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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:alpha-methyltryptamine
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Accession:CHEBI:59020 term browser browse the term
Definition:A tryptamine derivative having a methyl substituent at the alpha-position.
Synonyms:exact_synonym: 1-(1H-indol-3-yl)propan-2-amine
 related_synonym: 1-(1H-Indol-3-yl)-2-propanamine;   3-(2-Aminopropyl)indole;   DL-3-(2-Aminopropyl)indole;   Formula=C11H14N2;   InChI=1S/C11H14N2/c1-8(12)6-9-7-13-11-5-3-2-4-10(9)11/h2-5,7-8,13H,6,12H2,1H3;   InChIKey=QSQQQURBVYWZKJ-UHFFFAOYSA-N;   Indopan;   SMILES=CC(N)Cc1c[nH]c2ccccc12;   alpha-Methyl-1H-indole-3-ethanamine;   alpha-Methyl-3-indoleethanamine;   alpha-Methyl-beta-indoleethylamine
 alt_id: CHEBI:144615
 xref: Beilstein:140457;   CAS:299-26-3;   DrugBank:DB01446
 xref_mesh: MESH:C015293


show annotations for term's descendants           Sort by:
alpha-methyltryptamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity		 ISO [indopan analog results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin; [indopan results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin
indopan analog results in decreased activity of CYP1A2 protein; indopan results in decreased activity of CYP1A2 protein		 CTD PMID:26599973 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
decreases activity		 ISO [indopan analog results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion; [indopan results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion
indopan analog results in decreased activity of CYP2B6 protein; indopan results in decreased activity of CYP2B6 protein		 CTD PMID:26599973 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity
multiple interactions		 ISO indopan results in decreased activity of CYP2C19 protein
[indopan results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole		 CTD PMID:26599973 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions
decreases activity		 ISO [indopan analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; [indopan results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan
indopan analog results in decreased activity of CYP2D6 protein; indopan results in decreased activity of CYP2D6 protein		 CTD PMID:26599973 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases activity		 ISO [indopan analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone; [indopan results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone
indopan analog results in decreased activity of CYP2E1 protein; indopan results in decreased activity of CYP2E1 protein		 CTD PMID:26599973 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Maoa monoamine oxidase A decreases activity ISO indopan results in decreased activity of MAOA protein CTD PMID:28302559 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19844
    chemical entity 19842
      atom 19842
        nonmetal atom 19780
          nitrogen atom 18958
            nitrogen molecular entity 18958
              organonitrogen compound 18808
                organonitrogen heterocyclic compound 18149
                  benzopyrrole 9735
                    indoles 9421
                      tryptamines 523
                        alpha-methyltryptamine 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19844
    subatomic particle 19842
      composite particle 19842
        hadron 19842
          baryon 19842
            nucleon 19809
              atomic nucleus 19842
                atom 19842
                  main group element atom 19792
                    p-block element atom 19792
                      carbon group element atom 19738
                        carbon atom 19734
                          organic molecular entity 19734
                            organic molecule 19687
                              organic cyclic compound 19498
                                organic heterocyclic compound 18870
                                  organic heteropolycyclic compound 18300
                                    organic heterobicyclic compound 17247
                                      benzopyrrole 9735
                                        indoles 9421
                                          tryptamines 523
                                            alpha-methyltryptamine 6
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