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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pyrimidine 2'-deoxyribonucleoside
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Accession:CHEBI:19255 term browser browse the term
Synonyms:related_synonym: pyrimidine 2'-deoxyribonucleosides


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2'-deoxycytidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO Deoxycytidine inhibits the reaction [[9-deaza-9-(3-thienylmethyl)guanine co-treated with Deoxyguanosine] results in increased activity of CASP3 protein] CTD PMID:9297556, PMID:9403342 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Dck deoxycytidine kinase affects binding ISO Deoxycytidine binds to DCK protein CTD PMID:17530837 NCBI chr14:20,935,442...20,952,939
Ensembl chr14:20,935,369...20,953,095
JBrowse link
G Slc28a1 solute carrier family 28 member 1 increases transport ISO SLC28A1 protein results in increased transport of Deoxycytidine CTD PMID:10772724 NCBI chr 1:142,948,942...142,992,410
Ensembl chr 1:142,950,540...142,992,615
JBrowse link
5-bromo-2'-deoxyuridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgef26 Rho guanine nucleotide exchange factor 26 multiple interactions ISO [Bromodeoxyuridine co-treated with furan] affects the expression of ARHGEF26 mRNA CTD PMID:24910943 NCBI chr 2:27,107,263...27,236,336
Ensembl chr 2:27,107,318...27,236,672
JBrowse link
G Atoh8 atonal bHLH transcription factor 8 decreases expression ISO Bromodeoxyuridine results in decreased expression of ATOH8 mRNA CTD PMID:24910943 NCBI chr 4:100,067,341...100,099,517
Ensembl chr 4:100,067,341...100,099,517
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Bromodeoxyuridine co-treated with furan] results in increased expression of BAX mRNA CTD PMID:24910943 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO [Bromodeoxyuridine co-treated with furan] results in increased expression of BIRC5 mRNA CTD PMID:24910943 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [Bromodeoxyuridine co-treated with furan] results in increased expression of CDKN1A mRNA CTD PMID:24910943 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Ces2c carboxylesterase 2C multiple interactions ISO [Bromodeoxyuridine co-treated with furan] affects the expression of CES2C mRNA CTD PMID:24910943 NCBI chr 1:282,640,752...282,648,319
Ensembl chr 1:282,638,017...282,702,424
JBrowse link
G Dnase1 deoxyribonuclease 1 multiple interactions ISO [Bromodeoxyuridine co-treated with furan] affects the expression of DNASE1 mRNA CTD PMID:24910943 NCBI chr10:11,757,681...11,760,672
Ensembl chr10:11,757,682...11,760,620
JBrowse link
G Dusp6 dual specificity phosphatase 6 multiple interactions ISO [Bromodeoxyuridine co-treated with furan] results in increased expression of DUSP6 mRNA CTD PMID:24910943 NCBI chr 7:41,475,163...41,479,393
Ensembl chr 7:41,475,163...41,479,392
JBrowse link
G Dusp8 dual specificity phosphatase 8 multiple interactions ISO [Bromodeoxyuridine co-treated with furan] results in increased expression of DUSP8 mRNA CTD PMID:24910943 NCBI chr 1:215,030,429...215,043,111
Ensembl chr 1:215,030,429...215,033,460
JBrowse link
G Elovl6 ELOVL fatty acid elongase 6 increases expression ISO Bromodeoxyuridine results in increased expression of ELOVL6 mRNA CTD PMID:24910943 NCBI chr 2:234,187,490...234,296,124
Ensembl chr 2:234,189,105...234,296,145
Ensembl chr 2:234,189,105...234,296,145
JBrowse link
G Fam47e family with sequence similarity 47, member E increases expression ISO Bromodeoxyuridine results in increased expression of FAM47E mRNA CTD PMID:24910943 NCBI chr14:16,991,496...17,027,563 JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO [Bromodeoxyuridine co-treated with furan] results in increased expression of GCLC mRNA CTD PMID:24910943 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gdf15 growth differentiation factor 15 multiple interactions ISO [Bromodeoxyuridine co-treated with furan] results in increased expression of GDF15 mRNA CTD PMID:24910943 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 multiple interactions ISO [Bromodeoxyuridine co-treated with furan] results in increased expression of GSTA1 mRNA CTD PMID:24910943 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta6 glutathione S-transferase alpha 6 multiple interactions ISO [Bromodeoxyuridine co-treated with furan] results in increased expression of GSTA1 mRNA CTD PMID:24910943 NCBI chr 9:27,475,273...27,533,939
Ensembl chr 9:27,475,273...27,511,176
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
increases expression
ISO [Bromodeoxyuridine co-treated with furan] affects the expression of HMGCR mRNA
Bromodeoxyuridine results in increased expression of HMGCR mRNA
CTD PMID:24910943 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmox1 heme oxygenase 1 affects abundance
multiple interactions
ISO HMOX1 protein affects the abundance of Bromodeoxyuridine
[Bromodeoxyuridine co-treated with furan] results in increased expression of HMOX1 mRNA
CTD PMID:17401437, PMID:24910943 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hnrnpc heterogeneous nuclear ribonucleoprotein C multiple interactions ISO [HNRNPC protein binds to HNRNPC protein alternative form] which results in decreased susceptibility to Bromodeoxyuridine CTD PMID:16960656 NCBI chr15:28,486,605...28,517,353
Ensembl chr15:28,486,617...28,517,353
JBrowse link
G Itga5 integrin subunit alpha 5 increases expression ISO Bromodeoxyuridine results in increased expression of ITGA5 mRNA; Bromodeoxyuridine results in increased expression of ITGA5 protein CTD PMID:7519154 NCBI chr 7:144,970,444...144,993,652
Ensembl chr 7:144,970,444...144,993,652
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Bromodeoxyuridine co-treated with furan] results in increased expression of JUN mRNA CTD PMID:24910943 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Mogat2 monoacylglycerol O-acyltransferase 2 multiple interactions ISO [Bromodeoxyuridine co-treated with furan] affects the expression of MOGAT2 mRNA CTD PMID:24910943 NCBI chr 1:164,181,762...164,205,222
Ensembl chr 1:164,181,764...164,205,222
JBrowse link
G Msmo1 methylsterol monooxygenase 1 increases expression ISO Bromodeoxyuridine results in increased expression of MSMO1 mRNA CTD PMID:24910943 NCBI chr16:26,859,441...26,875,880
Ensembl chr16:26,859,397...26,875,973
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [Bromodeoxyuridine co-treated with furan] results in increased expression of MYC mRNA CTD PMID:24910943 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Ngfr nerve growth factor receptor multiple interactions ISO [Bromodeoxyuridine co-treated with furan] results in increased expression of TNFRSF10B mRNA CTD PMID:24910943 NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061
JBrowse link
G Nmrk1 nicotinamide riboside kinase 1 increases expression ISO Bromodeoxyuridine results in increased expression of NMRK1 mRNA CTD PMID:24910943 NCBI chr 1:234,721,992...234,749,452
Ensembl chr 1:234,721,974...234,749,447
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO [Bromodeoxyuridine co-treated with furan] results in increased expression of NQO1 mRNA CTD PMID:24910943 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G P2ry1 purinergic receptor P2Y1 multiple interactions ISO [Bromodeoxyuridine co-treated with furan] affects the expression of P2RY1 mRNA CTD PMID:24910943 NCBI chr 2:151,314,818...151,320,312
Ensembl chr 2:151,314,818...151,320,319
JBrowse link
G Pax3 paired box 3 increases response to substance ISO PAX3 gene polymorphism results in increased susceptibility to Bromodeoxyuridine CTD PMID:3902948 NCBI chr 9:84,004,004...84,101,226
Ensembl chr 9:84,005,183...84,101,172
JBrowse link
G Scgb1c1 secretoglobin, family 1C, member 1 multiple interactions ISO [Bromodeoxyuridine co-treated with furan] affects the expression of SCGB1C1 mRNA CTD PMID:24910943 NCBI chr 1:213,595,240...213,596,459
Ensembl chr 1:213,595,240...213,596,459
JBrowse link
G Slc17a8 solute carrier family 17 member 8 multiple interactions ISO [Bromodeoxyuridine co-treated with furan] affects the expression of SLC17A8 mRNA CTD PMID:24910943 NCBI chr 7:30,215,231...30,274,993
Ensembl chr 7:30,216,104...30,274,984
JBrowse link
G Sox17 SRY-box transcription factor 17 decreases localization ISO Bromodeoxyuridine results in decreased localization of SOX17 protein CTD PMID:24154490 NCBI chr 5:14,890,318...14,895,907
Ensembl chr 5:14,890,408...14,895,907
JBrowse link
G Sqle squalene epoxidase increases expression ISO Bromodeoxyuridine results in increased expression of SQLE mRNA CTD PMID:24910943 NCBI chr 7:99,609,929...99,624,803
Ensembl chr 7:99,609,191...99,624,732
JBrowse link
G Srxn1 sulfiredoxin 1 multiple interactions ISO [Bromodeoxyuridine co-treated with furan] results in increased expression of SRXN1 mRNA CTD PMID:24910943 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
JBrowse link
G Stmn1 stathmin 1 multiple interactions ISO [Bromodeoxyuridine co-treated with furan] results in increased expression of STMN1 mRNA CTD PMID:24910943 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806
JBrowse link
G Tnfrsf12a TNF receptor superfamily member 12A multiple interactions ISO [Bromodeoxyuridine co-treated with furan] results in increased expression of TNFRSF12A mRNA CTD PMID:24910943 NCBI chr10:12,995,904...12,997,930
Ensembl chr10:12,995,904...12,997,930
JBrowse link
G Trib3 tribbles pseudokinase 3 decreases expression ISO Bromodeoxyuridine results in decreased expression of TRIB3 mRNA CTD PMID:24910943 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571
JBrowse link
G Tubb2a tubulin, beta 2A class IIa multiple interactions ISO [Bromodeoxyuridine co-treated with furan] results in increased expression of TUBB2A mRNA CTD PMID:24910943 NCBI chr17:31,493,145...31,496,827
Ensembl chr17:31,493,107...31,498,651
JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions ISO [Bromodeoxyuridine co-treated with furan] results in increased expression of TXNRD1 mRNA CTD PMID:24910943 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Vsnl1 visinin-like 1 decreases response to substance ISO VSNL1 protein results in decreased susceptibility to Bromodeoxyuridine CTD PMID:20419170 NCBI chr 6:37,001,360...37,121,969
Ensembl chr 6:37,001,356...37,122,023
JBrowse link
5-iodo-2'-deoxyuridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mbd4 methyl-CpG binding domain 4 DNA glycosylase affects response to substance ISO MBD4 protein affects the susceptibility to Idoxuridine CTD PMID:16885370 NCBI chr 4:147,744,673...147,756,462
Ensembl chr 4:147,746,186...147,756,294
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Idoxuridine results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Slc28a1 solute carrier family 28 member 1 multiple interactions EXP Idoxuridine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine] CTD PMID:8713072 NCBI chr 1:142,948,942...142,992,410
Ensembl chr 1:142,950,540...142,992,615
JBrowse link
G Tyms thymidylate synthetase affects uptake ISO TYMS protein affects the uptake of Idoxuridine CTD PMID:15001691 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link
dTDP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gale UDP-galactose-4-epimerase affects binding ISO thymidine 5'-diphosphate binds to GALE protein CTD PMID:25526675 NCBI chr 5:154,310,453...154,314,959
Ensembl chr 5:154,310,453...154,314,955
JBrowse link
G Uxs1 UDP-glucuronate decarboxylase 1 multiple interactions ISO [thymidine 5'-diphosphate co-treated with NAD] binds to UXS1 protein CTD PMID:25526675 NCBI chr 9:11,165,006...11,240,329
Ensembl chr 9:11,164,715...11,339,790
JBrowse link
dTMP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions
increases abundance
ISO Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Thymidine Monophosphate] CTD PMID:27469509 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
JBrowse link
G Tyms thymidylate synthetase multiple interactions ISO [Fluorouracil results in decreased activity of TYMS protein] which results in decreased abundance of Thymidine Monophosphate CTD PMID:29258758 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link
floxuridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases response to substance
decreases response to substance
ISO APEX1 protein mutant form results in increased susceptibility to Floxuridine
APEX1 protein results in decreased susceptibility to Floxuridine
CTD PMID:19470598, PMID:22194930 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
JBrowse link
G Atr ATR serine/threonine kinase decreases response to substance ISO ATR protein results in decreased susceptibility to Floxuridine CTD PMID:21613406, PMID:22194930 NCBI chr 8:103,673,578...103,770,886
Ensembl chr 8:103,673,411...103,770,947
JBrowse link
G C1qbp complement C1q binding protein decreases response to substance ISO C1QBP protein results in decreased susceptibility to Floxuridine CTD PMID:25354864 NCBI chr10:57,613,876...57,618,527
Ensembl chr10:57,613,879...57,618,527
JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions ISO Floxuridine results in increased phosphorylation of and results in increased activity of CHEK1 protein CTD PMID:21613406, PMID:22194930 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions
increases activity
ISO Floxuridine results in increased phosphorylation of and results in increased activity of CHEK2 protein
Floxuridine results in increased activity of CHEK2 protein
CTD PMID:21613406, PMID:22194930 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Mlh1 mutL homolog 1 multiple interactions
decreases response to substance
ISO olaparib inhibits the reaction [MLH1 protein results in decreased susceptibility to Floxuridine] CTD PMID:22194930 NCBI chr 8:119,486,655...119,523,716
Ensembl chr 8:119,486,691...119,523,964
JBrowse link
G Msh2 mutS homolog 2 multiple interactions
decreases response to substance
ISO olaparib inhibits the reaction [MSH2 protein results in decreased susceptibility to Floxuridine] CTD PMID:22194930 NCBI chr 6:11,215,951...11,274,916
Ensembl chr 6:11,215,963...11,274,932
JBrowse link
G Mthfr methylenetetrahydrofolate reductase affects response to substance ISO MTHFR protein affects the susceptibility to Floxuridine CTD PMID:18202788 NCBI chr 5:164,844,642...164,864,360
Ensembl chr 5:164,845,925...164,860,910
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 decreases response to substance ISO PARP1 protein results in decreased susceptibility to Floxuridine CTD PMID:21613406 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 affects response to substance
decreases response to substance
ISO TIMP3 protein affects the susceptibility to Floxuridine
TIMP3 gene modified form results in decreased susceptibility to Floxuridine
CTD PMID:18202788 NCBI chr 7:23,543,125...23,594,170
Ensembl chr 7:23,544,215...23,594,133
JBrowse link
G Tk1 thymidine kinase 1 increases expression ISO Floxuridine results in increased expression of TK1 protein CTD PMID:16951200 NCBI chr10:106,817,556...106,828,888
Ensembl chr10:106,817,601...106,828,884
JBrowse link
G Tp53 tumor protein p53 increases expression ISO Floxuridine results in increased expression of TP53 protein CTD PMID:19015155 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tyms thymidylate synthetase affects response to substance
increases response to substance
decreases response to substance
ISO TYMS protein affects the susceptibility to Floxuridine
TYMS results in increased susceptibility to Floxuridine
TYMS protein results in decreased susceptibility to Floxuridine
CTD PMID:2537495, PMID:10482907, PMID:15040806, PMID:17018589 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link
G Ung uracil-DNA glycosylase affects expression
increases response to substance
affects stability
ISO Floxuridine affects the expression of UNG mRNA; Floxuridine affects the expression of UNG protein
UNG protein results in increased susceptibility to Floxuridine
Floxuridine affects the stability of UNG protein alternative form
CTD PMID:16951200 NCBI chr12:48,246,593...48,255,547
Ensembl chr12:48,246,569...48,254,822
JBrowse link
G Xrcc1 X-ray repair cross complementing 1 decreases response to substance ISO XRCC1 protein results in decreased susceptibility to Floxuridine CTD PMID:21613406, PMID:22194930 NCBI chr 1:81,412,635...81,441,680
Ensembl chr 1:81,413,353...81,441,678
JBrowse link
G Xrcc4 X-ray repair cross complementing 4 decreases response to substance ISO XRCC4 results in decreased susceptibility to Floxuridine CTD PMID:21785230 NCBI chr 2:18,674,496...18,927,463
Ensembl chr 2:18,677,220...18,927,365
JBrowse link
gemcitabine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin increases expression ISO gemcitabine results in increased expression of A2M protein CTD PMID:20531411 NCBI chr 4:154,309,426...154,359,138
Ensembl chr 4:154,309,426...154,359,137
JBrowse link
G Acp3 acid phosphatase 3 decreases expression ISO gemcitabine results in decreased expression of ACP3 protein CTD PMID:20531411 NCBI chr 8:112,838,574...112,884,062
Ensembl chr 8:112,834,707...112,884,077
JBrowse link
G Adam17 ADAM metallopeptidase domain 17 multiple interactions ISO ADAM17 protein promotes the reaction [gemcitabine results in increased cleavage of AREG protein] CTD PMID:20726858 NCBI chr 6:43,400,525...43,448,280
Ensembl chr 6:43,400,528...43,448,280
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO gemcitabine results in increased expression of ADIPOQ protein CTD PMID:20531411 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Afp alpha-fetoprotein decreases expression ISO gemcitabine results in decreased expression of AFP protein CTD PMID:20531411 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Agpat2 1-acylglycerol-3-phosphate O-acyltransferase 2 decreases expression ISO gemcitabine results in decreased expression of AGPAT2 mRNA CTD PMID:17039268 NCBI chr 3:4,044,741...4,055,384
Ensembl chr 3:4,044,542...4,055,806
JBrowse link
G Akt1 AKT serine/threonine kinase 1 affects response to substance
multiple interactions
ISO AKT1 protein affects the susceptibility to gemcitabine
[gemcitabine co-treated with licoricidin] results in decreased phosphorylation of AKT1 protein; [licoricidin co-treated with gemcitabine] results in decreased phosphorylation of AKT1 protein
CTD PMID:15867245, PMID:29782821 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases expression
multiple interactions
ISO gemcitabine results in decreased expression of ALDH1A1 protein
sulforafan promotes the reaction [gemcitabine results in decreased expression of ALDH1A1 protein]
CTD PMID:20940707 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 increases expression ISO gemcitabine results in increased expression of ALDH1A3 mRNA CTD PMID:17039268 NCBI chr 1:127,302,920...127,337,828
Ensembl chr 1:127,301,128...127,337,882
JBrowse link
G Aldh6a1 aldehyde dehydrogenase 6 family, member A1 increases expression ISO gemcitabine results in increased expression of ALDH6A1 mRNA CTD PMID:17039268 NCBI chr 6:108,146,552...108,167,185
Ensembl chr 6:108,146,582...108,167,185
JBrowse link
G Anapc1 anaphase promoting complex subunit 1 increases expression ISO gemcitabine results in increased expression of ANAPC1 mRNA CTD PMID:17039268 NCBI chr 3:121,147,484...121,226,125
Ensembl chr 3:121,147,547...121,226,125
JBrowse link
G Ank3 ankyrin 3 increases expression ISO gemcitabine results in increased expression of ANK3 mRNA CTD PMID:17039268 NCBI chr20:19,948,767...20,480,628
Ensembl chr20:20,105,047...20,480,623
JBrowse link
G Ankrd1 ankyrin repeat domain 1 increases expression ISO gemcitabine results in increased expression of ANKRD1 mRNA CTD PMID:17039268 NCBI chr 1:254,726,985...254,745,673
Ensembl chr 1:254,726,969...254,735,548
JBrowse link
G Antxr1 ANTXR cell adhesion molecule 1 affects expression ISO gemcitabine affects the expression of ANTXR1 mRNA CTD PMID:17039268 NCBI chr 4:118,946,267...119,131,202
Ensembl chr 4:118,946,268...119,131,202
JBrowse link
G Apcs amyloid P component, serum decreases expression ISO gemcitabine results in decreased expression of APCS protein CTD PMID:20531411 NCBI chr13:91,426,621...91,427,417
Ensembl chr13:91,426,479...91,427,575
JBrowse link
G Apoh apolipoprotein H increases expression ISO gemcitabine results in increased expression of APOH protein CTD PMID:20531411 NCBI chr10:96,640,013...96,653,939
Ensembl chr10:96,639,924...96,653,938
JBrowse link
G Ar androgen receptor multiple interactions ISO gemcitabine binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Areg amphiregulin multiple interactions
increases expression
increases cleavage
decreases response to substance
ISO ADAM17 protein promotes the reaction [gemcitabine results in increased cleavage of AREG protein]
gemcitabine results in increased expression of AREG protein
AREG protein results in decreased susceptibility to gemcitabine
CTD PMID:20726858 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
JBrowse link
G Arf1 ADP-ribosylation factor 1 decreases expression ISO gemcitabine results in decreased expression of ARF1 mRNA CTD PMID:17039268 NCBI chr10:45,562,700...45,579,214
Ensembl chr10:45,563,547...45,579,029
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator increases expression ISO gemcitabine results in increased expression of ARNT mRNA CTD PMID:20103597 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO gemcitabine results in increased expression of ATF3 mRNA CTD PMID:17039268 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Axin2 axin 2 affects expression ISO gemcitabine affects the expression of AXIN2 mRNA CTD PMID:20103597 NCBI chr10:97,212,483...97,238,824
Ensembl chr10:97,212,432...97,239,642
JBrowse link
G Axl Axl receptor tyrosine kinase multiple interactions ISO AXL protein promotes the reaction [Warfarin results in increased susceptibility to gemcitabine] CTD PMID:26206560 NCBI chr 1:82,550,892...82,580,761
Ensembl chr 1:82,549,420...82,580,761
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [alvocidib co-treated with gemcitabine] results in increased expression of BAX protein; [ICI 118551 co-treated with gemcitabine] results in increased expression of BAX protein; [Mastic Resin co-treated with gemcitabine] results in increased expression of BAX protein; [TNFSF10 co-treated with gemcitabine] affects the localization of BAX protein CTD PMID:15770523, PMID:17671697, PMID:20523344, PMID:21570961 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO gemcitabine results in decreased expression of BCL2 protein
[alvocidib co-treated with gemcitabine] results in decreased expression of BCL2 protein; [Aminophylline co-treated with gemcitabine] results in decreased expression of BCL2 protein; [ICI 118551 co-treated with gemcitabine] results in decreased expression of BCL2 protein; [Mastic Resin co-treated with gemcitabine] results in decreased expression of BCL2 protein; [Theophylline co-treated with gemcitabine] results in decreased expression of BCL2 protein; gemcitabine inhibits the reaction [Fluorouracil results in decreased expression of BCL2 mRNA]; gemcitabine inhibits the reaction [Fluorouracil results in decreased expression of BCL2 protein]; U 0126 inhibits the reaction [gemcitabine results in decreased expression of BCL2 protein]
[Curcumin co-treated with gemcitabine] results in decreased expression of BCL2 protein
CTD PMID:15476743, PMID:15645133, PMID:15770523, PMID:16929163, PMID:17440100, PMID:20523344, PMID:21570961 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression
ISO gemcitabine inhibits the reaction [Fluorouracil affects the expression of BCL2L1 mRNA]; gemcitabine inhibits the reaction [Fluorouracil affects the expression of BCL2L1 protein]
[Curcumin co-treated with gemcitabine] results in decreased expression of BCL2L1 protein
gemcitabine results in decreased expression of BCL2L1 protein
CTD PMID:15476743, PMID:16929163, PMID:17440100 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bcl2l11 BCL2 like 11 increases expression ISO gemcitabine results in increased expression of BCL2L11 mRNA CTD PMID:17039268 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Bcl6 BCL6, transcription repressor increases expression ISO gemcitabine results in increased expression of BCL6 mRNA CTD PMID:17039268 NCBI chr11:80,255,790...80,279,075
Ensembl chr11:80,255,790...80,279,075
JBrowse link
G Bdnf brain-derived neurotrophic factor decreases expression ISO gemcitabine results in decreased expression of BDNF protein CTD PMID:20531411 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Bid BH3 interacting domain death agonist increases cleavage ISO gemcitabine results in increased cleavage of BID protein CTD PMID:14750167 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 increases expression ISO gemcitabine results in increased expression of BIRC2 mRNA CTD PMID:17039268 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 affects expression
multiple interactions
ISO gemcitabine affects the expression of BIRC3 mRNA
[Curcumin co-treated with gemcitabine] results in decreased expression of BIRC3 protein
CTD PMID:17039268, PMID:17440100 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO gemcitabine inhibits the reaction [Fluorouracil results in decreased expression of BIRC5 mRNA]; gemcitabine inhibits the reaction [Fluorouracil results in decreased expression of BIRC5 protein]
[Curcumin co-treated with gemcitabine] results in decreased expression of BIRC5 protein
CTD PMID:16929163, PMID:17440100 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Bnip3l BCL2 interacting protein 3 like increases expression ISO gemcitabine results in increased expression of BNIP3L mRNA CTD PMID:17039268 NCBI chr15:43,643,897...43,667,123
Ensembl chr15:43,643,897...43,667,029
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase decreases expression ISO gemcitabine results in decreased expression of BRAF mRNA CTD PMID:20103597 NCBI chr 4:67,389,331...67,520,549
Ensembl chr 4:67,396,192...67,520,356
JBrowse link
G Brca1 BRCA1, DNA repair associated increases expression
decreases response to substance
ISO gemcitabine results in increased expression of BRCA1 mRNA
BRCA1 results in decreased susceptibility to gemcitabine
CTD PMID:20103597, PMID:21771338 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G Casp3 caspase 3 increases activity
increases expression
multiple interactions
increases cleavage
ISO gemcitabine results in increased activity of CASP3 protein
gemcitabine results in increased expression of CASP3 protein modified form
[10-propargyl-10-deazaaminopterin co-treated with gemcitabine] results in increased activity of CASP3 protein; [Curcumin co-treated with gemcitabine] results in decreased expression of CASP3 protein
gemcitabine results in increased cleavage of CASP3 protein
[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with gemcitabine] affects the activity of CASP3 protein; [3-(4-methylphenylsulfonyl)-2-propenenitrile co-treated with gemcitabine] affects the activity of CASP3 protein; [alvocidib co-treated with gemcitabine] results in increased cleavage of CASP3 protein; [Calcitriol co-treated with gemcitabine] results in increased expression of CASP3 protein; [gemcitabine co-treated with TNFRSF10B] affects the activity of CASP3 protein; [vorinostat co-treated with gemcitabine] results in increased activity of CASP3 protein; gemcitabine results in increased expression of and results in increased activity of CASP3 protein; licoricidin promotes the reaction [gemcitabine results in increased activity of CASP3 protein]; licoricidin promotes the reaction [gemcitabine results in increased expression of and results in increased activity of CASP3 protein]; Quercetin promotes the reaction [gemcitabine results in increased activity of CASP3 protein]; SMG1 protein inhibits the reaction [gemcitabine results in increased activity of CASP3 protein]
CTD PMID:12479703, PMID:15476743, PMID:15726400, PMID:15770523, PMID:16153448, PMID:16467107, PMID:17159604, PMID:17440100, PMID:18089714, PMID:20299819, PMID:20699664, PMID:20798217, PMID:21418860, PMID:26050647, PMID:29782821 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp6 caspase 6 multiple interactions ISO [Calcitriol co-treated with gemcitabine] results in increased expression of CASP6 protein CTD PMID:20699664 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967
JBrowse link
G Casp8 caspase 8 multiple interactions
increases cleavage
increases activity
ISO [Calcitriol co-treated with gemcitabine] results in increased expression of CASP8 protein; [gemcitabine co-treated with TNFRSF10B] affects the activity of CASP8 protein; [TNFSF10 co-treated with gemcitabine] results in increased activity of CASP8 protein; gemcitabine results in increased activity of and results in increased cleavage of CASP8 protein; SFN protein inhibits the reaction [gemcitabine results in increased activity of and results in increased cleavage of CASP8 protein]; YAP1 protein affects the reaction [gemcitabine results in increased activity of and results in increased cleavage of CASP8 protein]
gemcitabine results in increased cleavage of CASP8 protein
gemcitabine results in increased activity of CASP8 protein
CTD PMID:12479703, PMID:14750167, PMID:17159604, PMID:17671697, PMID:18089714, PMID:20699664, PMID:26894857 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage
increases activity
ISO [Calcitriol co-treated with gemcitabine] results in increased expression of CASP9 protein; Quercetin promotes the reaction [gemcitabine results in increased activity of CASP9 protein]; SMG1 protein inhibits the reaction [gemcitabine results in increased activity of CASP9 protein]
[Curcumin co-treated with gemcitabine] results in decreased expression of CASP9 protein
gemcitabine results in increased cleavage of CASP9 protein
CTD PMID:12479703, PMID:15476743, PMID:15726400, PMID:17159604, PMID:17440100, PMID:20699664, PMID:21418860, PMID:26050647 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO gemcitabine results in decreased expression of CCL2 protein CTD PMID:20531411 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression ISO gemcitabine results in increased expression of CCL20 mRNA CTD PMID:17039268 NCBI chr 9:88,918,359...88,921,017
Ensembl chr 9:88,918,433...88,921,001
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO gemcitabine results in increased expression of CCL3 protein CTD PMID:20531411 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccnb1 cyclin B1 decreases expression
increases expression
ISO gemcitabine results in decreased expression of CCNB1 mRNA
gemcitabine results in increased expression of CCNB1 protein
CTD PMID:11504793, PMID:20103597 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO Celecoxib promotes the reaction [gemcitabine results in decreased expression of CCND1 protein]
gemcitabine results in decreased expression of CCND1 mRNA; gemcitabine results in decreased expression of CCND1 protein
[Curcumin co-treated with gemcitabine] results in decreased expression of CCND1 protein
CTD PMID:16060994, PMID:17039268, PMID:17440100 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccng2 cyclin G2 increases expression ISO gemcitabine results in increased expression of CCNG2 mRNA CTD PMID:17039268 NCBI chr14:16,267,572...16,276,068
Ensembl chr14:16,267,573...16,276,068
JBrowse link
G Cd40 CD40 molecule decreases expression ISO gemcitabine results in decreased expression of CD40 mRNA; gemcitabine results in decreased expression of CD40 protein CTD PMID:17039268, PMID:20531411 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Cd40lg CD40 ligand decreases expression ISO gemcitabine results in decreased expression of CD40LG protein CTD PMID:20531411 NCBI chr  X:159,703,703...159,714,886
Ensembl chr  X:159,703,578...159,716,562
JBrowse link
G Cda cytidine deaminase affects response to substance
multiple interactions
ISO CDA protein affects the susceptibility to gemcitabine
[crizotinib results in decreased expression of CDA protein] which results in increased susceptibility to gemcitabine; CDA protein affects the susceptibility to [gemcitabine co-treated with Mitomycin]; CDA protein affects the susceptibility to [gemcitabine co-treated with oxaliplatin]
CTD PMID:18728667, PMID:22973962 NCBI chr 5:156,703,579...156,734,541
Ensembl chr 5:156,703,579...156,734,541
JBrowse link
G Cdc25c cell division cycle 25C multiple interactions ISO [gemcitabine co-treated with ON 01910] results in decreased expression of CDC25C protein CTD PMID:20103597 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cdh1 cadherin 1 increases expression ISO gemcitabine results in increased expression of CDH1 mRNA CTD PMID:17039268 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO [alvocidib co-treated with gemcitabine] results in increased expression of CDKN1A protein; [gemcitabine results in decreased susceptibility to gemcitabine] which results in increased expression of CDKN1A protein; Nicotine inhibits the reaction [gemcitabine results in increased expression of CDKN1A protein]
gemcitabine results in increased expression of CDKN1A mRNA; gemcitabine results in increased expression of CDKN1A protein
CTD PMID:15476743, PMID:15770523, PMID:16601104, PMID:17039268, PMID:25189999 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases response to substance ISO CDKN1B results in decreased susceptibility to gemcitabine CTD PMID:21652059 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression ISO gemcitabine results in increased expression of CEBPB mRNA CTD PMID:17039268 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Chrdl2 chordin-like 2 multiple interactions ISO [gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of CHRDL2 protein CTD PMID:24979617 NCBI chr 1:165,008,997...165,036,431
Ensembl chr 1:165,008,912...165,036,435
JBrowse link
G Ckb creatine kinase B decreases expression ISO gemcitabine results in decreased expression of CKB mRNA CTD PMID:17039268 NCBI chr 6:136,142,956...136,145,838
Ensembl chr 6:136,142,956...136,145,837
JBrowse link
G Clic4 chloride intracellular channel 4 increases expression ISO gemcitabine results in increased expression of CLIC4 mRNA CTD PMID:17039268 NCBI chr 5:153,568,937...153,625,669
Ensembl chr 5:153,568,745...153,625,869
JBrowse link
G Clu clusterin affects response to substance
increases expression
ISO CLU protein affects the susceptibility to gemcitabine
gemcitabine results in increased expression of CLU protein
CTD PMID:19007378 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions
increases expression
ISO BAY 11-7085 inhibits the reaction [gemcitabine results in increased expression of CNR1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [gemcitabine results in increased expression of CNR1 mRNA]; Dactinomycin inhibits the reaction [gemcitabine results in increased expression of CNR1 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [gemcitabine results in increased expression of CNR1 mRNA] CTD PMID:21525939 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Cnr2 cannabinoid receptor 2 multiple interactions
increases expression
ISO BAY 11-7085 inhibits the reaction [gemcitabine results in increased expression of CNR2 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [gemcitabine results in increased expression of CNR2 mRNA]; Dactinomycin inhibits the reaction [gemcitabine results in increased expression of CNR2 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [gemcitabine results in increased expression of CNR2 mRNA] CTD PMID:21525939 NCBI chr 5:154,242,010...154,268,126
Ensembl chr 5:154,260,062...154,268,126
JBrowse link
G Csf2 colony stimulating factor 2 decreases expression ISO gemcitabine results in decreased expression of CSF2 protein CTD PMID:20531411 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Csf3 colony stimulating factor 3 decreases expression ISO gemcitabine results in decreased expression of CSF3 protein CTD PMID:20531411 NCBI chr10:86,616,785...86,619,160
Ensembl chr10:86,616,785...86,619,157
JBrowse link
G Csrp2 cysteine and glycine-rich protein 2 increases expression ISO gemcitabine results in increased expression of CSRP2 mRNA CTD PMID:17039268 NCBI chr 7:53,630,675...53,649,309
Ensembl chr 7:53,630,621...53,649,310
JBrowse link
G Cthrc1 collagen triple helix repeat containing 1 increases expression ISO gemcitabine results in increased expression of CTHRC1 mRNA CTD PMID:17039268 NCBI chr 7:77,966,722...77,977,004
Ensembl chr 7:77,966,722...77,977,004
JBrowse link
G Ctnnb1 catenin beta 1 increases expression ISO gemcitabine results in increased expression of CTNNB1 mRNA CTD PMID:25605917 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression ISO gemcitabine results in increased expression of CXCL1 mRNA CTD PMID:17039268 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 multiple interactions ISO [gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of CXCL11 protein CTD PMID:24979617 NCBI chr14:17,195,395...17,198,170
Ensembl chr14:17,195,014...17,198,291
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO gemcitabine results in increased expression of CXCL2 mRNA CTD PMID:17039268 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO gemcitabine results in increased expression of CXCL1 mRNA CTD PMID:17039268 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 affects expression ISO gemcitabine affects the expression of CXCR4 mRNA CTD PMID:20103597 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 decreases expression ISO gemcitabine results in decreased expression of CYP24A1 mRNA CTD PMID:17039268 NCBI chr 3:168,097,484...168,111,920
Ensembl chr 3:168,097,485...168,111,920
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 affects expression ISO gemcitabine affects the expression of DDIT4 mRNA CTD PMID:17039268 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
JBrowse link
G Dhx9 DExH-box helicase 9 decreases expression ISO gemcitabine results in decreased expression of DHX9 mRNA CTD PMID:17039268 NCBI chr13:70,885,503...70,922,278
Ensembl chr13:70,885,504...70,922,245
JBrowse link
G Dlg2 discs large MAGUK scaffold protein 2 increases expression ISO gemcitabine results in increased expression of DLG2 mRNA CTD PMID:17039268 NCBI chr 1:154,916,274...157,274,077
Ensembl chr 1:156,552,328...157,269,747
JBrowse link
G Dnmt1 DNA methyltransferase 1 multiple interactions ISO [DNMT1 protein binds to SFN promoter] inhibits the reaction [gemcitabine results in decreased susceptibility to gemcitabine]; [gemcitabine results in decreased susceptibility to gemcitabine] inhibits the reaction [DNMT1 protein binds to SFN promoter]; [gemcitabine results in decreased susceptibility to gemcitabine] which results in increased expression of DNMT1 protein; [UHRF1 protein promotes the reaction [DNMT1 protein binds to SFN promoter]] inhibits the reaction [gemcitabine results in decreased susceptibility to gemcitabine]; DNMT1 protein inhibits the reaction [gemcitabine results in decreased susceptibility to gemcitabine] CTD PMID:25189999 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
JBrowse link
G Dnmt3b DNA methyltransferase 3 beta multiple interactions ISO [gemcitabine results in decreased susceptibility to gemcitabine] which results in increased expression of DNMT3B protein CTD PMID:25189999 NCBI chr 3:149,131,541...149,170,061
Ensembl chr 3:149,131,785...149,208,786
JBrowse link
G Dpyd dihydropyrimidine dehydrogenase multiple interactions ISO [TYMP protein co-treated with DPYD protein] affects the susceptibility to gemcitabine CTD PMID:18728667 NCBI chr 2:221,823,692...222,694,627
Ensembl chr 2:221,823,687...222,694,627
JBrowse link
G Dync1h1 dynein cytoplasmic 1 heavy chain 1 decreases expression ISO gemcitabine results in decreased expression of DYNC1H1 mRNA CTD PMID:17039268 NCBI chr 6:134,958,854...135,085,769
Ensembl chr 6:134,958,854...135,085,769
JBrowse link
G Edn1 endothelin 1 decreases expression ISO gemcitabine results in decreased expression of EDN1 protein CTD PMID:20531411 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Edn2 endothelin 2 decreases expression ISO gemcitabine results in decreased expression of EDN2 mRNA CTD PMID:17039268 NCBI chr 5:139,098,472...139,106,396
Ensembl chr 5:139,100,898...139,105,792
JBrowse link
G Egf epidermal growth factor multiple interactions
decreases expression
ISO 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]]; EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]; Erlotinib Hydrochloride inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]]; pyrazolanthrone inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]]; U 0126 inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]]
gemcitabine results in decreased expression of EGF protein
CTD PMID:20531411, PMID:21613822 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
increases phosphorylation
increases expression
decreases expression
increases degradation
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [gemcitabine results in increased phosphorylation of and results in increased degradation of EGFR protein]; EGFR gene mutant form results in increased susceptibility to [gemcitabine co-treated with Cisplatin co-treated with Erlotinib Hydrochloride]; Gefitinib inhibits the reaction [gemcitabine results in increased phosphorylation of and results in increased degradation of EGFR protein]; gemcitabine promotes the reaction [HER3 protein binds to EGFR protein]
gemcitabine results in increased phosphorylation of EGFR protein
gemcitabine results in increased expression of EGFR mRNA
gemcitabine results in decreased expression of EGFR mRNA; gemcitabine results in decreased expression of EGFR protein
gemcitabine results in increased degradation of EGFR protein
CTD PMID:17146438, PMID:20103597, PMID:20726858, PMID:21541241 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Egr1 early growth response 1 increases expression ISO gemcitabine results in increased expression of EGR1 mRNA CTD PMID:17039268 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO gemcitabine binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Etv1 ETS variant transcription factor 1 increases expression ISO gemcitabine results in increased expression of ETV1 mRNA CTD PMID:17039268 NCBI chr 6:58,467,215...58,558,640
Ensembl chr 6:58,467,254...58,558,631
JBrowse link
G Evi2b ecotropic viral integration site 2B decreases expression ISO gemcitabine results in decreased expression of EVI2B mRNA CTD PMID:17039268 NCBI chr10:66,856,980...66,858,598
Ensembl chr10:66,856,980...66,858,598
JBrowse link
G F7 coagulation factor VII decreases expression ISO gemcitabine results in decreased expression of F7 protein CTD PMID:20531411 NCBI chr16:81,824,610...81,834,923
Ensembl chr16:81,824,111...81,834,945
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO gemcitabine results in increased expression of FAS mRNA; gemcitabine results in increased expression of FAS protein CTD PMID:11138460, PMID:17159604 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fbxo25 F-box protein 25 increases expression ISO gemcitabine results in increased expression of FBXO25 mRNA CTD PMID:17039268 NCBI chr16:80,770,788...80,806,661
Ensembl chr16:80,771,596...80,798,041
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions
increases expression
ISO [gemcitabine co-treated with IFNA2 protein] results in increased expression of FGF2 protein
gemcitabine results in increased expression of FGF2 protein
CTD PMID:12738744, PMID:20531411 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fgg fibrinogen gamma chain affects expression ISO gemcitabine affects the expression of FGG mRNA CTD PMID:17039268 NCBI chr 2:181,987,080...181,994,523
Ensembl chr 2:181,987,217...181,994,514
JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit decreases expression ISO gemcitabine results in decreased expression of FOSL2 mRNA CTD PMID:17039268 NCBI chr 6:25,598,936...25,616,995
Ensembl chr 6:25,598,936...25,616,995
JBrowse link
G Fxyd3 FXYD domain-containing ion transport regulator 3 increases expression ISO gemcitabine results in increased expression of FXYD3 mRNA CTD PMID:17039268 NCBI chr 1:89,502,561...89,510,146
Ensembl chr 1:89,502,562...89,509,343
JBrowse link
G Gal3st1 galactose-3-O-sulfotransferase 1 decreases expression ISO gemcitabine results in decreased expression of GAL3ST1 mRNA CTD PMID:17039268 NCBI chr14:84,231,473...84,247,371
Ensembl chr14:84,231,639...84,247,369
JBrowse link
G Gas1 growth arrest-specific 1 decreases expression ISO gemcitabine results in decreased expression of GAS1 mRNA CTD PMID:17039268 NCBI chr17:4,846,116...4,849,350
Ensembl chr17:4,846,789...4,847,940
JBrowse link
G Gask1b golgi associated kinase 1B decreases expression ISO gemcitabine results in decreased expression of GASK1B mRNA CTD PMID:17039268 NCBI chr 2:178,678,946...178,751,459
Ensembl chr 2:178,679,041...178,750,668
JBrowse link
G Gdf15 growth differentiation factor 15 multiple interactions ISO [gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of GDF15 protein CTD PMID:24979617 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Gipc1 GIPC PDZ domain containing family, member 1 affects response to substance ISO GIPC1 affects the susceptibility to gemcitabine CTD PMID:25469510 NCBI chr19:24,786,604...24,798,231
Ensembl chr19:24,786,628...24,798,233
JBrowse link
G Gli2 GLI family zinc finger 2 affects expression ISO gemcitabine affects the expression of GLI2 mRNA CTD PMID:20103597 NCBI chr13:34,829,021...35,049,172
Ensembl chr13:34,829,139...35,048,444
JBrowse link
G Glrx glutaredoxin increases expression ISO gemcitabine results in increased expression of GLRX mRNA CTD PMID:17039268 NCBI chr 2:2,606,032...2,615,944
Ensembl chr 2:2,605,996...2,615,944
JBrowse link
G Gpc3 glypican 3 increases expression ISO gemcitabine results in increased expression of GPC3 mRNA CTD PMID:17039268 NCBI chr  X:139,579,268...139,947,093
Ensembl chr  X:139,579,268...139,916,883
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation ISO gemcitabine results in increased phosphorylation of GSK3B protein CTD PMID:16570353 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gtf2a1 general transcription factor 2A subunit 1 affects expression ISO gemcitabine affects the expression of GTF2A1 mRNA CTD PMID:17039268 NCBI chr 6:115,321,110...115,352,659
Ensembl chr 6:115,320,467...115,352,681
JBrowse link
G Hdac9 histone deacetylase 9 increases expression ISO gemcitabine results in increased expression of HDAC9 mRNA CTD PMID:17039268 NCBI chr 6:53,487,367...54,358,694
Ensembl chr 6:53,488,883...54,059,119
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha affects response to substance ISO HIF1A protein affects the susceptibility to gemcitabine CTD PMID:16628086 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hist2h4 histone cluster 2, H4 decreases expression ISO gemcitabine results in decreased expression of H4C2 mRNA CTD PMID:17039268 NCBI chr 2:198,411,955...198,412,350
Ensembl chr 2:198,411,955...198,412,350
JBrowse link
G Hoxb2 homeobox B2 increases expression ISO gemcitabine results in increased expression of HOXB2 mRNA CTD PMID:17039268 NCBI chr10:84,200,859...84,203,065
Ensembl chr10:84,200,880...84,202,688
JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like decreases expression ISO gemcitabine results in decreased expression of HSPA1L mRNA CTD PMID:17039268 NCBI chr20:4,879,998...4,965,191
Ensembl chr20:4,959,294...4,964,963
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO gemcitabine results in increased expression of HSPA5 mRNA CTD PMID:17039268 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases expression
ISO [Curcumin co-treated with gemcitabine] results in decreased expression of ICAM1 protein
gemcitabine results in decreased expression of ICAM1 protein
CTD PMID:17440100, PMID:20531411 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma decreases expression ISO gemcitabine results in decreased expression of IFNG protein CTD PMID:20531411 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases expression ISO gemcitabine results in decreased expression of IGF1R mRNA CTD PMID:20103597 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 affects expression ISO gemcitabine affects the expression of IGFBP3 mRNA CTD PMID:20103597 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
JBrowse link
G Il10 interleukin 10 decreases expression ISO gemcitabine results in decreased expression of IL10 protein CTD PMID:20531411 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il13 interleukin 13 increases expression ISO gemcitabine results in increased expression of IL13 protein CTD PMID:20531411 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il15 interleukin 15 decreases expression ISO gemcitabine results in decreased expression of IL15 protein CTD PMID:20531411 NCBI chr19:23,542,606...23,624,366
Ensembl chr19:23,542,889...23,554,594
JBrowse link
G Il16 interleukin 16 increases expression ISO gemcitabine results in increased expression of IL16 protein CTD PMID:20531411 NCBI chr 1:145,781,923...145,881,538
Ensembl chr 1:145,781,928...145,870,912
JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO gemcitabine results in decreased expression of IL1A protein CTD PMID:20531411 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta decreases expression ISO gemcitabine results in decreased expression of IL1B protein CTD PMID:20531411 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il4 interleukin 4 decreases expression ISO gemcitabine results in decreased expression of IL4 protein CTD PMID:20531411 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 decreases expression
increases secretion
increases expression
ISO gemcitabine results in decreased expression of IL6 protein
gemcitabine results in increased secretion of IL6 protein
gemcitabine results in increased expression of IL6 mRNA
CTD PMID:17039268, PMID:20531411, PMID:28007550 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ilk integrin-linked kinase affects response to substance ISO ILK protein affects the susceptibility to gemcitabine CTD PMID:15867245 NCBI chr 1:170,578,941...170,585,192
Ensembl chr 1:170,578,889...170,585,189
JBrowse link
G Ins2 insulin 2 increases expression ISO gemcitabine results in increased expression of INS protein CTD PMID:20531411 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Insig1 insulin induced gene 1 increases expression ISO gemcitabine results in increased expression of INSIG1 mRNA CTD PMID:17039268 NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515
JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 increases expression ISO gemcitabine results in increased expression of IQGAP1 mRNA CTD PMID:17039268 NCBI chr 1:142,525,041...142,615,673
Ensembl chr 1:142,525,046...142,615,673
JBrowse link
G Irak2 interleukin-1 receptor-associated kinase 2 increases expression ISO gemcitabine results in increased expression of IRAK2 mRNA CTD PMID:17039268 NCBI chr 4:145,594,575...145,651,066
Ensembl chr 4:145,594,575...145,651,053
JBrowse link
G Irf3 interferon regulatory factor 3 decreases expression ISO gemcitabine results in decreased expression of IRF3 mRNA CTD PMID:17039268 NCBI chr 1:100,992,244...100,997,202
Ensembl chr 1:100,992,405...100,997,198
JBrowse link
G Itgav integrin subunit alpha V multiple interactions ISO [ITGB6 co-treated with ITGAV] affects the susceptibility to gemcitabine CTD PMID:20150628 NCBI chr 3:71,113,269...71,205,958
Ensembl chr 3:71,114,100...71,202,411
JBrowse link
G Itgb6 integrin subunit beta 6 multiple interactions ISO [ITGB6 co-treated with ITGAV] affects the susceptibility to gemcitabine CTD PMID:20150628 NCBI chr 3:46,652,624...46,775,362
Ensembl chr 3:46,652,623...46,726,958
JBrowse link
G Itsn2 intersectin 2 increases expression ISO gemcitabine results in increased expression of ITSN2 mRNA CTD PMID:17039268 NCBI chr 6:30,098,378...30,208,694
Ensembl chr 6:30,098,380...30,187,337
JBrowse link
G Jam3 junctional adhesion molecule 3 decreases expression ISO gemcitabine results in decreased expression of JAM3 mRNA CTD PMID:17039268 NCBI chr 8:28,147,110...28,208,466
Ensembl chr 8:28,147,111...28,208,466
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Copper co-treated with Disulfiram co-treated with gemcitabine] results in increased expression of and results in increased phosphorylation of JUN protein CTD PMID:23033007 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kctd12 potassium channel tetramerization domain containing 12 decreases expression ISO gemcitabine results in decreased expression of KCTD12 mRNA CTD PMID:17039268 NCBI chr15:87,384,632...87,390,627 JBrowse link
G Kitlg KIT ligand decreases expression
multiple interactions
ISO gemcitabine results in decreased expression of KITLG protein
[gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of KITLG protein
CTD PMID:20531411, PMID:24979617 NCBI chr 7:42,269,784...42,351,054
Ensembl chr 7:42,269,784...42,351,054
JBrowse link
G Klf8 Kruppel-like factor 8 increases expression ISO gemcitabine results in increased expression of KLF8 mRNA CTD PMID:17039268 NCBI chr  X:18,836,902...19,032,012
Ensembl chr  X:18,835,827...18,890,090
JBrowse link
G Krt8 keratin 8 decreases expression ISO gemcitabine results in decreased expression of KRT8 mRNA CTD PMID:17039268 NCBI chr 7:143,596,511...143,603,745
Ensembl chr 7:143,596,511...143,603,803
JBrowse link
G Larp4b La ribonucleoprotein 4B increases expression ISO gemcitabine results in increased expression of LARP4B mRNA CTD PMID:17039268 NCBI chr17:63,236,007...63,317,298
Ensembl chr17:63,265,407...63,314,019
JBrowse link
G Lep leptin decreases expression ISO gemcitabine results in decreased expression of LEP protein CTD PMID:20531411 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lifr LIF receptor subunit alpha increases expression ISO gemcitabine results in increased expression of LIFR mRNA CTD PMID:17039268 NCBI chr 2:56,424,910...56,489,346
Ensembl chr 2:56,426,367...56,489,415
JBrowse link
G LOC100360841 ribosomal protein L37-like increases expression ISO gemcitabine results in increased expression of RPL37 mRNA CTD PMID:17039268 NCBI chr 9:69,790,829...69,791,199
Ensembl chr 9:69,790,831...69,791,196
JBrowse link
G Lpar6 lysophosphatidic acid receptor 6 decreases expression ISO gemcitabine results in decreased expression of LPAR6 mRNA CTD PMID:17039268 NCBI chr15:55,126,953...55,128,762
Ensembl chr15:55,126,953...55,128,761
JBrowse link
G Lrrc28 leucine rich repeat containing 28 increases expression ISO gemcitabine results in increased expression of LRRC28 mRNA CTD PMID:17039268 NCBI chr 1:128,486,164...128,604,190
Ensembl chr 1:128,486,166...128,604,188
JBrowse link
G Lta lymphotoxin alpha increases expression ISO gemcitabine results in increased expression of LTA protein CTD PMID:20531411 NCBI chr20:4,851,889...4,854,677
Ensembl chr20:4,852,496...4,854,677
JBrowse link
G Lyz2 lysozyme 2 decreases expression ISO gemcitabine results in decreased expression of LYZ mRNA CTD PMID:17039268 NCBI chr 7:60,335,968...60,341,264
Ensembl chr 7:60,335,969...60,341,264
JBrowse link
G Maf MAF bZIP transcription factor increases expression ISO gemcitabine results in increased expression of MAF mRNA CTD PMID:17039268 NCBI chr19:48,179,826...48,200,995
Ensembl chr19:48,194,804...48,196,748
JBrowse link
G Magea10 MAGE family member A10 decreases expression ISO gemcitabine results in decreased expression of MAGEA10 mRNA CTD PMID:17039268 NCBI chr  X:152,365,785...152,371,961
Ensembl chr  X:152,366,893...152,367,861
JBrowse link
G Magi1 membrane associated guanylate kinase, WW and PDZ domain containing 1 increases expression ISO gemcitabine results in increased expression of MAGI1 mRNA CTD PMID:17039268 NCBI chr 4:125,684,816...126,300,013
Ensembl chr 4:125,687,307...125,958,112
JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 increases phosphorylation ISO gemcitabine results in increased phosphorylation of MAP2K3 protein CTD PMID:15003513 NCBI chr10:45,089,455...45,110,802
Ensembl chr10:47,182,433...47,203,753
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 increases phosphorylation ISO gemcitabine results in increased phosphorylation of MAP2K6 protein CTD PMID:15003513 NCBI chr10:98,707,160...98,823,054
Ensembl chr10:98,706,960...98,823,287
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO [Copper co-treated with Disulfiram co-treated with gemcitabine] results in increased phosphorylation of MAPK1 protein
gemcitabine results in increased phosphorylation of MAPK1 protein
CTD PMID:15476743, PMID:23033007 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO gemcitabine results in increased phosphorylation of MAPK3 protein
[Copper co-treated with Disulfiram co-treated with gemcitabine] results in increased phosphorylation of MAPK3 protein
CTD PMID:15476743, PMID:23033007 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate increases expression
increases phosphorylation
ISO gemcitabine results in increased expression of MARCKS mRNA
gemcitabine results in increased phosphorylation of MARCKS protein
CTD PMID:9523737, PMID:17039268 NCBI chr20:42,966,140...42,971,838
Ensembl chr20:42,966,140...42,971,838
JBrowse link
G Mars1 methionyl-tRNA synthetase 1 increases expression ISO gemcitabine results in increased expression of MARS1 mRNA CTD PMID:17039268 NCBI chr 7:70,585,011...70,602,425
Ensembl chr 7:70,585,013...70,602,310
JBrowse link
G Mdm2 MDM2 proto-oncogene decreases expression
increases expression
ISO gemcitabine results in decreased expression of MDM2 mRNA
gemcitabine results in increased expression of MDM2 mRNA
CTD PMID:17039268, PMID:20103597 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases expression ISO gemcitabine results in decreased expression of MGMT mRNA CTD PMID:17039268 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
JBrowse link
G Mir24-2 microRNA 24-2 multiple interactions ISO MIR24-2 mRNA affects the susceptibility to [betulinic acid co-treated with gemcitabine] CTD PMID:25841339 NCBI chr19:25,318,863...25,318,970
Ensembl chr19:25,318,863...25,318,970
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO [Curcumin co-treated with gemcitabine] results in decreased expression of MKI67 protein CTD PMID:17440100 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Mmp3 matrix metallopeptidase 3 decreases expression ISO gemcitabine results in decreased expression of MMP3 protein CTD PMID:20531411 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [Curcumin co-treated with gemcitabine] results in decreased expression of MMP9 protein
[gemcitabine co-treated with IFNA2 protein] results in increased expression of MMP9 protein
CTD PMID:12738744, PMID:17440100 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpo myeloperoxidase increases expression ISO gemcitabine results in increased expression of MPO protein CTD PMID:20531411 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Msln mesothelin multiple interactions EXP gemcitabine results in decreased expression of and results in decreased secretion of MSLN protein alternative form CTD PMID:25347530 NCBI chr10:15,119,700...15,129,129
Ensembl chr10:15,119,663...15,125,408
JBrowse link
G Mt-co3 mitochondrially encoded cytochrome c oxidase III decreases response to substance
multiple interactions
ISO COX3 protein results in decreased susceptibility to gemcitabine
Sodium Azide inhibits the reaction [COX3 protein results in decreased susceptibility to gemcitabine]
CTD PMID:17428446 NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382
JBrowse link
G Mxi1 MAX interactor 1, dimerization protein increases expression ISO gemcitabine results in increased expression of MXI1 mRNA CTD PMID:17039268 NCBI chr 1:274,030,748...274,090,071
Ensembl chr 1:274,030,978...274,090,071
JBrowse link
G Myb MYB proto-oncogene, transcription factor increases expression ISO gemcitabine results in increased expression of MYB mRNA CTD PMID:17039268 NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor affects response to substance
multiple interactions
ISO MYC affects the susceptibility to gemcitabine
[Curcumin co-treated with gemcitabine] results in decreased expression of MYC protein
[Oligonucleotides binds to MYC gene] which results in increased susceptibility to gemcitabine
CTD PMID:17440100, PMID:23681918 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nanog Nanog homeobox decreases expression ISO gemcitabine results in decreased expression of NANOG mRNA CTD PMID:25605917 NCBI chr 4:155,531,906...155,539,268
Ensembl chr 4:155,531,906...155,539,268
JBrowse link
G Ncbp1 nuclear cap binding protein subunit 1 increases expression ISO gemcitabine results in increased expression of NCBP1 mRNA CTD PMID:17039268 NCBI chr 5:61,734,118...61,767,098
Ensembl chr 5:61,734,118...61,766,481
JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 increases expression ISO gemcitabine results in increased expression of NEDD9 mRNA CTD PMID:17039268 NCBI chr17:22,984,792...23,179,701
Ensembl chr17:22,984,844...23,179,701
JBrowse link
G Neu1 neuraminidase 1 increases expression ISO gemcitabine results in increased expression of NEU1 mRNA CTD PMID:17039268 NCBI chr20:4,610,995...4,615,258
Ensembl chr20:4,610,995...4,615,247
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 decreases response to substance ISO NFE2L2 protein results in decreased susceptibility to gemcitabine CTD PMID:21489257 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 affects expression ISO gemcitabine affects the expression of NFKB2 mRNA CTD PMID:17039268 NCBI chr 1:266,050,634...266,059,277
Ensembl chr 1:266,053,002...266,059,256
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [Mastic Resin co-treated with gemcitabine] results in increased expression of NFKBIA protein CTD PMID:20523344 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nfkbie NFKB inhibitor epsilon affects expression ISO gemcitabine affects the expression of NFKBIE mRNA CTD PMID:17039268 NCBI chr 9:17,828,405...17,835,240
Ensembl chr 9:17,828,408...17,835,240
JBrowse link
G Nnmt nicotinamide N-methyltransferase increases expression ISO gemcitabine results in increased expression of NNMT mRNA CTD PMID:17039268 NCBI chr 8:52,918,437...52,938,172
Ensembl chr 8:52,925,175...52,937,972
JBrowse link
G Notch1 notch receptor 1 increases expression
multiple interactions
ISO gemcitabine results in increased expression of NOTCH1 protein
sulforafan inhibits the reaction [gemcitabine results in increased expression of NOTCH1 protein]
CTD PMID:20940707 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
G Npepps aminopeptidase puromycin sensitive decreases expression ISO gemcitabine results in decreased expression of NPEPPS mRNA CTD PMID:17039268 NCBI chr10:85,140,368...85,222,861
Ensembl chr10:85,140,370...85,222,861
JBrowse link
G Npm1 nucleophosmin 1 decreases response to substance ISO NPM1 protein results in decreased susceptibility to gemcitabine CTD PMID:24736981 NCBI chr10:18,080,949...18,091,062
Ensembl chr10:18,080,950...18,090,950
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 increases expression ISO gemcitabine results in increased expression of NR4A3 mRNA CTD PMID:17039268 NCBI chr 5:63,781,801...63,822,890
Ensembl chr 5:63,781,801...63,821,637
JBrowse link
G Nrg1 neuregulin 1 increases expression ISO gemcitabine results in increased expression of NRG1 mRNA CTD PMID:17039268 NCBI chr16:62,969,573...64,065,063
Ensembl chr16:63,837,216...64,057,434
JBrowse link
G Nrp1 neuropilin 1 decreases response to substance ISO NRP1 protein results in decreased susceptibility to gemcitabine CTD PMID:15956974 NCBI chr19:61,332,351...61,486,166
Ensembl chr19:61,332,351...61,485,858
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator decreases expression
affects response to substance
ISO gemcitabine results in decreased expression of NUPR1 mRNA
NUPR1 affects the susceptibility to gemcitabine
CTD PMID:16397047 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
JBrowse link
G Olr325 olfactory receptor 325 affects response to substance ISO OR4D6 gene SNP affects the susceptibility to gemcitabine CTD PMID:26378035 NCBI chr 1:228,545,913...228,546,857
Ensembl chr 1:228,545,913...228,546,857
JBrowse link
G Osm oncostatin M multiple interactions ISO [gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of OSM protein CTD PMID:24979617 NCBI chr14:84,457,487...84,469,426
Ensembl chr14:84,465,515...84,470,409
JBrowse link
G Pappa1 pappalysin 1 decreases expression ISO gemcitabine results in decreased expression of PAPPA protein CTD PMID:20531411 NCBI chr 5:80,919,932...81,153,904
Ensembl chr 5:80,920,568...81,150,940
JBrowse link
G Paqr8 progestin and adipoQ receptor family member 8 increases expression ISO gemcitabine results in increased expression of PAQR8 mRNA CTD PMID:17039268 NCBI chr 9:27,005,270...27,054,591
Ensembl chr 9:27,034,022...27,051,002
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO [alvocidib co-treated with gemcitabine] results in increased cleavage of PARP1 protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [gemcitabine results in increased cleavage of PARP1 protein]; SFN protein inhibits the reaction [gemcitabine results in increased cleavage of PARP1 protein]; YAP1 protein affects the reaction [gemcitabine results in increased cleavage of PARP1 protein] CTD PMID:15770523, PMID:17146438, PMID:26894857 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Parp2 poly (ADP-ribose) polymerase 2 decreases response to substance ISO PARP2 protein results in decreased susceptibility to gemcitabine CTD PMID:20798217 NCBI chr15:27,739,416...27,749,650
Ensembl chr15:27,739,251...27,749,648
JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 increases expression ISO gemcitabine results in increased expression of PCSK9 mRNA CTD PMID:17039268 NCBI chr 5:126,031,368...126,053,726
Ensembl chr 5:126,031,368...126,053,726
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 decreases response to substance ISO PDPK1 protein modified form results in decreased susceptibility to gemcitabine CTD PMID:16782806 NCBI chr10:13,446,373...13,525,248
Ensembl chr10:13,451,624...13,515,448
JBrowse link
G Pdzk1ip1 PDZK1 interacting protein 1 increases expression ISO gemcitabine results in increased expression of PDZK1IP1 mRNA CTD PMID:17039268 NCBI chr 5:133,895,849...133,900,720
Ensembl chr 5:133,896,141...133,900,726
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 multiple interactions ISO gemcitabine promotes the reaction [Curcumin results in decreased expression of PECAM1 protein] CTD PMID:17440100 NCBI chr10:94,850,971...94,913,202 JBrowse link
G Pgr progesterone receptor multiple interactions ISO gemcitabine binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pja2 praja ring finger ubiquitin ligase 2 increases expression ISO gemcitabine results in increased expression of PJA2 mRNA CTD PMID:17039268 NCBI chr 9:111,998,204...112,048,847
Ensembl chr 9:111,998,203...112,027,240
JBrowse link
G Plau plasminogen activator, urokinase increases expression ISO gemcitabine results in increased expression of PLAU mRNA CTD PMID:17039268 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
JBrowse link
G Plk1 polo-like kinase 1 decreases expression
affects response to substance
multiple interactions
ISO gemcitabine results in decreased expression of PLK1; gemcitabine results in decreased expression of PLK1 mRNA
PLK1 protein affects the susceptibility to gemcitabine
[gemcitabine results in decreased expression of PLK1] which results in increased susceptibility to gemcitabine; ON 01910 promotes the reaction [PLK1 protein affects the susceptibility to gemcitabine]
CTD PMID:20103597 NCBI chr 1:192,115,990...192,125,969
Ensembl chr 1:192,115,966...192,125,989
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha affects expression ISO gemcitabine affects the expression of PPARA mRNA CTD PMID:19427843 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta affects expression ISO gemcitabine affects the expression of PPARD mRNA CTD PMID:19427843 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects expression ISO gemcitabine affects the expression of PPARG mRNA CTD PMID:19427843 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppfia4 PTPRF interacting protein alpha 4 increases expression ISO gemcitabine results in increased expression of PPFIA4 mRNA CTD PMID:17039268 NCBI chr13:51,134,831...51,183,321
Ensembl chr13:51,134,525...51,183,269
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO gemcitabine results in increased expression of PPP1R15A mRNA CTD PMID:17039268 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
G Psat1 phosphoserine aminotransferase 1 increases expression ISO gemcitabine results in increased expression of PSAT1 mRNA CTD PMID:17039268 NCBI chr 1:233,124,089...233,145,941
Ensembl chr 1:233,124,092...233,145,941
JBrowse link
G Ptch1 patched 1 affects expression ISO gemcitabine affects the expression of PTCH1 mRNA CTD PMID:20103597 NCBI chr17:1,032,242...1,085,885
Ensembl chr17:1,029,048...1,093,873
JBrowse link
G Pten phosphatase and tensin homolog affects expression ISO gemcitabine affects the expression of PTEN mRNA CTD PMID:17039268 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression ISO gemcitabine results in decreased expression of PTGS1 mRNA CTD PMID:17039268 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Curcumin co-treated with gemcitabine] results in decreased expression of PTGS2 protein CTD PMID:17440100 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases response to substance ISO PTK2 protein results in decreased susceptibility to gemcitabine CTD PMID:14623342 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 affects expression ISO gemcitabine affects the expression of PTPN11 mRNA CTD PMID:17039268 NCBI chr12:40,895,515...40,955,999
Ensembl chr12:40,895,515...40,955,999
JBrowse link
G Rab8a RAB8A, member RAS oncogene family decreases expression ISO gemcitabine results in decreased expression of RAB8A mRNA CTD PMID:17039268 NCBI chr16:19,355,047...19,376,776
Ensembl chr16:19,355,048...19,376,776
JBrowse link
G Rbm17 RNA binding motif protein 17 decreases response to substance ISO RBM17 protein results in decreased susceptibility to gemcitabine CTD PMID:16061639 NCBI chr17:70,586,345...70,603,289
Ensembl chr17:70,586,394...70,603,267
JBrowse link
G Reg3b regenerating family member 3 beta decreases expression ISO gemcitabine results in decreased expression of REG3A mRNA CTD PMID:16570353 NCBI chr 4:109,467,272...109,470,510
Ensembl chr 4:109,467,272...109,470,510
JBrowse link
G Rel REL proto-oncogene, NF-kB subunit multiple interactions
decreases expression
ISO sulforafan promotes the reaction [gemcitabine results in decreased expression of REL protein] CTD PMID:20940707 NCBI chr14:108,490,794...108,517,582
Ensembl chr14:108,491,069...108,509,892
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases phosphorylation
increases expression
ISO [gemcitabine co-treated with Doxorubicin co-treated with Paclitaxel] affects the localization of RELA protein; [gemcitabine co-treated with Doxorubicin co-treated with Paclitaxel] results in increased expression of RELA protein; licoricidin inhibits the reaction [gemcitabine results in increased phosphorylation of RELA protein]; Mastic Resin inhibits the reaction [gemcitabine results in increased expression of RELA protein]
[Curcumin co-treated with gemcitabine] results in decreased expression of RELA protein
CTD PMID:17039268, PMID:17440100, PMID:20523344, PMID:29782821 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rgs2 regulator of G-protein signaling 2 increases expression ISO gemcitabine results in increased expression of RGS2 mRNA CTD PMID:17039268 NCBI chr13:60,846,458...60,849,061
Ensembl chr13:60,846,308...60,849,094
JBrowse link
G Rnf149 ring finger protein 149 increases expression ISO gemcitabine results in increased expression of RNF149 mRNA CTD PMID:17039268 NCBI chr 9:46,285,546...46,309,692
Ensembl chr 9:46,286,657...46,309,451
JBrowse link
G Rragd Ras-related GTP binding D increases expression ISO gemcitabine results in increased expression of RRAGD mRNA CTD PMID:17039268 NCBI chr 5:48,224,994...48,260,691
Ensembl chr 5:48,224,994...48,260,685
JBrowse link
G Rrm1 ribonucleotide reductase catalytic subunit M1 multiple interactions
affects response to substance
ISO [gemcitabine results in decreased susceptibility to gemcitabine] which results in increased expression of RRM1 mRNA; [gemcitabine results in decreased susceptibility to gemcitabine] which results in increased expression of RRM1 protein
RRM1 protein affects the susceptibility to gemcitabine
CTD PMID:25189999, PMID:26894857 NCBI chr 1:167,538,387...167,562,688
Ensembl chr 1:167,538,263...167,562,688
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 multiple interactions
affects response to substance
decreases response to substance
ISO [gemcitabine results in decreased susceptibility to gemcitabine] which results in increased expression of RRM2 protein
RRM2 protein affects the susceptibility to gemcitabine
RRM2 protein results in decreased susceptibility to gemcitabine
CTD PMID:14661056, PMID:25189999, PMID:26894857 NCBI chr 6:43,884,627...43,890,818
Ensembl chr 6:43,884,678...43,889,515
JBrowse link
G Rsl24d1 ribosomal L24 domain containing 1 increases expression ISO gemcitabine results in increased expression of RSL24D1 mRNA CTD PMID:17039268 NCBI chr 8:79,792,587...79,801,592
Ensembl chr 8:79,792,587...79,801,594
JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 increases expression ISO gemcitabine results in increased expression of SAT1 mRNA CTD PMID:17039268 NCBI chr  X:43,626,480...43,629,767
Ensembl chr  X:43,625,169...43,629,765
JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO gemcitabine results in increased expression of SCD mRNA CTD PMID:17039268 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Sfn stratifin multiple interactions
affects response to substance
decreases response to substance
increases methylation
ISO [DNMT1 protein binds to SFN promoter] inhibits the reaction [gemcitabine results in decreased susceptibility to gemcitabine]; [gemcitabine results in decreased susceptibility to gemcitabine] inhibits the reaction [DNMT1 protein binds to SFN promoter]; [gemcitabine results in decreased susceptibility to gemcitabine] which results in decreased methylation of SFN gene; [gemcitabine results in decreased susceptibility to gemcitabine] which results in increased expression of SFN mRNA; [gemcitabine results in decreased susceptibility to gemcitabine] which results in increased expression of SFN protein; [UHRF1 protein promotes the reaction [DNMT1 protein binds to SFN promoter]] inhibits the reaction [gemcitabine results in decreased susceptibility to gemcitabine]; SFN protein affects the reaction [YAP1 protein promotes the reaction [SFN protein results in decreased susceptibility to gemcitabine]]; SFN protein inhibits the reaction [gemcitabine results in increased activity of and results in increased cleavage of CASP8 protein]; SFN protein inhibits the reaction [gemcitabine results in increased cleavage of PARP1 protein]; SFN protein promotes the reaction [gemcitabine results in decreased susceptibility to gemcitabine]; YAP1 protein promotes the reaction [SFN protein results in decreased susceptibility to gemcitabine]
SFN protein affects the susceptibility to gemcitabine
gemcitabine results in increased methylation of SFN gene
CTD PMID:25189999, PMID:26894857 NCBI chr 5:151,823,422...151,824,937
Ensembl chr 5:151,823,887...151,824,633
JBrowse link
G Shh sonic hedgehog signaling molecule decreases expression ISO gemcitabine results in decreased expression of SHH mRNA CTD PMID:20103597 NCBI chr 4:718,538...727,691
Ensembl chr 4:718,538...727,691
JBrowse link
G Slc25a29 solute carrier family 25 member 29 increases expression ISO gemcitabine results in increased expression of SLC25A29 mRNA CTD PMID:17039268 NCBI chr 6:132,736,964...132,747,912
Ensembl chr 6:132,735,883...132,747,828
JBrowse link
G Slc28a1 solute carrier family 28 member 1 multiple interactions ISO
EXP
gemcitabine inhibits the reaction [SLC28A1 protein results in increased transport of Uridine]
gemcitabine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]
CTD PMID:8713072, PMID:10772724 NCBI chr 1:142,948,942...142,992,410
Ensembl chr 1:142,950,540...142,992,615
JBrowse link
G Slc29a1 solute carrier family 29 member 1 increases response to substance
decreases response to substance
increases uptake
affects response to substance
multiple interactions
ISO SLC29A1 mRNA results in increased susceptibility to gemcitabine; SLC29A1 protein results in increased susceptibility to gemcitabine
SLC29A1 protein results in decreased susceptibility to gemcitabine
SLC29A1 protein results in increased uptake of gemcitabine
SLC29A1 protein affects the susceptibility to gemcitabine
4-nitrobenzylthioinosine inhibits the reaction [SLC29A1 protein results in increased uptake of gemcitabine]; [S 1 (combination) results in increased expression of SLC29A1 mRNA] which results in increased uptake of gemcitabine; Fluorouracil promotes the reaction [SLC29A1 protein results in increased uptake of gemcitabine]
CTD PMID:15501974, PMID:16868479, PMID:17695509, PMID:18383843, PMID:18452103, PMID:18490900, PMID:18728667, PMID:18992248, PMID:26894857 NCBI chr 9:17,784,468...17,799,008
Ensembl chr 9:17,784,468...17,799,005
JBrowse link
G Slc29a3 solute carrier family 29 member 3 affects transport ISO SLC29A3 protein affects the transport of gemcitabine CTD PMID:19164483 NCBI chr20:30,289,527...30,327,343
Ensembl chr20:30,287,424...30,327,361
JBrowse link
G Slc2a3 solute carrier family 2 member 3 increases expression ISO gemcitabine results in increased expression of SLC2A3 mRNA CTD PMID:17039268 NCBI chr 4:155,549,991...155,626,018
Ensembl chr 4:155,408,233...155,631,856
JBrowse link
G Slc43a3 solute carrier family 43, member 3 decreases expression ISO gemcitabine results in decreased expression of SLC43A3 mRNA CTD PMID:17039268 NCBI chr 3:72,328,912...72,351,039
Ensembl chr 3:72,329,967...72,351,111
JBrowse link
G Slitrk2 SLIT and NTRK-like family, member 2 increases expression ISO gemcitabine results in increased expression of SLITRK2 mRNA CTD PMID:17039268 NCBI chr  X:151,099,388...151,111,816
Ensembl chr  X:151,103,576...151,107,016
JBrowse link
G Smg1 SMG1, nonsense mediated mRNA decay associated PI3K related kinase multiple interactions
decreases response to substance
ISO SMG1 protein inhibits the reaction [gemcitabine results in increased activity of CASP3 protein]; SMG1 protein inhibits the reaction [gemcitabine results in increased activity of CASP9 protein]
SMG1 protein results in decreased susceptibility to gemcitabine
CTD PMID:21418860 NCBI chr 1:187,781,577...187,882,833
Ensembl chr 1:187,784,270...187,883,157
JBrowse link
G Smo smoothened, frizzled class receptor increases expression ISO gemcitabine results in increased expression of SMO mRNA CTD PMID:25605917 NCBI chr 4:57,019,941...57,041,779
Ensembl chr 4:57,019,941...57,042,770
JBrowse link
G Sox2 SRY-box transcription factor 2 increases expression ISO gemcitabine results in increased expression of SOX2 mRNA CTD PMID:25605917 NCBI chr 2:121,165,137...121,167,545
Ensembl chr 2:121,165,137...121,167,545
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO gemcitabine results in increased expression of SPP1 mRNA CTD PMID:17039268 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions
decreases response to substance
affects response to substance
ISO [AG 1879 co-treated with SRC] results in increased susceptibility to gemcitabine
SRC protein modified form results in decreased susceptibility to gemcitabine; SRC protein results in decreased susceptibility to gemcitabine
SRC protein affects the susceptibility to gemcitabine
CTD PMID:15073106, PMID:15194078 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases activity ISO gemcitabine results in decreased activity of STAT3 protein CTD PMID:22348037 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Syncrip synaptotagmin binding, cytoplasmic RNA interacting protein decreases expression ISO gemcitabine results in decreased expression of SYNCRIP mRNA CTD PMID:17039268 NCBI chr 8:96,100,692...96,266,342
Ensembl chr 8:96,105,025...96,266,342
JBrowse link
G Szrd1 SUZ RNA binding domain containing 1 decreases expression ISO gemcitabine results in decreased expression of SZRD1 mRNA CTD PMID:17039268 NCBI chr 5:159,638,259...159,662,790
Ensembl chr 5:159,638,259...159,662,754
JBrowse link
G Tceal9 transcription elongation factor A like 9 increases expression ISO gemcitabine results in increased expression of TCEAL9 mRNA CTD PMID:17039268 NCBI chr  X:106,791,333...106,794,667
Ensembl chr  X:106,791,333...106,794,657
JBrowse link
G Tcof1 treacle ribosome biogenesis factor 1 decreases expression ISO gemcitabine results in decreased expression of TCOF1 mRNA CTD PMID:17039268 NCBI chr18:56,081,863...56,115,719
Ensembl chr18:56,082,195...56,115,593
JBrowse link
G Tert telomerase reverse transcriptase multiple interactions
decreases activity
ISO [Fluorouracil co-treated with gemcitabine] results in decreased activity of TERT protein
gemcitabine results in decreased activity of TERT protein
CTD PMID:16929163 NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476
JBrowse link
G Tfap2a transcription factor AP-2 alpha multiple interactions
increases response to substance
ISO [TFAP2A protein co-treated with TP53 gene mutant form] results in decreased susceptibility to gemcitabine
TFAP2A protein results in increased susceptibility to gemcitabine
CTD PMID:21489314 NCBI chr17:24,653,342...24,670,457
Ensembl chr17:24,654,902...24,670,457
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases response to substance
multiple interactions
ISO TGFB1 results in decreased susceptibility to gemcitabine
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]]; EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]; Erlotinib Hydrochloride inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]]; pyrazolanthrone inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]]; U 0126 inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]]
CTD PMID:21613822 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression ISO gemcitabine results in increased expression of TGFB2 mRNA CTD PMID:17039268 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Thpo thrombopoietin increases expression ISO gemcitabine results in increased expression of THPO protein CTD PMID:20531411 NCBI chr11:82,845,676...82,853,439
Ensembl chr11:83,868,655...83,873,910
Ensembl chr11:83,868,655...83,873,910
JBrowse link
G Tnf tumor necrosis factor increases expression
affects expression
ISO gemcitabine results in increased expression of TNF protein
gemcitabine affects the expression of TNF mRNA
CTD PMID:17039268, PMID:20531411 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 increases expression ISO gemcitabine results in increased expression of TNFAIP3 mRNA CTD PMID:17039268 NCBI chr 1:14,401,103...14,416,369
Ensembl chr 1:14,402,913...14,412,807
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases expression ISO gemcitabine results in increased expression of TNFRSF11B mRNA CTD PMID:17039268 NCBI chr 7:93,798,580...93,826,586
Ensembl chr 7:93,798,545...93,826,665
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [TNFSF10 co-treated with gemcitabine] affects the localization of BAX protein; [TNFSF10 co-treated with gemcitabine] results in increased activity of CASP8 protein CTD PMID:17671697 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tnfsf8 TNF superfamily member 8 multiple interactions ISO [gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of TNFSF8 protein CTD PMID:24979617 NCBI chr 5:79,664,779...79,691,547
Ensembl chr 5:79,664,765...79,691,258
JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
ISO gemcitabine results in increased expression of TP53 protein
[TFAP2A protein co-treated with TP53 gene mutant form] results in decreased susceptibility to gemcitabine; Nicotine inhibits the reaction [gemcitabine results in increased expression of TP53 protein]
CTD PMID:12082016, PMID:16601104, PMID:17671697, PMID:21489314 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 increases expression ISO gemcitabine results in increased expression of TP53BP1 mRNA CTD PMID:17039268 NCBI chr 3:113,160,030...113,259,701
Ensembl chr 3:113,160,000...113,231,790
JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 increases expression ISO gemcitabine results in increased expression of TP53INP1 mRNA CTD PMID:16570353, PMID:17039268 NCBI chr 5:24,402,895...24,419,651
Ensembl chr 5:24,410,863...24,416,888
JBrowse link
G Traf1 TNF receptor-associated factor 1 affects expression ISO gemcitabine affects the expression of TRAF1 mRNA CTD PMID:17039268 NCBI chr 3:14,003,340...14,022,955
Ensembl chr 3:14,003,340...14,022,672
JBrowse link
G Tube1 tubulin, epsilon 1 increases expression ISO gemcitabine results in increased expression of TUBE1 mRNA CTD PMID:17039268 NCBI chr20:44,220,823...44,238,830
Ensembl chr20:44,220,840...44,238,830
JBrowse link
G Tymp thymidine phosphorylase affects response to substance
multiple interactions
ISO TYMP protein affects the susceptibility to gemcitabine
[TYMP protein co-treated with DPYD protein] affects the susceptibility to gemcitabine; TYMP protein affects the susceptibility to [gemcitabine co-treated with Mitomycin]
CTD PMID:18728667 NCBI chr 7:130,342,481...130,347,845
Ensembl chr 7:130,342,483...130,347,587
JBrowse link
G Tyrp1 tyrosinase-related protein 1 affects expression ISO gemcitabine affects the expression of TYRP1 mRNA CTD PMID:17039268 NCBI chr 5:98,387,291...98,406,083
Ensembl chr 5:98,387,291...98,406,083
JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C decreases expression ISO gemcitabine results in decreased expression of UBE2C mRNA CTD PMID:17039268 NCBI chr 3:161,236,971...161,239,371
Ensembl chr 3:161,236,898...161,241,159
JBrowse link
G Uggt2 UDP-glucose glycoprotein glucosyltransferase 2 increases expression ISO gemcitabine results in increased expression of UGGT2 mRNA CTD PMID:17039268 NCBI chr15:104,235,678...104,405,308 JBrowse link
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 multiple interactions ISO [gemcitabine results in decreased susceptibility to gemcitabine] which results in decreased expression of UHRF1 protein; [UHRF1 protein promotes the reaction [DNMT1 protein binds to SFN promoter]] inhibits the reaction [gemcitabine results in decreased susceptibility to gemcitabine]; UHRF1 protein inhibits the reaction [gemcitabine results in decreased susceptibility to gemcitabine] CTD PMID:25189999 NCBI chr 9:10,738,211...10,758,403
Ensembl chr 9:10,738,222...10,757,954
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression ISO gemcitabine results in decreased expression of VCAM1 protein CTD PMID:20531411 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
multiple interactions
ISO gemcitabine results in increased expression of VEGFA mRNA
[Curcumin co-treated with gemcitabine] results in decreased expression of VEGFA protein
CTD PMID:17039268, PMID:17440100 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vgf VGF nerve growth factor inducible decreases expression ISO gemcitabine results in decreased expression of VGF mRNA CTD PMID:17039268 NCBI chr12:22,677,302...22,680,630
Ensembl chr12:22,677,607...22,680,630
JBrowse link
G Vldlr very low density lipoprotein receptor increases expression ISO gemcitabine results in increased expression of VLDLR mRNA CTD PMID:17039268 NCBI chr 1:245,236,819...245,273,688
Ensembl chr 1:245,237,736...245,269,205
JBrowse link
G Vmp1 vacuole membrane protein 1 increases expression ISO gemcitabine results in increased expression of VMP1 CTD PMID:20299819 NCBI chr10:73,901,988...74,001,900
Ensembl chr10:73,902,837...74,001,895
JBrowse link
G Vwf von Willebrand factor decreases expression ISO gemcitabine results in decreased expression of VWF protein CTD PMID:20531411 NCBI chr 4:158,085,059...158,219,525
Ensembl chr 4:158,088,505...158,219,523
JBrowse link
G Wnt5a Wnt family member 5A decreases expression ISO gemcitabine results in decreased expression of WNT5A mRNA CTD PMID:17039268 NCBI chr16:4,469,451...4,490,271
Ensembl chr16:4,469,468...4,489,860
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO gemcitabine promotes the reaction [1-(2,3-dichlorobenzoyl)-5-methoxy-2-methyl-(2-(mopholin-4-yl)ethyl)-1H-indole results in increased expression of XBP1 mRNA]; gemcitabine promotes the reaction [arachidonylcyclopropylamide results in increased expression of XBP1 mRNA]; gemcitabine promotes the reaction [rimonabant results in increased expression of XBP1 mRNA] CTD PMID:21525939 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
G Xiap X-linked inhibitor of apoptosis affects response to substance ISO XIAP affects the susceptibility to gemcitabine CTD PMID:16628085 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link
G Yap1 Yes1 associated transcriptional regulator multiple interactions
affects response to substance
ISO SFN protein affects the reaction [YAP1 protein promotes the reaction [SFN protein results in decreased susceptibility to gemcitabine]]; YAP1 protein affects the reaction [gemcitabine results in increased activity of and results in increased cleavage of CASP8 protein]; YAP1 protein affects the reaction [gemcitabine results in increased cleavage of PARP1 protein]; YAP1 protein promotes the reaction [SFN protein results in decreased susceptibility to gemcitabine]
YAP1 protein affects the susceptibility to gemcitabine
CTD PMID:26894857 NCBI chr 8:6,133,014...6,204,240
Ensembl chr 8:6,135,493...6,203,579
JBrowse link
G Zfp110 zinc finger protein 110 increases expression ISO gemcitabine results in increased expression of ZNF274 mRNA CTD PMID:17039268 NCBI chr 1:65,741,769...65,757,709
Ensembl chr 1:65,742,089...65,756,528
JBrowse link
G Zfp449 zinc finger protein 449 increases expression ISO gemcitabine results in increased expression of ZNF449 mRNA CTD PMID:17039268 NCBI chr  X:73,390,885...73,413,939
Ensembl chr  X:73,390,903...73,413,931
JBrowse link
G Zfp521 zinc finger protein 521 decreases expression ISO gemcitabine results in decreased expression of ZNF521 mRNA CTD PMID:17039268 NCBI chr18:5,022,042...5,315,242
Ensembl chr18:5,032,029...5,314,585
JBrowse link
thymidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle increases expression
multiple interactions
ISO Thymidine results in increased expression of ACTA2 mRNA
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Thymidine results in increased expression of ACTA2 mRNA]
CTD PMID:31170432 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Alpi alkaline phosphatase, intestinal multiple interactions ISO Thymidine promotes the reaction [Methotrexate results in increased activity of ALPI protein] CTD PMID:16598758 NCBI chr 9:94,197,616...94,201,910
Ensembl chr 9:94,197,618...94,201,084
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Thymidine inhibits the reaction [Adenosine results in increased localization of BAX protein] CTD PMID:11570579 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Thymidine inhibits the reaction [Adenosine results in increased activity of CASP3 protein]
Thymidine results in increased activity of CASP3 protein
CTD PMID:11570579, PMID:16419169 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Thymidine inhibits the reaction [Adenosine results in increased activity of CASP9 protein] CTD PMID:11570579 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Csf1 colony stimulating factor 1 increases uptake ISO CSF1 protein results in increased uptake of Thymidine CTD PMID:8193360 NCBI chr 2:210,522,370...210,550,546
Ensembl chr 2:210,522,375...210,550,560
JBrowse link
G Csf2 colony stimulating factor 2 increases uptake ISO CSF2 protein results in increased uptake of Thymidine CTD PMID:8193360 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Edn1 endothelin 1 increases uptake ISO EDN1 protein results in increased uptake of Thymidine CTD PMID:10100047 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Faslg Fas ligand increases expression ISO Thymidine results in increased expression of FASLG protein CTD PMID:16419169 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO [Thymidine co-treated with TYMP co-treated with Oxygen deficiency] results in increased expression of HIF1A protein CTD PMID:15841086 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [Thymidine co-treated with TYMP protein] results in increased expression of HMOX1 protein; [TYMP protein co-treated with Thymidine] results in increased expression of HMOX1 protein; Acetylcysteine inhibits the reaction [[TYMP protein co-treated with Thymidine] results in increased expression of HMOX1 protein]; Thymine inhibits the reaction [[TYMP protein co-treated with Thymidine] results in increased expression of HMOX1 protein] CTD PMID:11103787, PMID:15841086 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Igf1 insulin-like growth factor 1 decreases uptake
multiple interactions
ISO IGF1 protein results in decreased uptake of Thymidine
[Tetrachlorodibenzodioxin co-treated with Estradiol] inhibits the reaction [IGF1 protein results in increased uptake of Thymidine]; Tetrachlorodibenzodioxin inhibits the reaction [IGF1 protein results in decreased uptake of Thymidine]
CTD PMID:1332906 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO [Thymidine co-treated with TYMP protein] results in increased expression of MMP1 protein; Thymine inhibits the reaction [[Thymidine co-treated with TYMP protein] results in increased expression of MMP1 protein] CTD PMID:11103787 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase multiple interactions ISO [Thymidine co-treated with Hypoxanthine co-treated with 5,6,7,8-tetrahydrofolic acid] inhibits the reaction [Methotrexate results in decreased expression of MTR protein]; [Thymidine co-treated with Hypoxanthine] inhibits the reaction [Methotrexate results in decreased expression of MTR protein] CTD PMID:16598758 NCBI chr17:66,210,444...66,295,014
Ensembl chr17:66,210,461...66,295,014
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO Thymidine inhibits the reaction [Adenosine results in decreased expression of MYC protein] CTD PMID:9808420 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Slc28a1 solute carrier family 28 member 1 multiple interactions ISO Thymidine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine] CTD PMID:9124315 NCBI chr 1:142,948,942...142,992,410
Ensembl chr 1:142,950,540...142,992,615
JBrowse link
G Slc29a1 solute carrier family 29 member 1 multiple interactions ISO
EXP
Thymidine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine] CTD PMID:9353301, PMID:11085929 NCBI chr 9:17,784,468...17,799,008
Ensembl chr 9:17,784,468...17,799,005
JBrowse link
G Slc29a2 solute carrier family 29 member 2 multiple interactions ISO Thymidine inhibits the reaction [SLC29A2 protein results in increased uptake of Uridine] CTD PMID:11085929 NCBI chr 1:220,306,622...220,314,631
Ensembl chr 1:220,400,855...220,407,189
Ensembl chr 1:220,400,855...220,407,189
JBrowse link
G Tymp thymidine phosphorylase multiple interactions
increases phosphorylation
ISO [Thymidine co-treated with TYMP co-treated with Oxygen deficiency] results in increased expression of HIF1A protein; [Thymidine co-treated with TYMP protein] results in increased expression of HMOX1 protein; [Thymidine co-treated with TYMP protein] results in increased expression of MMP1 protein; [Thymidine co-treated with TYMP protein] results in increased secretion of CXCL8 protein; [TYMP protein co-treated with Thymidine] results in increased expression of HMOX1 protein; Acetylcysteine inhibits the reaction [[TYMP protein co-treated with Thymidine] results in increased expression of HMOX1 protein]; Thymine inhibits the reaction [[Thymidine co-treated with TYMP protein] results in increased expression of MMP1 protein]; Thymine inhibits the reaction [[Thymidine co-treated with TYMP protein] results in increased secretion of CXCL8 protein]; Thymine inhibits the reaction [[TYMP protein co-treated with Thymidine] results in increased expression of HMOX1 protein]
TYMP protein results in increased phosphorylation of Thymidine
CTD PMID:11103787, PMID:15841086 NCBI chr 7:130,342,481...130,347,845
Ensembl chr 7:130,342,483...130,347,587
JBrowse link
G Tyms thymidylate synthetase multiple interactions ISO Thymidine inhibits the reaction [Fluorouracil results in decreased expression of TYMS] CTD PMID:9050858 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link
trifluridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO CA 074 methyl ester inhibits the reaction [Trifluridine results in increased cleavage of CASP3 protein]; Trifluridine results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:19816940 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases cleavage ISO Trifluridine results in increased cleavage of CASP8 protein CTD PMID:19816940 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases cleavage ISO Trifluridine results in increased cleavage of CASP9 protein CTD PMID:19816940 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ctsb cathepsin B increases cleavage
multiple interactions
ISO Trifluridine results in increased cleavage of CTSB protein
CA 074 methyl ester inhibits the reaction [Trifluridine results in increased cleavage of CTSB protein]
CTD PMID:19816940 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO Trifluridine inhibits the reaction [Estradiol results in increased activity of ESR2 protein] CTD PMID:30818834 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions ISO Trifluridine inhibits the reaction [XCT790 results in decreased activity of ESRRA protein] CTD PMID:30818834 NCBI chr 1:222,168,729...222,178,842
Ensembl chr 1:222,168,730...222,178,725
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases activity ISO Trifluridine results in increased activity of NFE2L2 protein CTD PMID:30818834 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
ISO Trifluridine results in increased activity of NR1I2 protein
[Trifluridine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD PMID:25455453 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO Trifluridine inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased activity of NR1I3 protein] CTD PMID:30818834 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Trifluridine results in increased cleavage of PARP1 protein CTD PMID:19816940 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    chemical entity 19769
      atom 19768
        nonmetal atom 19642
          nitrogen atom 18532
            nitrogen molecular entity 18532
              nucleobase-containing molecular entity 5183
                nucleoside 5183
                  deoxyribonucleoside 2711
                    2'-deoxyribonucleoside 2195
                      pyrimidine 2'-deoxyribonucleoside 334
                        (beta-D-glucopyranosyloxymethyl)deoxyuridine + 0
                        1-(2-deoxy-beta-L-ribofuranosyl)cytosine 0
                        1-[(2R,5R)-4-hydroxy-5-(hydroxymethyl)-2-oxolanyl]-5-iodopyrimidine-2,4-dione 0
                        1-[(4S,5R)-4-hydroxy-5-(hydroxymethyl)-2-oxolanyl]-5-(trifluoromethyl)pyrimidine-2,4-dione 0
                        1-\{2-deoxy-3,5-O-[phenyl(phosphono)methylidene]-beta-L-threo-pentofuranosyl\}thymine 0
                        2',2'-difluoro-2'-deoxyuridine 0
                        2'-deoxy-5-(4,5-dihydroxypentyl)uridine 0
                        2'-deoxycytidine + 3
                        2'-deoxyuridine + 0
                        4-amino-1-[3,3-difluoro-4-hydroxy-5-(hydroxymethyl)-2-oxolanyl]-2-pyrimidinone 0
                        5,6-dihydrothymidine 0
                        5,6-dihydroxy-2'-deoxyuridine 0
                        5-(2-aminoethoxy)methyl-2'-deoxyuridine 0
                        5-(2-aminoethyl)-2'-deoxyuridine 0
                        5-bromo-2'-deoxyuridine 36
                        5-carboxy-2'-deoxyuridine 0
                        5-fluoro-1-[4-hydroxy-5-(hydroxymethyl)-2-oxolanyl]pyrimidine-2,4-dione 0
                        5-hydroxymethyl-2'-deoxyuridine + 0
                        5-iodo-2'-deoxyuridine 4
                        CNDAC + 0
                        N(4)-acetyl-2'-deoxycytidine 0
                        clevudine 0
                        edoxudine 0
                        epervudine 0
                        floxuridine 16
                        gemcitabine + 272
                        ibacitabine 0
                        telbivudine 0
                        thymidine + 23
                        trifluridine + 10
                        tritiated thymidine + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19655
                    p-block element atom 19655
                      carbon group element atom 19550
                        carbon atom 19539
                          organic molecular entity 19539
                            heteroorganic entity 19142
                              organochalcogen compound 18851
                                organooxygen compound 18772
                                  carbohydrates and carbohydrate derivatives 12172
                                    carbohydrate 12172
                                      carbohydrate derivative 11794
                                        glycosyl compound 10835
                                          N-glycosyl compound 5320
                                            nucleoside 5183
                                              deoxyribonucleoside 2711
                                                2'-deoxyribonucleoside 2195
                                                  pyrimidine 2'-deoxyribonucleoside 334
                                                    (beta-D-glucopyranosyloxymethyl)deoxyuridine + 0
                                                    1-(2-deoxy-beta-L-ribofuranosyl)cytosine 0
                                                    1-[(2R,5R)-4-hydroxy-5-(hydroxymethyl)-2-oxolanyl]-5-iodopyrimidine-2,4-dione 0
                                                    1-[(4S,5R)-4-hydroxy-5-(hydroxymethyl)-2-oxolanyl]-5-(trifluoromethyl)pyrimidine-2,4-dione 0
                                                    1-\{2-deoxy-3,5-O-[phenyl(phosphono)methylidene]-beta-L-threo-pentofuranosyl\}thymine 0
                                                    2',2'-difluoro-2'-deoxyuridine 0
                                                    2'-deoxy-5-(4,5-dihydroxypentyl)uridine 0
                                                    2'-deoxycytidine + 3
                                                    2'-deoxyuridine + 0
                                                    4-amino-1-[3,3-difluoro-4-hydroxy-5-(hydroxymethyl)-2-oxolanyl]-2-pyrimidinone 0
                                                    5,6-dihydrothymidine 0
                                                    5,6-dihydroxy-2'-deoxyuridine 0
                                                    5-(2-aminoethoxy)methyl-2'-deoxyuridine 0
                                                    5-(2-aminoethyl)-2'-deoxyuridine 0
                                                    5-bromo-2'-deoxyuridine 36
                                                    5-carboxy-2'-deoxyuridine 0
                                                    5-fluoro-1-[4-hydroxy-5-(hydroxymethyl)-2-oxolanyl]pyrimidine-2,4-dione 0
                                                    5-hydroxymethyl-2'-deoxyuridine + 0
                                                    5-iodo-2'-deoxyuridine 4
                                                    CNDAC + 0
                                                    N(4)-acetyl-2'-deoxycytidine 0
                                                    clevudine 0
                                                    edoxudine 0
                                                    epervudine 0
                                                    floxuridine 16
                                                    gemcitabine + 272
                                                    ibacitabine 0
                                                    telbivudine 0
                                                    thymidine + 23
                                                    trifluridine + 10
                                                    tritiated thymidine + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.