Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:levofloxacin
go back to main search page
Accession:CHEBI:63598 term browser browse the term
Definition:An optically active form of ofloxacin having (S)-configuration; an inhibitor of bacterial topoisomerase IV and DNA gyrase
Synonyms:exact_synonym: (3S)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid
 related_synonym: (3S)-(-)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid;   (S)-(-)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzooxazine-6-carboxylic acid;   (S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid;   (S)-Ofloxacin;   Formula=C18H20FN3O4;   InChI=1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)/t10-/m0/s1;   InChIKey=GSDSWSVVBLHKDQ-JTQLQIEISA-N;   L-Ofloxacin;   Ofloxacin;   Ofloxacin S-(-)-form;   SMILES=C[C@H]1COc2c(N3CCN(C)CC3)c(F)cc3c2n1cc(C(O)=O)c3=O;   levofloxacine;   levofloxacino;   levofloxacinum
 alt_id: CHEBI:6440
 xref: CAS:100986-85-4 "ChemIDplus";   CAS:100986-85-4 "KEGG COMPOUND";   DrugBank:DB01137;   Drug_Central:1569 "DrugCentral";   HMDB:HMDB0001929;   KEGG:C07660;   KEGG:D08120;   LINCS:LSM-5270
 xref_mesh: MESH:D064704
 xref: PMID:21075586 "Europe PMC";   PMID:21965436 "Europe PMC";   PMID:21974858 "Europe PMC";   PMID:22088660 "Europe PMC";   PMID:22221614 "Europe PMC";   Reaxys:5385660 "Reaxys";   VSDB:1899;   Wikipedia:Levofloxacin


show annotations for term's descendants       view all columns           Sort by:
 
levofloxacin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abhd1 abhydrolase domain containing 1 JBrowse link 6 26,787,807 26,792,795 RGD:6480464
G Acsf2 acyl-CoA synthetase family member 2 JBrowse link 10 82,284,719 82,326,771 RGD:6480464
G Acsl5 acyl-CoA synthetase long-chain family member 5 JBrowse link 1 276,240,703 276,290,012 RGD:6480464
G Actg1 actin, gamma 1 JBrowse link 10 109,518,429 109,521,288 RGD:6480464
G Acy1 aminoacylase 1 JBrowse link 8 115,134,792 115,140,171 RGD:6480464
G Afp alpha-fetoprotein JBrowse link 14 19,141,755 19,159,919 RGD:6480464
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 JBrowse link 5 61,382,351 61,387,359 RGD:6480464
G Angptl6 angiopoietin-like 6 JBrowse link 8 21,895,523 21,902,002 RGD:6480464
G Anxa1 annexin A1 JBrowse link 1 237,893,983 237,910,002 RGD:6480464
G Anxa2 annexin A2 JBrowse link 8 75,687,134 75,723,589 RGD:6480464
G Ap1s1 adaptor related protein complex 1 subunit sigma 1 JBrowse link 12 22,665,128 22,676,079 RGD:6480464
G Arl4a ADP-ribosylation factor like GTPase 4A JBrowse link 6 59,945,926 59,950,586 RGD:6480464
G Aspa aspartoacylase JBrowse link 10 59,839,693 59,888,244 RGD:6480464
G Atg2b autophagy related 2B JBrowse link 6 129,449,451 129,519,599 RGD:6480464
G Atp6v0e2 ATPase, H+ transporting V0 subunit e2 JBrowse link 4 78,168,117 78,171,265 RGD:6480464
G Bst2 bone marrow stromal cell antigen 2 JBrowse link 16 19,938,781 19,942,353 RGD:6480464
G Btg1 BTG anti-proliferation factor 1 JBrowse link 7 37,812,831 37,815,088 RGD:6480464
G C2cd2 C2 calcium-dependent domain containing 2 JBrowse link 11 38,354,746 38,420,133 RGD:6480464
G C4b complement C4B (Chido blood group) JBrowse link 20 4,302,344 4,316,752 RGD:6480464
G C5 complement C5 JBrowse link 3
3
14,049,993
14,206,466
14,113,931
14,229,141
RGD:6480464
G Ca14 carbonic anhydrase 14 JBrowse link 2 198,010,142 198,017,635 RGD:6480464
G Ccdc6 coiled-coil domain containing 6 JBrowse link 20 19,729,005 19,825,219 RGD:6480464
G Ccdc80 coiled-coil domain containing 80 JBrowse link 11 60,645,660 60,679,249 RGD:6480464
G Cd302 CD302 molecule JBrowse link 3 46,327,382 46,361,092 RGD:6480464
G Cdc42ep4 CDC42 effector protein 4 JBrowse link 10 102,244,680 102,269,272 RGD:6480464
G Cdk1 cyclin-dependent kinase 1 JBrowse link 20 20,576,341 20,591,510 RGD:6480464
G Cdkn3 cyclin-dependent kinase inhibitor 3 JBrowse link 15 23,553,171 23,564,538 RGD:6480464
G Cebpb CCAAT/enhancer binding protein beta JBrowse link 3 164,424,502 164,425,933 RGD:6480464
G Cfhr1 complement factor H-related 1 JBrowse link 13 56,862,666 56,877,650 RGD:6480464
G Cgn cingulin JBrowse link 2 195,909,691 195,937,130 RGD:6480464
G Chpt1 choline phosphotransferase 1 JBrowse link 7 29,019,518 29,070,928 RGD:6480464
G Cks2 CDC28 protein kinase regulatory subunit 2 JBrowse link 17 13,587,664 13,593,423 RGD:6480464
G Clec14a C-type lectin domain containing 14A JBrowse link 6 79,303,301 79,306,443 RGD:6480464
G Cmbl carboxymethylenebutenolidase homolog JBrowse link 2 84,645,084 84,666,836 RGD:6480464
G Cpt1a carnitine palmitoyltransferase 1A JBrowse link 1 218,568,157 218,629,679 RGD:6480464
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 JBrowse link 9 81,968,285 81,998,213 RGD:6480464
G Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 JBrowse link 5 134,508,728 134,526,103 RGD:6480464
G Cyp51 cytochrome P450, family 51 JBrowse link 4 27,175,564 27,194,018 RGD:6480464
G Ddc dopa decarboxylase JBrowse link 14 91,905,919 91,996,816 RGD:6480464
G Ddhd1 DDHD domain containing 1 JBrowse link 15 19,963,639 20,032,263 RGD:6480464
G Dhfr dihydrofolate reductase JBrowse link 2 21,931,887 21,958,927 RGD:6480464
G Dnajc9 DnaJ heat shock protein family (Hsp40) member C9 JBrowse link 15 4,356,512 4,360,788 RGD:6480464
G Dnph1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 JBrowse link 9 16,845,764 16,848,514 RGD:6480464
G Dtymk deoxythymidylate kinase JBrowse link 9 100,921,565 100,930,399 RGD:6480464
G Dut deoxyuridine triphosphatase JBrowse link 3 117,514,399 117,525,450 RGD:6480464
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 JBrowse link 4 140,886,644 140,918,654 RGD:6480464
G Elovl5 ELOVL fatty acid elongase 5 JBrowse link 8 85,220,941 85,287,449 RGD:6480464
G Enc1 ectodermal-neural cortex 1 JBrowse link 2 28,049,217 28,061,023 RGD:6480464
G Ephx1 epoxide hydrolase 1 JBrowse link 13 99,271,390 99,300,580 RGD:6480464
G Erg28 ergosterol biosynthesis 28 homolog JBrowse link 6 109,683,252 109,692,218 RGD:6480464
G Ergic1 endoplasmic reticulum-golgi intermediate compartment 1 JBrowse link 10 16,821,393 16,912,050 RGD:6480464
G Fgl1 fibrinogen-like 1 JBrowse link 16 54,153,086 54,188,120 RGD:6480464
G Fkbp4 FKBP prolyl isomerase 4 JBrowse link 4 161,748,993 161,757,447 RGD:6480464
G Fkbp5 FKBP prolyl isomerase 5 JBrowse link 20 7,976,704 8,097,290 RGD:6480464
G Flna filamin A JBrowse link X 156,460,785 156,487,245 RGD:6480464
G Fndc3b fibronectin type III domain containing 3B JBrowse link 2 113,109,949 113,415,171 RGD:6480464
G Fzd8 frizzled class receptor 8 JBrowse link 17 62,259,910 62,267,239 RGD:6480464
G Gas6 growth arrest specific 6 JBrowse link 16 81,213,364 81,243,824 RGD:6480464
G Gclc glutamate-cysteine ligase, catalytic subunit JBrowse link 8 85,059,051 85,097,471 RGD:6480464
G Gpd1 glycerol-3-phosphate dehydrogenase 1 JBrowse link 7 141,368,928 141,377,931 RGD:6480464
G Hacd3 3-hydroxyacyl-CoA dehydratase 3 JBrowse link 8 70,471,572 70,509,874 RGD:6480464
G Haus4 HAUS augmin-like complex, subunit 4 JBrowse link 15 33,182,139 33,193,880 RGD:6480464
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 JBrowse link 19 11,046,905 11,057,440 RGD:6480464
G Hmgb2 high mobility group box 2 JBrowse link 16 36,077,615 36,080,191 RGD:6480464
G Hmgn2 high mobility group nucleosomal binding domain 2 JBrowse link 5 152,195,359 152,198,813 RGD:6480464
G Htatip2 HIV-1 Tat interactive protein 2 JBrowse link 1 105,094,272 105,109,459 RGD:6480464
G Idi1 isopentenyl-diphosphate delta isomerase 1 JBrowse link 17 57,976,266 57,984,036 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Il6r interleukin 6 receptor JBrowse link 2 189,196,180 189,255,987 RGD:6480464
G Ip6k2 inositol hexakisphosphate kinase 2 JBrowse link 8 117,574,136 117,599,849 RGD:6480464
G Ivns1abp influenza virus NS1A binding protein JBrowse link 13 68,702,970 68,722,472 RGD:6480464
G Klf15 Kruppel-like factor 15 JBrowse link 4 122,364,688 122,377,690 RGD:6480464
G Klf9 Kruppel-like factor 9 JBrowse link 1 240,908,483 240,933,198 RGD:6480464
G Kpna2 karyopherin subunit alpha 2 JBrowse link 10 95,200,029 95,212,111 RGD:6480464
G Kpnb1 karyopherin subunit beta 1 JBrowse link 10 85,096,517 85,124,641 RGD:6480464
G Krt18 keratin 18 JBrowse link 7 143,629,455 143,633,131 RGD:6480464
G Lbp lipopolysaccharide binding protein JBrowse link 3 154,786,232 154,812,910 RGD:6480464
G Lcmt1 leucine carboxyl methyltransferase 1 JBrowse link 1 193,335,629 193,391,620 RGD:6480464
G Lmnb1 lamin B1 JBrowse link 18 51,785,111 51,822,264 RGD:6480464
G Lmo7 LIM domain 7 JBrowse link 15 86,242,911 86,458,512 RGD:6480464
G Lpin1 lipin 1 JBrowse link 6 41,796,214 41,905,149 RGD:6480464
G Lurap1l leucine rich adaptor protein 1-like JBrowse link 5 98,468,039 98,515,126 RGD:6480464
G Manba mannosidase beta JBrowse link 2 240,668,213 240,760,264 RGD:6480464
G Mfsd2a major facilitator superfamily domain containing 2A JBrowse link 5 140,642,865 140,657,759 RGD:6480464
G Nampt nicotinamide phosphoribosyltransferase JBrowse link 6 52,122,085 52,156,473 RGD:6480464
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 JBrowse link 17 22,984,792 23,179,701 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:6480464
G Nfkbiz NFKB inhibitor zeta JBrowse link 11 47,243,342 47,271,487 RGD:6480464
G Nrbp2 nuclear receptor binding protein 2 JBrowse link 7 117,145,106 117,151,694 RGD:6480464
G Nudt4 nudix hydrolase 4 JBrowse link 7 36,643,916 36,660,334 RGD:6480464
G Nupr1 nuclear protein 1, transcriptional regulator JBrowse link 1 194,767,484 194,769,519 RGD:6480464
G Omd osteomodulin JBrowse link 17 15,476,100 15,484,324 RGD:6480464
G Osbpl1a oxysterol binding protein-like 1A JBrowse link 18 4,097,011 4,294,136 RGD:6480464
G Palmd palmdelphin JBrowse link 2 220,481,292 220,536,004 RGD:6480464
G Pbld1 phenazine biosynthesis-like protein domain containing 1 JBrowse link 20 27,103,300 27,118,650 RGD:6480464
G Pid1 phosphotyrosine interaction domain containing 1 JBrowse link 9 91,667,748 91,683,468 RGD:6480464
G Pigu phosphatidylinositol glycan anchor biosynthesis, class U JBrowse link 3 150,803,096 150,885,597 RGD:6480464
G Pla2g12a phospholipase A2, group XIIA JBrowse link 2 235,311,664 235,327,972 RGD:6480464
G Plgrkt plasminogen receptor with a C-terminal lysine JBrowse link 1 247,502,274 247,514,540 RGD:6480464
G Plin3 perilipin 3 JBrowse link 9 10,769,739 10,781,659 RGD:6480464
G Plp2 proteolipid protein 2 JBrowse link X 15,679,254 15,682,653 RGD:6480464
G Polg2 DNA polymerase gamma 2, accessory subunit JBrowse link 10 94,968,836 94,979,259 RGD:6480464
G Ppara peroxisome proliferator activated receptor alpha JBrowse link 7 126,618,872 126,687,282 RGD:6480464
G Ppcs phosphopantothenoylcysteine synthetase JBrowse link 5 138,466,298 138,470,108 RGD:6480464
G Ppif peptidylprolyl isomerase F JBrowse link 16 1,979,191 1,985,912 RGD:6480464
G Ppp1r14a protein phosphatase 1, regulatory (inhibitor) subunit 14A JBrowse link 1 87,224,683 87,232,842 RGD:6480464
G Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 JBrowse link 4 6,559,153 6,799,888 RGD:6480464
G Proser2 proline and serine rich 2 JBrowse link 17 76,079,641 76,140,428 RGD:6480464
G Prxl2b peroxiredoxin like 2B JBrowse link 5 172,304,799 172,307,402 RGD:6480464
G Pttg1 PTTG1 regulator of sister chromatid separation, securin JBrowse link 10 29,014,332 29,026,088 RGD:6480464
G Rapgef4 Rap guanine nucleotide exchange factor 4 JBrowse link 3 58,632,338 58,925,127 RGD:6480464
G Retreg1 reticulophagy regulator 1 JBrowse link 2 78,391,921 78,401,569 RGD:6480464
G RGD1308742 similar to Complement C5 precursor JBrowse link 3 14,273,552 14,291,401 RGD:6480464
G RGD1309534 similar to RIKEN cDNA 4931406C07 JBrowse link 8 13,838,549 13,861,120 RGD:6480464
G RGD1311251 similar to RIKEN cDNA 4930550C14 JBrowse link 8 57,983,168 58,012,474 RGD:6480464
G Rmdn2 regulator of microtubule dynamics 2 JBrowse link 6 2,215,062 2,292,288 RGD:6480464
G Rnd2 Rho family GTPase 2 JBrowse link 10 89,376,530 89,380,101 RGD:6480464
G Rnf4 ring finger protein 4 JBrowse link 14 81,658,400 81,679,756 RGD:6480464
G Rnpepl1 arginyl aminopeptidase like 1 JBrowse link 9 100,080,144 100,089,834 RGD:6480464
G Rpa1 replication protein A1 JBrowse link 10 62,140,419 62,191,518 RGD:6480464
G Rrm2 ribonucleotide reductase regulatory subunit M2 JBrowse link 6 43,884,627 43,890,818 RGD:6480464
G Rsrp1 arginine and serine rich protein 1 JBrowse link 5 153,260,930 153,264,669 RGD:6480464
G Rxra retinoid X receptor alpha JBrowse link 3 6,272,560 6,295,354 RGD:6480464
G Sc5d sterol-C5-desaturase JBrowse link 8 46,525,406 46,537,014 RGD:6480464
G Sdc4 syndecan 4 JBrowse link 3 160,872,503 160,891,190 RGD:6480464
G Serpina11 serpin family A member 11 JBrowse link 6 127,647,180 127,656,603 RGD:6480464
G Serpinh1 serpin family H member 1 JBrowse link 1 164,301,010 164,308,306 RGD:6480464
G Sesn2 sestrin 2 JBrowse link 5 150,684,891 150,703,846 RGD:6480464
G Sfpq splicing factor proline and glutamine rich JBrowse link 5 145,079,803 145,088,517 RGD:6480464
G Sh3bp5 SH3-domain binding protein 5 JBrowse link 16 7,473,367 7,559,976 RGD:6480464
G Slc13a3 solute carrier family 13 member 3 JBrowse link 3 162,084,336 162,147,398 RGD:6480464
G Slc17a3 solute carrier family 17 member 3 JBrowse link 17 43,518,760 43,545,160 RGD:6480464
G Slc38a2 solute carrier family 38, member 2 JBrowse link 7 138,088,654 138,100,869 RGD:6480464
G Spa17 sperm autoantigenic protein 17 JBrowse link 8 40,066,954 40,078,131 RGD:6480464
G Srxn1 sulfiredoxin 1 JBrowse link 3 147,608,850 147,614,410 RGD:6480464
G Ssx2ip SSX family member 2 interacting protein JBrowse link 2 252,263,323 252,296,049 RGD:6480464
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:6480464
G Steap3 STEAP3 metalloreductase JBrowse link 13 36,257,220 36,274,144 RGD:6480464
G Stmn1 stathmin 1 JBrowse link 5 152,680,412 152,686,807 RGD:6480464
G Sumf1 sulfatase modifying factor 1 JBrowse link 4 140,139,017 140,220,482 RGD:6480464
G Synrg synergin, gamma JBrowse link 10 71,278,698 71,357,791 RGD:6480464
G Syvn1 synoviolin 1 JBrowse link 1 221,409,281 221,416,229 RGD:6480464
G Tcirg1 T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 JBrowse link 1 219,126,687 219,139,466 RGD:6480464
G Tef TEF transcription factor, PAR bZIP family member JBrowse link 7 123,033,971 123,058,606 RGD:6480464
G Tjp2 tight junction protein 2 JBrowse link 1 241,945,816 242,084,044 RGD:6480464
G Tkt transketolase JBrowse link 16 6,609,670 6,634,608 RGD:6480464
G Tmem176b transmembrane protein 176B JBrowse link 4 78,450,724 78,458,600 RGD:6480464
G Tmem38b transmembrane protein 38B JBrowse link 5 70,639,156 70,675,055 RGD:6480464
G Tnfrsf9 TNF receptor superfamily member 9 JBrowse link 5 168,009,245 168,035,813 RGD:6480464
G Tob2 transducer of ERBB2, 2 JBrowse link 7 123,079,520 123,088,240 RGD:6480464
G Tpm3 tropomyosin 3 JBrowse link 2 189,423,534 189,451,340 RGD:6480464
G Tsc22d3 TSC22 domain family, member 3 JBrowse link X 111,884,285 111,944,693 RGD:6480464
G Tstd3 thiosulfate sulfurtransferase like domain containing 3 JBrowse link 5 35,892,783 35,902,243 RGD:6480464
G Tuba1c tubulin, alpha 1C JBrowse link 7 140,716,113 140,723,717 RGD:6480464
G Tubb4b tubulin, beta 4B class IVb JBrowse link 3 2,441,585 2,444,369 RGD:6480464
G Tubb5 tubulin, beta 5 class I JBrowse link 20 3,422,448 3,426,420 RGD:6480464
G Tubb6 tubulin, beta 6 class V JBrowse link 18 63,130,542 63,140,181 RGD:6480464
G Usp2 ubiquitin specific peptidase 2 JBrowse link 8 48,403,985 48,432,525 RGD:6480464
G Vcam1 vascular cell adhesion molecule 1 JBrowse link 2 219,071,193 219,090,931 RGD:6480464
G Vim vimentin JBrowse link 17 80,882,715 80,891,200 RGD:6480464
G Vmp1 vacuole membrane protein 1 JBrowse link 10 73,901,988 74,001,900 RGD:6480464
G Wasl WASP like actin nucleation promoting factor JBrowse link 4 51,677,722 51,726,212 RGD:6480464
G Wipi1 WD repeat domain, phosphoinositide interacting 1 JBrowse link 10 97,859,730 97,896,949 RGD:6480464
G Xpo1 exportin 1 JBrowse link 14 108,007,421 108,049,088 RGD:6480464
G Zfp354a zinc finger protein 354A JBrowse link 10 36,586,495 36,600,172 RGD:6480464
G Zfp446 zinc finger protein 446 JBrowse link 1 65,595,518 65,608,757 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19679
    role 19623
      biological role 19621
        antimicrobial agent 17158
          quinolone antibiotic 576
            levofloxacin 167
Path 2
Term Annotations click to browse term
  CHEBI ontology 19679
    subatomic particle 19675
      composite particle 19675
        hadron 19675
          baryon 19675
            nucleon 19675
              atomic nucleus 19675
                atom 19675
                  main group element atom 19555
                    p-block element atom 19555
                      carbon group element atom 19438
                        carbon atom 19430
                          organic molecular entity 19430
                            organic group 18351
                              organic divalent group 18340
                                organodiyl group 18340
                                  carbonyl group 18225
                                    carbonyl compound 18225
                                      carboxylic acid 17930
                                        monocarboxylic acid 17259
                                          oxo monocarboxylic acid 6254
                                            3-oxo monocarboxylic acid 213
                                              ofloxacin 187
                                                levofloxacin 167
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.