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omaveloxolone - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:omaveloxolone
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Accession:CHEBI:229661 term browser browse the term
Definition:A semi-synthetic triterpenoid drug. It is an Nrf2 activator that is approved for the treatment of Friedreich's ataxia in adults and adolescents aged 16 years and older.
Synonyms:exact_synonym: N-[(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-hexadecahydropicen-4a(2H)-yl]-2,2-difluoropropanamide
 related_synonym: Formula=C33H44F2N2O3;   InChI=1S/C33H44F2N2O3/c1-27(2)11-13-33(37-26(40)32(8,34)35)14-12-31(7)24(20(33)17-27)21(38)15-23-29(5)16-19(18-36)25(39)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3,(H,37,40)/t20-,22-,24-,29-,30+,31+,33-/m0/s1;   InChIKey=RJCWBNBKOKFWNY-IDPLTSGASA-N;   N-(2-cyano-3,12-dioxo-28-noroleana-1,9(11)-dien-17-yl)-2,2-difluoropropanamide;   RTA 408;   RTA408;   SMILES=[H][C@@]12CC(C)(C)CC[C@@]1(CC[C@]1(C)[C@]2([H])C(=O)C=C2[C@@]1(C)CC[C@@]1([H])C(C)(C)C(=O)C(=C[C@]21C)C#N)NC(=O)C(C)(F)F;   Skyclarys;   omaveloxolona;   omaveloxolonum
 xref: CAS:1474034-05-3;   DrugBank:DB12513;   KEGG:D10964
 xref_mesh: MESH:C000589490
 xref: PMID:28919776;   PMID:29476889;   PMID:29925185;   PMID:31118567;   PMID:31185608;   PMID:31256292;   PMID:31487581;   PMID:33017422;   PMID:33295701;   PMID:34573098;   PMID:34709651;   PMID:34721761;   PMID:35285087;   PMID:35883884;   PMID:36032663;   PMID:36444905;   PMID:36708320;   PMID:37077825;   PMID:37094050;   PMID:37137161;   PMID:37142519;   PMID:37155124;   PMID:37219716;   PMID:37352984;   PMID:37691319;   PMID:37773082;   PMID:37795909;   PMID:37951537;   PMID:38047307;   PMID:38145457;   PMID:38269532;   PMID:38272714;   Wikipedia:Omaveloxolone


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omaveloxolone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO omaveloxolone analog inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of ADIPOQ protein] CTD PMID:32410268 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions ISO omaveloxolone analog promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of FTH1 mRNA]; omaveloxolone promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of FTH1 mRNA] CTD PMID:32410268 NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:206,627,103...206,725,424
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO [omaveloxolone analog co-treated with Streptozocin co-treated with Dietary Fats] results in increased expression of GPT protein CTD PMID:32410268 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Lep leptin multiple interactions ISO omaveloxolone analog promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of LEP protein] CTD PMID:32410268 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO [omaveloxolone analog co-treated with Streptozocin co-treated with Dietary Fats] results in increased activity of NQO1 protein; [omaveloxolone co-treated with Streptozocin co-treated with Dietary Fats] results in increased activity of NQO1 protein; omaveloxolone analog promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NQO1 mRNA]; omaveloxolone promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NQO1 mRNA] CTD PMID:32410268 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Srxn1 sulfiredoxin 1 multiple interactions ISO omaveloxolone analog promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of SRXN1 mRNA]; omaveloxolone promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of SRXN1 mRNA] CTD PMID:32410268 NCBI chr 3:161,064,812...161,070,372
Ensembl chr 3:140,599,608...140,628,448
JBrowse link

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  CHEBI ontology 20856
    role 20816
      chemical role 20394
        antioxidant 16461
          omaveloxolone 6
Path 2
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  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    p-block element atom 20777
                      carbon group element atom 20710
                        carbon atom 20704
                          organic molecular entity 20704
                            heteroorganic entity 20215
                              organochalcogen compound 19902
                                organooxygen compound 19804
                                  carbon oxoacid 19150
                                    carboxylic acid 19147
                                      carboacyl group 18082
                                        univalent carboacyl group 18082
                                          carbamoyl group 17918
                                            carboxamide 17918
                                              secondary carboxamide 1342
                                                omaveloxolone 6
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