Kcnq1 (potassium voltage-gated channel subfamily Q member 1) - Rat Genome Database

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Gene: Kcnq1 (potassium voltage-gated channel subfamily Q member 1) Rattus norvegicus
Analyze
Symbol: Kcnq1
Name: potassium voltage-gated channel subfamily Q member 1
RGD ID: 621503
Description: Enables delayed rectifier potassium channel activity; identical protein binding activity; and outward rectifier potassium channel activity. Involved in several processes, including male gonad development; negative regulation of insulin secretion; and response to anesthetic. Located in basolateral plasma membrane; sarcolemma; and zymogen granule membrane. Part of voltage-gated potassium channel complex. Used to study hypertension and long QT syndrome. Human ortholog(s) of this gene implicated in heart conduction disease (multiple); long QT syndrome (multiple); and type 2 diabetes mellitus. Orthologous to human KCNQ1 (potassium voltage-gated channel subfamily Q member 1); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; KQT-like 1; Kvlqt1; potassium channel, voltage-gated KQT-like subfamily Q, member 1; potassium voltage-gated channel subfamily KQT member 1; potassium voltage-gated channel, KQT-like subfamily, member 1; potassium voltage-gated channel, subfamily Q, member 1; voltage-gated potassium channel subunit Kv7.1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Kcnq1em9Mcwi ; Kcnq1em14Mcwi ; Kcnq1dfk ; Kcnq1em5Mcwi
Genetic Models: SS-Kcnq1em14Mcwi ; SS-Kcnq1em9Mcwi ; SS-Kcnq1em5Mcwi ; WTC-Kcnq1dfkKyo
Is Marker For: Strains:   WTC-Kcnq1dfkKyo
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81207,721,134 - 208,054,073 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1207,721,131 - 208,054,072 (+)EnsemblGRCr8
mRatBN7.21198,291,711 - 198,624,683 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1198,291,766 - 198,624,669 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1206,670,364 - 207,003,324 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01213,756,445 - 214,089,840 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01206,430,601 - 206,763,990 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01216,293,087 - 216,630,339 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1216,293,087 - 216,630,339 (+)Ensemblrn6Rnor6.0
Rnor_5.01223,154,713 - 223,490,458 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41203,383,401 - 203,803,687 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1195,860,199 - 196,193,008 (+)NCBICelera
RGSC_v3.11203,536,853 - 203,957,140 (+)NCBI
Cytogenetic Map1q42NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-ropivacaine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-(hydroxymethyl)cytosine  (ISO)
8-Br-cAMP  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
aprindine  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atenolol  (ISO)
atrazine  (EXP)
barium chloride  (ISO)
barium(0)  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bupivacaine  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (EXP)
C60 fullerene  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
Chromanol 293B  (ISO)
clofibrate  (ISO)
daunorubicin  (ISO)
Dibutyl phosphate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
glycidol  (EXP)
isoprenaline  (EXP,ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
mepivacaine  (ISO)
methapyrilene  (ISO)
mitoxantrone  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
naphthalene  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
pentanal  (ISO)
perfluorooctanoic acid  (EXP)
phenylmercury acetate  (ISO)
piperonyl butoxide  (ISO)
potassium atom  (ISO)
propranolol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
Terfenadine  (ISO)
testosterone  (EXP)
thallium atom  (EXP)
thallium sulfate  (EXP)
titanium dioxide  (ISO)
trazodone  (ISO)
tributylstannane  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vanadium atom  (EXP)
vanadium(0)  (EXP)
vinclozolin  (EXP)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
action potential  (IBA)
adrenergic receptor signaling pathway  (IEA,ISO)
atrial cardiac muscle cell action potential  (IEA,ISO)
auditory receptor cell development  (IEA,ISO)
cardiac conduction  (IEA,ISO)
cardiac muscle contraction  (IEA,ISO)
cellular response to cAMP  (IEA,ISO)
cellular response to epinephrine stimulus  (IEA,ISO)
cellular response to xenobiotic stimulus  (IEA,ISO)
chloride ion homeostasis  (IEA,ISO)
cochlea development  (IEA,ISO)
corticosterone secretion  (IEA,ISO)
detection of mechanical stimulus involved in sensory perception of sound  (IEA,ISO)
digestive system process  (IEA,ISO)
erythrocyte differentiation  (IEA,ISO)
gastric acid secretion  (IEA,ISO)
gastrin-induced gastric acid secretion  (IEA,ISO)
glucose metabolic process  (IEA,ISO)
heart development  (IEA,ISO)
inner ear development  (IEA,ISO,ISS)
inner ear morphogenesis  (IEA,ISO)
intestinal absorption  (IMP)
intracellular chloride ion homeostasis  (IEA,ISO)
iodide transport  (IEA,ISO)
male gonad development  (IEP)
membrane repolarization  (IEA,ISO,ISS)
membrane repolarization during action potential  (IEA,ISO)
membrane repolarization during atrial cardiac muscle cell action potential  (IEA,ISO)
membrane repolarization during cardiac muscle cell action potential  (IEA,ISO)
membrane repolarization during ventricular cardiac muscle cell action potential  (IBA,IEA,ISO)
monoatomic ion transmembrane transport  (IEA)
monoatomic ion transport  (IEA)
negative regulation of delayed rectifier potassium channel activity  (ISO)
negative regulation of insulin secretion  (IDA)
negative regulation of voltage-gated potassium channel activity  (ISO)
non-motile cilium assembly  (IEA,ISO)
positive regulation of cardiac muscle contraction  (IEA,ISO)
positive regulation of heart rate  (IEA,ISO)
positive regulation of potassium ion transmembrane transport  (IEA,ISO)
potassium ion export across plasma membrane  (IBA,IEA,ISO)
potassium ion homeostasis  (IEA,ISO)
potassium ion import across plasma membrane  (IEA,ISO)
potassium ion transmembrane transport  (IEA,ISO)
potassium ion transport  (IDA,IEA)
regulation of atrial cardiac muscle cell membrane repolarization  (IEA,ISO)
regulation of blood pressure  (IEA,ISO)
regulation of gastric acid secretion  (IEA,ISO,ISS)
regulation of heart rate  (IEA,ISO)
regulation of heart rate by cardiac conduction  (IEA,ISO)
regulation of hormone levels  (IEA)
regulation of membrane potential  (IDA,IEA,ISO)
regulation of membrane repolarization  (IEA,ISO)
regulation of transport  (IEA)
regulation of ventricular cardiac muscle cell membrane repolarization  (IEA,ISO)
regulation of voltage-gated sodium channel activity  (ISO)
renal absorption  (IEA,ISO,ISS)
renal sodium ion absorption  (IEA,ISO)
response to anesthetic  (IDA)
response to insulin  (IEA,ISO)
rhythmic behavior  (IEA,ISO)
sensory perception of sound  (IEA,ISO)
social behavior  (IEA,ISO)
sodium ion transport  (IEA,ISO)
stomach development  (IEA,ISO)
transmembrane transport  (IEA)
ventricular cardiac muscle cell action potential  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Sexual dimorphism and oestrogen regulation of KCNE3 expression modulates the functional properties of KCNQ1 K(+) channels. Alzamora R, etal., J Physiol. 2011 Nov 1;589(Pt 21):5091-107. doi: 10.1113/jphysiol.2011.215772. Epub 2011 Sep 12.
2. Variants in the 3' untranslated region of the KCNQ1-encoded Kv7.1 potassium channel modify disease severity in patients with type 1 long QT syndrome in an allele-specific manner. Amin AS, etal., Eur Heart J. 2012 Mar;33(6):714-23. doi: 10.1093/eurheartj/ehr473. Epub 2011 Dec 23.
3. Inhibitory effects of volatile anesthetics on currents produced on heterologous expression of KvLQT1 and minK in Xenopus oocytes. Chen X, etal., Vascul Pharmacol. 2002 Jul;39(1-2):33-8.
4. KCNQ1 gain-of-function mutation in familial atrial fibrillation. Chen YH, etal., Science. 2003 Jan 10;299(5604):251-4.
5. Properties of KvLQT1 K+ channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias. Chouabe C, etal., EMBO J. 1997 Sep 1;16(17):5472-9.
6. Air pollution and diabetes association: Modification by type 2 diabetes genetic risk score. Eze IC, etal., Environ Int. 2016 Sep;94:263-271. doi: 10.1016/j.envint.2016.04.032. Epub 2016 Jun 6.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. WTC deafness Kyoto (dfk): a rat model for extensive investigations of Kcnq1 functions. Gohma H, etal., Physiol Genomics. 2006 Feb 14;24(3):198-206. Epub 2005 Dec 20.
9. The cardiac K+ channel KCNQ1 is essential for gastric acid secretion. Grahammer F, etal., Gastroenterology. 2001 May;120(6):1363-71.
10. Localization, trafficking, and significance for acid secretion of parietal cell Kir4.1 and KCNQ1 K+ channels. Kaufhold MA, etal., Gastroenterology. 2008 Apr;134(4):1058-69. Epub 2008 Jan 18.
11. Cloning and function of the rat colonic epithelial K+ channel KVLQT1. Kunzelmann K, etal., J Membr Biol 2001 Jan 15,;179(2):155-64.
12. Pancreatic metaplasia in the gastro-achlorhydria in WTC-dfk rat, a potassium channel Kcnq1 mutant. Kuwamura M, etal., Vet Pathol. 2008 Jul;45(4):586-91.
13. Evidence for KCNQ1 K+ channel expression in rat zymogen granule membranes and involvement in cholecystokinin-induced pancreatic acinar secretion. Lee WK, etal., Am J Physiol Cell Physiol. 2008 Apr;294(4):C879-92. Epub 2008 Jan 23.
14. K+ channel KVLQT1 located in the basolateral membrane of distal colonic epithelium is not essential for activating Cl- secretion. Liao T, etal., Am J Physiol Cell Physiol. 2005 Sep;289(3):C564-75. Epub 2005 Apr 20.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Stoichiometry of the KCNQ1 - KCNE1 ion channel complex. Nakajo K, etal., Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18862-7. doi: 10.1073/pnas.1010354107. Epub 2010 Oct 20.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Molecular and functional characterization of ERG, KCNQ, and KCNE subtypes in rat stomach smooth muscle. Ohya S, etal., Am J Physiol Gastrointest Liver Physiol 2002 Feb;282(2):G277-87.
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
21. Oestrogen promotes KCNQ1 potassium channel endocytosis and postendocytic trafficking in colonic epithelium. Rapetti-Mauss R, etal., J Physiol. 2013 Jun 1;591(Pt 11):2813-31. doi: 10.1113/jphysiol.2013.251678. Epub 2013 Mar 25.
22. Subcellular localization of the delayed rectifier K(+) channels KCNQ1 and ERG1 in the rat heart. Rasmussen HB, etal., Am J Physiol Heart Circ Physiol 2004 Apr;286(4):H1300-9. Epub 2003 Dec 11.
23. GOA pipeline RGD automated data pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Compendium of cardiac channel mutations in 541 consecutive unrelated patients referred for long QT syndrome genetic testing. Tester DJ, etal., Heart Rhythm. 2005 May;2(5):507-17.
27. KCNQ1/KCNE1 channels during germ-cell differentiation in the rat: expression associated with testis pathologies. Tsevi I, etal., J Cell Physiol. 2005 Feb;202(2):400-10.2: id: 27199802 Error occurred: Document retrieval error: document does notexist
28. Effects of I(Ks) channel inhibitors in insulin-secreting INS-1 cells. Ullrich S, etal., Pflugers Arch. 2005 Dec;451(3):428-36. Epub 2005 Aug 30.
29. KCNQ1-dependent transport in renal and gastrointestinal epithelia. Vallon V, etal., Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17864-9. Epub 2005 Nov 28.
30. Compound heterozygous mutations in KvLQT1 cause Jervell and Lange-Nielsen syndrome. Wang Z, etal., Mol Genet Metab. 2002 Apr;75(4):308-16.
31. A truncated splice variant of KCNQ1 cloned from rat heart. Yamada Y, etal., Biochem Biophys Res Commun 2002 Jun 7;294(2):199-204.
Additional References at PubMed
PMID:8528244   PMID:8900282   PMID:8900283   PMID:9108097   PMID:9305853   PMID:9314834   PMID:9354802   PMID:10400998   PMID:10646604   PMID:11101505   PMID:11120752   PMID:11299204  
PMID:11799244   PMID:12324418   PMID:12410230   PMID:15004216   PMID:15340049   PMID:16002409   PMID:16452155   PMID:16476578   PMID:17289006   PMID:17556370   PMID:17631610   PMID:18093912  
PMID:18165683   PMID:18331828   PMID:19006182   PMID:19372749   PMID:19491250   PMID:19646991   PMID:20196769   PMID:20533308   PMID:20861072   PMID:21228319   PMID:21957902   PMID:22024150  
PMID:22251082   PMID:22348007   PMID:24184248   PMID:24269949   PMID:24855057   PMID:25037568   PMID:25616413   PMID:25705178   PMID:25786344   PMID:25856227   PMID:27413020   PMID:28059450  
PMID:28189443   PMID:28611207   PMID:32248813   PMID:33667331   PMID:34907346  


Genomics

Comparative Map Data
Kcnq1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81207,721,134 - 208,054,073 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1207,721,131 - 208,054,072 (+)EnsemblGRCr8
mRatBN7.21198,291,711 - 198,624,683 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1198,291,766 - 198,624,669 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1206,670,364 - 207,003,324 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01213,756,445 - 214,089,840 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01206,430,601 - 206,763,990 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01216,293,087 - 216,630,339 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1216,293,087 - 216,630,339 (+)Ensemblrn6Rnor6.0
Rnor_5.01223,154,713 - 223,490,458 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41203,383,401 - 203,803,687 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1195,860,199 - 196,193,008 (+)NCBICelera
RGSC_v3.11203,536,853 - 203,957,140 (+)NCBI
Cytogenetic Map1q42NCBI
KCNQ1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38112,445,008 - 2,849,105 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl112,444,654 - 2,849,105 (+)Ensemblhg38GRCh38
GRCh37112,466,238 - 2,870,335 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36112,422,797 - 2,826,916 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34112,439,259 - 2,826,915NCBI
Celera112,501,049 - 2,905,069 (+)NCBICelera
Cytogenetic Map11p15.5-p15.4NCBI
HuRef112,256,184 - 2,658,673 (+)NCBIHuRef
CHM1_1112,465,155 - 2,869,215 (+)NCBICHM1_1
T2T-CHM13v2.0112,534,332 - 2,938,419 (+)NCBIT2T-CHM13v2.0
Kcnq1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397142,660,614 - 142,980,787 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7142,660,099 - 142,980,779 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm387143,106,877 - 143,427,050 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7143,106,362 - 143,427,042 (+)Ensemblmm10GRCm38
MGSCv377150,293,159 - 150,612,947 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367142,916,644 - 143,236,432 (+)NCBIMGSCv36mm8
Celera7142,862,859 - 143,182,707 (+)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.12NCBI
Kcnq1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542214,212,553 - 14,544,556 (+)Ensembl
ChiLan1.0NW_00495542214,212,563 - 14,544,556 (+)NCBIChiLan1.0ChiLan1.0
KCNQ1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v294,855,419 - 5,260,218 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1114,067,311 - 4,472,166 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0112,469,750 - 2,874,467 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1112,498,001 - 2,902,198 (+)NCBIPanPan1.1PanPan1.1panPan2
KCNQ1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11846,554,390 - 46,830,533 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1846,518,908 - 46,830,043 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1845,116,523 - 45,440,309 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01847,186,461 - 47,510,762 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1847,186,461 - 47,517,416 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11846,634,218 - 46,955,821 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01846,214,974 - 46,538,652 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01846,962,029 - 47,285,048 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Kcnq1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049472,763,921 - 3,051,025 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936794707,119 - 994,778 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936794707,122 - 994,206 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNQ1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl21,675,360 - 1,989,111 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.121,675,323 - 1,989,110 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
KCNQ1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112,261,448 - 2,661,840 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl12,261,845 - 2,661,863 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603899,462,284 - 99,862,831 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnq1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476715,252,950 - 15,613,562 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476715,252,961 - 15,613,373 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnq1
3640 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:458
Count of miRNA genes:224
Interacting mature miRNAs:257
Transcripts:ENSRNOT00000027875
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1207243873252243873Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1193964073238964073Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1194575422239575422Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1193400541238400541Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1207243873252243873Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1205674651250674651Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1207243873252243873Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1203300512229359342Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1191190115223964326Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631260Tcas2Tongue tumor susceptibility QTL 24.93tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1201915593208479939Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1192995199237995199Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1205674651250674651Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1197807365233480676Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1193400541238400541Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1202851915223964440Rat
6480783Insul19Insulin level QTL 194.33blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1203300512213659238Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1207099883252099883Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1191260175236260175Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat

Markers in Region
D1Wox9  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81207,753,768 - 207,753,891 (+)Marker Load Pipeline
mRatBN7.21198,324,342 - 198,324,465 (+)MAPPERmRatBN7.2
Rnor_6.01216,325,697 - 216,325,819NCBIRnor6.0
Rnor_5.01223,187,127 - 223,187,249UniSTSRnor5.0
RGSC_v3.41203,416,020 - 203,416,143RGDRGSC3.4
RGSC_v3.41203,416,021 - 203,416,143UniSTSRGSC3.4
Celera1195,892,798 - 195,892,916UniSTS
RGSC_v3.11203,569,473 - 203,569,596RGD
RH 2.0 Map11090.4RGD
Cytogenetic Map1q41UniSTS
BF389163  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21198,432,655 - 198,432,778 (+)MAPPERmRatBN7.2
Rnor_6.01216,433,507 - 216,433,629NCBIRnor6.0
Rnor_5.01223,294,687 - 223,294,809UniSTSRnor5.0
Celera1196,001,646 - 196,001,768UniSTS
RH 3.4 Map11562.8UniSTS
Cytogenetic Map1q41UniSTS
AA964210  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21198,440,181 - 198,440,334 (+)MAPPERmRatBN7.2
Rnor_6.01216,440,655 - 216,440,807NCBIRnor6.0
Rnor_5.01223,302,427 - 223,302,579UniSTSRnor5.0
Celera1196,009,173 - 196,009,325UniSTS
Cytogenetic Map1q41UniSTS
Kcnq1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21198,376,261 - 198,377,441 (+)MAPPERmRatBN7.2
Rnor_6.01216,378,790 - 216,379,969NCBIRnor6.0
Rnor_5.01223,238,047 - 223,239,226UniSTSRnor5.0
RGSC_v3.41203,468,249 - 203,469,428UniSTSRGSC3.4
Celera1195,944,729 - 195,945,908UniSTS
Cytogenetic Map1q41UniSTS
RH134033  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21198,624,450 - 198,624,663 (+)MAPPERmRatBN7.2
Rnor_6.01216,630,124 - 216,630,336NCBIRnor6.0
Rnor_5.01223,490,243 - 223,490,455UniSTSRnor5.0
RGSC_v3.41203,803,472 - 203,803,684UniSTSRGSC3.4
Celera1196,192,793 - 196,193,005UniSTS
Cytogenetic Map1q41UniSTS
BE120633  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1196,055,838 - 196,056,016UniSTS
RH 3.4 Map11521.6UniSTS
Cytogenetic Map1q41UniSTS
AU047567  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81207,835,453 - 207,835,709 (+)Marker Load Pipeline
mRatBN7.21198,406,029 - 198,406,285 (+)MAPPERmRatBN7.2
Rnor_6.01216,407,652 - 216,407,907NCBIRnor6.0
Rnor_5.01223,266,918 - 223,267,173UniSTSRnor5.0
Celera1195,974,267 - 195,974,522UniSTS
Cytogenetic Map1q41UniSTS
AU047338  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21198,549,957 - 198,550,091 (+)MAPPERmRatBN7.2
Rnor_6.01216,555,699 - 216,555,832NCBIRnor6.0
Celera1196,118,406 - 196,118,539UniSTS
Cytogenetic Map1q41UniSTS
AU049425  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81207,889,494 - 207,889,625 (+)Marker Load Pipeline
mRatBN7.21198,460,069 - 198,460,200 (+)MAPPERmRatBN7.2
Rnor_6.01216,460,860 - 216,460,988NCBIRnor6.0
Rnor_5.01223,322,674 - 223,322,802UniSTSRnor5.0
Celera1196,028,682 - 196,028,810UniSTS
Cytogenetic Map1q41UniSTS
UniSTS:465396  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21198,472,540 - 198,472,837 (+)MAPPERmRatBN7.2
Rnor_6.01216,473,690 - 216,473,986NCBIRnor6.0
Rnor_6.01216,480,009 - 216,480,305NCBIRnor6.0
Rnor_5.01223,341,181 - 223,341,477UniSTSRnor5.0
Rnor_5.01223,335,504 - 223,335,800UniSTSRnor5.0
Celera1196,041,145 - 196,041,441UniSTS
Cytogenetic Map1q41UniSTS
Kcnq1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21198,292,160 - 198,292,200 (+)MAPPERmRatBN7.2
Rnor_6.01216,293,482 - 216,293,521NCBIRnor6.0
Rnor_5.01223,155,108 - 223,155,147UniSTSRnor5.0
RGSC_v3.41203,383,796 - 203,383,835UniSTSRGSC3.4
Celera1195,860,594 - 195,860,633UniSTS
Cytogenetic Map1q41UniSTS
Kcnq1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21198,367,696 - 198,367,736 (+)MAPPERmRatBN7.2
Rnor_6.01216,370,232 - 216,370,271NCBIRnor6.0
Rnor_5.01223,229,489 - 223,229,528UniSTSRnor5.0
RGSC_v3.41203,459,643 - 203,459,682UniSTSRGSC3.4
Celera1195,936,161 - 195,936,200UniSTS
Cytogenetic Map1q41UniSTS
Kcnq1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21198,334,404 - 198,334,444 (+)MAPPERmRatBN7.2
Rnor_6.01216,335,834 - 216,335,873NCBIRnor6.0
Rnor_5.01223,197,264 - 223,197,303UniSTSRnor5.0
RGSC_v3.41203,426,076 - 203,426,115UniSTSRGSC3.4
Celera1195,902,856 - 195,902,895UniSTS
Cytogenetic Map1q41UniSTS
Kcnq1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21198,623,523 - 198,623,667 (+)MAPPERmRatBN7.2
Rnor_6.01216,629,197 - 216,629,340NCBIRnor6.0
Rnor_5.01223,489,316 - 223,489,459UniSTSRnor5.0
RGSC_v3.41203,802,545 - 203,802,688UniSTSRGSC3.4
Celera1196,191,866 - 196,192,009UniSTS
Cytogenetic Map1q41UniSTS


Related Rat Strains
The following Strains have been annotated to Kcnq1
WTC-Kcnq1dfkKyo    


Genetic Models
This gene Kcnq1 is modified in the following models/strains:
SS-Kcnq1em14Mcwi     SS-Kcnq1em9Mcwi     SS-Kcnq1em5Mcwi     WTC-Kcnq1dfkKyo    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
23 13 86 205 91 90 59 109 59 6 447 239 23 183 118 131 31 29 29

Sequence


Ensembl Acc Id: ENSRNOT00000027875   ⟹   ENSRNOP00000027875
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1207,721,131 - 208,054,072 (+)Ensembl
mRatBN7.2 Ensembl1198,291,766 - 198,624,666 (+)Ensembl
Rnor_6.0 Ensembl1216,293,087 - 216,630,339 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000075927   ⟹   ENSRNOP00000068229
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1216,381,579 - 216,514,739 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076526
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1198,293,698 - 198,334,440 (+)Ensembl
Rnor_6.0 Ensembl1216,295,010 - 216,335,869 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076661
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1207,721,131 - 208,054,033 (+)Ensembl
mRatBN7.2 Ensembl1198,291,766 - 198,624,669 (+)Ensembl
Rnor_6.0 Ensembl1216,371,824 - 216,394,321 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000087153   ⟹   ENSRNOP00000074437
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1207,721,131 - 208,052,923 (+)Ensembl
mRatBN7.2 Ensembl1198,291,766 - 198,392,293 (+)Ensembl
Rnor_6.0 Ensembl1216,293,109 - 216,575,599 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095400   ⟹   ENSRNOP00000080022
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1207,721,131 - 208,054,072 (+)Ensembl
mRatBN7.2 Ensembl1198,291,766 - 198,624,666 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096911   ⟹   ENSRNOP00000093603
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1207,721,131 - 208,054,072 (+)Ensembl
mRatBN7.2 Ensembl1198,291,766 - 198,624,666 (+)Ensembl
RefSeq Acc Id: NM_032073   ⟹   NP_114462
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,721,198 - 208,054,073 (+)NCBI
mRatBN7.21198,291,766 - 198,624,666 (+)NCBI
Rnor_6.01216,293,087 - 216,630,339 (+)NCBI
Rnor_5.01223,154,713 - 223,490,458 (+)NCBI
RGSC_v3.41203,383,401 - 203,803,687 (+)RGD
Celera1195,860,199 - 196,193,008 (+)RGD
Sequence:
RefSeq Acc Id: XM_039092702   ⟹   XP_038948630
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,721,136 - 208,000,612 (+)NCBI
mRatBN7.21198,291,712 - 198,570,863 (+)NCBI
RefSeq Acc Id: XM_039092705   ⟹   XP_038948633
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,721,137 - 208,054,073 (+)NCBI
mRatBN7.21198,291,713 - 198,624,683 (+)NCBI
RefSeq Acc Id: XM_039092713   ⟹   XP_038948641
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,721,134 - 207,888,391 (+)NCBI
mRatBN7.21198,291,711 - 198,434,452 (+)NCBI
RefSeq Acc Id: XM_039092720   ⟹   XP_038948648
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,721,134 - 207,821,364 (+)NCBI
mRatBN7.21198,291,711 - 198,395,481 (+)NCBI
RefSeq Acc Id: XM_039092725   ⟹   XP_038948653
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,721,135 - 207,821,382 (+)NCBI
mRatBN7.21198,291,712 - 198,395,481 (+)NCBI
RefSeq Acc Id: XM_039092732   ⟹   XP_038948660
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,806,379 - 208,054,073 (+)NCBI
mRatBN7.21198,377,101 - 198,624,683 (+)NCBI
RefSeq Acc Id: NP_114462   ⟸   NM_032073
- UniProtKB: Q9Z0N7 (UniProtKB/Swiss-Prot),   O08655 (UniProtKB/Swiss-Prot),   F1LMY9 (UniProtKB/TrEMBL),   A6HYA9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068229   ⟸   ENSRNOT00000075927
Ensembl Acc Id: ENSRNOP00000074437   ⟸   ENSRNOT00000087153
Ensembl Acc Id: ENSRNOP00000027875   ⟸   ENSRNOT00000027875
RefSeq Acc Id: XP_038948641   ⟸   XM_039092713
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZN79 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948648   ⟸   XM_039092720
- Peptide Label: isoform X4
- UniProtKB: A0A8I5ZN79 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948630   ⟸   XM_039092702
- Peptide Label: isoform X1
- UniProtKB: Q9Z0N7 (UniProtKB/Swiss-Prot),   O08655 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038948653   ⟸   XM_039092725
- Peptide Label: isoform X5
- UniProtKB: A0A8I5ZN79 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948633   ⟸   XM_039092705
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AHW5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948660   ⟸   XM_039092732
- Peptide Label: isoform X6
Ensembl Acc Id: ENSRNOP00000080022   ⟸   ENSRNOT00000095400
Ensembl Acc Id: ENSRNOP00000093603   ⟸   ENSRNOT00000096911
Protein Domains
Ion transport   Potassium channel voltage dependent KCNQ C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z0N7-F1-model_v2 AlphaFold Q9Z0N7 1-669 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690571
Promoter ID:EPDNEW_R1096
Type:initiation region
Name:Kcnq1_1
Description:potassium voltage-gated channel subfamily Q member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01216,293,084 - 216,293,144EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621503 AgrOrtholog
BioCyc Gene G2FUF-56877 BioCyc
Ensembl Genes ENSRNOG00000020532 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000027875 ENTREZGENE
  ENSRNOT00000076661 ENTREZGENE
  ENSRNOT00000087153 ENTREZGENE
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot
  1.20.120.350 UniProtKB/Swiss-Prot
  6.10.140.1910 UniProtKB/Swiss-Prot
InterPro Ion_trans_dom UniProtKB/Swiss-Prot
  K_chnl_volt-dep_KCNQ UniProtKB/Swiss-Prot
  K_chnl_volt-dep_KCNQ_C UniProtKB/Swiss-Prot
  K_chnl_volt-dep_KCQN1 UniProtKB/Swiss-Prot
  Volt_channel_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:84020 UniProtKB/Swiss-Prot
NCBI Gene 84020 ENTREZGENE
PANTHER POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 1 UniProtKB/Swiss-Prot
  POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4 UniProtKB/Swiss-Prot
Pfam Ion_trans UniProtKB/Swiss-Prot
  KCNQ_channel UniProtKB/Swiss-Prot
PharmGKB KCNQ1 RGD
PhenoGen Kcnq1 PhenoGen
PRINTS KCHANNEL UniProtKB/Swiss-Prot
  KCNQ1CHANNEL UniProtKB/Swiss-Prot
  KCNQCHANNEL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020532 RatGTEx
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/Swiss-Prot
UniProt A0A0G2K819_RAT UniProtKB/TrEMBL
  A0A8I5ZN79 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZPT1_RAT UniProtKB/TrEMBL
  A0A8I6AHW5 ENTREZGENE, UniProtKB/TrEMBL
  A6HYA9 ENTREZGENE, UniProtKB/TrEMBL
  A6HYB0_RAT UniProtKB/TrEMBL
  A6HYB1_RAT UniProtKB/TrEMBL
  F1LMY9 ENTREZGENE, UniProtKB/TrEMBL
  KCNQ1_RAT UniProtKB/Swiss-Prot
  O08655 ENTREZGENE
  Q9Z0N7 ENTREZGENE
UniProt Secondary O08655 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-12-15 Kcnq1  potassium voltage-gated channel, KQT-like subfamily, member 1  Kcnq1  potassium voltage-gated channel, subfamily Q, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Kcnq1  potassium voltage-gated channel, subfamily Q, member 1    potassium voltage-gated channel, KQT-like subfamily, member 1  Name updated 1299863 APPROVED
2002-08-07 Kcnq1  potassium voltage-gated channel, KQT-like subfamily, member 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localizes to both the peripheral sarcolemma and in the T tubules 1304271
gene_expression expressed in the antrum of the stomach, adrenal gland, thymus, retina, and skeletal muscle 625508
gene_process coexpressed with Kcne1 and involved in the activation of the channel 625508
gene_process generates potassium currents in the smooth muscles of the rat stomach 625508
gene_product 453 bp 625508
gene_transcript truncated splice variant is expressed in fetal and neonatal rat heart and suppresses potassium currents when expressed with the full length transcript 625471