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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:24,25-Dihydroxyvitamin D
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Accession:CHEBI:89324 term browser browse the term
Definition:A sesterterpene that has formula C27H44O3.
Synonyms:related_synonym: (3b,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-3,24,25-triol;   (6R)-6-[(1R,3aS,4E,7aR)-4-{2-[(1Z,5R)-5-hydroxy-2-methylidenecyclohexylidene]ethylidene}-7a-methyl-octahydro-1H-inden-1-yl]-2-methylheptane-2,3-diol;   24,25-Dihydroxycholecalciferol;   24,25-Dihydroxyvitamin;   24,25-Dihydroxyvitamin D3;   24-Hydroxycalcidiol;   Formula=C27H44O3;   InChI=1S/C27H44O3/c1-18-8-12-22(28)17-21(18)11-10-20-7-6-16-27(5)23(13-14-24(20)27)19(2)9-15-25(29)26(3,4)30/h10-11,19,22-25,28-30H,1,6-9,12-17H2,2-5H3/b20-10+,21-11-/t19-,22-,23-,24+,25?,27-/m1/s1;   InChIKey=FCKJYANJHNLEEP-OIMXRAFZSA-N;   SMILES=[C@H]1(CCC(\\C(\\C1)=C/C=C\\2/[C@@]3(CC[C@H]([C@@H](CCC(C(C)(C)O)O)C)[C@@]3(C)CCC2)[H])=C)O;   Vitamin D
 xref: CAS:40013-87-4;   HMDB:HMDB0000430
 xref_mesh: MESH:D015650
 xref: PMID:11179746;   PMID:3501463;   PMID:6600461;   PMID:6604593;   PMID:6610503;   PMID:6753604;   PMID:6892691;   PMID:6982126;   PMID:749564;   PMID:9296336;   Wikipedia:vitamin_D


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24,25-Dihydroxyvitamin D term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL2 C-C motif chemokine ligand 2 decreases expression EXP 24,25-Dihydroxyvitamin D 3 results in decreased expression of CCL2 protein CTD PMID:18379402 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G COL1A1 collagen type I alpha 1 chain multiple interactions EXP 24,25-Dihydroxyvitamin D 3 inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA] CTD PMID:27936102 NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 decreases expression EXP 24,25-Dihydroxyvitamin D 3 results in decreased expression of CXCL8 protein CTD PMID:18379402 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G CYP24A1 cytochrome P450 family 24 subfamily A member 1 decreases abundance EXP CYP24A1 gene mutant form results in decreased abundance of 24,25-Dihydroxyvitamin D 3 CTD PMID:22337913 NCBI chr20:54,143,538...54,173,986
Ensembl chr20:54,153,446...54,173,986 		JBrowse link
G LEP leptin decreases expression EXP 24,25-Dihydroxyvitamin D 3 results in decreased expression of LEP protein CTD PMID:18379402 NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 multiple interactions
increases response to substance		 ISO [resveratrol results in decreased activity of PTGS1 protein] which results in decreased susceptibility to 24,25-Dihydroxyvitamin D 3
PTGS1 protein results in increased susceptibility to 24,25-Dihydroxyvitamin D 3		 CTD PMID:10653606 NCBI chr 9:122,370,533...122,395,703
Ensembl chr 9:122,370,530...122,395,703 		JBrowse link
G PTH parathyroid hormone increases expression
decreases expression		 EXP
ISO		 24,25-Dihydroxyvitamin D 3 results in increased expression of PTH protein
24,25-Dihydroxyvitamin D 3 results in decreased expression of PTH protein		 CTD PMID:6760236 PMID:11305809 NCBI chr11:13,492,054...13,496,181
Ensembl chr11:13,492,054...13,496,181 		JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions EXP 24,25-Dihydroxyvitamin D 3 inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA] CTD PMID:27936102 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TIMP2 TIMP metallopeptidase inhibitor 2 decreases expression EXP 24,25-Dihydroxyvitamin D 3 results in decreased expression of TIMP2 protein CTD PMID:18379402 NCBI chr17:78,852,977...78,925,387
Ensembl chr17:78,852,977...78,925,387 		JBrowse link
G VDR vitamin D receptor increases activity EXP
ISO		 24,25-Dihydroxyvitamin D 3 results in increased activity of VDR protein CTD PMID:17997857 NCBI chr12:47,841,537...47,904,994
Ensembl chr12:47,841,537...47,943,048 		JBrowse link
G VEGFD vascular endothelial growth factor D increases expression EXP 24,25-Dihydroxyvitamin D 3 results in increased expression of VEGFD protein CTD PMID:18379402 NCBI chr  X:15,345,596...15,384,413
Ensembl chr  X:15,345,596...15,384,413 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26504
    chemical entity 26484
      atom 26480
        nonmetal atom 25742
          carbon atom 25624
            organic molecular entity 25624
              isoprenoid 14726
                terpene 14726
                  sesterterpene 23
                    24,25-Dihydroxyvitamin D 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 26504
    subatomic particle 26480
      composite particle 26480
        hadron 26480
          baryon 26480
            nucleon 26480
              atomic nucleus 26480
                atom 26480
                  main group element atom 26217
                    main group molecular entity 26217
                      s-block molecular entity 25454
                        hydrogen molecular entity 24861
                          hydrides 23080
                            organic hydride 22044
                              organic fundamental parent 22044
                                hydrocarbon 21482
                                  terpene 14726
                                    sesterterpene 23
                                      24,25-Dihydroxyvitamin D 11
paths to the root