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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:reboxetine
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Accession:CHEBI:135342 term browser browse the term
Synonyms:related_synonym: Formula=C19H23NO3;   InChI=1S/C19H23NO3/c1-2-21-16-10-6-7-11-17(16)23-19(15-8-4-3-5-9-15)18-14-20-12-13-22-18/h3-11,18-20H,2,12-14H2,1H3/t18-,19-/m1/s1;   InChIKey=CBQGYUDMJHNJBX-RTBURBONSA-N;   SMILES=[C@](OC1=C(OCC)C=CC=C1)(C2=CC=CC=C2)([C@]3(CNCCO3)[H])[H];   edronax;   norebox;   reboxetine mesilate;   reboxetine mesylate;   reboxitine
 xref: CAS:71620-89-8;   Drug_Central:2361
 xref_mesh: MESH:C074679


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reboxetine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen decreases expression ISO reboxetine results in decreased expression of AGT protein modified form CTD PMID:16717144 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Dbh dopamine beta-hydroxylase increases response to substance ISO DBH protein results in increased susceptibility to reboxetine CTD PMID:15148402 NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP reboxetine results in increased expression of FOS protein CTD PMID:15609068 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions ISO reboxetine results in increased phosphorylation of and results in increased activity of NTRK2 protein CTD PMID:21666748 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Ren renin decreases activity ISO reboxetine results in decreased activity of REN protein CTD PMID:16717144 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Slc6a2 solute carrier family 6 member 2 decreases expression ISO reboxetine results in decreased expression of SLC6A2 protein CTD PMID:18923402 NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 affects response to substance ISO SLC6A3 protein affects the susceptibility to reboxetine CTD PMID:11312315 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    chemical entity 19839
      group 19798
        polyatomic entity 19797
          molecule 19701
            organic molecule 19686
              organic cyclic compound 19498
                organic aromatic compound 19367
                  aromatic ether 16529
                    reboxetine 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    main group molecular entity 19789
                      p-block molecular entity 19789
                        carbon group molecular entity 19737
                          organic molecular entity 19733
                            heteroorganic entity 19492
                              organochalcogen compound 19255
                                organooxygen compound 19172
                                  ether 17284
                                    aromatic ether 16529
                                      reboxetine 7
paths to the root