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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:olomoucine
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Accession:CHEBI:44661 term browser browse the term
Definition:A 9H-purine that is substituted by a (2-hydroxyethyl)nitrilo, benzylnitrilo and a methyl group at positions 2,6 and 9, respectively. It is a cyclin-dependent kinase inhibitor.
Synonyms:exact_synonym: 2-{[6-(benzylamino)-9-methyl-9H-purin-2-yl]amino}ethanol
 related_synonym: 2-(2-hydroxyethylamino)-6-(benzylamino)-9-methylpurine;   2-(hydroxyethylamino)-6-benzylamino-9-methylpurine;   2-[[9-methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-ethanol;   2-{[6-(benzylamino)-9-methyl-9H-purin-2-yl]amino}ethan-1-ol;   Formula=C15H18N6O;   InChI=1S/C15H18N6O/c1-21-10-18-12-13(17-9-11-5-3-2-4-6-11)19-15(16-7-8-22)20-14(12)21/h2-6,10,22H,7-9H2,1H3,(H2,16,17,19,20);   InChIKey=GTVPOLSIJWJJNY-UHFFFAOYSA-N;   SMILES=CN1C=NC2=C1N=C(N=C2NCC3=CC=CC=C3)NCCO;   olomucine
 xref: CAS:101622-51-9;   DrugBank:DB02116;   FooDB:FDB013890;   HMDB:HMDB0035233;   LINCS:LSM-3857
 xref_mesh: MESH:C090046
 xref: MetaCyc:CPD-5442;   PDBeChem:OLO;   PMID:12147712;   PMID:17094472;   PMID:18385789;   PMID:19723061;   PMID:25422646;   PMID:27241721;   PMID:27345388;   PMID:7523194;   PMID:7549905;   PMID:7925396


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olomoucine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO olomoucine inhibits the reaction [TP53 protein promotes the reaction [Amifostine results in decreased phosphorylation of CDK1 protein]]; olomoucine inhibits the reaction [TP53 results in decreased phosphorylation of CDK1 protein] CTD PMID:16628227 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases activity
multiple interactions		 ISO
EXP		 olomoucine results in decreased activity of CDK2 protein
olomoucine inhibits the reaction [CDK2 protein results in increased phosphorylation of TPI1 protein]		 CTD PMID:12387751 PMID:15026556 PMID:20149834 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Rb1 RB transcriptional corepressor 1 increases expression ISO olomoucine results in increased expression of RB1 mRNA; olomoucine results in increased expression of RB1 protein CTD PMID:14653808 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Sp1 Sp1 transcription factor increases expression ISO olomoucine results in increased expression of SP1 mRNA; olomoucine results in increased expression of SP1 protein CTD PMID:14653808 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO olomoucine inhibits the reaction [TP53 protein promotes the reaction [Amifostine results in decreased phosphorylation of CDK1 protein]]; olomoucine inhibits the reaction [TP53 results in decreased phosphorylation of CDK1 protein] CTD PMID:16628227 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tpi1 triosephosphate isomerase 1 multiple interactions ISO olomoucine inhibits the reaction [CDK2 protein results in increased phosphorylation of TPI1 protein] CTD PMID:20149834 NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19868
      application 19714
        NMR chemical shift reference compound 18086
          ammonia 17885
            organic amino compound 17885
              amino alcohol 1078
                ethanolamines 829
                  olomoucine 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19771
                          organic molecular entity 19771
                            organic molecule 19724
                              organic cyclic compound 19515
                                organic heterocyclic compound 18890
                                  organic heteropolycyclic compound 18310
                                    organic heterobicyclic compound 17252
                                      imidazopyrimidine 7759
                                        purines 7758
                                          aminopurine 6727
                                            2,6-diaminopurines 39
                                              olomoucine 6
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