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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621503
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcnq1
Name: potassium voltage-gated channel subfamily Q member 1
Acc ID: CHEBI:34637
Term: Chromanol 293B
Definition: A 1-benzopyran that has formula C15H20N2O4S.
Chemical ID: MESH:C103474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnq1decreases activityISOKCNQ1 (Homo sapiens)6480464CTD6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane results in decreased activity of KCNQ1 proteinPMID:20050851
Kcnq1multiple interactionsISOKCNQ1 (Homo sapiens)6480464CTD6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane results in decreased activity of [KCNQ1 protein binds to KCNE1 protein]PMID:16909339
Kcnq1multiple interactionsISOKcnq1 (Mus musculus)6480464CTD6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane inhibits the reaction [[KCNQ1 protein binds to KCNE3 protein] which affects the transport of Potassium]PMID:11527966
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