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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2-hydroxyestrone
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Accession:CHEBI:1156 term browser browse the term
Definition:A 2-hydroxy steroid that is estrone substituted by a hydroxy group at position 2.
Synonyms:exact_synonym: 2,3-dihydroxyestra-1,3,5(10)-trien-17-one
 related_synonym: Formula=C18H22O3;   InChI=1S/C18H22O3/c1-18-7-6-11-12(14(18)4-5-17(18)21)3-2-10-8-15(19)16(20)9-13(10)11/h8-9,11-12,14,19-20H,2-7H2,1H3/t11-,12+,14-,18-/m0/s1;   InChIKey=SWINWPBPEKHUOD-JPVZDGGYSA-N;   SMILES=[H][C@]12CC[C@]3(C)C(=O)CC[C@@]3([H])[C@]1([H])CCc1cc(O)c(O)cc21
 xref: CAS:362-06-1;   HMDB:HMDB0000343;   KEGG:C05298;   LIPID_MAPS_instance:LMST02010032
 xref_mesh: MESH:C024980
 xref: PMID:11054642;   PMID:29713726;   PMID:8337235;   Reaxys:2221833


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2-hydroxyestrone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ckb creatine kinase B multiple interactions EXP 2-hydroxyestrone inhibits the reaction [Estradiol results in increased expression of CKB] CTD PMID:10030690 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315 		JBrowse link
G Esr1 estrogen receptor 1 affects binding
multiple interactions		 ISO 2-hydroxyestrone binds to ESR1 protein
2-hydroxyestrone binds to and results in increased activity of ESR1 protein		 CTD PMID:16728493 PMID:17713618 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO 2-hydroxyestrone binds to and results in increased activity of ESR2 protein CTD PMID:17713618 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression ISO 2-hydroxyestrone results in decreased expression of FSHB protein CTD PMID:6401747 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression ISO 2-hydroxyestrone results in decreased expression of LHB protein CTD PMID:6401747 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of 2-hydroxyestrone CTD PMID:15117964 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of 2-hydroxyestrone CTD PMID:15117964 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of 2-hydroxyestrone CTD PMID:15117964 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19890
    role 19839
      application 19703
        pharmaceutical 19518
          drug 19538
            antineoplastic agent 17812
              estrone 128
                2-hydroxyestrone 8
                  2-hydroxy-3-O-methyl estrone 0
                  2-hydroxyestrone 2-O-(beta-D-glucuronide) 0
                  2-hydroxyestrone 3-O-(beta-D-glucuronide) 0
                  estra-1(10),4-diene-2,3,17-trione 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19890
    subatomic particle 19867
      composite particle 19888
        hadron 19888
          baryon 19888
            nucleon 19867
              atomic nucleus 19888
                atom 19888
                  main group element atom 19806
                    p-block element atom 19806
                      carbon group element atom 19746
                        carbon atom 19743
                          organic molecular entity 19743
                            organic molecule 19714
                              organic cyclic compound 19485
                                organic polycyclic compound 17282
                                  steroid 14714
                                    hydroxy steroid 14463
                                      3-hydroxy steroid 12819
                                        phenolic steroid 11323
                                          estrone 128
                                            2-hydroxyestrone 8
                                              2-hydroxy-3-O-methyl estrone 0
                                              2-hydroxyestrone 2-O-(beta-D-glucuronide) 0
                                              2-hydroxyestrone 3-O-(beta-D-glucuronide) 0
                                              estra-1(10),4-diene-2,3,17-trione 0
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