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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2834
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hsd11b1
Name: hydroxysteroid 11-beta dehydrogenase 1
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hsd11b1decreases activityEXP 6480464CTDresveratrol results in decreased activity of HSD11B1 proteinPMID:23814014
Hsd11b1multiple interactionsEXP 6480464CTDResveratrol inhibits the reaction [HSD11B1 protein results in increased chemical synthesis of Corticosterone]; Resveratrol inhibits the reaction [HSD11B1 protein results in increased metabolism of 11-dehydrocorticosterone]PMID:23814014
Hsd11b1decreases activityISOHsd11b1 (Mus musculus)6480464CTDresveratrol results in decreased activity of HSD11B1 proteinPMID:23814014
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