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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621503
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcnq1
Name: potassium voltage-gated channel subfamily Q member 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnq1affects methylationISOKCNQ1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of KCNQ1 intron; Benzo(a)pyrene affects the methylation of KCNQ1 promoterPMID:27901495 PMID:30157460
Kcnq1decreases expressionISOKCNQ1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of KCNQ1 mRNAPMID:31555880
Kcnq1decreases expressionISOKcnq1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of KCNQ1 mRNAPMID:22228805
Kcnq1decreases methylationISOKcnq1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased methylation of KCNQ1 intronPMID:27901495
Kcnq1increases expressionISOKCNQ1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of KCNQ1 mRNAPMID:22316170
Kcnq1increases methylationISOKCNQ1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of KCNQ1 exon; Benzo(a)pyrene results in increased methylation of KCNQ1 genePMID:27901495 PMID:31555880
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