RGD Reference Report - A truncated splice variant of KCNQ1 cloned from rat heart. - Rat Genome Database

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A truncated splice variant of KCNQ1 cloned from rat heart.

Authors: Yamada, Y  Chen, X  Kobayashi, T  Kamada, Y  Nagashima, M  Tsutsuura, M  Seki, S  Yamakage, M  Namiki, A  Tohse, N 
Citation: Yamada Y, etal., Biochem Biophys Res Commun 2002 Jun 7;294(2):199-204.
RGD ID: 625471
Pubmed: PMID:12051693   (View Abstract at PubMed)
DOI: DOI:10.1016/S0006-291X(02)00459-X   (Journal Full-text)

KCNQ1 encodes a pore-forming subunit of potassium channels. Mutations in this gene cause inherited diseases, i.e., Romano-Ward syndrome and Jervell and Lange-Nielsen syndrome. A truncated isoform of KCNQ1 was reported to be expressed physiologically and to suppress a delayed rectifier potassium current dominant-negatively in human heart. However, it is not known whether this way of modulation occurs in other species. We cloned another truncated splice variant of KCNQ1 (tr-rKCNQ1) from rat heart. Judging from the deleted sequence of the tr-rKCNQ1, the genomic structure of rat in this portion might be different from those of human and mouse. Otherwise, an unknown exon might exist. RT-PCR analysis demonstrated that the tr-rKCNQ1 was expressed in fetal and neonatal hearts. When this gene was expressed along with a full-length KCNQ1, it suppressed potassium currents, whether a regulatory subunit minK was co-expressed or not.

Objects referenced in this article
Gene Kcnq1 potassium voltage-gated channel subfamily Q member 1 Rattus norvegicus

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