Hsd11b1 (hydroxysteroid 11-beta dehydrogenase 1) - Rat Genome Database

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Gene: Hsd11b1 (hydroxysteroid 11-beta dehydrogenase 1) Rattus norvegicus
Analyze
Symbol: Hsd11b1
Name: hydroxysteroid 11-beta dehydrogenase 1
RGD ID: 2834
Description: Enables NADP binding activity and steroid binding activity. Involved in several processes, including cellular response to estradiol stimulus; glucocorticoid metabolic process; and regulation of pentose-phosphate shunt. Located in apical part of cell and nuclear membrane. Used to study obesity. Biomarker of familial hyperlipidemia; status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in cortisone reductase deficiency (multiple); hypertension (multiple); and type 2 diabetes mellitus. Orthologous to human HSD11B1 (hydroxysteroid 11-beta dehydrogenase 1); PARTICIPATES IN 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; 21-alpha-hydroxylase deficiency pathway; INTERACTS WITH (S)-nicotine; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 11-dehydrocorticosterone.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 11-beta-HSD1; 11-beta-hydroxysteroid dehydrogenase 1; 11-beta-hydroxysteroid dehydrogenase, type 1; 11-DH; 11beta-HSD1; 7-oxosteroid reductase; corticosteroid 11-beta-dehydrogenase isozyme 1; cortocosteroid 11-beta dehydrogenase; hydroxysteroid dehydrogenase 11 beta type 1; hydroxysteroid dehydrogenase, 11 beta type 1; LRRGT00065
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813107,277,526 - 107,327,462 (-)NCBIGRCr8
mRatBN7.213104,728,539 - 104,798,884 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl13104,728,539 - 104,788,687 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13107,266,432 - 107,292,403 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013108,650,289 - 108,676,261 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.013105,868,245 - 105,894,215 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013111,946,626 - 111,996,536 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13111,926,442 - 111,972,603 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013116,502,230 - 116,551,778 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413109,063,491 - 109,089,468 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113109,252,609 - 109,278,318 (-)NCBI
Celera13104,178,893 - 104,204,865 (-)NCBICelera
Cytogenetic Map13q27NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (EXP,ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
11-dehydrocorticosterone  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3,7-dihydropurine-6-thione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanic acid  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (ISO)
4-tert-Octylphenol  (EXP)
6-propyl-2-thiouracil  (EXP,ISO)
6alpha-methylprednisolone  (ISO)
7-oxolithocholic acid  (ISO)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
ammonium chloride  (EXP)
androstane-3,17-diol  (ISO)
arsenic acid  (ISO)
atrazine  (EXP)
azathioprine  (ISO)
benzamide  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
bezafibrate  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) adipate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP,ISO)
Butylbenzyl phthalate  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calcitriol  (ISO)
CARBENOXOLONE  (EXP,ISO)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
cholic acid  (ISO)
chromium atom  (EXP)
cisplatin  (EXP)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
copper(II) chloride  (ISO)
cordycepin  (ISO)
corticosterone  (EXP,ISO)
cortisol  (EXP,ISO)
cortisone  (EXP,ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Di-n-hexyl phthalate  (EXP)
dibenz[a,h]anthracene  (EXP)
dibenzo[a,l]pyrene  (EXP)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
Dicyclohexyl phthalate  (EXP)
diethyl hydrogen phosphate  (EXP)
diethylstilbestrol  (EXP)
diiodine  (ISO)
disulfiram  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
drospirenone  (ISO)
ethanol  (EXP,ISO)
fenofibrate  (ISO)
fenthion  (ISO)
ferric oxide  (EXP)
fipronil  (ISO)
fluoranthene  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
furosemide  (EXP)
genistein  (EXP,ISO)
glycochenodeoxycholic acid  (ISO)
glycolithocholic acid  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
herbicide  (EXP)
hyodeoxycholic acid  (ISO)
indometacin  (ISO)
inulin  (ISO)
isotretinoin  (ISO)
kainic acid  (ISO)
ketamine  (EXP)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
medroxyprogesterone acetate  (ISO)
mercaptopurine  (EXP)
methidathion  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
metyrapone  (ISO)
mifepristone  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
morphine  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-nitrosodiethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
NADP zwitterion  (EXP,ISO)
NADP(+)  (EXP,ISO)
nickel atom  (ISO)
nicotine  (EXP,ISO)
nitrofen  (EXP)
Nonylphenol  (EXP)
oxaliplatin  (EXP)
oxycodone  (EXP)
ozone  (ISO)
p-tert-Amylphenol  (EXP)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parathion  (ISO)
perfluorododecanoic acid  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (EXP)
phenobarbital  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
prednisolone  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP,ISO)
Propiverine  (EXP)
prostaglandin E2  (ISO)
purine-6-thiol  (EXP)
pyrazinecarboxamide  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
SB 203580  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
spironolactone  (ISO)
sulforaphane  (ISO)
taurolithocholic acid  (ISO)
tauroursodeoxycholic acid  (EXP,ISO)
tenofovir disoproxil fumarate  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
triadimefon  (EXP)
trimethyltin  (EXP,ISO)
triphenylstannane  (EXP)
troglitazone  (EXP,ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zearalenone  (EXP)
zidovudine  (ISO)
zinc protoporphyrin  (ISO)
zinc sulfate  (ISO)
ziram  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Cloning and expression of rat cDNA encoding corticosteroid 11 beta-dehydrogenase. Agarwal AK, etal., J Biol Chem 1989 Nov 15;264(32):18939-43.
2. The role of mediastinal adipose tissue 11β-hydroxysteroid d ehydrogenase type 1 and glucocorticoid expression in the development of coronary atherosclerosis in obese patients with ischemic heart disease. Atalar F, etal., Cardiovasc Diabetol. 2012 Sep 25;11:115. doi: 10.1186/1475-2840-11-115.
3. 11β-hydroxysteroid dehydrogenase type 1 gene expression is increased in ascending aorta tissue of metabolic syndrome patients with coronary artery disease. Atalar F, etal., Genet Mol Res. 2012 Aug 31;11(3):3122-32. doi: 10.4238/2012.August.31.10.
4. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
5. Light and electron microscopy localization of the 11beta-hydroxysteroid dehydrogenase type I enzyme in the rat. Brereton PS, etal., Endocrinology. 2001 Apr;142(4):1644-51.
6. Cooperativity between 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase is based on a common pyridine nucleotide pool in the lumen of the endoplasmic reticulum. Czegle I, etal., Mol Cell Endocrinol. 2006 Mar 27;248(1-2):24-5. Epub 2005 Dec 6.
7. Association of HSD11B1 gene polymorphisms with type 2 diabetes and metabolic syndrome in South Indian population. Devang N, etal., Diabetes Res Clin Pract. 2017 Sep;131:142-148. doi: 10.1016/j.diabres.2017.07.011. Epub 2017 Jul 13.
8. Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency. Draper N, etal., Nat Genet. 2003 Aug;34(4):434-9.
9. Increased expression and activity of 11beta-HSD-1 in diabetic islets and prevention with troglitazone. Duplomb L, etal., Biochem Biophys Res Commun. 2004 Jan 16;313(3):594-9.
10. Interaction between an 11betaHSD1 gene variant and birth era modifies the risk of hypertension in Pima Indians. Franks PW, etal., Hypertension. 2004 Nov;44(5):681-8. doi: 10.1161/01.HYP.0000144294.28985.d5. Epub 2004 Sep 27.
11. A combination of polymorphisms in HSD11B1 associates with in vivo 11{beta}-HSD1 activity and metabolic syndrome in women with and without polycystic ovary syndrome. Gambineri A, etal., Eur J Endocrinol. 2011 Aug;165(2):283-92. doi: 10.1530/EJE-11-0091. Epub 2011 May 27.
12. Association between a 11β-hydroxysteroid dehydrogenase type 1 gene polymorphism and metabolic syndrome in a South Indian population. Gandhi K, etal., Metab Syndr Relat Disord. 2013 Dec;11(6):397-402. doi: 10.1089/met.2013.0049. Epub 2013 Jul 20.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. 11{beta}-Hydroxysteroid dehydrogenase 2 in rat leydig cells: its role in blunting glucocorticoid action at physiological levels of substrate. Ge RS, etal., Endocrinology. 2005 Jun;146(6):2657-64. Epub 2005 Mar 10.
15. Stimulation of testosterone production in rat Leydig cells by aldosterone is mineralocorticoid receptor mediated. Ge RS, etal., Mol Cell Endocrinol. 2005 Nov 24;243(1-2):35-42. Epub 2005 Sep 26.
16. Association between ins4436A in 11beta-hydroxysteroid dehydrogenase type 1 gene and essential hypertension in Polish population. Hejduk P, etal., Postepy Hig Med Dosw (Online). 2015 Nov 17;69:1245-50.
17. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
18. Maternal low protein diet restricted to the preimplantation period induces a gender-specific change on hepatic gene expression in rat fetuses. Kwong WY, etal., Mol Reprod Dev. 2007 Jan;74(1):48-56.
19. Different responsiveness in body weight and hepatic 11beta-hydroxysteroid dehydrogenase (11beta-HSD) type 1 mrna to 11beta-HSD inhibition by glycyrrhetinic acid treatment in obese and lean zucker rats. Li RS, etal., Metabolism. 2004 May;53(5):600-6.
20. Adipose tissue 11beta-hydroxysteroid dehydrogenase type 1 expression in obesity and Cushing's syndrome. Mariniello B, etal., Eur J Endocrinol. 2006 Sep;155(3):435-41.
21. A transgenic model of visceral obesity and the metabolic syndrome. Masuzaki H, etal., Science 2001 Dec 7;294(5549):2166-70.
22. Evidence that the 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD1) is regulated by pentose pathway flux. Studies in rat adipocytes and microsomes. McCormick KL, etal., J Biol Chem. 2006 Jan 6;281(1):341-7. Epub 2005 Oct 18.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. Variants in HSD11B1 gene modulate susceptibility to diabetes kidney disease and to insulin resistance in type 1 diabetes. Mori RC, etal., Diabetes Metab Res Rev. 2021 Jan;37(1):e3352. doi: 10.1002/dmrr.3352. Epub 2020 Jun 21.
25. 11β-HSD1 suppresses cardiac fibroblast CXCL2, CXCL5 and neutrophil recruitment to the heart post MI. Mylonas KJ, etal., J Endocrinol. 2017 Jun;233(3):315-327. doi: 10.1530/JOE-16-0501.
26. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
27. Purification of full-length recombinant human and rat type 1 11beta-hydroxysteroid dehydrogenases with retained oxidoreductase activities. Nobel CS, etal., Protein Expr Purif. 2002 Dec;26(3):349-56.
28. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
29. Effect of cellular differentiation on 11beta-hydroxysteroid dehydrogenase activity in the intestine. Pacha J, etal., Steroids 2002 Feb;67(2):119-26.
30. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
31. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
32. GOA pipeline RGD automated data pipeline
33. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. Metabolic gene expression changes in the hippocampus of obese epileptic male rats in the pilocarpine model of temporal lobe epilepsy. Ruiz N, etal., Brain Res. 2011 Dec 2;1426:86-95. Epub 2011 Oct 8.
36. 11Beta-hydroxysteroid dehydrogenase 1 transforms 11-dehydrocorticosterone into transcriptionally active glucocorticoid in neonatal rat heart. Sheppard KE and Autelitano DJ, Endocrinology 2002 Jan;143(1):198-204.
37. Glucocorticoid synthesis-related genes: HSD11B1 and HSD11B2 in hypertensive disorders in pregnancy. Shimodaira M, etal., Gynecol Endocrinol. 2013 Jul;29(7):657-61. doi: 10.3109/09513590.2013.788623. Epub 2013 May 9.
38. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
39. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
40. 17Beta-estradiol inhibits 11beta-hydroxysteroid dehydrogenase type 1 activity in rodent adipocytes. Tagawa N, etal., J Endocrinol. 2009 Jul;202(1):131-9. Epub 2009 Apr 20.
41. Localization of 11beta-hydroxysteroid dehydrogenase types 1 and 2 in the male reproductive tract. Waddell BJ, etal., Endocrinology. 2003 Jul;144(7):3101-6.
42. Cardiomyocyte and Vascular Smooth Muscle-Independent 11beta-Hydroxysteroid Dehydrogenase 1 Amplifies Infarct Expansion, Hypertrophy, and the Development of Heart Failure After Myocardial Infarction in Male Mice. White CI, etal., Endocrinology. 2016 Jan;157(1):346-57. doi: 10.1210/en.2015-1630. Epub 2015 Oct 14.
43. Di (n-butyl) phthalate inhibits testosterone synthesis through a glucocorticoid-mediated pathway in rats. Xiao-feng Z, etal., Int J Toxicol. 2009 Sep-Oct;28(5):448-56.
Additional References at PubMed
PMID:1417845   PMID:1508221   PMID:1733955   PMID:3460996   PMID:8940387   PMID:10497248   PMID:10906322   PMID:12439781   PMID:12700160   PMID:12810555   PMID:14599119   PMID:14973125  
PMID:15095019   PMID:15152005   PMID:15489334   PMID:15512857   PMID:15513927   PMID:15862976   PMID:17070044   PMID:17303657   PMID:17332068   PMID:17919905   PMID:18029473   PMID:18039793  
PMID:18069989   PMID:18187395   PMID:18379559   PMID:18485702   PMID:18550363   PMID:18553955   PMID:18716005   PMID:18826995   PMID:19009916   PMID:19118409   PMID:19208548   PMID:19217779  
PMID:19583995   PMID:19766266   PMID:19946888   PMID:20016029   PMID:20130180   PMID:20358345   PMID:20484633   PMID:20932307   PMID:21083914   PMID:21163329   PMID:21440566   PMID:21513799  
PMID:21696642   PMID:21825133   PMID:21879473   PMID:22142627   PMID:22173247   PMID:22739210   PMID:22792090   PMID:23832962   PMID:23979791   PMID:24397806   PMID:24586766   PMID:25430643  
PMID:26399510   PMID:26528718   PMID:27268236   PMID:33722534   PMID:35563271   PMID:37300580   PMID:38712392  


Genomics

Comparative Map Data
Hsd11b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813107,277,526 - 107,327,462 (-)NCBIGRCr8
mRatBN7.213104,728,539 - 104,798,884 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl13104,728,539 - 104,788,687 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13107,266,432 - 107,292,403 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013108,650,289 - 108,676,261 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.013105,868,245 - 105,894,215 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013111,946,626 - 111,996,536 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13111,926,442 - 111,972,603 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013116,502,230 - 116,551,778 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413109,063,491 - 109,089,468 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113109,252,609 - 109,278,318 (-)NCBI
Celera13104,178,893 - 104,204,865 (-)NCBICelera
Cytogenetic Map13q27NCBI
HSD11B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381209,686,179 - 209,734,929 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1209,686,178 - 209,734,949 (+)EnsemblGRCh38hg38GRCh38
GRCh371209,859,524 - 209,908,274 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361207,926,173 - 207,974,918 (+)NCBINCBI36Build 36hg18NCBI36
Build 341206,266,585 - 206,296,690NCBI
Celera1183,090,437 - 183,139,187 (+)NCBICelera
Cytogenetic Map1q32.2NCBI
HuRef1180,534,794 - 180,583,575 (+)NCBIHuRef
CHM1_11211,131,921 - 211,180,673 (+)NCBICHM1_1
T2T-CHM13v2.01208,932,934 - 208,981,687 (+)NCBIT2T-CHM13v2.0
Hsd11b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391192,903,917 - 192,946,345 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1192,903,942 - 192,946,383 (-)EnsemblGRCm39 Ensembl
GRCm381193,221,640 - 193,264,045 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1193,221,634 - 193,264,075 (-)EnsemblGRCm38mm10GRCm38
MGSCv371195,047,834 - 195,090,239 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361194,922,413 - 194,964,769 (-)NCBIMGSCv36mm8
Celera1200,096,784 - 200,141,189 (-)NCBICelera
Cytogenetic Map1H6NCBI
cM Map197.67NCBI
Hsd11b1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554892,497,680 - 2,524,805 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554892,500,928 - 2,524,715 (-)NCBIChiLan1.0ChiLan1.0
HSD11B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2139,662,235 - 39,715,349 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1139,632,569 - 39,681,576 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01185,262,599 - 185,311,417 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11190,086,449 - 190,116,765 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1190,086,449 - 190,116,765 (+)Ensemblpanpan1.1panPan2
HSD11B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.178,344,380 - 8,409,901 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl78,344,447 - 8,409,897 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha77,959,522 - 7,986,906 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.078,045,319 - 8,110,393 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl78,045,392 - 8,110,389 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.178,012,426 - 8,039,787 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.078,109,437 - 8,136,847 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.078,170,917 - 8,198,302 (+)NCBIUU_Cfam_GSD_1.0
Hsd11b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934466,118,456 - 66,179,043 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365573,357,016 - 3,403,714 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365573,358,809 - 3,403,461 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSD11B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9133,231,451 - 133,278,396 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19133,231,451 - 133,278,396 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
HSD11B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12519,720,096 - 19,772,806 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2519,719,848 - 19,750,200 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605520,319,360 - 20,369,697 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hsd11b1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248072,261,006 - 2,293,804 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248072,260,702 - 2,293,962 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hsd11b1
349 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:293
Count of miRNA genes:182
Interacting mature miRNAs:209
Transcripts:ENSRNOT00000007870, ENSRNOT00000048074
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1366451204106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat

Markers in Region
D13Wox22  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.213104,772,782 - 104,772,955 (+)MAPPERmRatBN7.2
Rnor_6.013111,970,579 - 111,970,751NCBIRnor6.0
Rnor_5.013116,526,349 - 116,526,521UniSTSRnor5.0
RGSC_v3.413109,087,444 - 109,087,616UniSTSRGSC3.4
Celera13104,202,844 - 104,203,016UniSTS
Cytogenetic Map13q27UniSTS
X83202  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.213104,749,033 - 104,749,159 (+)MAPPERmRatBN7.2
Rnor_6.013111,946,831 - 111,946,956NCBIRnor6.0
Rnor_5.013116,502,435 - 116,502,560UniSTSRnor5.0
RGSC_v3.413109,063,696 - 109,063,821UniSTSRGSC3.4
Celera13104,179,098 - 104,179,223UniSTS
Cytogenetic Map13q27UniSTS
AU048742  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14q11UniSTS
Cytogenetic Map13q27UniSTS
Cytogenetic Map13q24UniSTS
Cytogenetic Map20q11UniSTS
RH128149  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.213104,748,954 - 104,749,140 (+)MAPPERmRatBN7.2
Rnor_6.013111,946,752 - 111,946,937NCBIRnor6.0
Rnor_5.013116,502,356 - 116,502,541UniSTSRnor5.0
RGSC_v3.413109,063,617 - 109,063,802UniSTSRGSC3.4
Celera13104,179,019 - 104,179,204UniSTS
RH 3.4 Map13760.1UniSTS
Cytogenetic Map13q27UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001429463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_017080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC126166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF542063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY387051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC078865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK474613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J05107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y10420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000007870   ⟹   ENSRNOP00000007870
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl13104,748,824 - 104,779,108 (-)Ensembl
Rnor_6.0 Ensembl13111,946,630 - 111,972,603 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000048074   ⟹   ENSRNOP00000050581
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl13104,728,539 - 104,750,956 (-)Ensembl
Rnor_6.0 Ensembl13111,926,442 - 111,948,753 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116672   ⟹   ENSRNOP00000089436
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl13104,748,829 - 104,788,687 (-)Ensembl
RefSeq Acc Id: NM_017080   ⟹   NP_058776
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813107,277,526 - 107,303,501 (-)NCBI
mRatBN7.213104,748,829 - 104,774,809 (-)NCBI
Rnor_6.013111,946,626 - 111,972,603 (-)NCBI
Rnor_5.013116,502,230 - 116,551,778 (-)NCBI
RGSC_v3.413109,063,491 - 109,089,468 (-)RGD
Celera13104,178,893 - 104,204,865 (-)RGD
Sequence:
RefSeq Acc Id: XM_006250473   ⟹   XP_006250535
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813107,277,526 - 107,327,462 (-)NCBI
mRatBN7.213104,748,829 - 104,798,770 (-)NCBI
Rnor_6.013111,946,626 - 111,996,536 (-)NCBI
Rnor_5.013116,502,230 - 116,551,778 (-)NCBI
Sequence:
RefSeq Acc Id: NP_058776   ⟸   NM_017080
- UniProtKB: O09170 (UniProtKB/Swiss-Prot),   Q6LDH6 (UniProtKB/Swiss-Prot),   P16232 (UniProtKB/Swiss-Prot),   A6JH26 (UniProtKB/TrEMBL),   A0A8I6GHA3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250535   ⟸   XM_006250473
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000050581   ⟸   ENSRNOT00000048074
Ensembl Acc Id: ENSRNOP00000007870   ⟸   ENSRNOT00000007870
Ensembl Acc Id: ENSRNOP00000089436   ⟸   ENSRNOT00000116672
Protein Domains
Reverse transcriptase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P16232-F1-model_v2 AlphaFold P16232 1-288 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699127
Promoter ID:EPDNEW_R9652
Type:multiple initiation site
Name:Hsd11b1_1
Description:hydroxysteroid 11-beta dehydrogenase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.013111,972,368 - 111,972,428EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2834 AgrOrtholog
BioCyc Gene G2FUF-16787 BioCyc
BioCyc Pathway PWY-8202 [11-oxyandrogens biosynthesis] BioCyc
BioCyc Pathway Image PWY-8202 BioCyc
Ensembl Genes ENSRNOG00000005861 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007870.6 UniProtKB/TrEMBL
  ENSRNOT00000048074.5 UniProtKB/TrEMBL
  ENSRNOT00000116672.1 UniProtKB/TrEMBL
Gene3D-CATH L1 transposable element, RRM domain UniProtKB/TrEMBL
  L1 transposable element, trimerization domain UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7109256 IMAGE-MGC_LOAD
InterPro 11-beta-HSD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA/RNA_pol_sf UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RVT UniProtKB/TrEMBL
  Sc_DH/Rdtase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SDR_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25116 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93529 IMAGE-MGC_LOAD
NCBI Gene 25116 ENTREZGENE
PANTHER CORTICOSTEROID 11-BETA-DEHYDROGENASE ISOZYME 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HYDROXYSTEROID (11-BETA) DEHYDROGENASE 1-LIKE B-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LINE-1 RETROTRANSPOSABLE ELEMENT ORF2 PROTEIN UniProtKB/TrEMBL
  REVERSE TRANSCRIPTASES UniProtKB/TrEMBL
Pfam adh_short UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RVT_1 UniProtKB/TrEMBL
PhenoGen Hsd11b1 PhenoGen
PRINTS GDHRDH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ADH_SHORT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RT_POL UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005861 RatGTEx
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56672 UniProtKB/TrEMBL
UniProt A0A8I6GHA3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q3E0_RAT UniProtKB/TrEMBL
  A6JH26 ENTREZGENE, UniProtKB/TrEMBL
  DHI1_RAT UniProtKB/Swiss-Prot
  O09170 ENTREZGENE
  P16232 ENTREZGENE
  Q6LDH6 ENTREZGENE
  Q6TUH9_RAT UniProtKB/TrEMBL
UniProt Secondary O09170 UniProtKB/Swiss-Prot
  Q6LDH6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Hsd11b1  hydroxysteroid 11-beta dehydrogenase 1    hydroxysteroid dehydrogenase, 11 beta type 1  Name updated 629478 APPROVED
2002-06-10 Hsd11b1  hydroxysteroid dehydrogenase, 11 beta type 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression highly expressed in both cardiac myocytes and fibroblasts 70436
gene_expression widely expressed 70436
gene_function acts as a reductase converting inactive 11-dehydrocorticosterone to corticosterone 70436
gene_process stimulates serum and glucocorticiod-induced kinase gene 70436