GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Hsd11b1 | affects response to substance | EXP | | 6480464 | CTD | HSD11B1 protein affects the susceptibility to Cortisone | PMID:22606287 | Hsd11b1 | increases expression | EXP | | 6480464 | CTD | Cortisone results in increased expression of HSD11B1 mRNA | PMID:30993381 | Hsd11b1 | multiple interactions | EXP | | 6480464 | CTD | [HSD11B1 protein affects the susceptibility to Cortisone] which results in decreased activity of NFE2L2 protein; [HSD11B1 protein co-treated with Cortisone] results in decreased expression of NQO1 mRNA; Cortisone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA] | PMID:22606287 PMID:30993381 | Hsd11b1 | affects metabolic processing | ISO | HSD11B1 (Homo sapiens) | 6480464 | CTD | HSD11B1 protein affects the metabolism of Cortisone | PMID:16054388 | Hsd11b1 | increases expression | ISO | Hsd11b1 (Mus musculus) | 6480464 | CTD | Cortisone results in increased expression of HSD11B1 mRNA | PMID:24135201 | Hsd11b1 | increases metabolic processing | ISO | HSD11B1 (Homo sapiens) | 6480464 | CTD | HSD11B1 protein results in increased metabolism of Cortisone | PMID:16751407 | Hsd11b1 | increases reduction | ISO | HSD11B1 (Homo sapiens) | 6480464 | CTD | HSD11B1 protein results in increased reduction of Cortisone | PMID:26859423 | Hsd11b1 | multiple interactions | ISO | Hsd11b1 (Mus musculus) | 6480464 | CTD | 2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Cortisone results in increased expression of and results in increased activity of HSD11B1 protein]; Cortisone results in increased expression of and results in increased activity of HSD11B1 protein | PMID:21315688 | Hsd11b1 | multiple interactions | ISO | HSD11B1 (Homo sapiens) | 6480464 | CTD | [Calcitriol co-treated with Cortisone] results in increased expression of HSD11B1 mRNA; [HSD11B1 protein results in increased activity of Cortisone] inhibits the reaction [sulforaphane results in increased activity of NFE2L2 protein]; [HSD11B1 protein results in increased oxidation of Hydrocortisone] which results in increased chemical synthesis of Cortisone; [HSD11B1 protein results in increased reduction of Cortisone] which results in increased chemical synthesis of Hydrocortisone; [Mifepristone binds to and results in decreased activity of NR3C1 protein] inhibits the reaction [[HSD11B1 protein results in increased activity of Cortisone] inhibits the reaction [sulforaphane results in increased activity of NFE2L2 protein]] | PMID:19918113 PMID:22606287 PMID:26859423 | | ||||||||||||||||||||||
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