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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:telbivudine
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Accession:CHEBI:63624 term browser browse the term
Definition:A pyrimidine 2'-deoxyribonucleoside that is the L-enantiomer of thymine. A synthetic thymidine nucleoside analogue with activity against HBV DNA polymerase.
Synonyms:exact_synonym: 1-(2-deoxy-beta-L-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione
 related_synonym: 1-(2-deoxy-beta-L-ribofuranosyl)-5-methyluracil;   2'-Deoxy-L-thymidine;   Beta-l-thymidine;   Epavudine;   Formula=C10H14N2O5;   InChI=1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m1/s1;   InChIKey=IQFYYKKMVGJFEH-CSMHCCOUSA-N;   L-DT;   L-deoxythymidine;   L-thymidine;   LDT;   SMILES=Cc1cn([C@@H]2C[C@@H](O)[C@H](CO)O2)c(=O)[nH]c1=O;   beta-L-2'-deoxythymidine
 xref: CAS:3424-98-4;   DrugBank:DB01265;   Drug_Central:4220;   KEGG:D06675
 xref_mesh: MESH:D000077712
 xref: PMID:21040410;   PMID:21147187;   PMID:21457439;   PMID:21586234;   PMID:21642814;   PMID:21670922;   PMID:21703206;   PMID:21748522;   PMID:22093034;   PMID:22132702;   PMID:22174039;   PMID:22233255;   PMID:22257108;   Reaxys:754297;   Wikipedia:Telbivudine
 cyclic_relationship: is_enantiomer_of CHEBI:17748


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telbivudine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calcb calcitonin-related polypeptide, beta increases expression EXP Telbivudine results in increased expression of CALCB mRNA CTD PMID:37852574 NCBI chr 1:168,965,383...168,970,259
Ensembl chr 1:168,966,465...168,970,125 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression EXP Telbivudine results in increased expression of CEBPB mRNA CTD PMID:37852574 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Ddx3y DEAD box helicase 3, Y-linked increases expression EXP Telbivudine results in increased expression of DDX3Y mRNA CTD PMID:37852574 NCBI chr  Y:1,115,095...1,135,754
Ensembl chr  Y:1,116,309...1,135,706 		JBrowse link
G Kdm5d lysine demethylase 5D increases expression EXP Telbivudine results in increased expression of KDM5D mRNA CTD PMID:37852574 NCBI chr  Y:527,069...624,019
Ensembl chr  Y:530,401...624,018 		JBrowse link
G Mc2r melanocortin 2 receptor decreases expression EXP Telbivudine results in decreased expression of MC2R mRNA CTD PMID:37852574 NCBI chr18:62,001,980...62,015,567
Ensembl chr18:62,004,948...62,015,488 		JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II decreases expression ISO Telbivudine results in decreased expression of COX2 protein CTD PMID:37659625 NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689 		JBrowse link
G Mtarc1 mitochondrial amidoxime reducing component 1 decreases expression EXP Telbivudine results in decreased expression of MTARC1 mRNA CTD PMID:37852574 NCBI chr13:96,324,377...96,362,677
Ensembl chr13:96,339,757...96,397,796 		JBrowse link
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 decreases expression ISO Telbivudine results in decreased expression of NDUFB8 protein CTD PMID:37659625 NCBI chr 1:243,408,656...243,413,715
Ensembl chr 1:243,408,619...243,413,817 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 decreases expression EXP Telbivudine results in decreased expression of PCK1 mRNA CTD PMID:37852574 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    role 19893
      biological role 19891
        antimicrobial agent 18273
          antiviral agent 11338
            antiviral drug 1989
              telbivudine 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19865
                    p-block element atom 19865
                      carbon group element atom 19804
                        carbon atom 19801
                          organic molecular entity 19801
                            heteroorganic entity 19558
                              organochalcogen compound 19317
                                organooxygen compound 19233
                                  carbohydrates and carbohydrate derivatives 15293
                                    carbohydrate 15293
                                      carbohydrate derivative 14303
                                        glycosyl compound 13061
                                          N-glycosyl compound 5827
                                            nucleoside 5685
                                              deoxyribonucleoside 2894
                                                2'-deoxyribonucleoside 2248
                                                  pyrimidine 2'-deoxyribonucleoside 354
                                                    telbivudine 9
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