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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Painful Neuropathy
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Accession:DOID:9004974 term browser browse the term
Synonyms:primary_id: MESH:C564945
 alt_id: OMIM:256870


show annotations for term's descendants           Sort by:
Painful Neuropathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL2 C-C motif chemokine ligand 2 ISO protein:increased expression:medulla oblongata, dorsal horn of spinal cord (mouse)
protein:increased expression:ipsilateral side, dorsal root ganglion (rat)		 RGD PMID:22721162 PMID:15041200 RGD:8548831, RGD:8548884 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G EP300 E1A binding protein p300 treatment ISO mRNA:increased expression:lumbar spinal cord (rat) RGD PMID:23176208 PMID:23176208 RGD:7327202, RGD:7327202 NCBI chr22:41,092,592...41,180,077
Ensembl chr22:41,092,592...41,180,077 		JBrowse link
G HMGB1 high mobility group box 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:27474498 NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597 		JBrowse link
G THBD thrombomodulin EXP CTD Direct Evidence: therapeutic CTD PMID:27474498 NCBI chr20:23,045,633...23,049,672
Ensembl chr20:23,045,633...23,049,672 		JBrowse link
G TLR4 toll like receptor 4 treatment ISO RGD PMID:18615568 RGD:7815041 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735 		JBrowse link
G TNF tumor necrosis factor IEP
ISO		 protein:increased expression:Schwann cell RGD PMID:11376190 PMID:10825476 PMID:9514564 PMID:18394803 RGD:7394735, RGD:7394741, RGD:7394740, RGD:7394739 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 41189
    disease of anatomical entity 32346
      nervous system disease 26235
        peripheral nervous system disease 5386
          neuropathy 5133
            Painful Neuropathy 6
paths to the root