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gitoxigenin - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:gitoxigenin
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Accession:CHEBI:38105 term browser browse the term
Definition:A 16beta-hydroxy steroid that has formula C23H34O5.
Synonyms:exact_synonym: 3beta,14,16beta-trihydroxy-5beta-card-20(22)-enolide
 related_synonym: 16beta-Hydroxydigitoxigenin;   Formula=C23H34O5;   InChI=1S/C23H34O5/c1-21-7-5-15(24)10-14(21)3-4-17-16(21)6-8-22(2)20(13-9-19(26)28-12-13)18(25)11-23(17,22)27/h9,14-18,20,24-25,27H,3-8,10-12H2,1-2H3/t14-,15+,16+,17-,18+,20+,21+,22-,23+/m1/s1;   InChIKey=PVAMXWLZJKTXFW-VQMOFDJESA-N;   SMILES=[H][C@]12CC[C@]3([H])[C@]([H])(CC[C@]4(C)[C@]([H])([C@@H](O)C[C@]34O)C3=CC(=O)OC3)[C@@]1(C)CC[C@H](O)C2
 xref: Beilstein:96483;   CAS:545-26-6

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oleandrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO oleandrin results in increased activity of CASP3 protein CTD PMID:24172227 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases activity ISO oleandrin results in increased activity of CASP8 protein CTD PMID:24172227 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 increases expression ISO oleandrin results in increased expression of CXCR1 mRNA; oleandrin results in increased expression of CXCR1 protein CTD PMID:24172227 NCBI chr 9:83,216,040...83,220,225
Ensembl chr 9:75,766,770...75,771,084 		JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 increases expression ISO oleandrin results in increased expression of CXCR2 mRNA; oleandrin results in increased expression of CXCR2 protein CTD PMID:24172227 NCBI chr 9:83,178,645...83,185,017
Ensembl chr 9:75,729,115...75,739,425 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO oleandrin results in increased expression of CXCR4 mRNA CTD PMID:24172227 NCBI chr13:42,630,383...42,634,288
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20845
    chemical entity 20843
      molecular entity 20842
        polyatomic entity 20786
          heteroatomic molecular entity 20723
            hydroxides 20216
              organic hydroxy compound 19754
                hydroxy steroid 15113
                  16-hydroxy steroid 158
                    16beta-hydroxy steroid 9
                      gitoxigenin 5
                        (1R,5R,6S,11S,12R,14R)-22-[(1S)-1-Hydroxyethyl]-6,16-dimethyl-10,19-dioxa-16-azahexacyclo[12.5.3.15,9.01,14.02,11.06,11]tricosa-2,21-diene-9,12-diol 0
                        Abikoviromycin 0
                        Awajanomycin 0
                        Batrachotoxinin A 0
                        Kobutimycin A 0
                        Kobutimycin B 0
                        LSM-1903 0
                        Latumcidin 0
                        Nocarditriene 0
                        digitalin 0
                        gitoxigenin 3-acetate 0
                        gitoxin + 0
                        oleandrigenin + 5
                        strospeside 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20845
    subatomic particle 20843
      composite particle 20843
        hadron 20843
          baryon 20843
            nucleon 20843
              atomic nucleus 20843
                atom 20843
                  main group element atom 20766
                    p-block element atom 20766
                      carbon group element atom 20699
                        carbon atom 20693
                          organic molecular entity 20693
                            heteroorganic entity 20202
                              organochalcogen compound 19890
                                organooxygen compound 19792
                                  ester 17771
                                    carboxylic ester 17149
                                      lactone 13357
                                        steroid lactone 481
                                          cardanolide 49
                                            5beta-cardanolide 49
                                              gitoxigenin 5
                                                (1R,5R,6S,11S,12R,14R)-22-[(1S)-1-Hydroxyethyl]-6,16-dimethyl-10,19-dioxa-16-azahexacyclo[12.5.3.15,9.01,14.02,11.06,11]tricosa-2,21-diene-9,12-diol 0
                                                Abikoviromycin 0
                                                Awajanomycin 0
                                                Batrachotoxinin A 0
                                                Kobutimycin A 0
                                                Kobutimycin B 0
                                                LSM-1903 0
                                                Latumcidin 0
                                                Nocarditriene 0
                                                digitalin 0
                                                gitoxigenin 3-acetate 0
                                                gitoxin + 0
                                                oleandrigenin + 5
                                                strospeside 0
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