.
trimethylenediamine - Ontology Report - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:trimethylenediamine
go back to main search page
Accession:CHEBI:15725 term browser browse the term
Definition:An alkane-alpha,omega-diamine comprising a propane skeleton with amino substituents at positions 1 and 3.
Synonyms:related_synonym: 1,3-Diaminopropane;   1,3-Propanediamine;   1,3-diamino-n-propane;   1,3-propylenediamine;   1,3-trimethylenediamine;   3-aminopropylamine;   Formula=C3H10N2;   InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2;   InChIKey=XFNJVJPLKCPIBV-UHFFFAOYSA-N;   Propane-1,3-diamine;   SMILES=NCCCN;   alpha,omega-propanediamine;   tn
 alt_id: CHEBI:11166;   CHEBI:14901;   CHEBI:26285;   CHEBI:39528;   CHEBI:519
 xref: CAS:109-76-2;   Gmelin:1298;   HMDB:HMDB0000002;   KEGG:C00986;   KNApSAcK:C00007404
 xref_mesh: MESH:C009475
 xref: MetaCyc:CPD-313;   PDBeChem:13D;   PMID:1035932;   PMID:10930630;   PMID:1238529;   PMID:17668437;   PMID:4798530;   PMID:6042782;   PMID:739391;   PMID:987217;   Reaxys:605277;   Wikipedia:1\,3-Diaminopropane
 cyclic_relationship: is_conjugate_base_of CHEBI:57484

1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
X

show annotations for term's descendants           Sort by:
trimethylenediamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO [Copper binds to Isatin binds to trimethylenediamine] which results in increased cleavage of CASP3 protein CTD PMID:17327230 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO [Copper binds to Isatin binds to trimethylenediamine] which results in increased cleavage of CASP9 protein CTD PMID:17327230 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of CDKN1A protein; Tretinoin inhibits the reaction [[Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of CDKN1A protein] CTD PMID:17327230 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO [Copper binds to Isatin binds to trimethylenediamine] which affects the localization of CYCS protein CTD PMID:17327230 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [trimethylenediamine binds to TEMPO] inhibits the reaction [MPO protein results in increased chemical synthesis of Hypochlorous Acid]; [trimethylenediamine binds to TEMPO] inhibits the reaction [MPO protein results in increased degradation of Hydrogen Peroxide]; [trimethylenediamine binds to TEMPO] inhibits the reaction [MPO protein results in increased oxidation of Nitric Oxide]; Heparin inhibits the reaction [[trimethylenediamine binds to TEMPO] inhibits the reaction [MPO protein results in increased chemical synthesis of Hypochlorous Acid]] CTD PMID:34085520 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO SOD1 protein results in decreased susceptibility to [Copper binds to Isatin binds to trimethylenediamine] CTD PMID:17327230 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of TP53 protein; Tretinoin inhibits the reaction [[Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of TP53 protein] CTD PMID:17327230 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19887
    role 19858
      application 19697
        reagent 18061
          trimethylenediamine 7
            N-(3-aminopropyl)-N-hydroxyacetamide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    main group molecular entity 19824
                      s-block molecular entity 19658
                        hydrogen molecular entity 19640
                          hydrides 19145
                            inorganic hydride 18162
                              pnictogen hydride 18152
                                nitrogen hydride 18059
                                  azane 17869
                                    ammonia 17868
                                      organic amino compound 17868
                                        polyamine 9024
                                          diamine 8959
                                            primary diamine 5705
                                              alkane-alpha,omega-diamine 3781
                                                trimethylenediamine 7
                                                  N-(3-aminopropyl)-N-hydroxyacetamide 0
paths to the root