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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:oleandrigenin
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Accession:CHEBI:63508 term browser browse the term
Definition:A steroid ester that is the 16-acetyl derivative of gitoxigenin.
Synonyms:exact_synonym: (3beta,5beta,16beta)-16-acetoxy-3,14-dihydroxycard-20(22)-enolide
 related_synonym: 16-Acetylgitoxigenin;   16-O-acetylgitoxigenin;   16beta-acetoxy-3beta,14-dihydroxy-5beta,14beta-card-20(22)-enolide;   3beta,14,16beta-Trihydroxy-5-betacard-20(22)-enolide 16-acetate;   Formula=C25H36O6;   Gitoxigenin 16-acetate;   InChI=1S/C25H36O6/c1-14(26)31-20-12-25(29)19-5-4-16-11-17(27)6-8-23(16,2)18(19)7-9-24(25,3)22(20)15-10-21(28)30-13-15/h10,16-20,22,27,29H,4-9,11-13H2,1-3H3/t16-,17+,18+,19-,20+,22+,23+,24-,25+/m1/s1;   InChIKey=IWCNCUVTGOMGKG-YOVVEKLRSA-N;   Oleandrisenin;   SMILES=[H][C@]12CC[C@]3([H])[C@]([H])(CC[C@]4(C)[C@H]([C@H](C[C@]34O)OC(C)=O)C3=CC(=O)OC3)[C@@]1(C)CC[C@H](O)C2
 xref: CAS:465-15-6;   PMID:10952541;   PMID:12054363;   PMID:12416031;   PMID:19274509;   PMID:7739045;   PMID:8855150;   PMID:9263390;   Reaxys:98733



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oleandrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO oleandrin results in increased activity of CASP3 protein CTD PMID:24172227 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity ISO oleandrin results in increased activity of CASP8 protein CTD PMID:24172227 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 increases expression ISO oleandrin results in increased expression of CXCR1 mRNA; oleandrin results in increased expression of CXCR1 protein CTD PMID:24172227 NCBI chr 9:75,768,124...75,771,122
Ensembl chr 9:75,766,770...75,771,084
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 increases expression ISO oleandrin results in increased expression of CXCR2 mRNA; oleandrin results in increased expression of CXCR2 protein CTD PMID:24172227 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO oleandrin results in increased expression of CXCR4 mRNA CTD PMID:24172227 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      biological role 20007
        biochemical role 19640
          metabolite 19623
            oleandrigenin 5
              oleandrin 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic group 18961
                              organic divalent group 18947
                                organodiyl group 18947
                                  carbonyl group 18900
                                    carbonyl compound 18900
                                      carboxylic ester 15933
                                        lactone 11283
                                          steroid lactone 423
                                            cardanolide 49
                                              5beta-cardanolide 49
                                                gitoxigenin 5
                                                  oleandrigenin 5
                                                    oleandrin 5
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