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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621503
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcnq1
Name: potassium voltage-gated channel subfamily Q member 1
Acc ID: CHEBI:29866
Term: arsenite(3-)
Definition: An arsenite ion resulting from the removal of all three protons from the hydroxy groups of arsenous acid.
Chemical ID: MESH:C015001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnq1increases methylationISOKCNQ1 (Homo sapiens)6480464CTDarsenite results in increased methylation of KCNQ1 promoterPMID:23974009
Kcnq1multiple interactionsISOKcnq1 (Mus musculus)6480464CTD[sodium arsenite results in increased abundance of arsenite] which results in decreased expression of KCNQ1 mRNAPMID:35090851
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