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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ofloxacin
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Accession:CHEBI:7731 term browser browse the term
Definition:A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Synonyms:exact_synonym: rac-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid
 related_synonym: (3RS)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid;   DL 8280;   Exocin;   Floxin;   Formula=C18H20FN3O4;   Gailuoxian;   HOE-280;   OFLX;   ORF 18489;   Ocuflox;   Oxaldin;   Prifloxcin;   Prifloxin;   Tarivid;   Visiren;   ofloxacine;   ofloxacino;   ofloxacinum;   rac-8-fluoro-3-methyl-9-(4-methyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid;   rac-ofloxacin;   racemic ofloxacin
 alt_id: CHEBI:100146
 xref: CAS:82419-36-1;   DrugBank:DB01165;   Drug_Central:1981;   HMDB:HMDB0015296;   KEGG:C07321;   KEGG:D00453;   LINCS:LSM-4370
 xref_mesh: MESH:D015242
 xref: MetaCyc:CPD-12843;   PMID:11710934;   PMID:11903499;   PMID:12827054;   PMID:15008519;   PMID:15557076;   PMID:16669862;   PMID:1804789;   PMID:19646516;   PMID:24497308;   PMID:24550337;   PMID:3469159;   PMID:3546152;   PMID:35897550;   PMID:36004580;   PMID:36228398;   PMID:36268299;   PMID:6960805;   PMID:7884650;   PMID:9228220;   Reaxys:3657947;   VSDB:1898;   Wikipedia:Ofloxacin


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ofloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAPN1 calpain 1 increases expression EXP Ofloxacin results in increased expression of CAPN1 mRNA CTD PMID:24582689 NCBI chr18:51,983,266...52,010,831
Ensembl chr18:51,983,824...52,010,757 		JBrowse link
G CASP12 caspase 12 increases expression EXP Ofloxacin results in increased expression of CASP12 mRNA; Ofloxacin results in increased expression of CASP12 protein CTD PMID:24582689 NCBI chr 5:27,162,840...27,176,964
Ensembl chr 5:27,161,700...27,177,683 		JBrowse link
G CASP8 caspase 8 multiple interactions
increases expression		 EXP TNFRSF1A mutant form inhibits the reaction [Ofloxacin results in increased expression of CASP8 mRNA] CTD PMID:24582689 NCBI chr37:10,362,071...10,402,108
Ensembl chr37:10,391,048...10,401,822 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 increases expression EXP Ofloxacin results in increased expression of DDIT3 mRNA CTD PMID:24582689 NCBI chr10:1,606,693...1,612,410
Ensembl chr10:1,606,693...1,611,303 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP Ofloxacin results in increased expression of HSPA5 mRNA CTD PMID:24582689 NCBI chr 9:57,850,870...57,855,607
Ensembl chr 9:57,850,922...57,855,257 		JBrowse link
G TNF tumor necrosis factor increases expression EXP Ofloxacin results in increased expression of TNF mRNA; Ofloxacin results in increased expression of TNF protein CTD PMID:24582689 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425 		JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A multiple interactions
increases expression		 EXP TNFRSF1A mutant form inhibits the reaction [Ofloxacin results in increased expression of CASP8 mRNA]; TNFRSF1A mutant form inhibits the reaction [Ofloxacin results in increased expression of TRADD mRNA]
Ofloxacin results in increased expression of TNFRSF1A mRNA; Ofloxacin results in increased expression of TNFRSF1A protein		 CTD PMID:24582689 NCBI chr27:38,641,837...38,654,693
Ensembl chr27:38,638,753...38,700,282 		JBrowse link
G TRADD TNFRSF1A associated via death domain multiple interactions
increases expression		 EXP TNFRSF1A mutant form inhibits the reaction [Ofloxacin results in increased expression of TRADD mRNA] CTD PMID:24582689 NCBI chr 5:82,200,430...82,211,430
Ensembl chr 5:82,206,111...82,210,963 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 501
    chemical entity 501
      chemical substance 39
        mixture 39
          racemate 26
            ofloxacin 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 501
    subatomic particle 501
      composite particle 501
        hadron 501
          baryon 501
            nucleon 501
              atomic nucleus 501
                atom 501
                  main group element atom 494
                    main group molecular entity 494
                      s-block molecular entity 438
                        hydrogen molecular entity 437
                          hydrides 368
                            inorganic hydride 333
                              pnictogen hydride 332
                                nitrogen hydride 332
                                  azane 327
                                    ammonia 327
                                      organic amino compound 327
                                        tertiary amino compound 177
                                          N-alkylpiperazine 172
                                            N-methylpiperazine 10
                                              9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid 8
                                                levofloxacin 8
                                                  ofloxacin 8
paths to the root