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G |
Hsd11b1 |
hydroxysteroid 11-beta dehydrogenase 1 |
decreases abundance |
ISO |
HSD11B1 gene mutant form results in decreased abundance of glycolithocholic acid |
CTD |
PMID:25061560 |
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NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
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G |
Por |
cytochrome p450 oxidoreductase |
increases abundance |
ISO |
POR gene mutant form results in increased abundance of glycolithocholic acid |
CTD |
PMID:25034404 |
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NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
EXP |
glycoursodeoxycholic acid inhibits the reaction [TP53 protein results in increased expression of BAX mRNA] |
CTD |
PMID:17881359 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Edn1 |
endothelin 1 |
decreases expression |
ISO |
glycoursodeoxycholic acid results in decreased expression of EDN1 protein |
CTD |
PMID:15556138 |
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NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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G |
Slc4a2 |
solute carrier family 4 member 2 |
multiple interactions |
ISO |
[glycoursodeoxycholic acid co-treated with Dexamethasone] results in increased expression of SLC4A2 mRNA alternative form |
CTD |
PMID:18188457 |
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NCBI chr 4:10,736,419...10,754,407
Ensembl chr 4:10,736,425...10,752,965
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
EXP |
glycoursodeoxycholic acid inhibits the reaction [TP53 protein results in increased expression of BAX mRNA] |
CTD |
PMID:17881359 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Abcc3 |
ATP binding cassette subfamily C member 3 |
multiple interactions |
ISO |
hippuric acid promotes the reaction [ABCC3 protein results in increased uptake of Taurocholic Acid] |
CTD |
PMID:30639138 |
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NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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G |
Abcc4 |
ATP binding cassette subfamily C member 4 |
multiple interactions |
ISO |
hippuric acid inhibits the reaction [ABCC4 protein results in increased export of Methotrexate] |
CTD |
PMID:21483698 |
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NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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G |
Abcg2 |
ATP binding cassette subfamily G member 2 |
multiple interactions |
ISO |
hippuric acid inhibits the reaction [ABCG2 protein results in increased export of estrone sulfate] |
CTD |
PMID:21483698 |
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NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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G |
Col2a1 |
collagen type II alpha 1 chain |
multiple interactions |
EXP |
[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of hippuric acid |
CTD |
PMID:24709313 |
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NCBI chr 7:129,098,489...129,127,620
Ensembl chr 7:129,098,786...129,127,546
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G |
Slc10a1 |
solute carrier family 10 member 1 |
increases expression |
ISO |
hippuric acid results in increased expression of SLC10A1 mRNA |
CTD |
PMID:30639138 |
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NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
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G |
Abca8 |
ATP binding cassette subfamily A member 8 |
affects transport |
ISO |
ABCA8 protein affects the transport of p-Aminohippuric Acid |
CTD |
PMID:12379217 |
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NCBI chr10:94,917,520...94,991,199
Ensembl chr10:94,917,520...94,990,988
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G |
Col2a1 |
collagen type II alpha 1 chain |
multiple interactions |
EXP |
[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of p-Aminohippuric Acid |
CTD |
PMID:24709313 |
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NCBI chr 7:129,098,489...129,127,620
Ensembl chr 7:129,098,786...129,127,546
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G |
Slc17a3 |
solute carrier family 17 member 3 |
affects transport |
ISO |
SLC17A3 gene SNP affects the transport of p-Aminohippuric Acid |
CTD |
PMID:21282933 |
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NCBI chr17:41,270,804...41,300,132
Ensembl chr17:41,270,812...41,295,256
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G |
Slc22a12 |
solute carrier family 22 member 12 |
multiple interactions increases uptake |
ISO |
Barium promotes the reaction [SLC22A12 protein results in increased uptake of p-Aminohippuric Acid]; Diethyl Pyrocarbonate inhibits the reaction [SLC22A12 protein results in increased uptake of p-Aminohippuric Acid]; Ouabain promotes the reaction [SLC22A12 protein results in increased uptake of p-Aminohippuric Acid]; Potassium promotes the reaction [SLC22A12 protein results in increased uptake of p-Aminohippuric Acid] |
CTD |
PMID:15284287 |
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NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555
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G |
Slc22a2 |
solute carrier family 22 member 2 |
multiple interactions |
ISO |
p-Aminohippuric Acid inhibits the reaction [SLC22A2 protein results in increased uptake of Cimetidine] |
CTD |
PMID:15496291 |
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NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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G |
Slc22a20 |
solute carrier family 22 member 20 |
multiple interactions |
ISO |
p-Aminohippuric Acid inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate] |
CTD |
PMID:16478971 |
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NCBI chr 1:203,257,374...203,273,848
Ensembl chr 1:203,257,374...203,273,822
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G |
Slc22a6 |
solute carrier family 22 member 6 |
affects transport increases import increases uptake multiple interactions increases export increases secretion |
ISO EXP |
SLC22A6 protein affects the transport of p-Aminohippuric Acid SLC22A6 protein results in increased import of p-Aminohippuric Acid SLC22A6 protein results in increased uptake of p-Aminohippuric Acid; SLC22A6 results in increased uptake of p-Aminohippuric Acid 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; 9-((2-phosphonylmethoxy)ethyl)guanine analog inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; adefovir inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; Amitriptyline inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; aristolochic acid I inhibits the reaction [SLC22A6 results in increased uptake of p-Aminohippuric Acid]; aristolochic acid I promotes the reaction [SLC22A6 results in increased export of p-Aminohippuric Acid]; bis(4-hydroxyphenyl)sulfone inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; bisphenol A promotes the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; bisphenol F promotes the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; Cefaclor inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; Cefdinir inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; cefoselis inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; Cefotiam inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; Ceftibuten inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; Ceftizoxime inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; Cephaloridine inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; Chlorides promotes the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; chlorpyrifos-methyl inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; Cimetidine inhibits the reaction [SLC22A6 protein affects the transport of p-Aminohippuric Acid]; cyazofamid inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; Diazepam inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; Fenitrothion inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; Fluorescein inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; Glutarates promotes the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; glutaric acid promotes the reaction [SLC22A6 results in increased export of p-Aminohippuric Acid]; Malathion inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; Mianserin inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; p-Aminohippuric Acid inhibits the reaction [SLC22A6 protein results in increased susceptibility to [mercuric oxide co-treated with Acetylcysteine]]; p-Aminohippuric Acid inhibits the reaction [SLC22A6 protein results in increased transport of 2-amino-3-(2-amino-2-carboxyethylsulfanyl-mercuricsulfanyl)-propionic acid analog]; p-Aminohippuric Acid inhibits the reaction [SLC22A6 protein results in increased transport of 2-amino-3-(2-amino-2-carboxyethylsulfanyl-mercuricsulfanyl)-propionic acid]; p-Aminohippuric Acid inhibits the reaction [SLC22A6 protein results in increased uptake of 2,4-Dichlorophenoxyacetic Acid]; p-Aminohippuric Acid inhibits the reaction [SLC22A6 protein results in increased uptake of Cimetidine]; p-Aminohippuric Acid inhibits the reaction [SLC22A6 protein results in increased uptake of Uric Acid]; Penicillin G inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; Probenecid inhibits the reaction [SLC22A6 protein results in increased import of p-Aminohippuric Acid]; Probenecid inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; quercetin 3'-sulfate inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; Quercetin inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; Resveratrol inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; rhein inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; rhein metabolite inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; Sulfobromophthalein inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; Taurocholic Acid inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; Tenofovir inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; Tobacco Smoke Pollution inhibits the reaction [SLC22A6 protein results in increased import of p-Aminohippuric Acid]; Triazolam inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; Unithiol inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; Unithiol metabolite inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; Unithiol metabolite promotes the reaction [SLC22A6 protein results in increased secretion of p-Aminohippuric Acid]; Unithiol promotes the reaction [SLC22A6 protein results in increased secretion of p-Aminohippuric Acid] p-Aminohippuric Acid inhibits the reaction [SLC22A6 protein results in increased uptake of ochratoxin A]; perfluoro-n-heptanoic acid inhibits the reaction [SLC22A6 protein results in increased import of p-Aminohippuric Acid]; perfluorohexanoic acid inhibits the reaction [SLC22A6 protein results in increased import of p-Aminohippuric Acid]; perfluorooctanoic acid inhibits the reaction [SLC22A6 protein results in increased import of p-Aminohippuric Acid] |
CTD |
PMID:10336520 PMID:11602689 PMID:12472777 PMID:12606766 PMID:15200431 PMID:15284288 PMID:15496291 PMID:16098483 PMID:17255469 PMID:17353191 PMID:18216144 PMID:19605544 PMID:19643159 PMID:19915082 PMID:21244849 PMID:21256917 PMID:21561794 PMID:23856525 PMID:27377006 PMID:27989701 PMID:28629854 PMID:28890383 PMID:32003934 PMID:32305507 More...
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NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
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G |
Slc22a7 |
solute carrier family 22 member 7 |
increases uptake |
ISO |
SLC22A7 protein results in increased uptake of p-Aminohippuric Acid |
CTD |
PMID:12065749 PMID:15901346 PMID:21256917 |
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NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921
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G |
Slc22a8 |
solute carrier family 22 member 8 |
multiple interactions increases uptake affects transport increases export |
ISO EXP |
Cimetidine inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid]; Enalapril inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid]; Famotidine inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid]; Ibuprofen inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid]; tenoxicam inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid] SLC22A8 protein affects the transport of p-Aminohippuric Acid SLC22A8 results in increased export of p-Aminohippuric Acid aristolochic acid I promotes the reaction [SLC22A8 results in increased export of p-Aminohippuric Acid]; estrone sulfate promotes the reaction [SLC22A8 results in increased export of p-Aminohippuric Acid] p-Aminohippuric Acid inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine] |
CTD |
PMID:10224140 PMID:11306713 PMID:15100168 PMID:15319347 PMID:16098483 PMID:19643159 More...
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NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
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G |
Col2a1 |
collagen type II alpha 1 chain |
multiple interactions |
EXP |
[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of phenylacetylglycine; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of phenylacetylglycine]; Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of phenylacetylglycine]; huang-lien-chieh-tu-tang inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of phenylacetylglycine] |
CTD |
PMID:24709313 |
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NCBI chr 7:129,098,489...129,127,620
Ensembl chr 7:129,098,786...129,127,546
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G |
Atg5 |
autophagy related 5 |
multiple interactions |
EXP |
roxadustat promotes the reaction [Hyaluronic Acid results in increased cleavage of ATG5 protein] |
CTD |
PMID:27082295 |
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NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209
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G |
Bnip3 |
BCL2 interacting protein 3 |
multiple interactions |
EXP |
roxadustat promotes the reaction [Hyaluronic Acid results in increased expression of BNIP3 protein] |
CTD |
PMID:27082295 |
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NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions increases activity |
ISO EXP |
[Cadmium Chloride results in increased abundance of Cadmium] inhibits the reaction [roxadustat results in increased activity of HIF1A protein] roxadustat promotes the reaction [Hyaluronic Acid results in increased expression of HIF1A protein] |
CTD |
PMID:27082295 PMID:29741670 |
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NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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G |
Hk2 |
hexokinase 2 |
increases expression |
ISO |
roxadustat results in increased expression of HK2 mRNA |
CTD |
PMID:33596451 |
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NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530
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G |
Ldha |
lactate dehydrogenase A |
increases expression |
ISO |
roxadustat results in increased expression of LDHA mRNA |
CTD |
PMID:33596451 |
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NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
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G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
multiple interactions |
EXP |
roxadustat promotes the reaction [Hyaluronic Acid results in increased cleavage of MAP1LC3B protein] |
CTD |
PMID:27082295 |
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NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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G |
Slc2a1 |
solute carrier family 2 member 1 |
increases expression |
ISO |
roxadustat results in increased expression of SLC2A1 mRNA |
CTD |
PMID:33596451 |
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NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
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G |
Alb |
albumin |
multiple interactions |
ISO |
ALB protein binds to and affects the transport of salicylurate |
CTD |
PMID:8831264 |
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NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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G |
Elane |
elastase, neutrophil expressed |
decreases activity |
ISO |
sivelestat results in decreased activity of ELANE protein |
CTD |
PMID:19088179 |
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NCBI chr 7:9,817,251...9,819,174
Ensembl chr 7:9,817,252...9,819,100
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G |
Slc10a1 |
solute carrier family 10 member 1 |
increases uptake |
ISO |
SLC10A1 protein results in increased uptake of sulfolithocholylglycine |
CTD |
PMID:29024779 |
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NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
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