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prunetin - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:prunetin
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Accession:CHEBI:8600 term browser browse the term
Definition:A hydroxyisoflavone that is genistein in which the hydroxy group at position 7 is replaced by a methoxy group.
Synonyms:exact_synonym: 5-hydroxy-3-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one
 related_synonym: 4',5-dihydroxy-7-methoxygenistein;   4',5-dihydroxy-7-methoxyisoflavone;   5-Hydroxy-3-(4-hydroxyphenyl)-7-methoxy-4-benzopyrone;   5-Hydroxy-3-(4-hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one;   7-O-methyl-genistein;   Formula=C16H12O5;   InChI=1S/C16H12O5/c1-20-11-6-13(18)15-14(7-11)21-8-12(16(15)19)9-2-4-10(17)5-3-9/h2-8,17-18H,1H3;   InChIKey=KQMVAGISDHMXJJ-UHFFFAOYSA-N;   Padmakastein;   Prunusetin;   SMILES=COc1cc(O)c2c(c1)occ(-c1ccc(O)cc1)c2=O
 xref: CAS:552-59-0;   HMDB:HMDB0034127;   KEGG:C10521;   KNApSAcK:C00002564;   LINCS:LSM-3283;   LIPID_MAPS_instance:LMPK12050353
 xref_mesh: MESH:C083295
 xref: MetaCyc:CPD-3521;   PMID:15408466;   PMID:21305630;   PMID:22010824;   PMID:22148193;   PMID:23265084;   PMID:23438470;   PMID:23597450;   PMID:9105397;   Patent:CN101669935;   Reaxys:292155;   Wikipedia:Prunetin
 cyclic_relationship: is_conjugate_acid_of CHEBI:147403

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prunetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2 family member decreases activity EXP prunetin results in decreased activity of ALDH2 protein CTD PMID:11142365 NCBI chr12:40,610,244...40,643,220
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA]; prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein] CTD PMID:23597450 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein] CTD PMID:23597450 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:23597450 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression		 ISO [prunetin results in decreased expression of NOS2 mRNA] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased chemical synthesis of Nitric Oxide]; prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein] CTD PMID:23597450 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression		 ISO [prunetin results in decreased expression of PTGS2 mRNA] which results in decreased chemical synthesis of Dinoprostone; prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein] CTD PMID:23597450 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein] CTD PMID:23597450 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19887
    role 19858
      application 19697
        anti-inflammatory agent 16678
          prunetin 7
            prunetin 4'-O-glucoside 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    p-block element atom 19824
                      carbon group element atom 19763
                        carbon atom 19760
                          organic molecular entity 19760
                            organic molecule 19713
                              organic cyclic compound 19505
                                organic heterocyclic compound 18875
                                  oxacycle 17906
                                    benzopyran 11990
                                      1-benzopyran 11744
                                        isoflavonoid 3871
                                          isoflavones 3853
                                            hydroxyisoflavone 3786
                                              7-hydroxyisoflavones 3763
                                                genistein 3658
                                                  prunetin 7
                                                    prunetin 4'-O-glucoside 0
paths to the root