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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:glycoursodeoxycholic acid
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Accession:CHEBI:89929 term browser browse the term
Definition:A bile acid glycine conjugate derived from ursoodeoxycholic acid.
Synonyms:related_synonym: 3alpha,7beta-dihydroxy-5beta-cholanoylglycine;   Formula=C26H43NO5;   GUDCA;   Glycine ursodeoxycholic acid;   Glycylursodeoxycholic acid;   InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/t15-,16+,17-,18-,19+,20+,21+,24+,25+,26-/m1/s1;   InChIKey=GHCZAUBVMUEKKP-XROMFQGDSA-N;   N-(3alpha,7beta-dihydroxy-5beta-cholan-24-oyl)glycine;   N-[(3alpha,5beta,7beta)-3,7-dihydroxy-24-oxocholan-24-yl]glycine;   SMILES=C1[C@@]2([C@]3(CC[C@]4([C@]([C@@]3([C@H](C[C@@]2(C[C@@H](C1)O)[H])O)[H])(CC[C@]4([H])[C@@H](CCC(NCC(O)=O)=O)C)[H])C)[H])C;   Ursodeoxycholylglycine
 xref: CAS:64480-66-6;   HMDB:HMDB0000708
 xref_mesh: MESH:C024033
 xref: PMID:24848512;   PMID:26009005;   PMID:26382575;   PMID:26639449;   PMID:27322559;   Reaxys:3226178
 cyclic_relationship: is_conjugate_acid_of CHEBI:132030


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glycoursodeoxycholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator multiple interactions ISO glycoursodeoxycholic acid inhibits the reaction [TP53 protein results in increased expression of BAX mRNA] CTD PMID:17881359 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases hydroxylation EXP CYP3A4 protein results in increased hydroxylation of glycoursodeoxycholic acid CTD PMID:36473578 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G EDN1 endothelin 1 decreases expression EXP glycoursodeoxycholic acid results in decreased expression of EDN1 protein CTD PMID:15556138 NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194 		JBrowse link
G SLC4A2 solute carrier family 4 member 2 multiple interactions EXP [glycoursodeoxycholic acid co-treated with Dexamethasone] results in increased expression of SLC4A2 mRNA alternative form CTD PMID:18188457 NCBI chr 7:151,058,200...151,076,527
Ensembl chr 7:151,057,210...151,076,526 		JBrowse link
G TP53 tumor protein p53 multiple interactions ISO glycoursodeoxycholic acid inhibits the reaction [TP53 protein results in increased expression of BAX mRNA] CTD PMID:17881359 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    role 25961
      application 25172
        pharmaceutical 24558
          drug 24544
            protective agent 20758
              neuroprotective agent 17678
                glycoursodeoxycholic acid 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    main group molecular entity 25834
                      s-block molecular entity 25166
                        hydrogen molecular entity 24765
                          hydrides 22965
                            inorganic hydride 20483
                              pnictogen hydride 20424
                                nitrogen hydride 20200
                                  azane 19942
                                    ammonia 19941
                                      organic amino compound 19941
                                        amino acid 17170
                                          alpha-amino acid 14690
                                            L-alpha-amino acid 13792
                                              serine family amino acid 6179
                                                glycine 3001
                                                  glycine derivative 2991
                                                    N-acylglycine 32
                                                      glycoursodeoxycholic acid 5
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