Kcne1 (potassium voltage-gated channel subfamily E regulatory subunit 1) - Rat Genome Database

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Gene: Kcne1 (potassium voltage-gated channel subfamily E regulatory subunit 1) Rattus norvegicus
Analyze
Symbol: Kcne1
Name: potassium voltage-gated channel subfamily E regulatory subunit 1
RGD ID: 2956
Description: Enables delayed rectifier potassium channel activity; potassium channel regulator activity; and transmembrane transporter binding activity. Involved in several processes, including cellular response to acidic pH; male gonad development; and negative regulation of protein targeting to membrane. Located in Z disc and apical plasma membrane. Part of voltage-gated potassium channel complex. Biomarker of congestive heart failure. Human ortholog(s) of this gene implicated in Jervell-Lange Nielsen syndrome; atrial fibrillation; long QT syndrome; and long QT syndrome 5. Orthologous to human KCNE1 (potassium voltage-gated channel subfamily E regulatory subunit 1); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; all-trans-retinoic acid; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: delayed rectifier potassium channel subunit IsK; IKs producing slow voltage-gated potassium channel subunit beta Mink; Isk; m; minimal potassium channel; mink; Potassium (K+) channel protein slowly activating (Isk); potassium (K+) channel protein, slowly activating (Isk); potassium channel, voltage gated subfamily E regulatory beta subunit 1; potassium channel, voltage-gated Isk-related subfamily E regulatory beta subunit 1; potassium voltage-gated channel Shaw-related subfamily member 1; potassium voltage-gated channel subfamily E member 1; potassium voltage-gated channel, Isk-related family, member 1; potassium voltage-gated channel, Isk-related subfamily, member 1; potassium voltage-gated channel, Shaw-related subfamily, member 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81145,066,875 - 45,080,024 (-)NCBIGRCr8
mRatBN7.21131,580,951 - 31,594,116 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1131,580,742 - 31,593,901 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1140,275,474 - 40,285,587 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01132,946,932 - 32,957,045 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01132,105,499 - 32,115,642 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01132,498,260 - 32,511,202 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1132,498,261 - 32,508,420 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01136,101,918 - 36,117,002 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41132,344,529 - 32,355,189 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11132,400,771 - 32,411,432 (-)NCBI
Celera1131,234,627 - 31,244,787 (-)NCBICelera
RH 3.4 Map11214.7RGD
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Regulation of neuronal type genes in congestive heart failure rats. Andersson KB, etal., Acta Physiol (Oxf). 2006 Jan;186(1):17-27.
2. Electrogram prolongation and nifedipine-suppressible ventricular arrhythmias in mice following targeted disruption of KCNE1. Balasubramaniam R, etal., J Physiol. 2003 Oct 15;552(Pt 2):535-46.
3. Mutation of the gene for IsK associated with both Jervell and Lange-Nielsen and Romano-Ward forms of Long-QT syndrome. Duggal P, etal., Circulation. 1998 Jan 20;97(2):142-6.
4. Cloning and expression of the delayed-rectifier IsK channel from neonatal rat heart and diethylstilbestrol-primed rat uterus. Folander K, etal., Proc Natl Acad Sci U S A 1990 Apr;87(8):2975-9.
5. Specific interaction of the potassium channel beta-subunit minK with the sarcomeric protein T-cap suggests a T-tubule-myofibril linking system. Furukawa T, etal., J Mol Biol. 2001 Nov 2;313(4):775-84.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Characterization of gene organization and generation of heterogeneous mRNA species of rat ISK protein. Iwai M, etal., J Biochem (Tokyo) 1990 Aug;108(2):200-6.
9. A large candidate gene survey identifies the KCNE1 D85N polymorphism as a possible modulator of drug-induced torsades de pointes. Kaab S, etal., Circ Cardiovasc Genet. 2012 Feb 1;5(1):91-9. doi: 10.1161/CIRCGENETICS.111.960930. Epub 2011 Nov 18.
10. KCNE1 and KCNE2 inhibit forward trafficking of homomeric N-type voltage-gated potassium channels. Kanda VA, etal., Biophys J. 2011 Sep 21;101(6):1354-63. doi: 10.1016/j.bpj.2011.08.015. Epub 2011 Sep 20.
11. KCNE1 and KCNE2 provide a checkpoint governing voltage-gated potassium channel a-subunit composition. Kanda VA, etal., Biophys J. 2011 Sep 21;101(6):1364-75. doi: 10.1016/j.bpj.2011.08.014. Epub 2011 Sep 20.
12. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
13. Association of the human minK gene 38G allele with atrial fibrillation: evidence of possible genetic control on the pathogenesis of atrial fibrillation. Lai LP, etal., Am Heart J. 2002 Sep;144(3):485-90.
14. Inhibitory effect of somatostatin on secretin-induced augmentation of the slowly activating K+ current (IKs) in the rat pancreatic acinar cell. Lee E, etal., Pflugers Arch 2002 Jan;443(3):405-10.
15. MinK, MiRP1, and MiRP2 diversify Kv3.1 and Kv3.2 potassium channel gating. Lewis A, etal., J Biol Chem. 2004 Feb 27;279(9):7884-92. Epub 2003 Dec 16.
16. Millimeter wave promotes the synthesis of extracellular matrix and the proliferation of chondrocyte by regulating the voltage-gated K+ channel. Li X, etal., J Bone Miner Metab. 2014 Jul;32(4):367-77. doi: 10.1007/s00774-013-0513-2. Epub 2013 Nov 8.
17. Regulation of the Kv2.1 potassium channel by MinK and MiRP1. McCrossan ZA, etal., J Membr Biol. 2009 Mar;228(1):1-14. doi: 10.1007/s00232-009-9154-8. Epub 2009 Feb 14.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Stoichiometry of the KCNQ1 - KCNE1 ion channel complex. Nakajo K, etal., Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18862-7. doi: 10.1073/pnas.1010354107. Epub 2010 Oct 20.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. D85N, a KCNE1 polymorphism, is a disease-causing gene variant in long QT syndrome. Nishio Y, etal., J Am Coll Cardiol. 2009 Aug 25;54(9):812-9. doi: 10.1016/j.jacc.2009.06.005.
22. Molecular and functional characterization of ERG, KCNQ, and KCNE subtypes in rat stomach smooth muscle. Ohya S, etal., Am J Physiol Gastrointest Liver Physiol 2002 Feb;282(2):G277-87.
23. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
24. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
25. GOA pipeline RGD automated data pipeline
26. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. Immunohistochemical study of a rat membrane protein which induces a selective potassium permeation: its localization in the apical membrane portion of epithelial cells. Sugimoto T, etal., J Membr Biol. 1990 Jan;113(1):39-47.
29. Compendium of cardiac channel mutations in 541 consecutive unrelated patients referred for long QT syndrome genetic testing. Tester DJ, etal., Heart Rhythm. 2005 May;2(5):507-17.
30. KCNQ1/KCNE1 channels during germ-cell differentiation in the rat: expression associated with testis pathologies. Tsevi I, etal., J Cell Physiol. 2005 Feb;202(2):400-10.2: id: 27199802 Error occurred: Document retrieval error: document does notexist
31. min K channels form by assembly of at least 14 subunits. Tzounopoulos T, etal., Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9593-7.
32. Upregulation of KCNE1 induces QT interval prolongation in patients with chronic heart failure. Watanabe E, etal., Circ J. 2007 Apr;71(4):471-8.
33. Changes in activation gating of IsK potassium currents brought about by mutations in the transmembrane sequence. Wilson GG, etal., FEBS Lett. 1994 Oct 24;353(3):251-4.
34. Dynamic changes in HCN2, HCN4, KCNE1, and KCNE2 expression in ventricular cells from acute myocardial infarction rat hearts. Xia S, etal., Biochem Biophys Res Commun. 2010 May 7;395(3):330-5. doi: 10.1016/j.bbrc.2010.04.003. Epub 2010 Apr 8.
35. External pH regulates the slowly activating potassium current IsK expressed in Xenopus oocytes. Yamane T, etal., FEBS Lett. 1993 Mar 22;319(3):229-32.
36. Skipping of Exon 1 in the KCNQ1 gene causes Jervell and Lange-Nielsen syndrome. Zehelein J, etal., J Biol Chem. 2006 Nov 17;281(46):35397-403. Epub 2006 Sep 19.
Additional References at PubMed
PMID:1553557   PMID:2344412   PMID:3194754   PMID:7605639   PMID:8900282   PMID:8900283   PMID:9354802   PMID:10400998   PMID:11220365   PMID:11223304   PMID:11299204   PMID:12522251  
PMID:16780588   PMID:17289006   PMID:17698596   PMID:19646991   PMID:21669976   PMID:23504710   PMID:24269949   PMID:28064310   PMID:28611207   PMID:34907346  


Genomics

Comparative Map Data
Kcne1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81145,066,875 - 45,080,024 (-)NCBIGRCr8
mRatBN7.21131,580,951 - 31,594,116 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1131,580,742 - 31,593,901 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1140,275,474 - 40,285,587 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01132,946,932 - 32,957,045 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01132,105,499 - 32,115,642 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01132,498,260 - 32,511,202 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1132,498,261 - 32,508,420 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01136,101,918 - 36,117,002 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41132,344,529 - 32,355,189 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11132,400,771 - 32,411,432 (-)NCBI
Celera1131,234,627 - 31,244,787 (-)NCBICelera
RH 3.4 Map11214.7RGD
Cytogenetic Map11q11NCBI
KCNE1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382134,446,688 - 34,512,210 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2134,446,688 - 34,512,214 (-)EnsemblGRCh38hg38GRCh38
GRCh372135,818,986 - 35,884,508 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362134,740,858 - 34,806,443 (-)NCBINCBI36Build 36hg18NCBI36
Build 342134,740,858 - 34,806,443NCBI
Celera2121,018,555 - 21,083,181 (-)NCBICelera
Cytogenetic Map21q22.12ENTREZGENE
HuRef2121,297,857 - 21,363,444 (-)NCBIHuRef
CHM1_12135,381,239 - 35,446,817 (-)NCBICHM1_1
T2T-CHM13v2.02132,829,243 - 32,898,958 (-)NCBIT2T-CHM13v2.0
Kcne1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391692,142,889 - 92,156,356 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1692,142,870 - 92,156,356 (-)EnsemblGRCm39 Ensembl
GRCm381692,346,001 - 92,359,468 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1692,345,982 - 92,359,468 (-)EnsemblGRCm38mm10GRCm38
MGSCv371692,346,246 - 92,359,713 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361692,234,860 - 92,248,327 (-)NCBIMGSCv36mm8
Celera1693,429,327 - 93,442,798 (-)NCBICelera
Cytogenetic Map16C4NCBI
cM Map1653.57NCBI
Kcne1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540733,807,581 - 33,814,356 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540733,807,581 - 33,814,356 (-)NCBIChiLan1.0ChiLan1.0
KCNE1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22230,566,300 - 30,634,574 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12125,424,445 - 25,492,209 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02120,818,395 - 20,884,053 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12134,187,482 - 34,252,573 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2134,190,043 - 34,190,441 (-)Ensemblpanpan1.1panPan2
KCNE1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13129,858,428 - 29,868,315 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3128,958,149 - 28,967,760 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03129,159,562 - 29,169,178 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13129,025,740 - 29,034,430 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03129,040,518 - 29,050,143 (-)NCBIUNSW_CanFamBas_1.0
Kcne1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497129,459,975 - 29,505,317 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365008,007,291 - 8,007,680 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365007,998,464 - 8,007,848 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNE1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13198,051,282 - 198,059,296 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113198,051,281 - 198,059,444 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213207,879,823 - 207,887,895 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNE1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1278,500,755 - 78,557,275 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl278,503,317 - 78,503,757 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660546,317,391 - 6,329,488 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcne1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474522,624,765 - 22,631,609 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474522,624,414 - 22,631,625 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcne1
82 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:15
Count of miRNA genes:15
Interacting mature miRNAs:15
Transcripts:ENSRNOT00000002717
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11135331169Rat
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111647204744285911Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat

Markers in Region
RH94732  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21131,580,951 - 31,581,051 (+)MAPPERmRatBN7.2
Rnor_6.01132,498,261 - 32,498,360NCBIRnor6.0
Rnor_5.01136,101,919 - 36,102,018UniSTSRnor5.0
RGSC_v3.41132,344,529 - 32,344,628UniSTSRGSC3.4
Celera1131,234,627 - 31,234,726UniSTS
RH 3.4 Map11214.7UniSTS
Cytogenetic Map11q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system appendage
High
Medium 4 12
Low 33 9 9 7 9 27 8
Below cutoff 10 11 9 3 9 2 3 12 4 17 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000002717   ⟹   ENSRNOP00000002717
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1131,580,952 - 31,581,962 (-)Ensembl
Rnor_6.0 Ensembl1132,498,261 - 32,508,420 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096553   ⟹   ENSRNOP00000086617
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1131,580,742 - 31,593,901 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098014   ⟹   ENSRNOP00000087251
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1131,580,952 - 31,582,831 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114695   ⟹   ENSRNOP00000092414
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1131,580,742 - 31,593,901 (-)Ensembl
RefSeq Acc Id: NM_012973   ⟹   NP_037105
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81145,066,876 - 45,077,033 (-)NCBI
mRatBN7.21131,580,952 - 31,591,112 (-)NCBI
Rnor_6.01132,498,261 - 32,508,420 (-)NCBI
Rnor_5.01136,101,918 - 36,117,002 (-)NCBI
RGSC_v3.41132,344,529 - 32,355,189 (-)RGD
Celera1131,234,627 - 31,244,787 (-)RGD
Sequence:
RefSeq Acc Id: XM_006248034   ⟹   XP_006248096
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81145,066,875 - 45,068,479 (-)NCBI
mRatBN7.21131,580,951 - 31,582,534 (-)NCBI
Rnor_6.01132,498,260 - 32,499,844 (-)NCBI
Rnor_5.01136,101,918 - 36,117,002 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006248035   ⟹   XP_006248097
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81145,066,875 - 45,076,782 (-)NCBI
mRatBN7.21131,580,951 - 31,591,006 (-)NCBI
Rnor_6.01132,498,260 - 32,508,107 (-)NCBI
Rnor_5.01136,101,918 - 36,117,002 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597886   ⟹   XP_017453375
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81145,066,875 - 45,080,024 (-)NCBI
mRatBN7.21131,580,951 - 31,594,116 (-)NCBI
Rnor_6.01132,498,260 - 32,511,202 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597887   ⟹   XP_017453376
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81145,066,875 - 45,069,079 (-)NCBI
mRatBN7.21131,580,951 - 31,582,926 (-)NCBI
Rnor_6.01132,498,260 - 32,499,917 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_037105   ⟸   NM_012973
- UniProtKB: P15383 (UniProtKB/Swiss-Prot),   A6JLJ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248097   ⟸   XM_006248035
- Peptide Label: isoform X1
- UniProtKB: P15383 (UniProtKB/Swiss-Prot),   A6JLJ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248096   ⟸   XM_006248034
- Peptide Label: isoform X1
- UniProtKB: P15383 (UniProtKB/Swiss-Prot),   A6JLJ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453375   ⟸   XM_017597886
- Peptide Label: isoform X1
- UniProtKB: P15383 (UniProtKB/Swiss-Prot),   A6JLJ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453376   ⟸   XM_017597887
- Peptide Label: isoform X1
- UniProtKB: P15383 (UniProtKB/Swiss-Prot),   A6JLJ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000002717   ⟸   ENSRNOT00000002717
RefSeq Acc Id: ENSRNOP00000086617   ⟸   ENSRNOT00000096553
RefSeq Acc Id: ENSRNOP00000087251   ⟸   ENSRNOT00000098014
RefSeq Acc Id: ENSRNOP00000092414   ⟸   ENSRNOT00000114695

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P15383-F1-model_v2 AlphaFold P15383 1-130 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2956 AgrOrtholog
BioCyc Gene G2FUF-21838 BioCyc
Ensembl Genes ENSRNOG00000001984 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055017447 UniProtKB/Swiss-Prot
  ENSRNOG00060017747 UniProtKB/Swiss-Prot
  ENSRNOG00065013426 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002717 ENTREZGENE
  ENSRNOT00000002717.3 UniProtKB/Swiss-Prot
  ENSRNOT00000096553.1 UniProtKB/Swiss-Prot
  ENSRNOT00000098014.1 UniProtKB/Swiss-Prot
  ENSRNOT00000114695.1 UniProtKB/Swiss-Prot
  ENSRNOT00055029526 UniProtKB/Swiss-Prot
  ENSRNOT00055029527 UniProtKB/Swiss-Prot
  ENSRNOT00055029528 UniProtKB/Swiss-Prot
  ENSRNOT00055029530 UniProtKB/Swiss-Prot
  ENSRNOT00060030360 UniProtKB/Swiss-Prot
  ENSRNOT00060030378 UniProtKB/Swiss-Prot
  ENSRNOT00060030400 UniProtKB/Swiss-Prot
  ENSRNOT00060030405 UniProtKB/Swiss-Prot
  ENSRNOT00065022081 UniProtKB/Swiss-Prot
  ENSRNOT00065022085 UniProtKB/Swiss-Prot
  ENSRNOT00065022087 UniProtKB/Swiss-Prot
  ENSRNOT00065022089 UniProtKB/Swiss-Prot
InterPro K_chnl_KCNE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_bsu_KCNE1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25471 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25471 ENTREZGENE
PANTHER POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY E MEMBER 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY E MEMBER 1, 3 UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
Pfam ISK_Channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB KCNE1 RGD
PhenoGen Kcne1 PhenoGen
PRINTS KCNE1CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KCNECHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001984 RatGTEx
  ENSRNOG00055017447 RatGTEx
  ENSRNOG00060017747 RatGTEx
  ENSRNOG00065013426 RatGTEx
UniProt A6JLJ7 ENTREZGENE, UniProtKB/TrEMBL
  KCNE1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcne1  potassium voltage-gated channel subfamily E regulatory subunit 1  Kcne1  potassium channel, voltage gated subfamily E regulatory beta subunit 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-01-27 Kcne1  potassium channel, voltage gated subfamily E regulatory beta subunit 1  Kcne1  potassium channel, voltage-gated Isk-related subfamily E regulatory beta subunit 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcne1  potassium channel, voltage-gated Isk-related subfamily E regulatory beta subunit 1  Kcne1  potassium voltage-gated channel, Isk-related family, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-01-14 Kcne1  Potassium voltage-gated channel, Isk-related subfamily, member 1      Correction to spelling of name 68913 APPROVED
2001-10-23 Kcne1  Potassium voltage-gated channel, Shaw-related subfamily, member 1      Name updated to reflect Human and Mouse nomenclature 68913 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the fundus and antrum of the stomach, brain, adrenal gland, thymus, retina, and skeletal muscle 625508
gene_expression expressed in antrum and but not in fundus of the stomach 625508
gene_process responsible for the potassium current deactivation by depolarization 625508
gene_process curents generated by channel may counteract in the increase of muscle tone resulting in the regulation of the rhythms in stomach smooth muscle contraction 625508
gene_product 471 bp 625508