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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sesterterpene
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Accession:CHEBI:35192 term browser browse the term
Definition:A C25 terpene.
Synonyms:related_synonym: Sesterterpen;   sesterterpenes;   sesterterpeno;   sesterterpenos


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24,25-Dihydroxyvitamin D term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO 24,25-Dihydroxyvitamin D 3 results in decreased expression of CCL2 protein CTD PMID:18379402 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO 24,25-Dihydroxyvitamin D 3 inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA] CTD PMID:27936102 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 decreases abundance ISO CYP24A1 gene mutant form results in decreased abundance of 24,25-Dihydroxyvitamin D 3 CTD PMID:22337913 NCBI chr 3:168,097,484...168,111,920
Ensembl chr 3:168,097,485...168,111,920
JBrowse link
G Lep leptin decreases expression ISO 24,25-Dihydroxyvitamin D 3 results in decreased expression of LEP protein CTD PMID:18379402 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions
increases response to substance
EXP [resveratrol results in decreased activity of PTGS1 protein] which results in decreased susceptibility to 24,25-Dihydroxyvitamin D 3
PTGS1 protein results in increased susceptibility to 24,25-Dihydroxyvitamin D 3
CTD PMID:10653606 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Pth parathyroid hormone increases expression
decreases expression
ISO
EXP
24,25-Dihydroxyvitamin D 3 results in increased expression of PTH protein
24,25-Dihydroxyvitamin D 3 results in decreased expression of PTH protein
CTD PMID:6760236 PMID:11305809 NCBI chr 1:178,215,829...178,218,761
Ensembl chr 1:178,215,829...178,218,761
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO 24,25-Dihydroxyvitamin D 3 inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA] CTD PMID:27936102 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 decreases expression ISO 24,25-Dihydroxyvitamin D 3 results in decreased expression of TIMP2 protein CTD PMID:18379402 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
JBrowse link
G Vdr vitamin D receptor increases activity ISO 24,25-Dihydroxyvitamin D 3 results in increased activity of VDR protein CTD PMID:17997857 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
JBrowse link
G Vegfd vascular endothelial growth factor D increases expression ISO 24,25-Dihydroxyvitamin D 3 results in increased expression of VEGFD protein CTD PMID:18379402 NCBI chr  X:31,816,480...31,852,239
Ensembl chr  X:31,816,436...31,851,715
JBrowse link
manoalide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1b interleukin 1 beta multiple interactions ISO manoalide inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:7575673 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO manoalide inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; manoalide inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] CTD PMID:7575673 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO manoalide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:7575673 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
ophiobolin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO ophiobolin A inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin] CTD PMID:16904803 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
Scalaradial term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1b interleukin 1 beta multiple interactions ISO scalaradial inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; scalaradial inhibits the reaction [IL1B protein results in increased expression of TNF protein]; scalaradial inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:7575673 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO scalaradial inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MPO protein] CTD PMID:8113982 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO scalaradial inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; scalaradial inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; scalaradial inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] CTD PMID:7575673 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO scalaradial inhibits the reaction [IL1B protein results in increased expression of TNF protein]; scalaradial inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:7575673 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
taraxerone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh1 alcohol dehydrogenase 1 (class I) multiple interactions ISO taraxerone promotes the reaction [Ethanol results in increased expression of ADH1 mRNA] CTD PMID:22554647 NCBI chr 2:243,550,655...243,562,243
Ensembl chr 2:243,550,627...243,687,857
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions ISO taraxerone promotes the reaction [Ethanol results in increased expression of ALDH2 mRNA] CTD PMID:22554647 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
JBrowse link
G Cat catalase multiple interactions ISO taraxerone inhibits the reaction [Ethanol results in decreased expression of CAT protein] CTD PMID:22554647 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19786
    chemical entity 19786
      atom 19784
        nonmetal atom 19666
          carbon atom 19586
            organic molecular entity 19586
              isoprenoid 12719
                terpene 12719
                  sesterterpene 18
                    24,25-Dihydroxyvitamin D 10
                    25,26-dihydroxyvitamin D 0
                    astellifadiene 0
                    beta-geranylfarnesene 0
                    ophiobolane + 1
                    quiannulatene 0
                    scalarane 0
                    sesterterpenoid + 8
                    stellata-2,6,19-triene 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19786
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19675
                    main group molecular entity 19675
                      s-block molecular entity 19443
                        hydrogen molecular entity 19439
                          hydrides 18763
                            organic hydride 18363
                              organic fundamental parent 18363
                                hydrocarbon 18078
                                  terpene 12719
                                    sesterterpene 18
                                      24,25-Dihydroxyvitamin D 10
                                      25,26-dihydroxyvitamin D 0
                                      astellifadiene 0
                                      beta-geranylfarnesene 0
                                      ophiobolane + 1
                                      quiannulatene 0
                                      scalarane 0
                                      sesterterpenoid + 8
                                      stellata-2,6,19-triene 0
paths to the root