr74 (WD repeat domain 74)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	T06E6.1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	NSA1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	l(2)k09848	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	205,631,769 - 205,636,563 (+)	NCBI	mRatBN7.2
mRatBN7.2 Ensembl	1	205,631,824 - 205,636,563 (+)	Ensembl
Rnor_6.0	1	224,933,906 - 224,938,659 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	224,933,529 - 224,938,662 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	231,871,371 - 231,876,117 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	211,403,239 - 211,407,978 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
Celera	1	203,144,719 - 203,149,458 (+)	NCBI		Celera
Cytogenetic Map	1	q43	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

COVID-19 (ISO)

disease of cellular proliferation (ISO)

familial temporal lobe epilepsy 8 (ISO)

intellectual disability (ISO)

melanoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(-)-alpha-phellandrene (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

acrylamide (ISO)

all-trans-retinoic acid (ISO)

alpha-phellandrene (ISO)

aristolochic acid (ISO)

biochanin A (ISO)

bisphenol A (EXP,ISO)

bortezomib (ISO)

carbon nanotube (ISO)

chlormequat chloride (EXP)

chromium(6+) (ISO)

copper(II) chloride (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

cylindrospermopsin (ISO)

deoxynivalenol (ISO)

dexamethasone (ISO)

dioxygen (ISO)

disodium selenite (ISO)

fenthion (ISO)

fipronil (EXP)

folic acid (ISO)

indometacin (ISO)

ivermectin (ISO)

methidathion (ISO)

paracetamol (ISO)

perfluorononanoic acid (ISO)

silicon dioxide (ISO)

sodium dichromate (EXP)

T-2 toxin (ISO)

tamoxifen (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichostatin A (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

blastocyst formation (ISO)

ribosomal large subunit biogenesis (IBA,ISO)

RNA metabolic process (ISO)

rRNA processing (ISO)

Cellular Component

cellular_component (ND)

nuclear exosome (RNase complex) (IEA,ISO)

nucleolus (IBA,ISO)

nucleoplasm (IEA,ISO)

nucleus (ISO)

preribosome, large subunit precursor (IBA)

Molecular Function

molecular_function (ND)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
4.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:12429849	PMID:12477932	PMID:21799883	PMID:26456651	PMID:27869233	PMID:28416111	PMID:29107693

Genomics

Comparative Map Data

Wdr74
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	205,631,769 - 205,636,563 (+)	NCBI	mRatBN7.2
mRatBN7.2 Ensembl	1	205,631,824 - 205,636,563 (+)	Ensembl
Rnor_6.0	1	224,933,906 - 224,938,659 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	224,933,529 - 224,938,662 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	231,871,371 - 231,876,117 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	211,403,239 - 211,407,978 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
Celera	1	203,144,719 - 203,149,458 (+)	NCBI		Celera
Cytogenetic Map	1	q43	NCBI

WDR74
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	62,832,905 - 62,841,809 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	11	62,832,342 - 62,841,809 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	62,600,377 - 62,609,281 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	62,356,960 - 62,364,204 (-)	NCBI	NCBI36		hg18	NCBI36
Celera	11	59,929,980 - 59,931,022 (-)	NCBI
Celera	11	51,134,558 - 51,137,689 (-)	NCBI
Cytogenetic Map	11	q12.3	NCBI
HuRef	11	58,929,412 - 58,936,657 (-)	NCBI		HuRef
CHM1_1	11	62,483,425 - 62,490,670 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	62,822,302 - 62,831,206 (-)	NCBI

Wdr74
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	8,713,159 - 8,717,988 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	19	8,713,191 - 8,717,988 (+)	Ensembl
GRCm38	19	8,735,795 - 8,740,624 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	8,735,827 - 8,740,624 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	8,810,329 - 8,815,114 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	19	8,802,884 - 8,807,669 (+)	NCBI			mm8
Celera	19	8,495,912 - 8,500,697 (+)	NCBI		Celera
Cytogenetic Map	19	A	NCBI

Wdr74
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955599	407,207 - 413,770 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955599	408,076 - 413,770 (+)	NCBI	ChiLan1.0	ChiLan1.0

WDR74
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	11	61,542,300 - 61,549,754 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	61,542,300 - 61,549,426 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	11	58,188,230 - 58,195,538 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

WDR74
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	53,855,207 - 53,861,700 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	53,855,282 - 53,861,698 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	52,461,069 - 52,467,744 (+)	NCBI
ROS_Cfam_1.0	18	54,907,385 - 54,914,153 (+)	NCBI
ROS_Cfam_1.0 Ensembl	18	54,907,414 - 54,914,149 (+)	Ensembl
UMICH_Zoey_3.1	18	54,004,274 - 54,010,799 (+)	NCBI
UNSW_CanFamBas_1.0	18	53,578,697 - 53,585,230 (+)	NCBI
UU_Cfam_GSD_1.0	18	54,374,793 - 54,381,506 (+)	NCBI

Wdr74
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	10,342,627 - 10,347,864 (+)	NCBI
SpeTri2.0	NW_004936581	456,354 - 461,610 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

WDR74
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	8,931,495 - 8,936,906 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	8,931,530 - 8,936,908 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	8,276,762 - 8,282,140 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

WDR74
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	11,063,294 - 11,070,215 (+)	NCBI	ChlSab1.1		chlSab2
ChlSab1.1 Ensembl	1	11,063,265 - 11,070,218 (+)	Ensembl	ChlSab1.1		chlSab2
Vero_WHO_p1.0	NW_023666038	108,405,836 - 108,412,795 (+)	NCBI	Vero_WHO_p1.0

Wdr74
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624926	1,287,012 - 1,301,658 (-)	Ensembl	HetGla_female_1.0		hetGla2
HetGla 1.0	NW_004624926	1,287,012 - 1,291,887 (-)	NCBI	HetGla_female_1.0		hetGla2

Position Markers

BE457658

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	205,636,388 - 205,636,477 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	224,938,485 - 224,938,573	NCBI	Rnor6.0
Rnor_5.0	1	231,875,943 - 231,876,031	UniSTS	Rnor5.0
RGSC_v3.4	1	211,407,804 - 211,407,892	UniSTS	RGSC3.4
Celera	1	203,149,284 - 203,149,372	UniSTS
Cytogenetic Map	1	q43	UniSTS

RH134005

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	205,636,914 - 205,637,098 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	224,939,011 - 224,939,194	NCBI	Rnor6.0
Rnor_5.0	1	231,876,469 - 231,876,652	UniSTS	Rnor5.0
RGSC_v3.4	1	211,408,330 - 211,408,513	UniSTS	RGSC3.4
Celera	1	203,149,810 - 203,149,993	UniSTS
RH 3.4 Map	1	1517.9	UniSTS
Cytogenetic Map	1	q43	UniSTS

H31976

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	205,636,032 - 205,636,476 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	224,938,129 - 224,938,572	NCBI	Rnor6.0
Rnor_5.0	1	231,875,587 - 231,876,030	UniSTS	Rnor5.0
RGSC_v3.4	1	211,407,448 - 211,407,891	UniSTS	RGSC3.4
Celera	1	203,148,928 - 203,149,371	UniSTS
RH 3.4 Map	1	1519.3	UniSTS
Cytogenetic Map	1	q43	UniSTS

RH124618

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	205,636,441 - 205,636,526 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	224,938,538 - 224,938,622	NCBI	Rnor6.0
Rnor_5.0	1	231,875,996 - 231,876,080	UniSTS	Rnor5.0
RGSC_v3.4	1	211,407,857 - 211,407,941	UniSTS	RGSC3.4
Celera	1	203,149,337 - 203,149,421	UniSTS
Cytogenetic Map	1	q43	UniSTS

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
737828	Hcas3	Hepatocarcinoma susceptibility QTL 3	4.9		liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	1	144267353	222987745	Rat
1298084	Thym4	Thymus enlargement QTL 4	10.68		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	1	197814409	242814409	Rat
631658	Cm7	Cardiac mass QTL 7	5.32	0.0001	aorta mass (VT:0002845)	aorta weight (CMO:0000076)	1	196248093	241248093	Rat
737977	Bp160	Blood pressure QTL 160		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	181133855	226133855	Rat
6903303	Scl34	Serum cholesterol QTL 34	2.5	0.0033	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	180359209	218108781	Rat
731168	Bp154	Blood pressure QTL 154	3.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	94642722	214537671	Rat
8655655	Arrd2	Age-related retinal degeneration QTL 2	7.79		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	183970203	243914901	Rat
7794788	Mcs32	Mammary carcinoma susceptibility QTL 32	2.61		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	1	115540693	238914717	Rat
738032	Hcas5	Hepatocarcinoma susceptibility QTL 5	3.12		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	176426412	257976495	Rat
631838	Niddm36	Non-insulin dependent diabetes mellitus QTL 36		0.01	insulin secretion trait (VT:0003564)	calculated pancreatic islet insulin release measurement (CMO:0001217)	1	184550676	229550676	Rat
634312	Bp143	Blood pressure QTL 143	3	0.0002	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	182623426	219932796	Rat
634321	Hc1	Hypercalciuria QTL 1	2.91		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	178810256	240830002	Rat
634338	Hcar4	Hepatocarcinoma resistance QTL 4	4.6		liver integrity trait (VT:0010547)	liver tumorous lesion number to liver area ratio (CMO:0001210)	1	193422268	214537671	Rat
7771612	Cm80	Cardiac mass QTL 80	8.4		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	1	149448574	221264292	Rat
7421630	Bp362	Blood pressure QTL 362		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118608292	241799120	Rat
8552891	Epfw5	Epididymal fat weight QTL 5	4.4		epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	1	193113876	238113876	Rat
7394701	Uae46	Urinary albumin excretion QTL 46	3.6	0.0056	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	201554356	246554356	Rat
1300145	Rf7	Renal function QTL 7	2.96		urine creatinine amount (VT:0010540)	urine creatinine level (CMO:0000125)	1	185145134	221264292	Rat
8655855	Arrd3	Age-related retinal degeneration QTL 3	3.07		lens clarity trait (VT:0001304)	cataract incidence/prevalence measurement (CMO:0001585)	1	183970203	243914901	Rat
10059590	Kidm44	Kidney mass QTL 44	3.42	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	191033875	236033875	Rat
10059600	Bp378	Blood pressure QTL 378	3.08	0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	176869060	221869060	Rat
1331790	Bp201	Blood pressure QTL 201	3.127		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	198211513	225126682	Rat
1354580	Scort1	Serum corticosterone level QTL 1	3.4		blood corticosterone amount (VT:0005345)	blood corticosterone level (CMO:0001172)	1	156677124	256448636	Rat
1302787	Stl25	Serum triglyceride level QTL 25	2.7	0.0073	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	1	180359209	210702199	Rat
1354606	Bp246	Blood pressure QTL 246	3.6		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	102813953	218753816	Rat
1354624	Cm35	Cardiac mass QTL35	5.7		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	177227632	256448636	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	151162512	256448636	Rat
1354652	Kidm20	Kidney mass QTL 20	4.3		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	177227632	256448636	Rat
1354653	Despr9	Despair related QTL 9		0.00019	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	167909849	212909849	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	153136852	260522016	Rat
1358191	Ept10	Estrogen-induced pituitary tumorigenesis QTL 10	3.8		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	1	192825253	243914732	Rat
1358886	Bp260	Blood pressure QTL 260	3.67		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	151162766	225824951	Rat
1358898	Bp255	Blood pressure QTL 255	3.6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	191019702	246062233	Rat
1549830	Bss1	Bone structure and strength QTL 1	4.8		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	1	172609619	217609619	Rat
1358292	Cm37	Cardiac mass QTL 37	6.2	0.00000081	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	1	196248093	241248093	Rat
1598853	Memor3	Memory QTL 3	4.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	1	143506580	212458660	Rat
1600363	Hc6	Hypercalciuria QTL 6	2.7		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	203995416	244113296	Rat
1578759	Uae30	Urinary albumin excretion QTL 30	3.3	0.003	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	150700247	252085048	Rat
1578778	Pur4	Proteinuria QTL 4	3.3	0.003	total urine protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	1	150700247	252085048	Rat
2292220	Bp306	Blood pressure QTL 306	3.47	0.00087	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	164310393	243914901	Rat
2292222	Bp307	Blood pressure QTL 307	3.06	0.0014	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	164310393	213533942	Rat
2293083	Iddm25	Insulin dependent diabetes mellitus QTL 25	4.18		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	181829673	224569684	Rat
631214	Bw61	Body weight QTL61	3.4	0.0001	intramuscular adipose amount (VT:0010044)	intramuscular fat area (CMO:0001162)	1	173108781	218108781	Rat
724531	Uae5	Urinary albumin excretion QTL 5	4		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	1	150700142	252085212	Rat
724562	Rends1	Renal damage susceptibility QTL 1		0.05	kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	1	169537671	214537671	Rat
2312420	Pur17	Proteinuria QTL 17	7.1	0.0001	urine protein amount (VT:0005160)	urine total protein excretion rate (CMO:0000756)	1	156677124	218753816	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
1600396	Niddm68	Non-insulin dependent diabetes mellitus QTL 68	4.97	0.0003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	195804352	257091168	Rat
2293677	Bss41	Bone structure and strength QTL 41	9.38	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra cross-sectional area (CMO:0001689)	1	171629477	216629477	Rat
1641926	Teswt2	Testicular weight QTL 2	2.82		testis mass (VT:1000644)	both testes wet weight (CMO:0000175)	1	197697768	238755659	Rat
1578763	Kidm29	Kidney mass QTL 29	3.3	0.0001	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	1	179567751	260522016	Rat
1600388	Niddm67	Non-insulin dependent diabetes mellitus QTL 67	5.84	0.000004	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	195804352	257091168	Rat
2293654	Bss30	Bone structure and strength QTL 30	32.65	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	1	171629477	216629477	Rat
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
2300175	Bmd40	Bone mineral density QTL 40	15.4	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	1	201554356	246554356	Rat
2302378	Insul11	Insulin level QTL 11	3.25		blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	1	144267353	251128347	Rat
1358294	Bw37	Body weight QTL 37	5	0.000011	body mass (VT:0001259)	body weight (CMO:0000012)	1	171310381	216310381	Rat
1558658	Bw59	Body weight QTL 59	3.5	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	1	178784622	223784622	Rat
61341	Bp26	Blood pressure QTL 26			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	169537671	214537671	Rat
61376	Bp42	Blood pressure QTL 42	23.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	197814409	242814409	Rat
2293674	Bss39	Bone structure and strength QTL 39	7.1	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	1	201554356	246554356	Rat
724559	Pancm1	Pancreatic morphology QTL 1	7.1		islet of Langerhans morphology trait (VT:0005215)	pancreatic islet damage composite score (CMO:0001156)	1	181759564	214537555	Rat
1578780	Cm52	Cardiac mass QTL 52	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	1	81591954	219808434	Rat
2300187	Bmd41	Bone mineral density QTL 41	8.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	171629477	216629477	Rat
1600380	Niddm70	Non-insulin dependent diabetes mellitus QTL 70	3.1	0.0008	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	176550523	221550523	Rat
634313	Niddm43	Non-insulin dependent diabetes mellitus QTL 43			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	199050459	259647894	Rat
2293693	Bss22	Bone structure and strength QTL 22	33.52	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	1	171629477	216629477	Rat
2302375	Bw83	Body weight QTL 83	4.87	0.0002	body mass (VT:0001259)	body weight (CMO:0000012)	1	197697768	242697768	Rat
1357335	Bw39	Body weight QTL 39	3.3		body mass (VT:0001259)	body weight (CMO:0000012)	1	197814409	242814409	Rat
2292218	Kidm35	Kidney mass QTL 35			kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	199368955	224569684	Rat
2300174	Bmd42	Bone mineral density QTL 42	8.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	bone mineral density (CMO:0001226)	1	171629477	216629477	Rat
1600395	Niddm69	Non-insulin dependent diabetes mellitus QTL 69	4.14	0.0002	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	195804352	257091168	Rat
1600374	Mcs17	Mammary carcinoma susceptibility QTL 17	3		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	1	197670404	242670404	Rat
2293694	Bss38	Bone structure and strength QTL 38	7.05	0.0001	femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	1	201554356	246554356	Rat
2312564	Glom18	Glomerulus QTL 18	2.4	0.003	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	1	185356336	231689108	Rat
2300161	Bmd43	Bone mineral density QTL 43	8.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	171629477	216629477	Rat
2293689	Bss47	Bone structure and strength QTL 47	7.25	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	1	171629477	216629477	Rat
70163	Bw20	Body weight QTL 20	5.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	174133260	219133260	Rat
10059587	Bw173	Body weight QTL 173	3.23	0.025	body mass (VT:0001259)	body weight (CMO:0000012)	1	202069611	247069611	Rat
619613	Bp77	Blood pressure QTL 77		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	164747424	209747424	Rat
619613	Bp77	Blood pressure QTL 77		0.01	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	164747424	209747424	Rat
2293655	Bss36	Bone structure and strength QTL 36	10.66	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	1	201554356	246554356	Rat
1582206	Kidm33	Kidney mass QTL 33	6.9		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	188377360	224054420	Rat
2293673	Bss27	Bone structure and strength QTL 27	18.63	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	1	171629477	216629477	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	100
Count of miRNA genes:	83
Interacting mature miRNAs:	88
Transcripts:	ENSRNOT00000066823
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	29	41	30	19	30			74	29	41	11
Low		14	16	11		11	8	11		6			8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001109569	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001401300	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006230999	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006231000	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091404	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC099294	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC158834	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000045	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000066823 ⟹ ENSRNOP00000060344

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	205,631,824 - 205,636,563 (+)	Ensembl
Rnor_6.0 Ensembl	1	224,933,920 - 224,938,659 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000088282 ⟹ ENSRNOP00000070315

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	205,631,834 - 205,636,555 (+)	Ensembl
Rnor_6.0 Ensembl	1	224,933,529 - 224,938,662 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000113119 ⟹ ENSRNOP00000091420

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	205,631,853 - 205,636,549 (+)	Ensembl

RefSeq Acc Id:

NM_001109569 ⟹ NP_001103039

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	205,631,824 - 205,636,563 (+)	NCBI
Rnor_6.0	1	224,933,920 - 224,938,659 (+)	NCBI
Rnor_5.0	1	231,871,371 - 231,876,117 (+)	NCBI
RGSC_v3.4	1	211,403,239 - 211,407,978 (+)	RGD
Celera	1	203,144,719 - 203,149,458 (+)	RGD

Sequence:

show sequence

CGCGCCGGAAGTGCAAGCCATAGGCTGGTCTGCGATGGCCGCTACCTCGGCTCGCTGGAACCAT
GTGTGGGTCGGCACTGAGACTGGAATCCTGAAAGGGGTGAACCTTCAGCGGAAACTTGCGGCAA
ATTTTACTCCGTCCGGACAGCCACGGCGGGAGGAGGCAGTGAATGCTTTGTGCTGGGGCACAGG
CGGCGAGACCCAGATTTTGGTGGGATGTGCGGACAGGACCGTGAGGCACTTTAATGCGGAGGAG
GGTACATTCCAGAGCCAGAGATACTGCCCAGGCGGGGAAGGCACGTTCCGAGGTCTCGCCCAGG
CCGATGATGGCACTCTTATCACATGTGTGGATTCTGGGATCCTCAGAGTCTGGTGTGAAAATGA
CAAGGAGGCGTCCTCTGACCCACTCTTGGAACTGAAGGTGGGTCCTGGGGTGTGTAGGATGCGC
CAAGATCCCACACACACACATGTGGTTGCAACATGTGGGAAAGAGAATGCTTTGAAAGTATGGG
ACCTACAGGGGTCTGAGGAGCCTGTGTTCAGGGCGAAGAATGTGCGGAATGATTGGCTTGATCT
GCGGGTTCCGATTTGGGACCAAGATATACAGTTCCTCCCTGGGTCACAGAAACTTGTCACATGT
ACAGGATACCACCAGGTCAGAATCTATGATCCAGCCTCCCCCCAGCGCCGGCCAGTCCTAGAGG
CCACCTATGGAGAATACCCACTGACAGCCATGACCCTGACTCCTGAGGGCAATTCTGTCATCGT
GGGGAACACTCATGGGCAGCTGGCAGAAATTGATTTTCGGCAAGGGCGTCTACTGGGCTGTCTG
AAGGGGCTTGCAGGCAGTGTACGTGGGCTGCAGTGTCATCCTTCGAAGCCCCTGTTAGCATCTT
GTGGCTTAGACAGAGTCCTGAGGATACACAGGATCCGCAATCCACGAGGGCTAGAGCATAAGGA
TGAGCCCCAAGAACCTCAAGAGCCCAACCTAGTGCCCCCAGAAGACACAGAGACAGATGAACTT
TGGGCGTCTTTGGAGGCAGCTGCCAAGCGAAAGCTCCCTGATTTGGACCAGAAACAAGGTGCTC
TCCAAAGAAGGAAGAAAAAGAAGCGTCCTGGATCCACCAGTCCTTGAAGCCCCTTGCTCACTTT
GTTAATAAACAGCCCAACACATACTGAGATCCTG

hide sequence

RefSeq Acc Id:

XM_006230999 ⟹ XP_006231061

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	205,631,769 - 205,636,558 (+)	NCBI
Rnor_6.0	1	224,933,906 - 224,938,652 (+)	NCBI
Rnor_5.0	1	231,871,371 - 231,876,117 (+)	NCBI

Sequence:

show sequence

GATGTAGGTGCTGGCGCGCCGGAAGTGCAAGCCATAGGCTGGTCTGCGATGGCCGCTACCTCGG
CTCGCTGGAACCATGTGTGGGTCGGCACTGAGACTGGAATCCTGAAAGGGGTGAACCTTCAGCG
GAAACTTGCGGCAAATTTTACTCCGTCCGGACAGCCACGGCGGGAGGAGGCAGTGAATGCTTTG
TGCTGGGGCACAGGCGGCGAGACCCAGATTTTGGTGGGATGTGCGGACAGGACCGTGAGGCACT
TTAATGCGGAGGAGGGTACATTCCAGAGCCAGAGATACTGCCCAGGCGGGGAAGGCACGTTCCG
AGGTCTCGCCCAGGCCGATGATGGCACTCTTATCACATGTGTGGATTCTGGGATCCTCAGAGTC
TGGTGTGAAAATGACAAGGAGGCGTCCTCTGACCCACTCTTGGAACTGAAGGTGGGTCCTGGGG
TGTGTAGGATGCGCCAAGATCCCACACACACACATGTGGTTGCAACATGTGGGAAAGAGAATGC
TTTGAAAGTATGGGACCTACAGGGGTCTGAGGAGCCTGTGTTCAGGGCGAAGAATGTGCGGAAT
GATTGGCTTGATCTGCGGGTTCCGATTTGGGACCAAGATATACAGTTCCTCCCTGGGTCACAGA
AACTTGTCACATGTACAGGATACCACCAGGTCAGAATCTATGATCCAGCCTCCCCCCAGCGCCG
GCCAGTCCTAGAGGCCACCTATGGAGAATACCCACTGACAGCCATGACCCTGACTCCTGAGGGC
AATTCTGTCATCGTGGGGAACACTCATGGGCAGCTGGCAGAAATTGATTTTCGGCAAGGGCGTC
TACTGGGCTGTCTGAAGGGGCTTGCAGGCAGTGTACGTGGGCTGCAGTGTCATCCTTCGAAGCC
CCTGTTAGCATCTTGTGGCTTAGACAGAGTCCTGAGGATACACAGGATCCGCAATCCACGAGGG
CTAGAGCATAAGGTTTATCTCAAGTCTCAACTGAACTGCCTTCTCCTGTCAGGCCGGGATAACT
GGGAGGATGAGCCCCAAGAACCTCAAGAGCCCAACCTAGTGCCCCCAGAAGACACAGAGACAGA
TGAACTTTGGGCGTCTTTGGAGGCAGCTGCCAAGCGAAAGCTCCCTGATTTGGACCAGAAACAA
GGTGCTCTCCAAAGAAGGAAGAAAAAGAAGCGTCCTGGATCCACCAGTCCTTGAAGCCCCTTGC
TCACTTTGTTAATAAACAGCCCAACACATACTGA

hide sequence

RefSeq Acc Id:

XM_006231000 ⟹ XP_006231062

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	205,631,769 - 205,636,558 (+)	NCBI
Rnor_6.0	1	224,933,906 - 224,938,652 (+)	NCBI
Rnor_5.0	1	231,871,371 - 231,876,117 (+)	NCBI

Sequence:

show sequence

GATGTAGGTGCTGGCGCGCCGGAAGTGCAAGCCATAGGCTGGTCTGCGATGGCCGCTACCTCGG
CTCGCTGGAACCATGTGTGGGTCGGCACTGAGACTGGAATCCTGAAAGGGGTGAACCTTCAGCG
GAAACTTGCGGCAAATTTTACTCCGTCCGGACAGCCACGGCGGGAGGAGGCAGTGAATGCTTTG
TGCTGGGGCACAGGCGGCGAGACCCAGATTTTGGTGGGATGTGCGGACAGGACCGTGAGGCACT
TTAATGCGGAGGAGGGTACATTCCAGAGCCAGAGATACTGCCCAGGCGGGGAAGGCACGTTCCG
AGGTCTCGCCCAGGCCGATGATGGCACTCTTATCACATGTGTGGATTCTGGGATCCTCAGAGTC
TGGTGTGAAAATGACAAGGAGGCGTCCTCTGACCCACTCTTGGAACTGAAGGTGCGGAATGATT
GGCTTGATCTGCGGGTTCCGATTTGGGACCAAGATATACAGTTCCTCCCTGGGTCACAGAAACT
TGTCACATGTACAGGATACCACCAGGTCAGAATCTATGATCCAGCCTCCCCCCAGCGCCGGCCA
GTCCTAGAGGCCACCTATGGAGAATACCCACTGACAGCCATGACCCTGACTCCTGAGGGCAATT
CTGTCATCGTGGGGAACACTCATGGGCAGCTGGCAGAAATTGATTTTCGGCAAGGGCGTCTACT
GGGCTGTCTGAAGGGGCTTGCAGGCAGTGTACGTGGGCTGCAGTGTCATCCTTCGAAGCCCCTG
TTAGCATCTTGTGGCTTAGACAGAGTCCTGAGGATACACAGGATCCGCAATCCACGAGGGCTAG
AGCATAAGGTTTATCTCAAGTCTCAACTGAACTGCCTTCTCCTGTCAGGCCGGGATAACTGGGA
GGATGAGCCCCAAGAACCTCAAGAGCCCAACCTAGTGCCCCCAGAAGACACAGAGACAGATGAA
CTTTGGGCGTCTTTGGAGGCAGCTGCCAAGCGAAAGCTCCCTGATTTGGACCAGAAACAAGGTG
CTCTCCAAAGAAGGAAGAAAAAGAAGCGTCCTGGATCCACCAGTCCTTGAAGCCCCTTGCTCAC
TTTGTTAATAAACAGCCCAACACATACTGA

hide sequence

RefSeq Acc Id:

XM_039091404 ⟹ XP_038947332

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	205,634,294 - 205,636,558 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001103039	(Get FASTA)	NCBI Sequence Viewer
	NP_001388229	(Get FASTA)	NCBI Sequence Viewer
	XP_006231061	(Get FASTA)	NCBI Sequence Viewer
	XP_006231062	(Get FASTA)	NCBI Sequence Viewer
	XP_038947332	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI58835	(Get FASTA)	NCBI Sequence Viewer
	EDM12711	(Get FASTA)	NCBI Sequence Viewer
	EDM12712	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001103039 ⟸ NM_001109569

- Sequence:

show sequence

MAATSARWNHVWVGTETGILKGVNLQRKLAANFTPSGQPRREEAVNALCWGTGGETQILVGCAD
RTVRHFNAEEGTFQSQRYCPGGEGTFRGLAQADDGTLITCVDSGILRVWCENDKEASSDPLLEL
KVGPGVCRMRQDPTHTHVVATCGKENALKVWDLQGSEEPVFRAKNVRNDWLDLRVPIWDQDIQF
LPGSQKLVTCTGYHQVRIYDPASPQRRPVLEATYGEYPLTAMTLTPEGNSVIVGNTHGQLAEID
FRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIRNPRGLEHKDEPQEPQEPNLV
PPEDTETDELWASLEAAAKRKLPDLDQKQGALQRRKKKKRPGSTSP

hide sequence

RefSeq Acc Id:	XP_006231061 ⟸ XM_006230999
- Peptide Label:	isoform X1
- UniProtKB:	B0BNI2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAATSARWNHVWVGTETGILKGVNLQRKLAANFTPSGQPRREEAVNALCWGTGGETQILVGCAD RTVRHFNAEEGTFQSQRYCPGGEGTFRGLAQADDGTLITCVDSGILRVWCENDKEASSDPLLEL KVGPGVCRMRQDPTHTHVVATCGKENALKVWDLQGSEEPVFRAKNVRNDWLDLRVPIWDQDIQF LPGSQKLVTCTGYHQVRIYDPASPQRRPVLEATYGEYPLTAMTLTPEGNSVIVGNTHGQLAEID FRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIRNPRGLEHKVYLKSQLNCLLL SGRDNWEDEPQEPQEPNLVPPEDTETDELWASLEAAAKRKLPDLDQKQGALQRRKKKKRPGSTS P hide sequence

RefSeq Acc Id:

XP_006231062 ⟸ XM_006231000

- Peptide Label:

isoform X2

- Sequence:

show sequence

MAATSARWNHVWVGTETGILKGVNLQRKLAANFTPSGQPRREEAVNALCWGTGGETQILVGCAD
RTVRHFNAEEGTFQSQRYCPGGEGTFRGLAQADDGTLITCVDSGILRVWCENDKEASSDPLLEL
KVRNDWLDLRVPIWDQDIQFLPGSQKLVTCTGYHQVRIYDPASPQRRPVLEATYGEYPLTAMTL
TPEGNSVIVGNTHGQLAEIDFRQGRLLGCLKGLAGSVRGLQCHPSKPLLASCGLDRVLRIHRIR
NPRGLEHKVYLKSQLNCLLLSGRDNWEDEPQEPQEPNLVPPEDTETDELWASLEAAAKRKLPDL
DQKQGALQRRKKKKRPGSTSP

hide sequence

RefSeq Acc Id:

ENSRNOP00000070315 ⟸ ENSRNOT00000088282

RefSeq Acc Id:

ENSRNOP00000060344 ⟸ ENSRNOT00000066823

RefSeq Acc Id:	XP_038947332 ⟸ XM_039091404
- Peptide Label:	isoform X3

RefSeq Acc Id:

ENSRNOP00000091420 ⟸ ENSRNOT00000113119

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B0BNI2-F1-model_v2	AlphaFold	B0BNI2	1-385	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13690730

Promoter ID:

EPDNEW_R1255

Type:

multiple initiation site

Name:

Wdr74_1

Description:

WD repeat domain 74

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	224,933,934 - 224,933,994	EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)

ACI/EurMcwi (2019)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

ACI/N (2020)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN-Lx/CubMcwi (2019)

Visual

CSV

TAB

Printer

Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/NHsdMcwi (2019)

Visual

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TAB

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/NHsdMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/SsN (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BUF/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BXH2/CubMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BXH3/CubMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

DA/OlaHsd (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Envigo
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/DuCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/NCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FHH/EurMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FXLE16/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FXLE18/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

GK/FarMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB10/IpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB2/IpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB20/IpcvMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB31/IpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB4/IpcvMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LE/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEW/Crl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF10A/StmMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF11/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF1A/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF1C/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF2B/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF3/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF4/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LH/MavRrrcAek (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LL/MavRrrcAek (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LN/MavRrrcAek (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

M520/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

M520/NRrrcMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

MR/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

MWF/Hsd (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

PVG/Seac (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SHR/OlalpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SHRSP/A3NCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SR/JrHsd (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Envigo
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SS/JrHsdMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WAG/RijCrl (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WKY/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WKY/NCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WN/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

Damaging Variants

Assembly: Rnor_6.0

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
1	224936260	224936261	G	A	snv	FHH/EurMcwi (2019), FHH/EurMcwi (MCW), FHL/EurMcwi (RGD), FHH/EurMcwi (RGD), FHL/EurMcwi (MCW)

Assembly: Rnor_5.0

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
1	231873718	231873719	G	A	snv	FHH/EurMcwi (MCW), FHL/EurMcwi (MCW), LEC/Tj (KyushuU), FHL/EurMcwi (KNAW), BUF/MNa (KyushuU), FHH/EurMcwi (KNAW)

Assembly: RGSC_v3.4

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
1	211405579	211405580	G	A	snv	FHH/EurMcwi (MCW), FHL/EurMcwi (MCW), FHL/EurMcwi (ICL), FHH/EurMcwi (ICL), FHH/EurMcwi (MDC)

Assembly: mRatBN7.2

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
1	205634164	205634165	G	A	snv	FHH/EurMcwi (2019)

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1582881	AgrOrtholog
BioCyc Gene	G2FUF-56503	BioCyc
Ensembl Genes	ENSRNOG00000042878	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000060344.1	UniProtKB/TrEMBL
	ENSRNOP00000070315	ENTREZGENE
	ENSRNOP00000070315.1	UniProtKB/TrEMBL
	ENSRNOP00000091420.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000066823.3	UniProtKB/TrEMBL
	ENSRNOT00000088282	ENTREZGENE
	ENSRNOT00000088282.2	UniProtKB/TrEMBL
	ENSRNOT00000113119.1	UniProtKB/TrEMBL
Gene3D-CATH	2.130.10.10	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7383724	IMAGE-MGC_LOAD
InterPro	Quinoprotein_ADH-like_supfam	UniProtKB/TrEMBL
	WD40/YVTN_repeat-like_dom	UniProtKB/TrEMBL
	WD40_repeat	UniProtKB/TrEMBL
	WD40_repeat_dom_sf	UniProtKB/TrEMBL
	WDR74/Nsa1	UniProtKB/TrEMBL
KEGG Report	rno:690229	UniProtKB/TrEMBL
MGC_CLONE	MGC:188293	IMAGE-MGC_LOAD
NCBI Gene	690229	ENTREZGENE
PANTHER	PTHR16038	UniProtKB/TrEMBL
Pfam	WD40	UniProtKB/TrEMBL
PhenoGen	Wdr74	PhenoGen
SMART	WD40	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50998	UniProtKB/TrEMBL
	WD40_like	UniProtKB/TrEMBL
UniProt	A0A8I6AFE4_RAT	UniProtKB/TrEMBL
	B0BNI2	ENTREZGENE, UniProtKB/TrEMBL
	D3ZMQ7_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-07-08	Wdr74	WD repeat domain 74	LOC686449	similar to WD repeat domain 74	Data Merged	1643240	APPROVED
2008-03-06	Wdr74	WD repeat domain 74	LOC690229	similar to WD repeat domain 74	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-20	LOC686449	similar to WD repeat domain 74			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-11-19	LOC690229	similar to WD repeat domain 74			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

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