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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:choriocarcinoma
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Accession:DOID:3594 term browser browse the term
Definition:A placenta cancer that has_material_basis_in trophoblastic cells. (DO)
Synonyms:exact_synonym: Choriocarcinomas;   chorioepithelioma
 narrow_synonym: Gastric Choriocarcinoma
 primary_id: MESH:D002822
 xref: EFO:0002893;   EFO:1000269;   GARD:6059;   ICD10CM:C58;   ICDO:9100/3;   NCI:C2948;   NCI:C60377
For additional species annotation, visit the Alliance of Genome Resources.

GViewer not supported for the selected species.

show annotations for term's descendants           Sort by:
choriocarcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FGF8 fibroblast growth factor 8 ISO protein:increased expression:testicular germ cell neoplasms RGD PMID:11764380 RGD:2289339 NCBI chr 9:94,797,157...94,803,725
Ensembl chr 9:94,798,088...94,803,629 		JBrowse link
G IGF2 insulin like growth factor 2 disease_progression ISO protein:increased expression:tumor:elevated IGF-II increased choriocarcinoma cell invasion via activation of INSR RGD PMID:17556377 RGD:2290454 NCBI chr 1:1,937,414...1,951,238
Ensembl chr 1:1,936,830...1,945,388 		JBrowse link
G INSR insulin receptor disease_progression ISO protein:increased activity:tumor:IGF-II increased choriocarcinoma cell invasion via activation of INSR RGD PMID:17556377 RGD:2290454 NCBI chr 6:6,625,951...6,803,610
Ensembl chr 6:6,630,777...6,803,592 		JBrowse link
G PDGFB platelet derived growth factor subunit B ISO mRNA:increased expression:mononuclear cytotrophoblast cell RGD PMID:8504434 RGD:2292200 NCBI chr19:21,865,792...21,888,068
Ensembl chr19:21,863,768...21,886,395 		JBrowse link
G PDGFRB platelet derived growth factor receptor beta ISO mRNA:increased expression:mononuclear cytotrophoblast cell RGD PMID:8504434 RGD:2292200 NCBI chr23:52,724,061...52,766,264
Ensembl chr23:52,724,005...52,766,234 		JBrowse link
G TIMP3 TIMP metallopeptidase inhibitor 3 ISO DNA, protein:hypermethylation, decreased expression:promoter, placenta RGD PMID:15507671 RGD:2290418 NCBI chr19:15,621,609...15,684,118
Ensembl chr19:15,622,431...15,680,449 		JBrowse link
placental site trophoblastic tumor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GPC3 glypican 3 ISO protein:increased expression:placenta, trophoblast cells (human) RGD PMID:20868507 RGD:243065141 NCBI chr  X:108,688,706...109,143,653 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15274
    disease of cellular proliferation 7181
      Neoplastic Pregnancy Complications 20
        trophoblastic neoplasm 20
          choriocarcinoma 7
            adult central nervous system choriocarcinoma 0
            childhood CNS choriocarcinoma 0
            choriocarcinoma of ovary + 0
            choriocarcinoma of the testis + 0
            gestational choriocarcinoma + 0
            non-gestational choriocarcinoma 0
            placental site trophoblastic tumor 1
            pulmonary artery choriocarcinoma 0
            uterine corpus choriocarcinoma + 0
Path 2
Term Annotations click to browse term
  disease 15274
    disease of anatomical entity 14909
      Urogenital Diseases 4678
        Female Urogenital Diseases and Pregnancy Complications 2323
          Female Urogenital Diseases 1918
            female reproductive system disease 1915
              uterine disease 490
                Uterine Neoplasms 444
                  uterine cancer 300
                    placenta cancer 7
                      choriocarcinoma 7
                        adult central nervous system choriocarcinoma 0
                        childhood CNS choriocarcinoma 0
                        choriocarcinoma of ovary + 0
                        choriocarcinoma of the testis + 0
                        gestational choriocarcinoma + 0
                        non-gestational choriocarcinoma 0
                        placental site trophoblastic tumor 1
                        pulmonary artery choriocarcinoma 0
                        uterine corpus choriocarcinoma + 0
paths to the root