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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pamoic acid
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Accession:CHEBI:50186 term browser browse the term
Definition:A dicarboxylic acid that has formula C23H16O6.
Synonyms:exact_synonym: 4,4'-methylenebis(3-hydroxynaphthalene-2-carboxylic acid)
 related_synonym: 4,4'-Methylen-bis-(3-hydroxy-2-naphthoesaeure);   4,4'-Methylenebis(3-hydroxy-2-naphthoic acid);   Embonic acid;   Formula=C23H16O6;   InChI=1S/C23H16O6/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29/h1-10,24-25H,11H2,(H,26,27)(H,28,29);   InChIKey=WLJNZVDCPSBLRP-UHFFFAOYSA-N;   Pamosaeure;   SMILES=OC(=O)c1cc2ccccc2c(Cc2c(O)c(cc3ccccc23)C(O)=O)c1O
 xref: Beilstein:901319;   CAS:130-85-8
 xref_mesh: MESH:C004368
 cyclic_relationship: is_conjugate_acid_of CHEBI:50187


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pamoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb2 arrestin, beta 2 multiple interactions ISO pamoic acid promotes the reaction [ARRB2 protein binds to GPR35 protein] CTD PMID:20826425 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850 		JBrowse link
G Gpr35 G protein-coupled receptor 35 multiple interactions
affects localization		 ISO 2-hydroxy-4-(4-(5-(2-methyl-3-phenylprop-2-enylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl)butanoylamino)benzoic acid inhibits the reaction [pamoic acid affects the localization of GPR35 protein]; 2-hydroxy-4-(4-(5-(2-methyl-3-phenylprop-2-enylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl)butanoylamino)benzoic acid inhibits the reaction [pamoic acid binds to and results in increased activity of GPR35 protein]; methyl 5-((tert-butylcarbamothioylhydrazinylidene)methyl)-1-(2,4-difluorophenyl)pyrazole-4-carboxylate inhibits the reaction [pamoic acid affects the localization of GPR35 protein]; methyl 5-((tert-butylcarbamothioylhydrazinylidene)methyl)-1-(2,4-difluorophenyl)pyrazole-4-carboxylate inhibits the reaction [pamoic acid binds to and results in increased activity of GPR35 protein]; pamoic acid binds to and results in increased activity of GPR35 protein; pamoic acid promotes the reaction [ARRB2 protein binds to GPR35 protein] CTD PMID:20826425 PMID:20919992 PMID:22967846 NCBI chr 9:93,527,165...93,539,573
Ensembl chr 9:93,527,127...93,539,299 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO pamoic acid results in increased phosphorylation of and results in increased activity of MAPK1 protein; Pertussis Toxin inhibits the reaction [pamoic acid results in increased phosphorylation of and results in increased activity of MAPK1 protein]; U 0126 inhibits the reaction [pamoic acid results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:20826425 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO pamoic acid results in increased phosphorylation of and results in increased activity of MAPK3 protein; Pertussis Toxin inhibits the reaction [pamoic acid results in increased phosphorylation of and results in increased activity of MAPK3 protein]; U 0126 inhibits the reaction [pamoic acid results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:20826425 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        biochemical role 19496
          metabolite 19484
            xenobiotic metabolite 15444
              2-naphthoic acid 14
                pamoic acid 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            organic molecule 19655
                              organic cyclic compound 19468
                                carbocyclic compound 18559
                                  carbopolycyclic compound 17167
                                    carbobicyclic compound 5872
                                      naphthalenes 3837
                                        naphthoic acid 44
                                          2-naphthoic acid 14
                                            pamoic acid 4
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