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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2834
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hsd11b1
Name: hydroxysteroid 11-beta dehydrogenase 1
Acc ID: CHEBI:9907
Term: ursodeoxycholic acid
Definition: A bile acid found in the bile of bears (Ursidae) as a conjugate with taurine. Used therapeutically, it prevents the synthesis and absorption of cholesterol and can lead to the dissolution of gallstones.
Chemical ID: MESH:D014580
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hsd11b1increases abundanceISOHsd11b1 (Mus musculus)6480464CTDHSD11B1 gene mutant form results in increased abundance of Ursodeoxycholic AcidPMID:25061560
Hsd11b1multiple interactionsISOHSD11B1 (Homo sapiens)6480464CTD[HSD11B1 protein results in increased reduction of 7-ketolithocholic acid] which results in increased chemical synthesis of Ursodeoxycholic AcidPMID:21453287
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