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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cardanolide
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Accession:CHEBI:35543 term browser browse the term
Definition:A steroid fundamental parent that has formula C23H36O2.
Synonyms:related_synonym: Formula=C23H36O2;   InChI=1S/C23H36O2/c1-22-11-4-3-5-16(22)6-7-17-19-9-8-18(15-13-21(24)25-14-15)23(19,2)12-10-20(17)22/h15-20H,3-14H2,1-2H3/t15-,16?,17-,18+,19+,20-,22-,23+/m0/s1;   InChIKey=AQARKTASOBROAE-OCYOQFCJSA-N;   SMILES=[H][C@]1(COC(=O)C1)[C@@]1([H])CC[C@]2([H])[C@]3([H])CCC4CCCC[C@]4(C)[C@@]3([H])CC[C@]12C


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digitoxigenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Digitoxigenin results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Digitoxigenin results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO Digitoxigenin results in decreased expression of CCL5 protein CTD PMID:20116850 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Digitoxigenin results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Digitoxigenin results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
digitoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases transport
ISO Digitoxin inhibits the reaction [ABCB1 protein results in increased transport of quinidinium]
ABCB1 protein results in increased transport of Digitoxin
CTD PMID:23104431, PMID:26708294 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Ar androgen receptor multiple interactions ISO Digitoxin binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO Digitoxin analog results in decreased expression of BIRC5 protein; Digitoxin results in decreased expression of BIRC5 protein CTD PMID:22037315 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Casp3 caspase 3 decreases expression ISO Digitoxin analog results in decreased expression of CASP3 protein; Digitoxin results in decreased expression of CASP3 protein CTD PMID:22037315 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases cleavage ISO Digitoxin analog results in increased cleavage of CASP8 protein; Digitoxin results in increased cleavage of CASP8 protein CTD PMID:22037315 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases cleavage ISO Digitoxin analog results in increased cleavage of CASP9 protein; Digitoxin results in increased cleavage of CASP9 protein CTD PMID:22037315 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]]; Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein] CTD PMID:19446813 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccnb1 cyclin B1 multiple interactions
decreases expression
ISO Digitoxin analog results in decreased expression of [CCNB1 protein binds to CDK1 protein]; Digitoxin results in decreased expression of [CCNB1 protein binds to CDK1 protein]
Digitoxin analog results in decreased expression of CCNB1 protein; Digitoxin results in decreased expression of CCNB1 protein
CTD PMID:22037315 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression
multiple interactions
ISO Digitoxin analog results in decreased expression of CDK1 protein; Digitoxin results in decreased expression of CDK1 protein
Digitoxin analog results in decreased expression of [CCNB1 protein binds to CDK1 protein]; Digitoxin results in decreased expression of [CCNB1 protein binds to CDK1 protein]
CTD PMID:22037315 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO Digitoxin analog results in decreased expression of CDKN1A protein; Digitoxin results in decreased expression of CDKN1A protein CTD PMID:22037315 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression ISO Digitoxin analog results in decreased expression of CDKN1B protein; Digitoxin results in decreased expression of CDKN1B protein CTD PMID:22037315 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Chek1 checkpoint kinase 1 decreases expression ISO Digitoxin analog results in decreased expression of CHEK1 protein; Digitoxin results in decreased expression of CHEK1 protein CTD PMID:22037315 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Chek2 checkpoint kinase 2 decreases expression ISO Digitoxin analog results in decreased expression of CHEK2 protein; Digitoxin results in decreased expression of CHEK2 protein CTD PMID:22037315 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Cycs cytochrome c, somatic increases expression ISO Digitoxin analog results in increased expression of CYCS protein; Digitoxin results in increased expression of CYCS protein CTD PMID:22037315 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Digitoxin binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO Digitoxin binds to and results in decreased activity of ESR2 protein CTD PMID:25752796 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fancd2 FA complementation group D2 multiple interactions ISO Digitoxin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein] CTD PMID:24124520 NCBI chr 4:145,489,869...145,551,479
Ensembl chr 4:145,489,869...145,551,479
JBrowse link
G Fanci FA complementation group I multiple interactions ISO Digitoxin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCI protein] CTD PMID:24124520 NCBI chr 1:141,116,565...141,172,997
Ensembl chr 1:141,120,166...141,172,483
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]]; Digitoxin inhibits the reaction [IL1B protein results in increased activity of MAPK1 protein]; Digitoxin inhibits the reaction [IL1B protein results in increased activity of MAPK3 protein]; Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]; Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]; Digitoxin inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] CTD PMID:19446813 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Digitoxin inhibits the reaction [IL1B protein results in increased activity of MAPK1 protein] CTD PMID:19446813 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Digitoxin inhibits the reaction [IL1B protein results in increased activity of MAPK3 protein] CTD PMID:19446813 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]]; Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein] CTD PMID:19446813 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha decreases phosphorylation ISO Digitoxin results in decreased phosphorylation of NFKBIA protein CTD PMID:15136726 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
increases activity
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin results in increased activity of NOS3 protein]; Calcium deficiency inhibits the reaction [Digitoxin results in increased activity of NOS3 protein] CTD PMID:19446813 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Digitoxin binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Digitoxin binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO Digitoxin binds to and results in decreased activity of THRB protein CTD PMID:25752796 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
G Tp53 tumor protein p53 decreases expression ISO Digitoxin analog results in decreased expression of TP53 protein; Digitoxin results in decreased expression of TP53 protein CTD PMID:22037315 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Digitoxin inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] CTD PMID:19446813 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
digoxigenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport ISO ABCB1 protein results in increased transport of Digoxigenin CTD PMID:26708294 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Digoxigenin results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Digoxigenin results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions
increases expression
ISO Digoxigenin promotes the reaction [RORC protein binds to G6PC promoter]
Digoxigenin results in increased expression of G6PC mRNA
CTD PMID:29981919 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G Il17a interleukin 17A multiple interactions ISO Digoxigenin results in increased expression of and results in increased secretion of IL17A protein CTD PMID:29981919 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il17f interleukin 17F multiple interactions ISO Digoxigenin results in increased expression of and results in increased secretion of IL17F protein CTD PMID:29981919 NCBI chr 9:26,885,702...26,897,219
Ensembl chr 9:26,885,708...26,897,219
JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Digoxigenin results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628
JBrowse link
G Npas2 neuronal PAS domain protein 2 increases expression
multiple interactions
ISO Digoxigenin results in increased expression of NPAS2 mRNA
Digoxigenin promotes the reaction [RORC protein binds to NPAS2 promoter]
CTD PMID:29981919 NCBI chr 9:45,901,262...46,081,880
Ensembl chr 9:45,901,741...46,081,880
JBrowse link
G Rorc RAR-related orphan receptor C increases expression
multiple interactions
ISO Digoxigenin results in increased expression of RORC mRNA
Digoxigenin promotes the reaction [RORC protein binds to G6PC promoter]; Digoxigenin promotes the reaction [RORC protein binds to NPAS2 promoter]; RORC protein promotes the reaction [Digoxigenin results in increased expression of RORC mRNA]
CTD PMID:29981919 NCBI chr 2:195,612,471...195,636,797
Ensembl chr 2:195,617,021...195,637,630
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Digoxigenin results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
oleandrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO oleandrin results in increased activity of CASP3 protein CTD PMID:24172227 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity ISO oleandrin results in increased activity of CASP8 protein CTD PMID:24172227 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 increases expression ISO oleandrin results in increased expression of CXCR1 mRNA; oleandrin results in increased expression of CXCR1 protein CTD PMID:24172227 NCBI chr 9:81,466,430...81,469,299
Ensembl chr 9:81,466,332...81,469,274
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 increases expression ISO oleandrin results in increased expression of CXCR2 mRNA; oleandrin results in increased expression of CXCR2 protein CTD PMID:24172227 NCBI chr 9:81,427,275...81,435,065
Ensembl chr 9:81,427,730...81,434,102
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO oleandrin results in increased expression of CXCR4 mRNA CTD PMID:24172227 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
strophanthidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport ISO ABCB1 protein results in increased transport of Strophanthidin CTD PMID:26708294 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 increases expression
multiple interactions
ISO Strophanthidin results in increased expression of G6PC mRNA
Strophanthidin promotes the reaction [RORC protein binds to G6PC promoter]
CTD PMID:29981919 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G Il17a interleukin 17A multiple interactions ISO Strophanthidin results in increased expression of and results in increased secretion of IL17A protein CTD PMID:29981919 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il17f interleukin 17F multiple interactions ISO Strophanthidin results in increased expression of and results in increased secretion of IL17F protein CTD PMID:29981919 NCBI chr 9:26,885,702...26,897,219
Ensembl chr 9:26,885,708...26,897,219
JBrowse link
G Npas2 neuronal PAS domain protein 2 increases expression
multiple interactions
ISO Strophanthidin results in increased expression of NPAS2 mRNA
Strophanthidin promotes the reaction [RORC protein binds to NPAS2 promoter]
CTD PMID:29981919 NCBI chr 9:45,901,262...46,081,880
Ensembl chr 9:45,901,741...46,081,880
JBrowse link
G Rorc RAR-related orphan receptor C multiple interactions
increases expression
ISO RORC protein promotes the reaction [Strophanthidin results in increased expression of RORC mRNA]; Strophanthidin promotes the reaction [RORC protein binds to G6PC promoter]; Strophanthidin promotes the reaction [RORC protein binds to NPAS2 promoter] CTD PMID:29981919 NCBI chr 2:195,612,471...195,636,797
Ensembl chr 2:195,617,021...195,637,630
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    chemical entity 19810
      atom 19808
        nonmetal atom 19683
          carbon atom 19588
            organic molecular entity 19588
              lipid 17055
                steroid 12793
                  steroid lactone 404
                    cardanolide 41
                      5alpha-cardanolide 0
                      5beta-cardanolide + 41
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic group 18527
                              organic divalent group 18520
                                organodiyl group 18520
                                  carbonyl group 18427
                                    carbonyl compound 18427
                                      carboxylic ester 14367
                                        lactone 5988
                                          steroid lactone 404
                                            cardanolide 41
                                              5alpha-cardanolide 0
                                              5beta-cardanolide + 41
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.