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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:3,3-diphenyl-N-(1-phenylethyl)-1-propanamine
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Accession:CHEBI:94434 term browser browse the term
Definition:A diarylmethane that has formula C23H25N.
Synonyms:related_synonym: (+/-)-Fendiline;   Formula=C23H25N;   InChI=1S/C23H25N/c1-19(20-11-5-2-6-12-20)24-18-17-23(21-13-7-3-8-14-21)22-15-9-4-10-16-22/h2-16,19,23-24H,17-18H2,1H3;   InChIKey=NMKSAYKQLCHXDK-UHFFFAOYSA-N;   SMILES=CC(C1=CC=CC=C1)NCCC(C2=CC=CC=C2)C3=CC=CC=C3;   fendilin;   fendiline HCl;   fendiline hydrochloride;   phendilin
 xref: CAS:13042-18-7;   Drug_Central:1148;   LINCS:LSM-5133
 xref_mesh: MESH:D005275


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3,3-diphenyl-N-(1-phenylethyl)-1-propanamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2 coagulation factor II, thrombin multiple interactions ISO Fendiline affects the reaction [F2 protein results in increased secretion of Adenosine Triphosphate] CTD PMID:2030746 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 multiple interactions ISO Fendiline inhibits the reaction [2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]] CTD PMID:15627515 NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994 		JBrowse link
G Gabbr2 gamma-aminobutyric acid type B receptor subunit 2 multiple interactions ISO Fendiline inhibits the reaction [2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABBR1 protein binds to GABBR2 protein]]] CTD PMID:15627515 NCBI chr 5:60,947,517...61,288,104
Ensembl chr 5:60,947,526...61,288,104 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Fendiline results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Nos3 nitric oxide synthase 3 decreases activity EXP Fendiline results in decreased activity of NOS3 protein CTD PMID:1374468 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 increases response to substance
decreases activity		 ISO SMPD1 protein results in increased susceptibility to Fendiline
Fendiline results in decreased activity of SMPD1 protein		 CTD PMID:23770692 NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19832
    chemical entity 19830
      group 19789
        polyatomic entity 19788
          molecule 19693
            cyclic compound 19509
              organic cyclic compound 19491
                organic aromatic compound 19361
                  diarylmethane 9438
                    3,3-diphenyl-N-(1-phenylethyl)-1-propanamine 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19832
    subatomic particle 19830
      composite particle 19830
        hadron 19830
          baryon 19830
            nucleon 19830
              atomic nucleus 19830
                atom 19830
                  main group element atom 19780
                    p-block element atom 19780
                      p-block molecular entity 19780
                        carbon group molecular entity 19729
                          organic molecular entity 19725
                            organic molecule 19678
                              organic cyclic compound 19491
                                organic aromatic compound 19361
                                  diarylmethane 9438
                                    3,3-diphenyl-N-(1-phenylethyl)-1-propanamine 6
paths to the root