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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 12388118
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: TNFRSF1A
Name: TNF receptor superfamily member 1A
Acc ID: CHEBI:7731
Term: ofloxacin
Definition: A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Chemical ID: MESH:D015242
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TNFRSF1Aincreases expressionEXP 6480464CTDOfloxacin results in increased expression of TNFRSF1A mRNA; Ofloxacin results in increased expression of TNFRSF1A proteinPMID:24582689
TNFRSF1Amultiple interactionsEXP 6480464CTDTNFRSF1A mutant form inhibits the reaction [Ofloxacin results in increased expression of CASP8 mRNA]; TNFRSF1A mutant form inhibits the reaction [Ofloxacin results in increased expression of TRADD mRNA]PMID:24582689
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