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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tubastatin A
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Accession:CHEBI:94186 term browser browse the term
Definition:A pyridoindole that is 1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indole which is substituted on the tetrahydropyridine nitrogen by a methyl group and on the indole nitrogen by a p-[N-(hydroxy)aminocarbonyl]benzyl group. It is a histone deacetylase 6 (HDAC6) inhibitor that is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold).
Synonyms:exact_synonym: N-hydroxy-4-[(2-methyl-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide
 related_synonym: Formula=C20H21N3O2;   InChI=1S/C20H21N3O2/c1-22-11-10-19-17(13-22)16-4-2-3-5-18(16)23(19)12-14-6-8-15(9-7-14)20(24)21-25/h2-9,25H,10-13H2,1H3,(H,21,24);   InChIKey=GOVYBPLHWIEHEJ-UHFFFAOYSA-N;   N-hydroxy-4-[(2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)methyl]benzamide;   SMILES=CN1CCC2=C(C1)C3=CC=CC=C3N2CC4=CC=C(C=C4)C(=O)NO
 xref: CAS:1252003-15-8;   LINCS:LSM-4806
 xref_mesh: MESH:C553587
 xref: PMID:20614936;   PMID:23541634;   PMID:24844691;   PMID:24909686;   PMID:25108326;   PMID:25921924;   PMID:26647018;   PMID:26790818;   Reaxys:20796421


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tubastatin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd274 CD274 antigen decreases expression EXP
ISO		 tubastatin A results in decreased expression of CD274 protein CTD PMID:26775640 NCBI chr19:29,339,428...29,365,495
Ensembl chr19:29,344,855...29,365,495 		JBrowse link
G Hdac6 histone deacetylase 6 multiple interactions
decreases activity		 ISO
EXP		 tubastatin A inhibits the reaction [[bisphenol A co-treated with mono-(2-ethylhexyl)phthalate] results in increased expression of HDAC6 protein]; tubastatin A inhibits the reaction [bisphenol A results in increased expression of HDAC6 protein]
tubastatin A results in decreased activity of HDAC6 protein		 CTD PMID:26775640 PMID:34910997 NCBI chr  X:7,796,355...7,814,284
Ensembl chr  X:7,796,359...7,814,128 		JBrowse link
G Myc myelocytomatosis oncogene multiple interactions ISO tubastatin A inhibits the reaction [[bisphenol A co-treated with mono-(2-ethylhexyl)phthalate] results in increased expression of MYC protein]; tubastatin A inhibits the reaction [bisphenol A results in increased expression of MYC protein] CTD PMID:34910997 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions ISO tubastatin A inhibits the reaction [sodium arsenite results in increased expression of NFE2L2 protein] CTD PMID:22367689 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase, isoenzyme 1 multiple interactions EXP tubastatin A affects the reaction [PDK1 protein affects the abundance of Cyclic AMP] CTD PMID:28887310 NCBI chr 2:71,703,398...71,734,202
Ensembl chr 2:71,703,568...71,734,202 		JBrowse link
G Pten phosphatase and tensin homolog increases expression
multiple interactions		 ISO tubastatin A results in increased expression of PTEN mRNA
[bisphenol A co-treated with tubastatin A] results in increased expression of PTEN mRNA; [mono-(2-ethylhexyl)phthalate co-treated with bisphenol A co-treated with tubastatin A] results in increased expression of PTEN mRNA; [mono-(2-ethylhexyl)phthalate co-treated with tubastatin A] results in increased expression of PTEN mRNA		 CTD PMID:34910997 NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation ISO
EXP		 tubastatin A results in decreased phosphorylation of STAT3 protein CTD PMID:26775640 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    role 22194
      application 21744
        NMR chemical shift reference compound 18719
          ammonia 18425
            organic amino compound 18425
              tertiary amino compound 10293
                tubastatin A 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    p-block element atom 22104
                      carbon group element atom 21904
                        carbon atom 21859
                          organic molecular entity 21830
                            heteroorganic entity 21482
                              organochalcogen compound 20966
                                organooxygen compound 20806
                                  carbon oxoacid 19593
                                    carboxylic acid 19589
                                      carboacyl group 18277
                                        univalent carboacyl group 18277
                                          carbamoyl group 18088
                                            carboxamide 18106
                                              hydroxamic acid 6364
                                                tubastatin A 7
paths to the root