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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2834
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hsd11b1
Name: hydroxysteroid 11-beta dehydrogenase 1
Acc ID: CHEBI:17650
Term: cortisol
Definition: A 17alpha-hydroxy-C21-steroid that is pregn-4-ene substituted by oxo groups at positions 3 and 20 and hydroxy groups at positions 11, 17 and 21. Cortisol is a corticosteroid hormone or glucocorticoid produced by zona fasciculata of the adrenal cortex, which is a part of the adrenal gland. It is usually referred to as the 'stress hormone' as it is involved in response to stress and anxiety, controlled by corticotropin-releasing hormone (CRH). It increases blood pressure and blood sugar, and reduces immune responses.
Chemical ID: MESH:D006854
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hsd11b1affects response to substanceEXP 6480464CTDHSD11B1 protein affects the susceptibility to HydrocortisonePMID:22606287
Hsd11b1multiple interactionsEXP 6480464CTD[HSD11B1 protein affects the susceptibility to Hydrocortisone] which results in decreased activity of NFE2L2 proteinPMID:22606287
Hsd11b1affects expressionISOHSD11B1 (Homo sapiens)6480464CTDHydrocortisone affects the expression of HSD11B1 mRNAPMID:30528684
Hsd11b1affects oxidationISOHSD11B1 (Homo sapiens)6480464CTDHSD11B1 protein affects the oxidation of HydrocortisonePMID:17761898
Hsd11b1increases activityISOHSD11B1 (Homo sapiens)6480464CTDHydrocortisone results in increased activity of HSD11B1 proteinPMID:20410225
Hsd11b1increases chemical synthesisISOHSD11B1 (Homo sapiens)6480464CTDHSD11B1 protein results in increased chemical synthesis of HydrocortisonePMID:16054388 PMID:16751407 PMID:22178014
Hsd11b1increases expressionISOHSD11B1 (Homo sapiens)6480464CTDHydrocortisone results in increased expression of HSD11B1; Hydrocortisone results in increased expression of HSD11B1 mRNA; Hydrocortisone results in increased expression of HSD11B1 proteinPMID:16054388 PMID:20410225 PMID:27288094 PMID:30528684 PMID:32535229
Hsd11b1increases oxidationISOHSD11B1 (Homo sapiens)6480464CTDHSD11B1 protein results in increased oxidation of HydrocortisonePMID:26859423
Hsd11b1multiple interactionsISOHSD11B1 (Homo sapiens)6480464CTD[HSD11B1 protein results in increased metabolism of Ketosteroids] which results in increased chemical synthesis of Hydrocortisone; [HSD11B1 protein results in increased oxidation of Hydrocortisone] which results in increased chemical synthesis of Cortisone; [HSD11B1 protein results in increased reduction of Cortisone] which results in increased chemical synthesis of Hydrocortisone; Dinoprostone promotes the reaction [HSD11B1 protein affects the oxidation of Hydrocortisone]; Hydrocortisone promotes the reaction [[Progesterone co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of HSD11B1 mRNA]; Mifepristone affects the reaction [Hydrocortisone affects the expression of HSD11B1 mRNA]; perfluorooctane sulfonic acid inhibits the reaction [Hydrocortisone results in increased expression of HSD11B1]PMID:17761898 PMID:22178014 PMID:23275455 PMID:26859423 PMID:27288094 PMID:30528684
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