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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2,3,4,3',4'-Pentachlorobiphenyl
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Accession:CHEBI:81518 term browser browse the term
Definition:A pentachlorobiphenyl that has formula C12H5Cl5.
Synonyms:related_synonym: Formula=C12H5Cl5;   InChI=1S/C12H5Cl5/c13-8-3-1-6(5-10(8)15)7-2-4-9(14)12(17)11(7)16/h1-5H;   InChIKey=WIDHRBRBACOVOY-UHFFFAOYSA-N;   PCB 105;   SMILES=Clc1ccc(cc1Cl)-c1ccc(Cl)c(Cl)c1Cl
 xref: CAS:32598-14-4;   KEGG:C18116
 xref_mesh: MESH:C067940



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2,3,4,3',4'-Pentachlorobiphenyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor increases activity
multiple interactions
EXP
ISO
2,3,3',4,4'-pentachlorobiphenyl results in increased activity of AHR protein
2,3,3',4,4'-pentachlorobiphenyl affects the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; 2,3,3',4,4'-pentachlorobiphenyl promotes the reaction [AHR protein results in increased expression of CYP1A2]; [3,4,3',4'-tetrachlorobiphenyl co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with 2,3,3',4,4'-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] promotes the reaction [AHR protein results in increased expression of CYP1A2 mRNA]; [AHR protein co-treated with CYP1A2 protein] affects the susceptibility to [3,4,3',4'-tetrachlorobiphenyl co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with 2,3,3',4,4'-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180]
2,3,3',4,4'-pentachlorobiphenyl binds to and results in increased activity of AHR protein
CTD PMID:10448124 PMID:12850102 PMID:20435555 PMID:20961953 PMID:25654323 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AR androgen receptor multiple interactions EXP 2,3,3',4,4'-pentachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions
increases expression
increases activity
ISO 2,3,3',4,4'-pentachlorobiphenyl inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; 2,3,3',4,4'-pentachlorobiphenyl inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
2,3,3',4,4'-pentachlorobiphenyl results in increased expression of CYP1A1 mRNA; 2,3,3',4,4'-pentachlorobiphenyl results in increased expression of CYP1A1 protein
2,3,3',4,4'-pentachlorobiphenyl results in increased activity of CYP1A1 protein
CTD PMID:10986007 PMID:16750337 PMID:18493746 PMID:25654323 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 decreases activity
decreases response to substance
multiple interactions
increases activity
EXP
ISO
2,3,3',4,4'-pentachlorobiphenyl results in decreased activity of CYP1A2 protein
CYP1A2 results in decreased susceptibility to 2,3,3',4,4'-pentachlorobiphenyl
2,3,3',4,4'-pentachlorobiphenyl inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
2,3,3',4,4'-pentachlorobiphenyl promotes the reaction [AHR protein results in increased expression of CYP1A2]; [3,4,3',4'-tetrachlorobiphenyl co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with 2,3,3',4,4'-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] promotes the reaction [AHR protein results in increased expression of CYP1A2 mRNA]; [AHR protein co-treated with CYP1A2 protein] affects the susceptibility to [3,4,3',4'-tetrachlorobiphenyl co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,5,3',4',5'-hexachlorobiphenyl co-treated with 2,3,3',4,4'-pentachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180]
2,3,3',4,4'-pentachlorobiphenyl results in increased activity of CYP1A2 protein
CTD PMID:10986007 PMID:15659567 PMID:18493746 PMID:20961953 PMID:21571617 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 increases expression ISO 2,3,3',4,4'-pentachlorobiphenyl results in increased expression of CYP1B1 mRNA CTD PMID:25654323 PMID:29738842 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 affects response to substance EXP CYP2B6 gene SNP affects the susceptibility to 2,3,3',4,4'-pentachlorobiphenyl CTD PMID:25839716 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398
JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 multiple interactions
increases activity
ISO 2,3,3',4,4'-pentachlorobiphenyl inhibits the reaction [Androstenols results in decreased activity of NR1I3 protein]
2,3,3',4,4'-pentachlorobiphenyl results in increased activity of NR1I3 protein
CTD PMID:19746742 NCBI chr 1:161,229,669...161,238,203
Ensembl chr 1:161,229,666...161,238,244
JBrowse link
G PIGA phosphatidylinositol glycan anchor biosynthesis class A increases mutagenesis
multiple interactions
EXP 2,3,3',4,4'-pentachlorobiphenyl results in increased mutagenesis of PIGA gene
1,2-dichloroethylene inhibits the reaction [2,3,3',4,4'-pentachlorobiphenyl results in increased mutagenesis of PIGA gene]
CTD PMID:32199159 NCBI chr  X:15,319,451...15,335,554
Ensembl chr  X:15,319,452...15,335,554
JBrowse link
G SERPINA7 serpin family A member 7 decreases expression EXP 2,3,3',4,4'-pentachlorobiphenyl results in decreased expression of SERPINA7 protein CTD PMID:19750101 NCBI chr  X:106,032,435...106,038,727
Ensembl chr  X:106,032,435...106,038,727
JBrowse link
G TSHB thyroid stimulating hormone subunit beta multiple interactions EXP 2,3,3',4,4'-pentachlorobiphenyl affects the expression of and affects the secretion of TSHB protein CTD PMID:19750101 NCBI chr 1:115,029,826...115,034,309
Ensembl chr 1:115,029,826...115,034,302
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    role 25961
      chemical role 24242
        environmental contaminant 20861
          persistent organic pollutant 17371
            polychlorobiphenyl 6084
              pentachlorobiphenyl 2689
                2,3,4,3',4'-Pentachlorobiphenyl 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    main group molecular entity 25834
                      s-block molecular entity 25166
                        hydrogen molecular entity 24765
                          hydrides 22965
                            organic hydride 21924
                              organic fundamental parent 21924
                                hydrocarbon 21350
                                  halohydrocarbon 15904
                                    haloarene 6450
                                      chloroarene 6073
                                        chlorobiphenyl 6073
                                          polychlorobiphenyl 6084
                                            pentachlorobiphenyl 2689
                                              2,3,4,3',4'-Pentachlorobiphenyl 10
paths to the root